Musculoskeletal System

Bone, Joint - Degeneration

    Narrative
    Bone, Joint - Degeneration in a female F344/N rat from a chronic study. The articular surface of the femorotibial joint is roughened and contains clefts (arrow).
    Bone, Joint - Degeneration in a female F344/N rat from a chronic study. The articular surface of the femorotibial joint is roughened and contains clefts (arrow).
    Bone, Joint - Degeneration in a female F344/N rat from a chronic study (higher magnification of Figure 1). There is roughening and cleft formation of the articular surface and thickening of the subchondral bone.
    Bone, Joint - Degeneration in a female F344/N rat from a chronic study (higher magnification of Figure 1). There is roughening and cleft formation of the articular surface and thickening of the subchondral bone.
    Bone, Joint - Degeneration in a male B6C3F1/N mouse from a chronic study. The synovial lining of the femorotibial joint is hyperplastic.
    Bone, Joint - Degeneration in a male B6C3F1/N mouse from a chronic study. The synovial lining of the femorotibial joint is hyperplastic.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC