Endocrine System

Adrenal Gland - Extramedullary Hematopoiesis

    Narrative
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female F344/N rat from a chronic study. There is a focus of hematopoietic cells (arrow) in the cortex (zona fasciculata).
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female F344/N rat from a chronic study. There is a focus of hematopoietic cells (arrow) in the cortex (zona fasciculata).
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female F344/N rat from a chronic study (higher magnification of Figure 1). There is a focus of immature hematopoietic cells (arrow) in the sinusoids of the cortex (zona fasciculata).
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female F344/N rat from a chronic study (higher magnification of Figure 1). There is a focus of immature hematopoietic cells (arrow) in the sinusoids of the cortex (zona fasciculata).
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a male F344/N rat from a chronic study. There are multiple foci of hematopoietic cells (arrows) in the adrenal zona fasciculata.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a male F344/N rat from a chronic study. There are multiple foci of hematopoietic cells (arrows) in the adrenal zona fasciculata.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a male F344/N rat from a chronic study (higher magnification of Figure 3). There is a focus of immature hematopoietic cells (arrow) within the sinusoids of the zona fasciculata.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a male F344/N rat from a chronic study (higher magnification of Figure 3). There is a focus of immature hematopoietic cells (arrow) within the sinusoids of the zona fasciculata.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female B6C3F1/N mouse from a chronic study. There are several foci of hematopoietic cells (arrows) at the corticomedullary junction.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female B6C3F1/N mouse from a chronic study. There are several foci of hematopoietic cells (arrows) at the corticomedullary junction.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 5). A focus of immature hematopoietic cells (arrow) is present at the corticomedullary junction.
    Adrenal gland, Cortex - Extramedullary hematopoiesis in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 5). A focus of immature hematopoietic cells (arrow) is present at the corticomedullary junction.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC