Respiratory System

Nose, Olfactory Epithelium - Metaplasia, Respiratory

    Narrative
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a female B6C3F1/N mouse from a chronic study. There is replacement of olfactory epithelium by ciliated, respiratory epithelium.
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a female B6C3F1/N mouse from a chronic study. There is replacement of olfactory epithelium by ciliated, respiratory epithelium.
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a treated male B6C3F1/N mouse (left) and normal olfactory epithelium from a control male B6C3F1/N mouse from a subchronic study (right). The olfactory epithelium of the treated mouse has been replaced by respiratory epithelium. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a treated male B6C3F1/N mouse (left) and normal olfactory epithelium from a control male B6C3F1/N mouse from a subchronic study (right). The olfactory epithelium of the treated mouse has been replaced by respiratory epithelium. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a male B6C3F1/N mouse from a chronic study. The olfactory mucosa has been completely replaced by respiratory epithelium, and there is concurrent atrophy of the olfactory nerves. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a male B6C3F1/N mouse from a chronic study. The olfactory mucosa has been completely replaced by respiratory epithelium, and there is concurrent atrophy of the olfactory nerves. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a control B6C3F1/N mouse from a chronic study. There is localized replacement of the olfactory mucosa by respiratory epithelial cells (arrow) and dilation of Bowman's glands. Image provided courtesy of Dr. R. Miller., basic_html
    Nose, Olfactory epithelium - Metaplasia, Respiratory in a control B6C3F1/N mouse from a chronic study. There is localized replacement of the olfactory mucosa by respiratory epithelial cells (arrow) and dilation of Bowman's glands. Image provided courtesy of Dr. R. Miller., basic_html

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC