Reproductive System, Male

Testis, Germinal Epithelium - Degeneration

    Narrative
    Testis, Germinal epithelium - Degeneration in a male F344/N rat from a chronic study. Various degenerative changes are present in multiple seminiferous tubules.
    Testis, Germinal epithelium - Degeneration in a male F344/N rat from a chronic study. This figure shows disorganized arrangement of germ cells in seminiferous tubules.
    Testis, Germinal epithelium - Degeneration in a male B6C3F1/N mouse from a subchronic study. Degeneration is characterized by disorganized arrangement of germ cells in seminiferous tubules, vacuolation, and the presence of multinucleated germ cells.
    Testis, Germinal epithelium - Degeneration in a male B6C3F1/N mouse from a subchronic study. A normal spectrum of germ cells is absent in seminiferous tubules owing to germ cell depletion.
    Testis, Germinal epithelium - Degeneration in a male BALB/c mouse 12 hours after exposure. Germ-cell-specific degeneration affecting dividing spermatocytes in a stage XII seminiferous tubule.
    Testis, Germinal epithelium - Degeneration in a male BALB/c mouse 12 hours after exposure. Germ-cell-specific degeneration of pachytene spermatocytes in a stage X tubule (asterisk).

    Authors

    Dianne M. Creasy, PhD, Dip RCPath, FRCPath
    Dianne Creasy Consulting LLC
    Pipersville, PA

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Dipak K. Giri, DVM, PHD, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC