Musculoskeletal System

Bone - Physeal Dysplasia

    Narrative
    Bone - Physeal dysplasia in a male F344/N rat from a subchronic study. The cartilaginous growth plate is thickened and disorganized.
    Bone - Physeal dysplasia in a male F344/N rat from a subchronic study. The cartilaginous growth plate is thickened and disorganized.
    Bone - Physeal dysplasia in a male F344/N rat from a subchronic study. The growth plate is irregular and disorganized, and there is a focal area of chondrocyte hypertrophy and hyperplasia (arrow).
    Bone - Physeal dysplasia in a male F344/N rat from a subchronic study. The growth plate is irregular and disorganized, and there is a focal area of chondrocyte hypertrophy and hyperplasia (arrow).
    Bone - Physeal dysplasia in a male F344/N rat from a subchronic study (higher magnification of Figure 2). There is focal area of chondrocyte hyperplasia, hypertrophy, and disorganization.
    Bone - Physeal dysplasia in a male F344/N rat from a subchronic study (higher magnification of Figure 2). There is focal area of chondrocyte hyperplasia, hypertrophy, and disorganization.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC