Respiratory System

Nose - Turbinate - Hyperostosis

    Narrative
    Nose, Turbinate - Hyperostosis in a male B6C3F1/N mouse from a chronic study. Thickening of the turbinate bone is present.
    Nose, Turbinate - Hyperostosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Numerous empty lacunae and reversal lines are present in the thickened turbinate bone.
    Nose, Turbinate - Hyperostosis in a male B6C3F1/N mouse from a chronic study. In addition to turbinate bone thickening, there is thickening of the bone in the nasal septum and atrophy of the olfactory mucosa.
    Nose, Turbinate - Hyperostosis in a male F344/N rat from a chronic study. There is atrophy of some turbinates (arrows) and hyperostosis of others.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC