Alimentary System

Esophagus - Ulcer

    Narrative
    Esophagus - Ulcer in a female F344/N rat from a chronic study. A portion of the epithelium is missing (arrow).
    Esophagus - Ulcer in a female F344/N rat from a chronic study. A portion of the epithelium is missing (arrow).
    Esophagus - Ulcer in a female F344/N rat from a chronic study (higher magnification of Figure 1). The ulcerated region (arrow) is flanked by a region with regeneration (arrowhead).
    Esophagus - Ulcer in a female F344/N rat from a chronic study (higher magnification of Figure 1). The ulcerated region (arrow) is flanked by a region with regeneration (arrowhead).
    Esophagus - Ulcer in a female F344/N rat from a chronic study. A portion of the epithelium is missing (arrow), and only the overlying keratin remains.
    Esophagus - Ulcer in a female F344/N rat from a chronic study. A portion of the epithelium is missing (arrow), and only the overlying keratin remains.
    Esophagus - Ulcer in a female F344/N rat from a chronic study (higher magnification of Figure 3). The denuded epithelium is replaced by necrotic debris and inflammatory cells (arrow).
    Esophagus - Ulcer in a female F344/N rat from a chronic study (higher magnification of Figure 3). The denuded epithelium is replaced by necrotic debris and inflammatory cells (arrow).
    Esophagus - Ulcer in a female F344/N rat from a chronic study (higher magnification of Figure 4). The denuded epithelium is replaced by necrotic debris and inflammatory cells (arrow).
    Esophagus - Ulcer in a female F344/N rat from a chronic study (higher magnification of Figure 4). The denuded epithelium is replaced by necrotic debris and inflammatory cells (arrow).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC