Urinary System
Kidney - Nephropathy, Chronic Progressive
Narrative
Early lesions consist of focal to multifocal foci of tubule basophilia, nuclear crowding, peritubular basement membrane thickening, and variable infiltration by mononuclear inflammatory cells (Figure 1





CPN is often accompanied by hyperplasia of the lining epithelium of the renal papilla. It is important to know that in advanced stages of CPN, there may be a small but significant increase in the incidence of proliferative lesions of the proximal tubule. Nephropathy is a bilateral lesion and differing severities of nephropathy between the two kidneys is rarely noted.
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Full Text: https://www.jstage.jst.go.jp/article/tox/21/4/21_4_199/_pdfKidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. The early cases of chronic progressive nephropathy (CPN) occur as focal to multifocal areas of tubule basophilia with or without hyaline (protein) casts.