Urinary System

Kidney - Nephropathy, Chronic Progressive

    Narrative
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. The early cases of chronic progressive nephropathy (CPN) occur as focal to multifocal areas of tubule basophilia with or without hyaline (protein) casts.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. The early cases of chronic progressive nephropathy (CPN) occur as focal to multifocal areas of tubule basophilia with or without hyaline (protein) casts.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a chronic study. This is a more severe case of CPN with prominent hyaline casts.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a chronic study. This is a more severe case of CPN with prominent hyaline casts.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a chronic study. As the severity of CPN progresses, all components of CPN become more prominent, with nearly all of the renal parenchyma involved.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a chronic study. As the severity of CPN progresses, all components of CPN become more prominent, with nearly all of the renal parenchyma involved.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. CPN may become quite severe, leading to an "end-stage" kidney with little normal parenchyma remaining.
    Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. CPN may become quite severe, leading to an "end-stage" kidney with little normal parenchyma remaining.
    Kidney - Nephropathy, Chronic progressive in a male B6C3F1 mouse from a subchronic study. Though usually less severe, CPN has a similar appearance in mice.
    Kidney - Nephropathy, Chronic progressive in a male B6C3F1 mouse from a subchronic study. Though usually less severe, CPN has a similar appearance in mice.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC