ICCVAM Annual and Biennial Reports

The ICCVAM Authorization Act of 2000 directed ICCVAM to prepare a progress report on its first anniversary and every other year thereafter. The latest ICCVAM Biennial Progress Report describes ICCVAM and ICCVAM agency activities from January 2020 through December 2021.

• ICCVAM Authorization Act of 2000
• ICCVAM 2020-2021 Biennial Report

The report highlights ICCVAM member agency activities supporting toxicology innovation, as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of new approach methodologies. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized in the report include:

• Recommendations on measuring progress in promoting use of alternative methods.
• Publication by OECD of a guideline describing a non-animal defined approach for identifying skin sensitizers that was drafted and sponsored by ICCVAM agency scientists and international sponsors.
• Establishment of a workgroup on microphysiological systems for COVID research.
• Further development of the Collaborative Acute Toxicity Modeling Suite, in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies.
• Expansion of the Integrated Chemical Environment.

In the website edition of the Biennial Report, menu items allow users to view articles by agency or find articles relevant to topics such as in vitro to in vivo extrapolation, cardiotoxicity, or mixtures toxicity. Reference pages list publications of interest as well as providing glossary terms and acronyms relevant to ICCVAM agencies and activities.