Immune System

Lymph Node - Hyperplasia, Lymphocyte

    Narrative
    Lymph node - Hyperplasia, Lymphocyte in a male F344/N rat from a subchronic study. The lymph node paracortex is expanded by increased numbers of lymphocytes (arrow).
    Lymph node - Hyperplasia, Lymphocyte in a male F344/N rat from a subchronic study. The lymph node paracortex is expanded by increased numbers of lymphocytes (arrow).
    Lymph node - Hyperplasia, Lymphocyte in a male F344/N rat from a subchronic study (higher magnification of Figure 1). The density of paracortical lymphocytes is increased (arrow), and the number of lymphocytes is increased within the subendothelial venules (arrowhead).
    Lymph node - Hyperplasia, Lymphocyte in a male F344/N rat from a subchronic study (higher magnification of Figure 1). The density of paracortical lymphocytes is increased (arrow), and the number of lymphocytes is increased within the subendothelial venules (arrowhead).
    Lymph node - Hyperplasia, Lymphocyte in a male B6C3F1/N mouse from a subchronic study. The paracortical regions are diffusely expanded (arrows).
    Lymph node - Hyperplasia, Lymphocyte in a male B6C3F1/N mouse from a subchronic study. The paracortical regions are diffusely expanded (arrows).
    Lymph node - Hyperplasia, Lymphocyte in a male B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). The paracortical region is expanded by lymphocytes, and there is some lymphocyte hyperplasia within the medullary cords (arrows).
    Lymph node - Hyperplasia, Lymphocyte in a male B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). The paracortical region is expanded by lymphocytes, and there is some lymphocyte hyperplasia within the medullary cords (arrows).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC