Alimentary System

Oral Mucosa - Necrosis

    Narrative
    Oral mucosa - Necrosis in a male F344/N rat from a subchronic study. There is necrosis of the epithelium on the hard palate (arrow).
    Oral mucosa - Necrosis in a male F344/N rat from a subchronic study. There is necrosis of the epithelium on the hard palate (arrow).
    Oral mucosa - Necrosis in a male F344/N rat from a subchronic study (higher magnification of Figure 1). There is necrosis of the epithelium on the hard palate mucosa, with bacterial colonies in the submucosa (arrow).
    Oral mucosa - Necrosis in a male F344/N rat from a subchronic study (higher magnification of Figure 1). There is necrosis of the epithelium on the hard palate mucosa, with bacterial colonies in the submucosa (arrow).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC