Nervous System
Brain - Mineralization
Narrative


On the other hand, mineral deposits, secondary to necrosis, are attributed to the commonly observed but complex process of dystrophic mineralization. Dystrophic mineralization is often seen as lamellar calcospherites found secondary to small clustered regions of neuronal necrosis at various neural sites, such as depicted in Figure 3





Figure 5

Eidelman N, Boyde A, Bushby AJ, Howell PGT, Sun J, Newbury DE, Miller FW, Robey PG, Rider LG. 2009. Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies. Arthritis Res Ther 11(5):R159.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19857267Kalueff A, Loseva E, Haapasalo H, Tuchimaa P. 2006. Thalamic mineralization in vitamin D receptor knock-out mice. Neuroreport 17:717-721.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16641675Landis WJ. 1996. Mineral characterization in calcifying tissues: Atomic, molecular and macromolecular perspectives. Connect Tissue Res 34:239-246.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9084632Morgan KT, Johnson BP, Frith CH, Townsend J. 1982. An ultrastructural study of spontaneous mineralization in the brains of ageing mice. Acta Neuropathol 58:120-124.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7180386Roach HI. 1992. Induction of normal and dystrophic mineralization by glycerophosphates in long-term bone organ culture. Calcif Tissue Int 50:553-563.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1525713Yanai T, Yamoto T, Manabe J, Takaoka M, Matsunuma N. 1987. X-ray microanalysis of mineralization in the thalamus of aged mice. Jap J Vet Sci 49:920-922.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/3682532Incidental thalamic mineralization in a female F344/N rat from a 16-week study. The arrows identify focal mineral deposits.