Alimentary System

Salivary Gland - Hyperplasia

    Narrative
    Normal submandibular salivary gland in a male F344/N rat from a subchronic study.
    Normal submandibular salivary gland in a male F344/N rat from a subchronic study.
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a subchronic study. There is an increase in the number of ductular epithelial cells within the gland (arrows).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a subchronic study. There is an increase in the number of ductular epithelial cells within the gland (arrows).
    Normal salivary gland in a male F344/N rat from a subchronic study (higher magnification of Figure 1).
    Normal salivary gland in a male F344/N rat from a subchronic study (higher magnification of Figure 1).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a subchronic study (higher magnification of Figure 2). There is an increase in the number of ductular epithelial cells within the gland (arrows).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a subchronic study (higher magnification of Figure 2). There is an increase in the number of ductular epithelial cells within the gland (arrows).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a chronic study. There is an increase in the number of ductal profiles within the gland. One duct is dilated and has an increased number of epithelial cells (arrow).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a chronic study. There is an increase in the number of ductal profiles within the gland. One duct is dilated and has an increased number of epithelial cells (arrow).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a chronic study (higher magnification of Figure 5). There is an increase in the number of ductal profiles within the gland. One duct is dilated and has an increased number of epithelial cells (arrow).
    Salivary gland, Sublingual, Duct - Hyperplasia in a male F344/N rat from a chronic study (higher magnification of Figure 5). There is an increase in the number of ductal profiles within the gland. One duct is dilated and has an increased number of epithelial cells (arrow).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC