Alimentary System

Tooth - Fibrosis

    Narrative
    Tooth - Fibrosis in a female Harlan Sprague-Dawley rat from a chronic study. There is fibrosis within the alveolar bone and a possible sequestrum of bone or osteodentin (arrow).
    Tooth - Fibrosis in a female Harlan Sprague-Dawley rat from a chronic study. There is fibrosis within the alveolar bone and a possible sequestrum of bone or osteodentin (arrow).
    Tooth - Fibrosis in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). There is fibrosis within the alveolar bone and a possible sequestrum of bone or osteodentin (arrow).
    Tooth - Fibrosis in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). There is fibrosis within the alveolar bone and a possible sequestrum of bone or osteodentin (arrow).
    Tooth - Fibrosis in a female B6C3F1 mouse from a chronic study. Fibrosis has replaced much of the alveolar bone.
    Tooth - Fibrosis in a female B6C3F1 mouse from a chronic study. Fibrosis has replaced much of the alveolar bone.
    Tooth - Fibrosis in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 3). Fibrosis with inflammatory cells has replaced much of the alveolar bone.
    Tooth - Fibrosis in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 3). Fibrosis with inflammatory cells has replaced much of the alveolar bone.

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC