National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17791

TDMS Study 92013-04 Pathology Tables

NTP Experiment-Test: 92013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96
Route: DOSED FEED                                                                                                 Time: 20:49:10

                                                       90-DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  822-36-6

       Lock Date:  01/12/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 92013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:49:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       7           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9            8            9           10            2           
    Accidently Killed                                  1            1            2            1                         1           

  Animals Examined Microscopically                    10            9            6           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (9)          (6)          (10)         (10)         (10)         
      Infiltration Cellular, Mixed Cell                1 (10%)                   1 (17%)                   1 (10%)                  
      Centrilobular, Vacuolization Cytoplasmic                                                                          3 (30%)     
      Periportal, Vacuolization Cytoplasmic            6 (60%)      9 (100%)     5 (83%)      5 (50%)      3 (30%)                  
   Salivary Glands                                    (10)                                                (10)         (7)          
      Infiltration Cellular, Lymphocyte                2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)         (9)          
      Valve, Pigmentation                              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (8)                                                 (7)          (5)          
      Cyst                                             1 (13%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 92013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:49:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                (10)         (7)          
      Hemorrhage                                       1 (10%)                                                                      
      Hyperplasia, Lymphoid                                                                                1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (10)         (7)          
      Infiltration Cellular, Mixed Cell                                                                    1 (10%)                  
      Perivascular, Infiltration Cellular, Mixed                                                                                    
          Cell                                         2 (20%)                                                          1 (14%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Urinary Bladder                                    (10)                                                (10)         (10)         
      Infiltration Cellular, Mixed Cell                                                                    1 (10%)                  
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 92013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:49:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Infiltration Cellular, Mixed Cell                                                       3 (30%)                               
      Centrilobular, Vacuolization Cytoplasmic                                                             1 (10%)      2 (20%)     
      Periportal, Vacuolization Cytoplasmic           10 (100%)    10 (100%)    10 (100%)    10 (100%)     9 (90%)      7 (70%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                      (1)                                    (10)         
      Cyst                                             6 (60%)                   1 (100%)                               8 (80%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                             (10)         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 92013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 4-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:49:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       1 (10%)                                                          1 (10%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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