Endocrine System

Adrenal Gland, Cortex - Cellular Atypia

    Narrative
    Adrenal gland, Cortex - Cellular atypia in a female F344/N rat from a chronic study. There is a focal area in the inner cortex (arrows) with scattered cells with enlarged, pleomorphic, irregular nuclei.
    Adrenal gland, Cortex - Cellular atypia in a female F344/N rat from a chronic study. There is a focal area in the inner cortex (arrows) with scattered cells with enlarged, pleomorphic, irregular nuclei.
    Adrenal gland, Cortex - Cellular atypia in a female F344/N rat from a chronic study (higher magnification of Figure 1). Enlarged cortical cells (arrows) have large, pleomorphic, irregular nuclei.
    Adrenal gland, Cortex - Cellular atypia in a female F344/N rat from a chronic study (higher magnification of Figure 1). Enlarged cortical cells (arrows) have large, pleomorphic, irregular nuclei.
    Adrenal gland, Cortex - Cellular atypia in a male F344/N rat from a chronic study. There is a focus of enlarged cells with large, pleomorphic nuclei (arrows).
    Adrenal gland, Cortex - Cellular atypia in a male F344/N rat from a chronic study. There is a focus of enlarged cells with large, pleomorphic nuclei (arrows).

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC