Endocrine System

Pancreatic Islets - Hypoplasia

    Narrative
    Pancreatic islet - hypoplasia. One small hypoplastic islet is present in the pancreas in a female F344/N rat from a chronic study.
    Pancreatic islet - hypoplasia. One small hypoplastic islet is present in the pancreas in a female F344/N rat from a chronic study.
    Pancreatic islet - hypoplasia. Higher magnification of the hypoplastic islet shown in Figure 1 in a female F344/N rat from a chronic study.
    Pancreatic islet - hypoplasia. Higher magnification of the hypoplastic islet shown in Figure 1 in a female F344/N rat from a chronic study.
    Pancreatic islet - hypoplasia. Another hypoplastic islet in the same female F344/N rat from a chronic study as shown in Figures 1 and 2.
    Pancreatic islet - hypoplasia. Another hypoplastic islet in the same female F344/N rat from a chronic study as shown in Figures 1 and 2.
    Pancreatic islet - hypoplasia. Islet hypoplasia diagnosed in a treated female F344/N rat from a chronic study: only a single hypoplastic islet (arrow) is present within a large sampling of pancreas.
    Pancreatic islet - hypoplasia. Islet hypoplasia diagnosed in a treated female F344/N rat from a chronic study: only a single hypoplastic islet (arrow) is present within a large sampling of pancreas.

    Authors

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist
    Assistant Pathology Program Manager
    Integrated Laboratory Systems, Inc. Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC