Atrophy of clitoral gland parenchyma is a spontaneous aging change in mice and rats. Atrophy also accompanies duct dilatation (Figure 1). Mild inflammatory cell infiltrate may also be associated with the reduction in glandular tissue. The hallmark of atrophy is a reduction in the amount of acinar tissue of the clitoral gland; individual acini are composed of small numbers of sebaceous cells containing variable amounts of dark eosinophilic secretory granules. Frequently the lateral ducts, distended by accumulated secretion, are prominent (Figure 2 and Figure 3). There is often an increase in the interstitial fibrous tissue (Figure 2, Figure 3, Figure 4, and Figure 5).
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National Toxicology Program. 1995. NTP TR-439. Toxicology and Carcinogenesis Studies of Methylphenidate Hydrochloride (CAS No. 298-59-9) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC.Abstract: https://ntp.niehs.nih.gov/go/6022
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