Immune System

Spleen - Extramedullary Hematopoiesis

    Narrative
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N mouse from a chronic study. The red pulp is markedly expanded by numerous hematopoietic cells (arrow).
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N mouse from a chronic study. The red pulp is markedly expanded by numerous hematopoietic cells (arrow).
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Extramedullary hematopoiesis in this case includes increased numbers of erythroid (arrow) and myeloid (arrowhead) precursor cells.
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Extramedullary hematopoiesis in this case includes increased numbers of erythroid (arrow) and myeloid (arrowhead) precursor cells.
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N from a chronic study. The red pulp is markedly expanded by numerous hematopoietic cells, including megakaryocytes (arrow).
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N from a chronic study. The red pulp is markedly expanded by numerous hematopoietic cells, including megakaryocytes (arrow).
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N from a chronic study (higher magnification of Figure 3). Increased extramedullary hematopoiesis also includes increased numbers of erythroid (arrow) and myeloid (arrowhead) precursor cells.
    Spleen, Red pulp - Extramedullary hematopoiesis, Increased in a treated male B6C3F1/N from a chronic study (higher magnification of Figure 3). Increased extramedullary hematopoiesis also includes increased numbers of erythroid (arrow) and myeloid (arrowhead) precursor cells.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC