Hematopoietic System

Bone Marrow - Necrosis

    Narrative
    Bone marrow necrosis in a female B6C3F1 mouse from a chronic study (low magnification).
    Bone marrow necrosis in a female B6C3F1 mouse from a chronic study (low magnification).
    Bone marrow in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1) showing bone marrow necrosis characterized by remnants of hematopoietic cells with indistinct borders, nuclear pyknosis, karyolysis, and karyorrhexis.
    Bone marrow in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1) showing bone marrow necrosis characterized by remnants of hematopoietic cells with indistinct borders, nuclear pyknosis, karyolysis, and karyorrhexis.
    Bone marrow in male B6C3F1 mouse from a chronic study (low magnification), showing a large well-demarcated eosinophilic area representing necrosis (asterisk). Arrows represent the line of demarcation between viable cells and the area of necrosis.
    Bone marrow in male B6C3F1 mouse from a chronic study (low magnification), showing a large well-demarcated eosinophilic area representing necrosis (asterisk). Arrows represent the line of demarcation between viable cells and the area of necrosis.
    Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3), showing the area of necrosis (asterisk) and the line of demarcation (arrows) between the viable cells and the area of necrosis.
    Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3), showing the area of necrosis (asterisk) and the line of demarcation (arrows) between the viable cells and the area of necrosis.
    Bone marrow in a male B6C3F1 mouse from a chronic study (low magnification), showing normal hematopoietic cells (white asterisk) transitioning to a large area of necrosis characterized by loss of cellular detail and areas of amorphous eosinophilic debris (black asterisk).
    Bone marrow in a male B6C3F1 mouse from a chronic study (low magnification), showing normal hematopoietic cells (white asterisk) transitioning to a large area of necrosis characterized by loss of cellular detail and areas of amorphous eosinophilic debris (black asterisk).

    Authors

    Michelle C. Cora, DVM, DACVP
    Veterinary Medical Officer
    NTP Clinical Pathologist
    NTP Clinical Pathology Group
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Gregory Travlos, DVM, DACVP
    Group Leader, Clinical Pathology Group
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Armando R. Irizarry, DVM, PHD, DACVP
    Adjunct Associate Professor of Veterinary Anatomic and Clinical Pathology
    Department of Comparative Pathobiology
    Purdue University College of Veterinary Medicine
    West Lafayette, IN

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC