Focal collections of mast cells can occasionally be found in the submucosa of the stomach. Mast cells have been shown to contribute importantly to acute allergic reactions, late-phase reactions, and chronic allergic inflammation. Focal accumulations of mast cells in the submucosa of the gastrointestinal tract are usually considered an incidental lesion in NTP studies. Such accumulations may be confused with mast cell tumor. Focal accumulations of mast cells tend to be smaller and less well circumscribed than mast cell tumors and infiltrate between structures rather than compressing or effacing adjacent structures.
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