Alimentary System

Salivary Gland, Duct - Concretion

    Narrative
    Salivary gland, Duct - Concretion in a female F344/N rat from a subchronic study. The relatively large concretion (arrow) is obstructing and expanding a salivary duct.
    Salivary gland, Duct - Concretion in a female F344/N rat from a subchronic study. The relatively large concretion (arrow) is obstructing and expanding a salivary duct.
    Salivary gland, Duct - Concretion in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The concretion became fragmented during processing.
    Salivary gland, Duct - Concretion in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The concretion became fragmented during processing.
    Salivary gland, Duct - Concretion in a male B6C3F1 mouse from a subchronic study. There is a basophilic concretion (arrow) in a salivary duct.
    Salivary gland, Duct - Concretion in a male B6C3F1 mouse from a subchronic study. There is a basophilic concretion (arrow) in a salivary duct.
    Salivary gland, Duct - Concretion in a male B6C3F1 mouse from a subchronic study (higher magnification of Figure 3). The concretion is eliciting a chronic inflammatory response around the duct with fibrosis.
    Salivary gland, Duct - Concretion in a male B6C3F1 mouse from a subchronic study (higher magnification of Figure 3). The concretion is eliciting a chronic inflammatory response around the duct with fibrosis.
    Salivary gland, Duct - Concretion in a female F344/N rat from an acute study. There is a basophilic concretion (arrow) in a salivary duct.
    Salivary gland, Duct - Concretion in a female F344/N rat from an acute study. There is a basophilic concretion (arrow) in a salivary duct.
    Salivary gland, Duct - Concretion in a female F344/N rat from an acute study (higher magnification of Figure 5). The concretion is eliciting a chronic inflammatory response around the duct with fibrosis.�
    Salivary gland, Duct - Concretion in a female F344/N rat from an acute study (higher magnification of Figure 5). The concretion is eliciting a chronic inflammatory response around the duct with fibrosis.�

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC