Urinary System
Kidney - Inflammation
Narrative
Comment:
In NTP studies, there are five standard categories of inflammation, according to the predominant inflammatory cell type present: acute, suppurative, chronic, chronic active, and granulomatous. In
).
Renal tubule inflammation (tubulitis) (Figure 1
and Figure 2) may be associated with a number of causes that may include the deposition of crystals, extension from the lower urinary tract (pyelonephritis), infectious processes, chronic progressive nephropathy, previous infarction, or direct chemical administration. Tubule inflammation is characterized by the presence of inflammatory cells within the tubule lumen, epithelium, or both.
Inflammation can also be localized to the renal pelvis (Figure 3, Figure 4, Figure 5, and Figure 6) or the interstitium (Figure 7 and Figure 8). Renal pelvis inflammation usually arises from conditions related to localized infections, which ascend from the lower urinary tract and extend into the renal papilla, medulla, and cortex. However, renal pelvis inflammation without lower urinary tract involvement may also be seen. There may be a number of causes for inflammation. Renal pelvis inflammation typically is acute or suppurative, with more chronic lesions noted in peripelvic tissues. Another diagnostic term occasionally used by pathologists to describe a similar condition is "pyelonephritis," which emphasizes renal involvement along with pelvis inflammation. Microabscesses may be noted in marked cases, due to either an ascending infection or a coinciding septicemic infection. Renal papillary ulceration and/or necrosis may occur as a result of renal pelvis inflammation. Reactive urothelial and/or papillary epithelial hyperplasia are often noted in more chronic cases. Interstitial inflammation, a cellular reaction to tissue injury from a variety of causes, may be observed frequently in the kidney of rodents. Chronic interstitial inflammation is often seen as a component of chronic progressive nephropathy (see
).
Renal tubule inflammation (tubulitis) (Figure 1
and Figure 2) may be associated with a number of causes that may include the deposition of crystals, extension from the lower urinary tract (pyelonephritis), infectious processes, chronic progressive nephropathy, previous infarction, or direct chemical administration. Tubule inflammation is characterized by the presence of inflammatory cells within the tubule lumen, epithelium, or both.Inflammation can also be localized to the renal pelvis (Figure 3
, Figure 4, Figure 5, and Figure 6) or the interstitium (Figure 7 and Figure 8). Renal pelvis inflammation usually arises from conditions related to localized infections, which ascend from the lower urinary tract and extend into the renal papilla, medulla, and cortex. However, renal pelvis inflammation without lower urinary tract involvement may also be seen. There may be a number of causes for inflammation. Renal pelvis inflammation typically is acute or suppurative, with more chronic lesions noted in peripelvic tissues. Another diagnostic term occasionally used by pathologists to describe a similar condition is "pyelonephritis," which emphasizes renal involvement along with pelvis inflammation. Microabscesses may be noted in marked cases, due to either an ascending infection or a coinciding septicemic infection. Renal papillary ulceration and/or necrosis may occur as a result of renal pelvis inflammation. Reactive urothelial and/or papillary epithelial hyperplasia are often noted in more chronic cases. Interstitial inflammation, a cellular reaction to tissue injury from a variety of causes, may be observed frequently in the kidney of rodents. Chronic interstitial inflammation is often seen as a component of chronic progressive nephropathy (see
).Recommendations:
Inflammation in the kidney should be diagnosed and graded when it is a primary lesion or is severe enough to warrant a separate diagnosis. The diagnosis should include a site modifier (e.g., interstitium, renal tubule, glomerulus) and the type of inflammation (e.g., acute, chronic, chronic active). Inflammatory reactions in the glomerulus should be diagnosed as glomerulonephritis and are covered in a separate document (see
). The pathologist should use his or her judgment in deciding whether or not secondary lesions such as necrosis or hemorrhage associated with inflammation are prominent enough to warrant a separate diagnosis. Inflammation as a component of chronic progressive nephropathy should not be diagnosed separately.
References:
Cattell V, Jennette JC. 1998. Mechanisms of acute inflammatory and immunologic renal injury. In: Heptistall’s Pathology of the Kidney (Jennette JC, Olson JL, Schwartz MM, Silva FG, eds). Lippincott-Raven, Philadelphia, 85-136.
Kidney, Renal tubule - Inflammation, Acute in a male F344/N rat from a chronic study. Acute inflammatory cells are present in the renal tubule.
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Kidney, Renal tubule - Inflammation, Acute in a male F344/N rat from a chronic study. Acute inflammatory cells are present in the renal tubule.
Kidney, Renal tubule - Inflammation, Acute in a female F344/N rat from a chronic study. Acute tubule inflammatory cells associated with extension from renal pelvis inflammation are present.
Kidney, Renal Pelvis - Inflammation, Chronic in a female F344/N rat from a chronic study. Inflammation involves the renal pelvis with infiltrates of inflammatory cells in the pelvis and peripelvic tissue; note the hyperplasia of the papillary epithelium and urothelium.
Kidney, Renal Pelvis - Inflammation, Acute in a male F344/N rat from a chronic study. Acute inflammation is present within the renal pelvis and along the renal papilla.
Kidney, Renal Pelvis - Inflammation, Suppurative in a male B6C3F1 mouse in a chronic study. Microabscesses may result from extension of renal pelvic inflammation into the renal medulla and cortex.
Kidney, Renal Pelvis - Inflammation, Acute in a female F344/N rat from a chronic study. Necrosis of the renal papilla may result from marked inflammation of the renal pelvis.
Kidney, Interstitium - Inflammation, Acute in a male F344/N rat from a chronic study. An acute interstitial inflammatory cell infiltrate and hemorrhage are present adjacent to the renal pelvis.
Kidney, Interstitium - Inflammation, Chronic in a female F344/N rat from a chronic study. An area of chronic interstitial inflammation is characterized by mononuclear inflammatory cell infiltrates and fibrosis.