Immune System

Spleen - Adipocyte Metaplasia

    Narrative
    Spleen - Adipocyte metaplasia in a female F344/N rat from a chronic study. Well-differentiated adipocytes (arrow) are present multifocally within the splenic red pulp.
    Spleen - Adipocyte metaplasia in a female F344/N rat from a chronic study. Well-differentiated adipocytes (arrow) are present multifocally within the splenic red pulp.
    Spleen - Adipocyte metaplasia in a female F344/N rat from a chronic study (higher magnification of Figure 1). Adipocytes (arrow) are surrounded by a fibrous stroma (arrowhead).
    Spleen - Adipocyte metaplasia in a female F344/N rat from a chronic study (higher magnification of Figure 1). Adipocytes (arrow) are surrounded by a fibrous stroma (arrowhead).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC