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ICCVAM Contributions to OECD Activities

ICCVAM member agencies participate in the development and national review of chemical testing guidelines issued by the Test Guidelines Programme of the Organisation for Economic Co-operation and Development (OECD). OECD test guidelines are used by government, industry, and independent laboratories of the 36 OECD member countries to assess chemical safety. ICCVAM members also serve on OECD expert groups for topic areas such as skin sensitization, eye irritation, and quantitative structure-activity relationship modeling.

The U.S. National Coordinator for the OECD Test Guidelines Programme, an ex officio member of ICCVAM, solicits and collates U.S. comments on draft test guidelines and other documents of the Test Guidelines Programme. The National Coordinator represents the United States at the Working Group of National Coordinators annual meeting and in other test guideline development activities. Beginning in 2018, one or more ICCVAM subject matter experts have joined the U.S. National Coordinator at the meeting.

Ongoing Activities and Documents Under Review
  • NICEATM scientists participate on a peer review panel for an OECD-coordinated study to evaluate the use of the kinetic direct peptide reactivity assay for classifying substances for skin sensitization potency.
  • ICCVAM members participate on an expert group to develop a guideline for skin sensitization defined approaches. The guideline will describe the adopted defined approaches with respect to their intended regulatory purposes of hazard identification or potency subcategorization.
    The proposal to develop the guideline for defined approaches was a product of a 2016 skin sensitization workshop convened by the International Cooperation on Alternative Test Methods.
  • NICEATM and ICCVAM scientists are participating in a group developing a "Case Study on the Use of an Integrated Approach to Testing and Assessment for Identifying Androgen Receptor Active Chemicals," submitted to the OECD Working Party on Hazard Assessment in 2019.
  • NICEATM and ICCVAM scientists participate in annual meetings of the OECD Validation Management Group-Non-animal, which focuses on evaluation of new methods for identifying endocrine disruptors.
Recent Activities
  • NICEATM and ICCVAM scientists participated in a group developing a "Case Study on the Use of an Integrated Approach to Testing and Assessment for Identifying Estrogen Receptor Active Chemicals," submitted to the OECD Working Party on Hazard Assessment. This case study was published in September 2019, and has since been adapted to create a proposal for a defined approach for estrogenic activity, submitted to the OECD in November 2019.
  • NICEATM and ICCVAM collaborated with international colleagues to revise the acute dermal toxicity test guideline (Test Guideline 402). The revision was adopted by OECD in 2017.
  • NICEATM and ICCVAM scientists participated in drafting a guidance document on integrated approaches to testing and assessment (IATAs) for eye irritation hazard potential; the guidance document was adopted in 2017.
  • An OECD survey collected information on how systematic literature review is used in the context of endocrine disrupting chemicals. Responses guided discussions at a workshop held in October 2018.
  • NICEATM scientists participated in expert meetings on skin sensitization and skin and eye irritation in 2016, 2017, and 2018, which produced at least 15 updates to OECD test guidelines issued in 2017 through 2019.