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https://ntp.niehs.nih.gov/go/iccvam-oecd

ICCVAM Contributions to OECD Activities

ICCVAM member agencies participate in the development and national review of guidelines for the testing of chemicals issued by the Test Guidelines Programme of the Organisation for Economic Co-operation and Development (OECD). OECD test guidelines are used by government, industry, and independent laboratories in the 36 member countries of the OECD to assess chemical safety. ICCVAM members also serve on OECD expert groups for topic areas such as skin sensitization, eye irritation, and quantitative structure-activity relationship modeling.

The U.S. National Coordinator for the OECD Test Guidelines Programme, an ex officio member of ICCVAM, solicits and collates U.S. comments on draft test guidelines and other documents of the Test Guidelines Programme. The National Coordinator represents the United States at the annual meeting of the Working Group of National Coordinators and in other test guideline development activities. Beginning in 2018, the U.S. National Coordinator has been joined at this meeting by one or more ICCVAM members who are subject matter experts in topics planned for discussion at the meeting.

Ongoing Activities and Documents Under Review
  • ICCVAM members are serving on an expert group developing a test guideline for defined approaches for skin sensitization. This guideline for defined approaches represents a new type of product for OECD. Approval of this guideline will facilitate regulatory acceptance of defined approaches, and is expected to more rapidly advance the goal to eliminate animal use for skin sensitization testing worldwide.
    The proposal to develop the guideline for defined approaches was a product of an October 2016 workshop on skin sensitization convened by the International Cooperation on Alternative Test Methods.
  • NICEATM and ICCVAM scientists are participating in a group developing a "Case Study on the Use of an Integrated Approach to Testing and Assessment for Identifying Estrogen Receptor Active Chemicals," submitted to the OECD Working Party on Hazard Assessment.
  • NICEATM and ICCVAM scientists participate in annual meetings of the OECD Validation Management Group-Non-animal, which focuses on evaluation of new methods for identifying endocrine disruptors.
Recent Activities
  • NICEATM and ICCVAM collaborated with international colleagues on a revision of the acute dermal toxicity test guideline (Test Guideline 402) adopted by OECD in 2017.
  • NICEATM and ICCVAM scientists participated in drafting a guidance document on integrated approaches to testing and assessment (IATAs) for eye irritation hazard potential; the guidance document was adopted in 2017.
  • An OECD survey collected information on how systematic literature review is used in the context of endocrine disrupting chemicals. Responses guided discussions at a workshop held in October 2018.
  • NICEATM scientists participated in expert meetings on skin sensitization and skin and eye irritation in 2016, 2017, and 2018, which produced 13 updates to OECD test guidelines issued in 2017 through 2019.