Nervous System

Brain - Hydrocephalus

    An example of bilateral noncommunicating, obstructive hydrocephalus of the lateral ventricles (arrows) in a male F344/N rat from a chronic study. It is secondary to a pituitary neoplasm (arrowhead) compressing and distorting the diencephalon while obstructing the ventral aspect of the third ventricle.
    The effect of obstructive hydrocephalic ventricular expansion, leading to flattened attenuation of normally cuboidal ependymal cells (arrow), in a female F344/N rat from a chronic study.


    Peter Little, DVM, MS, PhD, DACVP
    Neuropathology Consultant
    Experimental Pathology Laboratories, Inc.  
    Research Triangle Park, NC

    Deepa B. Rao, BVSc, MS, PhD, DABT, DACVP
    NTP Pathologist (Contractor)
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC


    James P. Morrison, DVM, DACVP
    Scientific Director
    Charles River Laboratories, Pathology Associates
    Research Triangle Park, NC

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC