Respiratory System

Nose, Epithelium - Hyperplasia, Atypical

    Narrative
    Nose, Respiratory epithelium - Hyperplasia, Atypical in a male B6C3F1/N mouse from a chronic study. An abnormal proliferation of basal cells has replaced respiratory epithelium on the turbinate.
    Nose, Respiratory epithelium - Hyperplasia, Atypical in a male B6C3F1/N mouse from a chronic study. An abnormal proliferation of basal cells has replaced respiratory epithelium on the turbinate.
    Nose, Respiratory epithelium - Hyperplasia, Atypical in a female B6C3F1/N mouse from a chronic study. Proliferation of atypical and poorly organized epithelium is present on the turbinate.
    Nose, Respiratory epithelium - Hyperplasia, Atypical in a female B6C3F1/N mouse from a chronic study. Proliferation of atypical and poorly organized epithelium is present on the turbinate.
    Nose, Squamous epithelium - Hyperplasia, Atypical in a female Osborne Mendel rat from a chronic study. There is some disorganization of the squamous cells and rete peg-like structures.
    Nose, Squamous epithelium - Hyperplasia, Atypical in a female Osborne Mendel rat from a chronic study. There is some disorganization of the squamous cells and rete peg-like structures.
    Nose, Olfactory epithelium - Hyperplasia, Atypical in a male F344/N rat from a chronic study. Nests of proliferative cells (arrows) have extended beneath the basement membrane.
    Nose, Olfactory epithelium - Hyperplasia, Atypical in a male F344/N rat from a chronic study. Nests of proliferative cells (arrows) have extended beneath the basement membrane.
    Nose, Olfactory epithelium - Hyperplasia, Atypical in a male F344/N rat from a chronic study. A proliferative band of neuronal-like cells is present beneath the basement membrane, and the overlying olfactory epithelium is disorganized.
    Nose, Olfactory epithelium - Hyperplasia, Atypical in a male F344/N rat from a chronic study. A proliferative band of neuronal-like cells is present beneath the basement membrane, and the overlying olfactory epithelium is disorganized.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC