Immune System

Spleen - Inflammation

    Narrative
    Spleen - Inflammation, Suppurative in a male F344/N rat from a chronic study. Suppurative inflammation (arrow) borders a large focus of bacteria (arrowhead) within the splenic red pulp.
    Spleen - Inflammation, Suppurative in a male F344/N rat from a chronic study. Suppurative inflammation (arrow) borders a large focus of bacteria (arrowhead) within the splenic red pulp.
    Spleen - Inflammation, Suppurative in a male F344/N rat from a chronic study (higher magnification of Figure 1). Bands of degenerate neutrophils admixed with necrotic cellular debris (arrow) surround the bacteria colonies (arrowhead).
    Spleen - Inflammation, Suppurative in a male F344/N rat from a chronic study (higher magnification of Figure 1). Bands of degenerate neutrophils admixed with necrotic cellular debris (arrow) surround the bacteria colonies (arrowhead).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC