Cardiovascular System

Heart - Amyloid

    Narrative
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study. Multiple amyloid plaques (arrows) are present in the myocardium.
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study. Multiple amyloid plaques (arrows) are present in the myocardium.
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study (higher magnification Figure 1). The amyloid (arrows) is composed of acellular, eosinophilic material.
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study (higher magnification Figure 1). The amyloid (arrows) is composed of acellular, eosinophilic material.
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study. Multiple pale areas contain amyloid (arrows).
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study. Multiple pale areas contain amyloid (arrows).
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study (higher magnification of Figure 3). Coalescing areas of pale, eosinophilic, homogeneous amyloid are present (arrows).
    Heart - Amyloid in a male Swiss Webster mouse from a chronic study (higher magnification of Figure 3). Coalescing areas of pale, eosinophilic, homogeneous amyloid are present (arrows).

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC