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TDMS Study 92013-03 Pathology Tables

NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96
Route: DOSED FEED                                                                                                 Time: 20:40:33

                                                       90-DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  822-36-6

       Lock Date:  01/12/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:40:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 3            2            2            2            2                        
    Accidently Killed                                  7            8            7            8            8           10           

  Animals Examined Microscopically                    10            2            5           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (1)          (2)          (10)         (10)         (10)         
      Congestion                                                                 1 (50%)                                            
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (100%)     1 (50%)      1 (10%)                   1 (10%)     
      Inflammation, Focal                                                                                  1 (10%)      1 (10%)     
      Hepatocyte, Vacuolization Cytoplasmic                                                                1 (10%)      8 (80%)     
   Mesentery                                          (1)                                                                           
      Fat, Necrosis                                    1 (100%)                                                                     
   Pancreas                                           (10)                      (1)                                    (10)         
      Acinus, Degeneration, Focal                      1 (10%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                      (1)                                    (10)         
      Inflammation, Focal                                                                                               3 (30%)     
      Artery, Inflammation                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                      (1)                                    (10)         
      Pars Distalis, Cyst                              1 (10%)                                                                      
   Thyroid Gland                                      (10)                      (1)                                    (10)         
      Follicle, Cyst                                                                                                    1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:40:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                      (1)          (1)                       (10)         
      Cyst                                                                                    1 (100%)                              
      Bilateral, Cyst                                                                                                   1 (10%)     
      Bursa, Cyst                                      1 (10%)                                                                      
   Uterus                                             (10)                      (4)          (10)         (10)         (10)         
      Bilateral, Cyst                                                            1 (25%)                                            
      Bilateral, Dilatation                            3 (30%)                   3 (75%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                      (1)                                    (10)         
      Infiltration Cellular, Focal, Histiocyte         1 (10%)                                                                      
   Lymph Node, Mandibular                             (10)                      (1)                                    (9)          
      Hemorrhage                                                                                                        2 (22%)     
   Lymph Node, Mesenteric                             (10)                      (1)                                    (10)         
      Infiltration Cellular, Histiocyte                1 (10%)                                                                      
   Spleen                                             (10)                      (1)                                    (10)         
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Pigmentation, Diffuse                            2 (20%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (1)          (1)                       (5)          (10)         
      Congestion                                                                 1 (100%)                                           
      Inflammation, Focal                              5 (50%)      1 (100%)                               5 (100%)     2 (20%)     
   Nose                                               (10)                      (1)                                    (10)         
      Olfactory Epithelium, Inflammation,                                                                                           
          Suppurative                                                                                                   1 (10%)     
      Respiratory Epithelium, Inflammation,                                                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:40:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
          Suppurative                                                            1 (100%)                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:40:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9            9           10            3            2           
    Accidently Killed                                               1            1                         7            7           

  Animals Examined Microscopically                    10            3           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                      (10)         (10)         (10)         (9)          
      Inflammation, Focal                                                                     1 (10%)                               
      Hepatocyte, Vacuolization Cytoplasmic            1 (10%)                   3 (30%)     10 (100%)    10 (100%)     9 (100%)    
   Pancreas                                           (10)                                                             (9)          
      Acinus, Degeneration, Focal                                                                                       2 (22%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (9)          
      Inflammation, Focal                              3 (30%)                                                          4 (44%)     
      Artery, Inflammation                             1 (10%)                                                          1 (11%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)                                                             (10)         
      Hypospermia                                                                                                       9 (90%)     
   Prostate                                           (10)         (1)          (10)         (10)         (10)         (10)         
      Atrophy                                                       1 (100%)     1 (10%)      2 (20%)      8 (80%)      8 (80%)     
      Inflammation                                     2 (20%)                   3 (30%)                   1 (10%)      8 (80%)     
   Testes                                             (10)         (1)          (10)         (10)         (10)         (10)         
      Degeneration                                     1 (10%)      1 (100%)                  4 (40%)      9 (90%)      9 (90%)     
      Hypospermia                                                                                                       1 (10%)     

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:40:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                             (8)          
      Hemorrhage                                       2 (20%)                                                                      
   Lymph Node, Mesenteric                             (10)                                                             (10)         
      Hemorrhage                                                                                                        2 (20%)     
      Infiltration Cellular, Histiocyte                1 (10%)                                                                      
   Spleen                                             (10)                                                (1)          (9)          
      Congestion                                                                                           1 (100%)                 
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
   Thymus                                             (10)                                                             (9)          
      Hemorrhage                                                                                                        3 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (2)          (4)          (1)          (6)          (9)          
      Inflammation, Focal                              4 (40%)      2 (100%)     4 (100%)     1 (100%)     6 (100%)     8 (89%)     
      Alveolar Epithelium, Hyperplasia                                                                     1 (17%)                  
   Nose                                               (10)                                                             (9)          
      Respiratory Epithelium, Inflammation,                                                                                         
          Suppurative                                  1 (10%)                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 92013-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:40:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
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