Reproductive System, Female

Ovary - Atrophy

    Narrative
    Ovary - Atrophy in a female F344/N rat from a chronic study. The ovary is small and lacking follicles and corpora lutea.
    Ovary - Atrophy in a female F344/N rat from a chronic study. The ovary is small and lacking follicles and corpora lutea.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 1). Few follicles are evident.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 1). Few follicles are evident.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 1). There are few follicles, and no corpora lutea is present.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 1). There are few follicles, and no corpora lutea is present.
    Ovary - Atrophy in a female F344/N rat from a chronic study. The ovary is small and lacks follicles and corpora lutea.
    Ovary - Atrophy in a female F344/N rat from a chronic study. The ovary is small and lacks follicles and corpora lutea.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 4). There are pigmented interstitial cells, an atretic follicle, and lack of corpora lutea.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 4). There are pigmented interstitial cells, an atretic follicle, and lack of corpora lutea.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 4). There are pigmented interstitial cells and residual granulosa cells.
    Ovary - Atrophy in a female F344/N rat from a chronic study (higher magnification of Figure 4). There are pigmented interstitial cells and residual granulosa cells.

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC