Nervous System

Brain - Inflammation

    Brain, cerebellum, leptomeninges-accumulation of acute inflammatory cells (arrow) in the leptomeninges of the cerebellum, subsequent to septicemia, resulting in acute suppurative meningitis, in a female B6C3F1 mouse.
    Brain, cerebellum, leptomeninges-inflammation in a female B6C3F1 mouse (higher magnification of Figure 1).
    Leptomeninges-focal aggregation of lymphocytes in the leptomeninges in a female B6C3F1 mouse from a chronic study. In this case, it was an incidental finding.


    Peter Little, DVM, MS, PhD, DACVP
    Neuropathology Consultant
    Experimental Pathology Laboratories, Inc.  
    Research Triangle Park, NC

    Deepa B. Rao, BVSc, MS, PhD, DABT, DACVP
    NTP Pathologist (Contractor)
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC


    James P. Morrison, DVM, DACVP
    Scientific Director
    Charles River Laboratories, Pathology Associates
    Research Triangle Park, NC

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC