Immune System

Lymph Node - Inflammation

    Narrative
    Lymph node - Inflammation, Suppurative in a male F344/N rat from a chronic study. Lymph node is focally expanded by a suppurative exudate.
    Lymph node - Inflammation, Suppurative in a male F344/N rat from a chronic study. Lymph node is focally expanded by a suppurative exudate.
    Lymph node - Inflammation, Suppurative in a male F344/N rat from a chronic study (higher magnification of Figure 1). The suppurative exudate consists of degenerate neutrophils (arrows), cell debris, proteinaceous fluid, and fibrin.
    Lymph node - Inflammation, Suppurative in a male F344/N rat from a chronic study (higher magnification of Figure 1). The suppurative exudate consists of degenerate neutrophils (arrows), cell debris, proteinaceous fluid, and fibrin.
    Lymph node - Inflammation, Granulomatous in a female F344/N rat from a chronic study. The lymph node is infiltrated by sheets and aggregates of large, activated macrophages (arrow).
    Lymph node - Inflammation, Granulomatous in a female F344/N rat from a chronic study. The lymph node is infiltrated by sheets and aggregates of large, activated macrophages (arrow).
    Lymph node - Inflammation, Granulomatous in a female F344/N rat from a chronic study (higher magnification of Figure 3). Multiple aggregates of macrophages (arrows) are admixed with mature lymphocytes.
    Lymph node - Inflammation, Granulomatous in a female F344/N rat from a chronic study (higher magnification of Figure 3). Multiple aggregates of macrophages (arrows) are admixed with mature lymphocytes.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC