Public Health Impact
The public impact of NTP's work can be measured through its use by other agencies, often to support the establishment of regulations or guidelines to protect human health. For example, OEHHA is the California agency responsible for the Safe Drinking Water and Toxic Enforcement Act of 1986; OEHHA has used NTP data in compiling their list of substances known to the state to cause cancer under Proposition 65.
The table below shows NTP citations in regulatory settings such as draft guidelines, final guidelines, rules, and regulations. To learn more and see the NTP information cited, click a title in the table. The table can be filtered by year or agency to view historical and/or agency-specific outcomes.
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| Year | Agency | Title | CASRN |
|---|---|---|---|
| 2023 | EPA |
Control of Air Pollution from New Motor Vehicles: Heavy-Duty Engine and Vehicle StandardsThe EPA finalizing a program to further reduce air pollution, including ozone and particulate matter (PM), from heavy-duty engines and vehicles across the United States. The requirements in the final rule will lower emissions of NOX and other air pollutants (PM, hydrocarbons (HC), carbon monoxide (CO), and air toxics) beginning no later than model year 2027. This final rule is effective on March 27, 2023. NTP Information Cited
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| 2023 | EPA |
Availability of New Approach Methodologies in the Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for CommentUS EPA published a white paper announcing their intention to accept NAMs as alternatives to four existing Tier 1 assays for the endocrine disruptor screening program, including the rodent uterotrophic assay. These NAMs cover in vitro based estrogen receptor (ER) and androgen receptor (AR) pathway models that were conceptualized (AR) and/or validated (ER and AR) by NICEATM. The EPA also identified NAMs acceptable for priority setting and WoE analysis including QSAR models developed by NICEATM for ER and AR activity that are available in the OPERA tool (https://github.com/NIEHS/OPERA). NTP Information Cited
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| 2023 | OSHA |
World Trade Center (WTC) Health Program; Addition of Uterine Cancer to the List of WTC-Related Health ConditionsIn accordance with the World Trade Center (WTC) Health Program’s regulations, which establish procedures for adding a new condition to the list of covered health conditions, this final rule adds malignant neoplasms of corpus uteri and uterus, part unspecified (uterine cancer) to the List of WTC-Related Health Conditions. This rule is effective on January 18, 2023. NTP Information Cited
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| 2022 | OEHHA |
Haloacetic Acids in Drinking Water - Adoption of Public Health Goals for Five Haloacetic AcidsOn December 30, 2022, the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) has adopted and published Public Health Goals (PHGs) for the five regulated haloacetic acids (HAAs) found in drinking water as a result of disinfection methods: monochloroacetic acid (MCA), dichloroacetic acid (DCA), trichloroacetic acid (TCA), monobromoacetic acid (MBA), and dibromoacetic acid (DBA). A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California. The technical support document presents the scientific information available on the toxicity of the HAAs and the calculation of the PHGs. The PHGs of 0.2 parts per billion (ppb) for DCA, 0.1 ppb for TCA, and 0.03 ppb for DBA are based on carcinogenicity and are set at a level of risk of one additional cancer case per one million persons exposed over a lifetime. The PHGs of 53 ppb for MCA and 25 ppb for MBA are based on noncancer health effects. OEHHA also presents health-protective drinking water concentrations for noncancer health effects for DCA, TCA, and DBA. The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has adopted and published Public Health Goals (PHGs) for the five regulated haloacetic acids (HAAs) found in drinking water as a result of disinfection methods: monochloroacetic acid (MCA), dichloroacetic acid (DCA), trichloroacetic acid (TCA), monobromoacetic acid (MBA), and dibromoacetic acid (DBA). NTP Information Cited
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79-43-6 76-03-9 79-11-8 631-64-1 5589-96-879-08-3631-64-1 |
| 2022 | OEHHA |
Notice of Adoption Title 27, California Code of Regulations Article 5, New Section 25506 Exposures to Acrylamide in Cooked or Heat Processed FoodsOn December 20, 2022, the Office of Administrative Law approved the Office of Environmental Health Hazard Assessment’s proposal to amend Title 27, California Code of Regulations by adopting Section 25506, originally proposed as Section 25505. The new section addresses acrylamide in food formed by cooking or heat processing. The regulation will be effective on April 1, 2023. NTP Information Cited
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79-06-1 5694-00-8 |
| 2022 | OEHHA |
Decline to List Proposition 65 - 2022 Carcinogen Identification CommitteeAt the December 14 meeting of the Carcinogen Identification Committee (CIC), the CIC declined to list Bisphenol A as a carcinogen under Proposition 65 by a vote of 5 (yes) to 6 (no). The CIC voted 10 — 0, with one abstention, to affirm the update to the Section 27000 list recommended in the staff report. NTP Information Cited
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80-05-7 |
| 2022 | OEHHA |
1-Bromopropane Cancer Inhalation Unit Risk Factor (IUR) Document - Scientific Notice of Adoption of Cancer Inhalation Unit Risk and Slope Factors for 1-BromopropaneThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting new cancer inhalation unit risk (IUR) and slope factors for 1-Bromopropane (1-BP) for use in the Air Toxics Hot Spots Program. IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In implementing this requirement, OEHHA develops new IURs and revises existing IURs for many air pollutants. The IUR for 1-BP was developed using the most recent guidance, “Air Toxics Hot Spots Program Technical Support Document for Cancer Potency Factors,” finalized by OEHHA in 2009. The values for 1-BP are as follows: Inhalation Unit Risk Factor 3.7 x 10e-6 (µg/m10e+3)10e-1 Inhalation Slope Factor 1.3 × 10e-2 (mg/kg-day)10e-1 A draft document for the 1-BP IUR was released on May 12, 2021, to solicit public comment and was discussed at a virtual public workshop during the subsequent 45-day public review period. No public comments were received on the document. The document was peer reviewed by the State’s Scientific Review Panel (SRP) on Toxic Air Contaminants in October 2021 before being finalized. NTP Information Cited
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106-94-5 75-25-2 75-27-4 96-12-8 106-93-4106-94-5 |
| 2022 | EPA |
Drinking Water Contaminant Candidate List 5-FinalThe U.S. Environmental Protection Agency (EPA) is issuing the Contaminant Candidate List (CCL) which is a list of contaminants in drinking water that are currently not subject to any proposed or promulgated national primary drinking water regulations. In addition, these contaminants are known or anticipated to occur in public water systems and may require regulation under the Safe Drinking Water Act (SDWA). This list is the Fifth Contaminant Candidate List (CCL 5) published by the agency since the SDWA amendments of 1996. CCL 5 includes 66 chemicals, 3 chemical groups (cyanotoxins, disinfection byproducts (DBPs), and per- and polyfluoroalkyl substances (PFAS)), and 12 microbial contaminants. NTP Information Cited
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27774-13-6 13718-26-8 |
| 2022 | OEHHA |
Safe Harbor Warning Regulation for Exposures to Acrylamide from FoodThe Office of Administrative Law approved the Office of Environmental Health Hazard Assessment’s proposal to amend Title 27, California Code of Regulations by adding new subsection 25607.2(b) to Section 25607.2. This new subsection addresses warning content for exposures to acrylamide in food by providing an additional non-mandatory, safe harbor warning option for businesses that cause significant exposures to acrylamide in foods. The regulation will be effective on January 1, 2023. NTP Information Cited
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79-06-1 5694-00-8 |
| 2022 | EPA |
Proposed Finding that Lead Emissions from Aircraft Engines that Operate on Leaded Fuel Cause or Contribute to Air Pollution that May Reasonably be Anticipated to Endanger Public Health and WelfareAdministrator is proposing to find that lead air pollution may reasonably be anticipated to endanger the public health and welfare within the meaning of section 231(a) of the Clean Air Act. NTP Information Cited
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7439-92-1 |
| 2022 | OEHHA |
Safe Harbor Warning Regulation for Exposures to Glyphosate from Consumer ProductsOn September 1, 2022, the Office of Administrative Law approved the Office of Environmental Health Hazard Assessment’s proposal to amend Title 27, California Code of Regulations by adopting Sections 25607.48 and 25607.49. These new sections provide safe harbor guidance for businesses that cause exposures to glyphosate from consumer products that require a warning under Proposition 65. The regulations will be effective on January 1, 2023. NTP Information Cited
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1071-83-6 |
| 2022 | EPA |
Designation of Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) as CERCLA Hazardous SubstancesUnder the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended (``CERCLA'' or ``Superfund''), the Environmental Protection Agency (EPA or the Agency) is proposing to designate perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), including their salts and structural isomers, as hazardous substances. NTP Information Cited National Toxicology Program (NTP). 2022. NTP Technical Report on the Toxicity studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 97. https://doi.org/10.22427/NTP-TOX-97 National Toxicology Program (NTP). 2022. NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 96. https://doi.org/10.22427/NTP-TOX-96
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335-76-2 307-24-4 375-95-1 335-67-1 375-73-53871-99-61763-23-1 50892-23-4 |
| 2022 | OEHHA |
Chromium, Trivalent (Inorganic Water-Soluble Compounds)The Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for Chromium, Trivalent (Inorganic Water-Soluble Compounds) (Cr(III)) for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to Cr(III) in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposure. NTP Information Cited
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1313-99-1 10101-97-0 27882-76-4 |
| 2022 | OEHHA |
Proposition 65: No Significant Risk Level for Antimony TrioxideThe Office of Environmental Health Hazard Assessment (OEHHA) is proposing to adopt a Proposition 65 No Significant Risk Level (NSRL) for antimony trioxide by amending Title 27, California Code of Regulations, section 25705(b). The proposed NSRL for antimony trioxide is 0.13 micrograms per day. NTP Information Cited
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1309-64-4 |
| 2022 | EPA |
Addition of Diisononyl Phthalate Category; Community Right-to-Know Toxic Chemical Release ReportingOn September 5, 2000, in response to a petition filed under the Emergency Planning and Community Right-to-Know Act (EPCRA), EPA issued a proposed rule to add a diisononyl phthalate (DINP) category to the list of toxic chemicals subject to the reporting requirements under EPCRA and the Pollution Prevention Act (PPA). EPA proposed to add this chemical category to the EPCRA toxic chemical list based on its preliminary conclusion that this category met the EPCRA toxicity criterion. EPA has updated its hazard assessment for DINP and is proposing to add DINP as a category defined to include branched alkyl di-esters of 1,2 benzenedicarboxylic acid in which alkyl ester moieties contain a total of nine carbons. The updated hazard assessment demonstrates that the proposed DINP category meets the EPCRA toxicity criterion because the members of the category can reasonably be anticipated to cause cancer and serious or irreversible chronic health effects in humans; specifically, developmental, kidney, and liver toxicity. EPA is proposing to add the DINP category to the toxic chemical list on this basis and is requesting comment on the updated DINP hazard assessment and associated updated economic analysis. NTP Information Cited
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117-81-7 68515-48-0 28553-12-0 |
| 2022 | OEHHA |
Adoption of Regulations: Warnings for Cannabis (Marijuana) Smoke and Delta-9-Tetrahydrocannabinol (Delta-9-THC) ExposureOn August 4, 2022, the Office of Administrative Law approved amendments to Title 27, California Code of Regulations by adopting Sections 25697.38 through 24607.47 into Title 27 of the California Code of Regulations. The new sections address exposures to listed cannabis (marijuana) smoke and Delta-9-THC. NTP Information Cited
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1972-08-3 |
| 2022 | OSHA |
Advance Notice of Proposed Rule Making (ANPRM)—Blood Lead Level for Medical RemovalOSHA is considering rulemaking to revise its standards for occupational exposure to lead based on medical findings since the issuance of OSHA’s lead standards that adverse health effects in adults can occur at Blood Lead Levels (BLLs) lower than the medical removal level (≥60 mg/dL in general industry, ≥50 mg/dL in construction) and lower than the level required under current standards for an employee to return to their former job status (<40 mg/dL).1 The agency is seeking input on reducing the current BLL triggers in the medical surveillance and medical removal protection provisions of the general industry and construction standards for lead. The agency is also seeking input about how current ancillary provisions in the lead standards can be modified to reduce worker BLLs. NTP Information Cited National Toxicology Program (NTP). (2012). NTP Monograph: Health effects of low- level lead. Retrieved from: https:// ntp.niehs.nih.gov/ntp/ohat/lead/final/ monographhealtheffectslowlevellead_ newissn_508.pdf. Accessed on November 10, 2020.
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7439-92-1 |
| 2022 | OEHHA |
Proposition 65: No Significant Risk Level for 1,3-Dichloropropene (1,3-D)The Office of Environmental Health Hazard Assessment (OEHHA) has adopted an NSRL of 3.7 micrograms per day for exposures to 1,3-dichloropropene by the oral and inhalation routes. NTP Information Cited National Toxicology Program (NTP). 1985. Toxicology and Carcinogenesis Studies of Telone II (Technical-Grade 1,3-Dichloropropene (CASRN 542-75-6) Containing 1.0% Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-269.
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542-75-6 |
| 2022 | CDC |
World Trade Center (WTC) Health Program; Addition of Uterine Cancer to the List of WTC-Related Health ConditionsTitle I of the James Zadroga 9/ 11 Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) to establish the World Trade Center (WTC) Health Program. The WTC Health Program (Program), which is administered by the Director of the National Institute for Occupational Safety and Health (NIOSH), within CDC, provides medical monitoring and treatment to eligible responders to the September 11, 2001, terrorist attacks in New York City, at the Pentagon, and in Shanksville, Pennsylvania, and to eligible survivors of the New York City attacks. In accordance with the WTC Health Program’s regulations, which establish procedures for adding a new condition to the list of health conditions covered by the Program, this proposed rule would add malignant neoplasms of corpus uteri and uterus, part unspecified (uterine cancer) to the List of WTC-Related Health Conditions (List). NTP Information Cited
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| 2022 | EPA |
Asbestos; Reporting and Recordkeeping Requirements Under the Toxic Substances Control Act (TSCA)The Environmental Protection Agency (EPA) is proposing reporting and recordkeeping requirements for asbestos under the Toxic Substances Control Act (TSCA). EPA proposes to require certain persons that manufactured (including imported) or processed asbestos and asbestoscontaining articles (including as an impurity) in the four years prior to the date of publication of the final rule to electronically report certain exposurerelated information. This action would result in a one-time reporting obligation. EPA emphasizes that this proposed requirement would include asbestos that is a component of a mixture. The information sought includes quantities of asbestos (including asbestos that is a component of a mixture) and asbestoscontaining articles that were manufactured (including imported) or processed, types of use, and employee data. Reported information would be used by EPA and other Federal agencies in considering potential future actions, including risk evaluation and risk management activities. EPA is requesting public comment on all aspects of this proposed rule and has also identified items of particular interest for public input. NTP Information Cited
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1332–21–4 132207–32–0 12001–28–4 2172–73–5 77536–67–577536–68–677536–66–4 |
| 2022 | FDA |
Action Levels for Lead in Juice; Draft Guidance for Industry; AvailabilityThe Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled "Action Levels for Lead in Juice: Guidance for Industry." The draft guidance, when finalized, would establish action levels of 10 parts per billion (ppb) for lead in single-strength (ready-to-drink) apple juice and 20 ppb for lead in all other single-strength juice types, including juice blends that contain apple juice. NTP Information Cited
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7439-92-1 |
| 2022 | EPA |
Restoring Protective Human Health Criteria in WashingtonThe Environmental Protection Agency (EPA) has determined that Washington's human health criteria (HHC) are not protective of Washington's designated uses and are not based on sound scientific rationale and, accordingly, is proposing to restore protective HHC for Washington's waters. EPA partially approved and partially disapproved Washington's HHC in November 2016, and simultaneously promulgated federal HHC based on sound scientific rationale. In May 2019, EPA reversed its November 2016 disapproval and approved Washington's HHC, and in June 2020 withdrew the 2016 HHC that EPA promulgated for Washington. Based on the best scientific information and analyses currently available, and consideration of these past decisions, EPA has concluded that Washington's existing HHC are not based on sound scientific rationale and are therefore not protective of the applicable designated uses in Washington. EPA is therefore proposing to reinstate the protective and science-based federal HHC that EPA withdrew in June 2020 to protect Washington's waters, including waters where tribes hold treaty-reserved rights to fish. NTP Information Cited
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| 2022 | EPA |
Control of Air Pollution From New Motor Vehicles: Heavy-Duty Engine and Vehicle StandardsThe Environmental Protection Agency (EPA) is proposing a rule that would reduce air pollution from highway heavy-duty vehicles and engines, including ozone, particulate matter, and greenhouse gases. This proposal would change the heavy-duty emission control program-- including the standards, test procedures, useful life, warranty, and other requirements--to further reduce the air quality impacts of heavy- duty engines across a range of operating conditions and over a longer period of the operational life of heavy-duty engines. NTP Information Cited
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| 2022 | OEHHA |
Notification Level Recommendation for Perfluorohexane Sulfonic Acid (PFHxS) in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) is recommending that the State Water Resources Control Board (Water Board) establish the notification level (NL) for perfluorohexane sulfonic acid (PFHxS) at 2 parts per trillion, or the lowest level at which it can be reliably detected in drinking water using currently available and appropriate technologies. This recommendation is based on OEHHA’s development of a health-protective concentration intended to prevent noncancer effects, including thyroid, liver, and developmental toxicity. NTP Information Cited
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375-73-5 3871-99-6 1763-23-1 50892-23-4 |
| 2022 | CPSC |
Notice of Availability: Final Guidance on Alternative Test Methods and Integrated Testing ApproachesThe Consumer Product Safety Commission (Commission or CPSC) is announcing the availability of a document titled, "Final Guidance for Industry and Test Method Developers: CPSC Staff Evaluation of Alternative Test Methods and Integrated Testing Approaches and Data Generated from Such Methods to Support FHSA Labeling Requirements.'' The final guidance will be available at: https://www.regulations.gov under docket number, CPSC-2021-0006, under “Supporting and Related Material". NTP Information Cited
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| 2022 | OEHHA |
Notice to Interested Parties Chemical Listed Effective February 25, 2022 As Known to the State of California to Cause Cancer: Perfluorooctanoic AcidEffective February 25, 2022, for purposes of Proposition 65, the Office of Environmental Health Hazard Assessment (OEHHA) is adding perfluorooctanoic acid (PFOA) (CASRN 335-67-1) to the list of chemicals known to the State of California to cause cancer. The listing of perfluorooctanoic acid (PFOA) is based on its formal identification by the National Toxicology Program (NTP), an authoritative body for purposes of Proposition 65, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306. The basis for the listing was described in a public notice published in the March 19, 2021, issue of the California Regulatory Notice Register (Register 2021, No. 12-Z). The title of the notice was “Notice of Intent to List Chemical by the Authoritative Bodies Mechanism: Perfluorooctanoic Acid.” The publication of the notice initiated a 45-day public comment period. OEHHA received five sets of comments during the comment period. NTP Information Cited National Toxicology Program (NTP 2011). Specifications for the conduct of studies to evaluate the toxic and carcinogenic potential of chemical, biological and physical agents in laboratory animals for the National Toxicology Program (NTP). January 2011. https://ntp.niehs.nih.gov/ntp/test_info/finalntp_toxcarspecsjan2011.pdf National Toxicology Program (NTP 2019a). NTP Historical Controls Report, All Routes and Vehicles, Harlan Sprague-Dawley Rats. Version April 2019. US Department of Health and Human Services, NTP, Research Triangle Park, NC. Available from: https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hcrpt_allrte20190400.pdf National Toxicology Program (NTP 2019b). NTP Historical Controls Report, All Routes and Vehicles, Harlan Sprague-Dawley Rats. Version November 2019. US Department of Health and Human Services, NTP, Research Triangle Park, NC. Available from: https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hcrpt_allrte20191100.pdf National Toxicology Program (NTP 2020). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats. Technical Report Series No. 598. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://doi.org/10.22427/NTP-TR-598
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335-67-1 |
| 2021 | EPA |
Review of the National Primary Drinking Water Regulation: Lead and Copper Rule Revisions (LCRR)On June 16, 2021, the U.S. Environmental Protection Agency (EPA) published the agency's decision to delay the effective and compliance dates of the National Primary Drinking Water Regulations: Lead and Copper Rule Revisions (LCRR), published on January 15, 2021, to allow time for EPA to review the rule in accordance with Presidential directives issued on January 20, 2021, to the heads of Federal agencies to review certain regulations, and conduct important consultations with affected parties. EPA has completed its review. The agency's review included a series of virtual public engagements to hear directly from a diverse set of stakeholders. This document describes the comments conveyed by stakeholders, EPA's decision to proceed with a proposed rule that would revise certain key sections of the LCRR while allowing the rule to take effect, and other non-regulatory actions that EPA and other Federal agencies can take to reduce exposure to lead in drinking water. NTP Information Cited National Toxicity Program (NTP). 2012. Monograph on Health Effects of Low-level Lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf
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7439-92-1 |
| 2021 | OEHHA |
Notice of Proposed Rulemaking Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: 1,3-DichloropropeneThe Office of Environmental Health Hazard Assessment (OEHHA) proposes to adopt Proposition 65 No Significant Risk Levels (NSRLs) for 1,3-dichloropropene by amending Title 27, California Code of Regulations, section 25705(b). The proposed NSRLs for oral and inhalation exposures to 1,3-dichloropropene are 3.7 micrograms per day. NTP Information Cited National Toxicology Program (NTP, 1985). Toxicology and carcinogenesis studies of Telone II (technical-grade 1,3-dichloropropene [CAS No. 542-75-6] containing 1.0% epichlorohydrin as a stabilizer) in F344/N rats and B6C3F1 mice (gavage studies). TR No. 269. US Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD. https://ntp.niehs.nih.gov/go/tr269abs
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542-75-6 |
| 2021 | EPA |
Addition of Certain Chemicals; Community Right-to-Know Toxic Chemical Release ReportingIn response to a petition filed under the Emergency Planning and Community Right-to-Know Act (EPCRA), EPA is proposing to add 12 chemicals to the list of toxic chemicals subject to the reporting requirements under EPCRA and the Pollution Prevention Act (PPA). EPA believes that each of the 12 chemicals meets the EPCRA criteria. In addition, based on the available bioaccumulation and persistence data, EPA believes that one chemical should be classified as a persistent, bioaccumulative, and toxic (PBT) chemical and designated as a chemical of special concern with a 100-pound reporting threshold. NTP Information Cited NTP. 2005. 1,3-Dichloro-2-propanol [CAS No. 96–23–1]. Review of toxicological literature. Prepared by Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina, for the National Toxicology Program, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf NTP. 1992. Final report on the reproductive toxicity of formamide (FORM) (CAS no. 75–12–7) in CD–1 Swiss mice: Volume 1 NTIS Technical Report 109213(327). https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB93109213.xhtml NTP. 1992. Final report on the reproductive toxicity of formamide (FORM) (CAS no. 75–12–7) CD–1 (trade name) Swiss mice: Volume 2. Laboratory supplement. NTIS Technical Report 109221(249). https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB93109221.xhtml NTP. 1998. Final report on the developmental toxicity of formamide (CAS No. 75–12–7) administered by gavage to Sprague-Dawley CD rats on gestational days 6–19. NTIS Technical Report 139701(106). https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB99139701.xhtml NTP. 2001. Developmental toxicity evaluation of formamide (CAS No. 75– 12–7) administered by gavage to New Zealand white rabbits on gestational days 6 through 29. NTIS Technical Report 104060(460) https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB2001104060.xhtml NTP. 1991. NTP toxicology and carcinogenesis studies of tris(2- chloroethyl) phosphate (CAS No. 115– 96–8) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series 391: 1– 233. https://ntp.niehs.nih.gov/go/tr391abs NTP. 1991. Final report on the reproductive toxicity of tris(2- chloroethyl)phosphate reproduction and fertility assessment in Swiss CD–1 mice when administered via gavage. NTIS Technical Report 129170(253). https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB92129170.xhtml Morrissey, R. E., B.A. Schwetz, J.C. Lamb, M.D. Ross, J.L. Teague, and R.W. Morris. 1988. Evaluation of rodent sperm vaginal cytology and reproductive organ weight data from National Toxicology Program 13-week studies. Fundam. Appl. Toxicol. 11(2): 343–358. https://doi.org/10.1016/0272-0590(88)90159-5
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96-23-1 75-12-7 115-96-8 |
| 2021 | FDA |
Termination of Listing of Color Additives Exempt From Certification; Lead AcetateThe Food and Drug Administration (FDA or we) is responding to objections and a public hearing request that we received from Combe Inc., on the final rule entitled "Termination of Listing of Color Additives Exempt From Certification; Lead Acetate," which published on October 31, 2018. The final rule amended the color additive regulations to no longer provide for the safe use of lead acetate in cosmetics intended for coloring hair on the scalp. After reviewing the objections, we have concluded that the objections do not raise issues of material fact that justify a hearing. Therefore, the stay of the effectiveness for the repeal and delisting of the color additive regulation is now lifted, and we are amending the color additive regulations to no longer provide for the safe use of lead acetate in cosmetics intended for coloring hair on the scalp. NTP Information Cited National Toxicity Program, 2012. Monograph on Health Effects of Low-level Lead. U.S. Department of Health and Human Services. June 2012. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf
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7439-92-1 |
| 2021 | OEHHA |
Announcement of the Carcinogen Identification Committee Meeting Scheduled for December 6, 2021; Notice of Availability of Hazard Identification Materials for Perfluorooctane Sulfonic Acid (PFOS) and Its Salts and Transformation and Degradation PrecursorsThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) will convene a meeting of the Carcinogen Identification Committee (CIC) for possible listing of perfluorooctane sulfonic acid (PFOS) and its salts and transformation and degradation precursors under the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65)[1]. OEHHA is also opening a 45-day public comment period on the hazard identification document for these chemicals. The public comment period will end on Monday, November 8, 2021. A copy of the document is available on OEHHA’s web site at https://oehha.ca.gov/proposition-65. The document may also be requested from OEHHA’s Proposition 65 Implementation Office by calling (916) 445-6900. NTP Information Cited
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335-67-1 |
| 2021 | OEHHA |
Notice of Proposed Rulemaking New Subsection 25607.2(b) Warning Content for Acrylamide Exposure from FoodNOTICE IS HEREBY GIVEN that the Office of Environmental Health Hazard Assessment (OEHHA) proposes to add a new subsection to Article 6 of Title 27 of the California Code of Regulations.[1] This rulemaking proposes to add the following new subsection to Section 25607.2: (b) A warning for food exposures to acrylamide meets the requirements of this subarticle if it is provided: (i) in accordance with subsection (a), or, (ii) via one or more of the methods specified in Section 25607.1 and includes both elements (1) and (2) below. (1) The words “CALIFORNIA WARNING:” in all capital letters and bold print. (2) The words, "Consuming this product can expose you to acrylamide, a probable human carcinogen formed in some foods during cooking or processing at high temperatures. Many factors affect your cancer risk, including the frequency and amount of the chemical consumed. For more information including ways to reduce your exposure, see www.P65Warnings.ca.gov/acrylamide." NTP Information Cited
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5694-00-8 79-06-1 |
| 2021 | OEHHA |
Amendment to Section 25705 No Significant Risk Level for Trichloroacetic AcidOn July 6, 2021, the Office of Administrative Law approved the amendment to Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical trichloroacetic acid. The regulation will be effective on October 1, 2021. This regulation establishes a No Significant Risk Level of 9.9 micrograms per day for trichloroacetic acid for purposes of Proposition 65 NTP Information Cited
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71133-14-7 |
| 2021 | OEHHA |
Amendment to Section 25705 No Significant Risk Level for Dichloroacetic AcidOn June 24, 2021, the Office of Administrative Law approved the amendment to Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical dichloroacetic acid. The regulation will be effective on October 1, 2021. This regulation establishes a No Significant Risk Level of 17 micrograms per day for dichloroacetic acid for purposes of Proposition 65. NTP Information Cited
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71133-14-7 |
| 2021 | OEHHA |
Amendment to Section 25705 No Significant Risk Level for Dibromoacetic AcidOn July 6, 2021, the Office of Administrative Law approved the amendment to Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical dibromoacetic acid. The regulation will be effective on October 1, 2021. This regulation establishes a No Significant Risk Level of 2.8 micrograms per day for dibromoacetic acid for purposes of Proposition 65. NTP Information Cited
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631-64-1 7632-00-0 7775-09-9 |
| 2021 | FDA |
Listing of Color Additives Exempt From Certification; Butterfly PeaThe Food and Drug Administration (FDA or we) is amending the color additive regulations to provide for the safe use of an aqueous extract of butterfly pea flower (Clitoria ternatea) as a color additive in various food categories at levels consistent with good manufacturing practice. We are taking this action in response to a color additive petition (CAP) submitted by Exponent, Inc., on behalf of Sensient Colors, LLC (Sensient). NTP Information Cited
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117-39-5 |
| 2021 | OEHHA |
Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) in Drinking WaterThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) announces the availability of a draft technical support document for proposed Public Health Goals (PHGs) for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in drinking water. NTP Information Cited NTP Tox-96. NTP (2019c). NTP Historical Controls Report: All Routes and Vehicles Harlan Sprague-Dawley Rats. Research Triangle Park, North Carolina, National Toxicology Program. https://doi.org/10.22427/NTP-TOX-96
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307-24-4 335-67-1 375-95-1 335-76-2 375-73-53871-99-61763-23-1 50892-23-4 |
| 2021 | EPA |
National Primary Drinking Water Regulations: Lead and Copper Rule Revisions; Delay of Effective and Compliance DatesThe effective date of the National Primary Drinking Water Regulations: Lead and Copper Rule Revisions (LCRR) that was published in the Federal Register on January 15, 2021. EPA is also delaying the January 16, 2024 compliance date established in the LCRR to October 16, 2024. The delay in the effective date is consistent with presidential directives issued on January 20, 2021, to the heads of Federal agencies to review certain regulations, including the LCRR. The delay allows EPA sufficient time to complete its review of the rule in accordance with those directives and conduct important consultations with affected parties. Delay of the LCRR compliance date ensures that any delay in the effective date will not reduce the time provided for drinking water systems and primacy states to take actions needed for ensuring compliance with the LCRR. NTP Information Cited
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7439-92-1 |
| 2021 | ATSDR |
Toxicological Profile for PerfluoroalkylsThe ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. NTP Information Cited National Toxicology Program (NTP). 2020. Technical Report on the Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd: Sprague Dawley SD) Rats. Research Triangle Park, NC: National Toxicology Program. TR-598.
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335-67-1 |
| 2021 | OEHHA |
Report Links Synthetic Food Dyes to Hyperactivity and other Neurobehavioral Effects in ChildrenA state report released today finds that consumption of synthetic food dyes can result in hyperactivity and other neurobehavioral problems in some children, and that children vary in their sensitivity to synthetic food dyes. The report by the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) also finds that current federal levels for safe intake of synthetic food dyes may not sufficiently protect children’s behavioral health. The levels were established by the US Food and Drug Administration decades ago and do not reflect newer research. The percentage of American children and adolescents diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD) has increased from an estimated 6.1% to 10.2% during the last 20 years. Concerns about increasing rates of ADHD and other behavioral disorders prompted the California Legislature to ask OEHHA to conduct the food dye assessment. Evidence shows that synthetic food dyes are associated with adverse neurobehavioral outcomes in some children, said OEHHA Director Dr. Lauren Zeise. With increasing numbers of U.S. children diagnosed with behavioral disorders, this assessment can inform efforts to protect children from exposures that may exacerbate behavioral problems. The report is the product of a two-year, multifaceted evaluation of seven synthetic food dyes that have been approved by the FDA. OEHHA extensively reviewed existing studies of the effects of these dyes on both humans and laboratory animals. NTP Information Cited
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| 2021 | OEHHA |
Notice of Intent to List Chemical by the Authoritative Bodies Mechanism: Perfluorooctanoic AcidThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list perfluorooctanoic acid (PFOA) (CAS RN 335-67-1) as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). This action is being proposed pursuant to the Authoritative Bodies listing mechanism. According to the National Toxicology Program (NTP 2020), PFOA was widely used in manufacturing of a variety of consumer products that included many nonstick applications, such as for clothing and cookware. PFOA is no longer produced in the US and its production and use worldwide was significantly curtailed with the 2019 ban of the compound under the Stockholm Convention on Persistent Organic Pollutants. However, its persistence in the environment and breakdown of certain other per- and polyfluoroalkyl substances result in continued PFOA exposure. NTP is one of several institutions designated as authoritative for the identification of chemicals as causing cancer [Section 25306(m) of the Title 27 of the Cal. Code of Regulations]. After an authoritative body has made a determination about a chemical, OEHHA evaluates whether listing under Proposition 65 is required using the criteria contained in the regulations. NTP Information Cited National Toxicology Program (NTP). 2020. NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 598. https://doi.org/10.22427/NTP-TR-598
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335-67-1 |
| 2021 | EPA |
National Primary Drinking Water Regulations: Lead and Copper Rule Revisions; Delay of Effective DateThe Environmental Protection Agency (EPA or Agency) is issuing a short delay of the March 16, 2021, effective date of the National Primary Drinking Water Regulations: Lead and Copper Rule Revisions (LCRR), published in the Federal Register on January 15, 2021. The LCRR will now become effective on June 17, 2021. This final rule does not change the compliance date of January 16, 2024. This delay in the effective date is consistent with Presidential directives issued on January 20, 2021, to heads of Federal agencies to review certain regulations, including the LCRR. The sole purpose of this delay is to enable EPA to take public comment on a longer extension of the effective date for EPA to undertake its review of the rule in a deliberate and thorough manner consistent with the public health purposes of the Safe Drinking Water Act and the terms and objectives of recent Presidential directives and in consultation with affected stakeholders. NTP Information Cited
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7439-92-1 |
| 2021 | EPA |
Announcement of Final Regulatory Determinations for Contaminants on the Fourth Drinking Water Contaminant Candidate ListThe U.S. Environmental Protection Agency (EPA or Agency) is announcing final regulatory determinations for eight of the 109 contaminants listed on the Fourth Contaminant Candidate List. Specifically, the Agency is making final determinations to regulate perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) and to not regulate 1,1-dichloroethane, acetochlor, methyl bromide (bromomethane), metolachlor, nitrobenzene, and RDX. The Safe Drinking Water Act (SDWA), as amended in 1996, requires EPA to make regulatory determinations every five years on at least five unregulated contaminants. A regulatory determination is a decision about whether or not to begin the process to propose and promulgate a national primary drinking water regulation for an unregulated contaminant. NTP Information Cited NTP. 1992. Toxicology and carcinogenesis studies of methyl bromide (CAS NO. 74–83–9) in B6C3F1 mice (inhalation studies). U.S. Department of Health and Human Services. Public Health Service. National Institutes of Health. https://ntp.niehs.nih.gov/go/tr385 NTP. 2020. Technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335–67–1) administered in feed to Sprague Dawley (Hsd: Sprague Dawley SD) rats. U.S. Department of Health and Human Services. Public Health Service. National Institutes of Health. https://doi.org/10.22427/NTP-TR-598
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98-95-3 74–83–9 335–67–1 |
| 2021 | EPA |
National Primary Drinking Water Regulations: Lead and Copper Rule RevisionsThe Environmental Protection Agency (EPA) is publishing final regulatory revisions to the National Primary Drinking Water Regulation (NPDWR) for lead and copper under the authority of the Safe Drinking Water Act (SDWA). These revised requirements provide greater and more effective protection of public health by reducing exposure to lead and copper in drinking water. The rule will better identify high levels of lead, improve the reliability of lead tap sampling results, strengthen corrosion control treatment requirements, expand consumer awareness and improve risk communication. This final rule requires, for the first time, community water systems to conduct lead-in-drinking-water testing and public education in schools and child care facilities. In addition, the rule will accelerate lead service line replacements by closing existing regulatory loopholes, propelling early action, and strengthening replacement requirements. NTP Information Cited
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7439-92-1 |
| 2021 | EPA |
Review of Dust-Lead Post Abatement Clearance LevelsReducing childhood lead exposure is a priority for the Environmental Protection Agency (EPA). As part of EPA's efforts to reduce childhood lead exposure, and in coordination with the President's Task Force on Environmental Health Risks and Safety Risks to Children, EPA reevaluated the 2001 dust-lead clearance levels (DLCL). Clearance levels indicate the amount of lead in dust on a surface following the completion of an abatement activity. Surface dust is collected via dust wipe samples that are sent to a laboratory for analysis to determine whether clearance has been achieved. The post-abatement dust-lead levels are evaluated against, and must be below, the applicable clearance levels. The DLCL have not changed since they were issued in 2001. EPA is finalizing its proposal to lower the DLCL from 40 micrograms of per square foot (µg/ft\2\) to 10 µg/ft\2\ for floors, and from 250 µg/ft\2\ to 100 µg/ft\2\ for window sills. NTP Information Cited
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7439-92-1 |
| 2020 | OEHHA |
Notice to Interested Parties Developmental Toxicity Endpoint Reinstated for the Listing of Bisphenol A (BPA) as Known to the State of California to Cause Reproductive ToxicityEffective December 18, 2020, the Office of Environmental Health Hazard Assessment (OEHHA) is adding the developmental endpoint to the existing reproductive toxicity (female endpoint) listing of bisphenol A (BPA) (CAS RN. 80-05-7) on the Proposition 65 list of chemicals known to the State to cause cancer or reproductive toxicity. Bisphenol A was added to the Proposition 65 list as known to cause reproductive toxicity for the female reproductive toxicity endpoint, effective May 15, 2015. The listing now includes an additional endpoint, developmental toxicity. The chemical was delisted effective April 19, 2013, based on a trial court injunction prohibiting the listing of BPA for the developmental endpoint pending final resolution of the case - American Chemistry Council [ACC] v Office of Environmental Health Hazard Assessment, et al., Sacramento County case number 34-2013-00140720. That court eventually denied the ACC’s challenge to the listing and the ACC appealed. The Court of Appeal kept an injunction in place pending their resolution of the case. On October 19, 2020 the Third District Court of Appeal entered a judgment affirming the trial court decision and an order dissolving the injunction. The time to seek California Supreme Court review has passed, so the Court of Appeal decision is final. Therefore, OEHHA is reinstating the developmental toxicity endpoint for the listing of BPA as causing reproductive toxicity at this time, on the same basis as the original listing for that endpoint https://oehha.ca.gov/proposition-65/crnr/notice-intent-list-bisphenol. NTP Information Cited
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80-05-07 |
| 2020 | OEHHA |
Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: p-Chloro-α,α,α-TrifluorotolueneOn December 2, 2020, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, which adopted a Proposition 65 No Significant Risk Level (NSRL) of 23 micrograms per day for the chemical p-chloro-α,α,α-trifluorotoluene (PCBTF). The regulation will be effective on April 1, 2021. NTP Information Cited
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98-56-6 |
| 2020 | OEHHA |
BPA Listing as Reproductive Toxicant Under Prop 65 Upheld by CourtThe California Court of Appeal, Third Appellate District (Sacramento), has upheld the listing of bisphenol A (BPA) as a reproductive toxicant under Proposition 65 (Prop 65). Prop 65 a right-to-know law that requires individuals to receive a clear and reasonable warning before being exposed to certain chemicals that California deems to be carcinogens or reproductive toxicants. NTP Information Cited
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80-05-7 |
| 2020 | CDC |
Proposed Data Collection Submitted for Public Comment and RecommendationsThe Centers for Disease Control and Prevention (CDC), as part of its continuing effort to reduce public burden and maximize the utility of government information, invites the general public and other Federal agencies the opportunity to comment on a proposed and/or continuing information collection, as required by the Paperwork Reduction Act of 1995. This notice invites comment on a proposed information collection project titled ``Blood Lead Surveillance System (BLSS)'' (OMB Control No. 0920-0931, Exp. Date 05/31/2021). The National Center for Environmental Health (NCEH) is leading a three-year extension information collection request (ICR) for two CDC information collections, one for childhood blood lead surveillance by NCEH and another for adult blood lead surveillance by the National Institute for Occupational Safety and Health (NIOSH). NTP Information Cited
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7439-92-1 |
| 2020 | OEHHA |
Notice of Adoption of Cancer Inhalation Unit Risk Factors for Cobalt and Cobalt CompoundsThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting new cancer inhalation unit risk (IUR) and slope factors for Cobalt and Cobalt Compounds for use in the Air Toxics Hot Spots Program. IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In implementing this requirement, OEHHA develops new IURs and revises existing IURs for many air pollutants. The IURs for cobalt and insoluble and soluble cobalt compounds were developed using the most recent guidance, “Air Toxics Hot Spots Program Technical Support Document for Cancer Potency Factors,” finalized by OEHHA in 2009. NTP Information Cited
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12035-72-2 10026-24-1 7440-48-4 |
| 2020 | EPA |
Use of Lead Free Pipes, Fittings, Fixtures, Solder, and Flux for Drinking WaterThe Environmental Protection Agency (EPA) is finalizing changes to existing regulations to protect the public from lead in plumbing materials used in public water systems or residential or nonresidential facilities providing water for human consumption. The changes in this rule codify aspects of the Reduction of Lead in Drinking Water Act of 2011 (RLDWA) and the Community Fire Safety Act of 2013 (CFSA). NTP Information Cited
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7439-92-1 |
| 2020 | OEHHA |
Notice of Adoption of Reference Exposure Levels for TolueneThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for Toluene for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to toluene in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposures. OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In response to this statutory requirement, OEHHA develops RELs for many air pollutants, including Toluene. The Toluene RELs were developed using the most recent “Air Toxics Hot Spots Program Technical Support Document for the Derivation of Noncancer Reference Exposure Levels” (OEHHA, 2008). Toluene has been demonstrated to have neurotoxic effects. This chemical will also be added to the list of Toxic Air Contaminants that may disproportionately impact children, pursuant to Health and Safety Code Section 39669.5(b)(1). NTP Information Cited
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108-88-3 |
| 2020 | OEHHA |
Notice of Adoption of Cancer Inhalation Unit Risk Factor for p-Chloro-a,a,a-TrifluorotolueneThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting a new cancer inhalation unit risk (IUR) and slope factor for p-Chloro-a,a,a-Trifluorotoluene for use in the Air Toxics Hot Spots Program. IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In implementing this requirement, OEHHA develops new IURs and revises existing IURs for many air pollutants. The IUR for PCBTF was developed using the most recent “Air Toxics Hot Spots Program Technical Support Document for Cancer Potency Factors,” finalized by OEHHA in 2009. NTP Information Cited NTP (2009). Chemical Information Profile for 1-Chloro-4-(trifluoromethyl)-benzene (CAS No. 98-56-6); Supporting Nomination for Toxicological Evaluation by the National Toxicology Program. National Toxicology Program, National Institute of Environmental Health Sciences, June 2009. https://ntp.niehs.nih.gov/ntp/noms/support_docs/pcbtf060409.pdf
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98-56-6 |
| 2020 | OEHHA |
Announcement of Publication of Updated Public Health Goal and Technical Support Document for 1,2-Dibromo-3-Chloropropane in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of the updated Public Health Goal (PHG) for 1,2-dibromo-3-chloropropane (DBCP). A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The updated Public Health Goal of 0.003 parts per billion (ppb) is based on carcinogenicity and is set at a level of risk of one additional cancer case per one million persons exposed over a 70-year lifetime. NTP Information Cited
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96-12-8 |
| 2020 | EPA |
Review of Dust-Lead Post-Abatement Clearance LevelsReducing childhood lead exposure is a priority for EPA. As part of EPA's efforts to reduce childhood lead exposure, backed by the President's Task Force on Environmental Health Risks and Safety Risks to Children, EPA evaluated the current dust-lead clearance levels (DLCL). Clearance levels are currently defined as the maximum amount of lead permitted in dust on a surface following completion of an abatement activity. Surface dust is collected via dust wipe samples that are sent to a laboratory for analysis. The post-abatement dust- lead levels must be below the clearance levels. The DLCL have not changed since they were issued in 2001. EPA is now proposing to lower the DLCL from 40 micrograms of per square feet (µg/feet squared) and 250 µg/feet squared to 10 µg/feet squared and 100 µg/feet squared for floors and window sills, respectively. NTP Information Cited
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7439-92-1 |
| 2020 | OEHHA |
Notice of Proposed Rulemaking Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: Trichloroacetic AcidOffice of Environmental Health Hazard Assessment (OEHHA) proposes to adopt a Proposition 65 No Significant Risk Level (NSRL) of 9.9 micrograms per day for trichloroacetic acid, by amending Title 27, California Code of Regulations, section 25705(b). NTP Information Cited
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76-03-9 71133-14-7 |
| 2020 | OEHHA |
Notice Of Proposed Rulemaking Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: Dibromoacetic AcidOffice of Environmental Health Hazard Assessment (OEHHA) proposes to adopt a Proposition 65 No Significant Risk Level (NSRL) of 2.8 micrograms per day for dibromoacetic acid, by amending Title 27, California Code of Regulations, section 25705(b). NTP Information Cited
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631-64-1 |
| 2020 | OEHHA |
Notice of Proposed Rulemaking Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: Dichloroacetic AcidOffice of Environmental Health Hazard Assessment (OEHHA) proposes to adopt a Proposition 65 No Significant Risk Level (NSRL) of 17 micrograms per day for dichloroacetic acid, by amending Title 27, California Code of Regulations, section 25705(b). NTP Information Cited
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71133-14-7 |
| 2020 | EPA , DOT |
The Safer Affordable Fuel-Efficient (SAFE) Vehicles Rule for Model Years 2021-2026 Passenger Cars and Light TrucksThe Environmental Protection Agency and the National Highway Traffic Safety Administration, on behalf of the Department of Transportation, are issuing final rules to amend and establish carbon dioxide and fuel economy standards. Specifically, EPA is amending carbon dioxide standards for model years 2021 and later, and NHTSA is amending fuel economy standards for model year 2021 and setting new fuel economy standards for model years 2022-2026. The standards set by this action apply to passenger cars and light trucks, and will continue our nation's progress toward energy independence and carbon dioxide reduction, while recognizing the realities of the marketplace and consumers' interest in purchasing vehicles that meet all of their diverse needs. These final rules represent the second part of the Administration's action related to the August 24, 2018 proposed Safer Affordable Fuel-Efficient (SAFE) Vehicles Rule. These final rules follow the agencies' actions, taken September 19, 2019, to ensure One National Program for automobile fuel economy and carbon dioxide emissions standards, by finalizing regulatory text related to preemption under the Energy Policy and Conservation Act and withdrawing a waiver previously provided to California under the Clean Air Act. NTP Information Cited
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75-07-0 71-43-2 106-99-0 50-00-0 91-20-3 |
| 2020 | OEHHA |
Issuance of Safe Use Determination for Exposures to Bisphenol A from Certain Polycarbonate Eyewear Products Manufactured, Distributed, or Sold by The Vision Council Member CompaniesThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986. OEHHA received a request for a Safe Use Determination (SUD) for exposures to bisphenol A (BPA) from certain polycarbonate eyewear products manufactured, distributed, or sold by The Vision Council (TVC) member companies. Based on OEHHA’s screening-level analysis of the information and data provided by TVC, the upper-end estimate of dermal exposure to BPA for users of certain polycarbonate eyewear products (prescription glasses and sunglasses, OTC reading glasses, non-prescription sunglasses, and safety glasses) manufactured, distributed, or sold by TVC member companies, with acetonitrile extractable concentrations of BPA as specified above, is 0.53 µg/day. This exposure estimate falls below the "Maximum Allowable Dose Level (MADL)” for BPA (dermal exposure from solid materials) of 3 µg per day. The MADL is defined as the level of exposure that corresponds to the “no observed effect level” divided by 1000. Thus, exposures to BPA from use of such eyewear products, under the conditions described in OEHHA’s assessment, would not require a Proposition 65 warning. NTP Information Cited
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80-05-7 |
| 2020 | OEHHA |
Announcement of Publication of Public Health Goals and Technical Support Document for Trihalomethanes In Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of Public Health Goals (PHGs) for four trihalomethanes (THMs) found in drinking water as a result of disinfection methods: chloroform, bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. NTP Information Cited
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67-66-3 75-25-2 75-27-4 124-48-1 8001-30-78001-23-8538-23-8 |
| 2020 | OEHHA |
Chemicals Listed Effective January 3, 2020 As Known to The State of California To Cause Reproductive Toxicity (Developmental Endpoint): Cannabis (Marijuana) Smoke and Δ9-Tetrahydrocannabinol (Δ9-THC)Effective January 3, 2020, the Office of Environmental Health Hazard Assessment is adding cannabis (marijuana) smoke and Δ9-tetrahydrocannabinol (Δ9-THC) to the list of chemicals known to the state to cause reproductive toxicity (developmental endpoint) for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65) NTP Information Cited
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1972-08-3 |
| 2019 | EPA |
Addition of Certain Per- and Polyfluoroalkyl Substances; Community Right-to-Know Toxic Chemical Release ReportingIn this advance notice of proposed rulemaking (ANPRM), EPA is soliciting information from the public as EPA considers proposing a future rule on adding certain per- and polyfluoroalkyl substances (PFAS) to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 6607 of the Pollution Prevention Act (PPA). In this ANPRM, EPA outlines what PFAS are, why the Agency is considering adding certain PFAS to EPCRA section 313, what listing actions are being considered, who may be required to report, the current understanding of hazard concerns for PFAS, EPA’s hazard assessments on PFAS, and other information available on these chemicals. In considering a chemical for addition to the EPCRA section 313 list, EPA bases its listing decision on the chemical’s hazard (i.e., toxicity), not the risk (i.e., toxicity plus potential exposures) related to that chemical. EPA is requesting comment on which, if any, PFAS should be evaluated for listing, how to list them, and what would be appropriate reporting thresholds given their persistence and bioaccumulation potential. Lastly, EPA asks for any additional data to inform the Agency’s evaluation and determination of which PFAS may meet the EPCRA section 313 listing criteria. NTP Information Cited
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N/A |
| 2019 | EPA |
Community Right-to-Know; Corrections to Toxics Release Inventory (TRI) Reporting RequirementsEPA is proposing corrections to existing regulatory language for the Toxics Release Inventory (TRI) Program. EPA is proposing corrections that will update identifiers, formulas, and names for certain TRI-listed chemicals and updates to the text that identifies which chemicals the 0.1 percent de minimis concentration applies to in order to remedy a cross-reference to a no-longer-accurate Occupational Safety and Health Administration (OSHA) regulatory citation. These proposed corrections maintain previous regulatory actions and do not alter existing reporting requirements or impact compliance burdens or costs. NTP Information Cited
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N/A |
| 2019 | EPA |
National Primary Drinking Water Regulations: Proposed Lead and Copper Rule RevisionsThe Environmental Protection Agency (EPA) proposes regulatory revisions to the National Primary Drinking Water Regulation (NPDWR) for lead and copper under the authority of the Safe Drinking Water Act (SDWA). This proposed rule provides more effective protection of public health by reducing exposure to lead and copper in drinking water. This proposed rule also strengthens procedures and requirements related to health protection and the implementation of the existing Lead and Copper Rule (LCR) in the following areas: Lead tap sampling; corrosion control treatment; lead service line replacement; consumer awareness; and public education. This proposal does not include revisions to the copper requirements of the existing LCR. In addition, this proposal includes new requirements for community water systems to conduct lead in drinking water testing and public education in schools and child care facilities. NTP Information Cited National Toxicity Program (NTP). 2012. Monograph on Health Effects of Low-level Lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf
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N/A |
| 2019 | OEHHA |
Notice of Proposed Rulemaking Title 27, California Code of Regulations Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: P-Chloro-α,α,α-Trifluorotoluene (PCBTF)On Oct. 18, 2019, the Office of Environmental Health Hazard Assessment (OEHHA) proposes to adopt a Proposition 65 No Significant Risk Level (NSRL) of 23 micrograms per day for p-chloro-α,α,α-trifluorotoluene (PCBTF), by amending Title 27, California Code of Regulations, section 25705(b). https://oehha.ca.gov/proposition-65/crnr/notice-proposed-rulemaking-title-27-california-code-regulations-amendment-13 NTP Information Cited
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98-56-6 |
| 2019 | CDC |
World Trade Center Health Program; Petition 023—Uterine Cancer, Including Endometrial Cancer; Finding of Insufficient EvidenceOn April 23, 2019, the Administrator of the World Trade Center (WTC) Health Program received a petition (Petition 023) to add "endometrial cancer'' to the List of WTC-Related Health Conditions (List). Upon reviewing the scientific and medical literature, including information provided by the petitioner, the Administrator has determined that the available evidence does not have the potential to provide a basis for a decision on whether to add the major site uterine cancer, including its subtype, endometrial cancer, to the List. The Administrator also finds that insufficient evidence exists to request a recommendation of the WTC Health Program Scientific/Technical Advisory Committee (STAC), to publish a proposed rule, or to publish a determination not to publish a proposed rule. NTP Information Cited
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N/A |
| 2019 | OEHHA |
Notification Level Recommendations for Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Drinking WaterThis document presents final notification level (NL) recommendations by the Office of Environmental Health Hazard Assessment (OEHHA) for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in drinking water. This supersedes the underlying scientific analysis (OEHHA, 2018) that supported the interim NLs that were adopted in 2018. NTP Information Cited NTP (2016). NTP Monograph Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate. National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf NTP (2018a). Tox-96: Perfluorinated Compounds: Sulfonates - Pathology Tables, Survival and Growth Curves from NTP Short-Term Studies. National Toxicology Program, Research Triangle Park, NC. https://tools.niehs.nih.gov/cebs3/views/?action=main.dataReview&bin_id=3874 (last accessed March 20, 2019). NTP (2018b). Tox-97: Perfluorinated Compounds: Carboxylates - Pathology Tables, Survival and Growth Curves from NTP Short-Term Studies. National Toxicology Program, Research Triangle Park, NC. https://tools.niehs.nih.gov/cebs3/views/?action=main.dataReview&bin_id=3875 (last accessed March 20, 2019). NTP (2018c). TR-598: Technical Report Pathology Tables and Curves - PFOA. National Toxicology Program, Research Triangle Park, NC. https://tools.niehs.nih.gov/cebs3/views/?action=main.dataReview&bin_id=13658 (last accessed March 20, 2019).
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335-67-11763-23-1 |
| 2019 | EPA |
Review of the Dust-Lead Hazard Standards and the Definition of Lead-Based PaintAddressing childhood lead exposure is a priority for EPA. As part of EPA's efforts to reduce childhood lead exposure, EPA evaluated the current dust-lead hazard standards (DLHS) and the definition of lead-based paint (LBP). Based on this evaluation, this final rule revises the DLHS from 40 [micro]g/ft\2\ and 250 [micro]g/ft\2\ to 10 [micro]g/ft\2\ and 100 [micro]g/ft\2\ on floors and window sills, respectively. EPA is also finalizing its proposal to make no change to the definition of LBP because insufficient information exists to support such a change at this time. NTP Information Cited
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N/A |
| 2019 | ATSDR |
Availability of Draft Toxicological ProfilesThis notice announces the availability of Set 26 Toxicological Profiles for review and comment. Comments can include additional information or reports on studies about the health effects of Set 26 substances. Although ATSDR considered key studies for each of these substances during the profile development process, this Federal Register notice solicits any relevant, additional studies, particularly unpublished data. ATSDR will evaluate the quality and relevance of such data or studies for possible inclusion into the profile. ATSDR remains committed to providing a public comment period for this document as a means to best serve public health and our clients. The Set 26 Toxicological Profiles are available online at https://www.atsdr.cdc.gov/toxprofiles/index.asp and https://www.regulations.gov/#!home, docket ATSDR–2014–0001. The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), § 104(i)(3),[42 U.S.C. 9604(i)(3)], directs the ATSDR administrator to prepare Toxicological Profiles of priority hazardous substances and, as necessary, to revise and publish each updated toxicological profile. NTP Information Cited National Toxicology Program (NTP). 1988a. Developmental toxicity evaluation of 1,1,1-trichloroethane (CASRN 71-55-6) administered to CD rats. Final report part 1. Research Triangle Park, NC: National Toxicology Program. PB88131321. https://ntp.niehs.nih.gov/go/t0151abs
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71-55-6 79-01-6 127-18-4 7783-06-4 463-58-156-38-2 |
| 2019 | EPA |
Restrictions on Discontinued Uses of Asbestos; Significant New Use RuleUnder the Toxic Substances Control Act (TSCA), EPA is promulgating a rule to ensure that any discontinued uses of asbestos cannot re-enter the marketplace without EPA review, closing a loophole in the regulatory regime for asbestos. NTP Information Cited
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1332-21-4 |
| 2019 | OEHHA |
Current Proposition 65 No Significant Risk Levels (NSRLs) Maximum Allowable Dose Levels (MADLs)Safe harbor levels, which include No Significant Risk Levels (NSRLs) for cancer-causing chemicals and Maximum Allowable Dose Levels (MADLs) for chemicals causing reproductive toxicity, have been established for many of the chemicals listed under Proposition 65. Exposure levels and discharges to drinking water sources that are below the safe harbor levels are exempt from the requirements of Proposition 65. In some instances, enforcement actions may have resulted in negotiated exposure levels relative to specific settlement agreements. Please visit the Attorney General's Proposition 65 web site at https://ag.ca.gov/prop65 (link is external) for further information about specific enforcement actions. NTP Information Cited National Cancer Institute (NCI, 1980). Bioassay of 4,4'-0xydianiline for Possible Carcinogenicity. Carcinogenesis Technical Report Series No. 205. NIH Publication No. 80-1761. US Department of Health and Human Services, NCI Carcinogenesis Testing Program, and National Toxicology Program. https://ntp.niehs.nih.gov/go/tr205 National Toxicology Program (NTP, 1982). Toxicology and Carcinogenesis Studies of D & C Red 9 in F344/N Rats and B6C3F1 Mice (Feed Study). NTP Technical Report Series No. 225. NIH Publication No. 82-1781. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr225 National Toxicology Program (NTP, 1991). Chemical Status Report. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/msr
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101-80-4 5160-02-1 13552-44-8 124-48-1108171-26-2563-47-3 87-29-6 101-90-6 513-37-1 2475-45-8 26471-62-5 115-28-6 67-72-1 |
| 2019 | FDA |
Sunscreen Drug Products for Over-the-Counter Human UseThe Food and Drug Administration (FDA or Agency) is issuing this proposed rule to put into effect a final monograph for nonprescription, over-the-counter (OTC) sunscreen drug products. This proposed rule describes the conditions under which FDA proposes that OTC sunscreen monograph products are generally recognized as safe and effective (GRASE) and not misbranded. It is being published as part of the ongoing review of OTC drug products conducted by FDA. It is also being published to comply with the Federal Food, Drug, and Cosmetic Act (FD&C Act), as amended by the Sunscreen Innovation Act (SIA). NTP Information Cited
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131–57–7 |
| 2019 | OEHHA |
Amendment to Section 25705 No Significant Risk Level for Bromodichloroacetic AcidOn February 5, 2019, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical bromodichloroacetic acid. The regulation will be effective on April 1, 2019. This regulation establishes a No Significant Risk Level of 0.95 micrograms per day for bromodichloroacetic acid for purposes of Proposition 65. NTP Information Cited
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71133-14-7 |
| 2019 | OEHHA |
Amendment to Section 25705 No Significant Risk Level for Bromochloroacetic AcidOn February 5, 2019, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical bromochloroacetic acid. The regulation will be effective on April 1, 2019. This regulation establishes a No Significant Risk Level of 0.70 micrograms per day for bromochloroacetic acid for purposes of Proposition 65. NTP Information Cited
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5589-96-8 |
| 2018 | EPA |
Chlorate; Pesticide Exemptions From ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of chlorate in or on cantaloupe and tomato under the Federal Food, Drug, and Cosmetic Act (FFDCA). NTP Information Cited
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N/A |
| 2018 | OEHHA |
Notice of Intent to List p-Chloro-α,α,α-trifluorotoluene (Para-Chlorobenzotrifluoride, PCBTF)The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list p-chloro-α,α,α-trifluorotoluene (also known as para-chlorobenzotrifluoride, or PCBTF) as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986[1]. This action is being proposed under the authoritative bodies listing mechanism. NTP Information Cited
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98-56-6 |
| 2018 | FDA |
FDA Removes 7 Synthetic Flavoring Substances from Food Additives ListThe Food and Drug Administration (FDA, the Agency, or we) is partially granting a petition submitted by the Breast Cancer Fund (now known as the Breast Cancer Prevention Partners), Center for Environmental Health, Center for Food Safety, Center for Science in the Public Interest, Consumers Union, Environmental Defense Fund, Environmental Working Group, Improving Kids’ Environment, Natural Resources Defense Council, WE ACT for Environmental Justice, and Mr. James Huff, by amending the food additive regulations to no longer authorize the use of benzophenone, ethyl acrylate, eugenyl methyl ether, myrcene, pulegone, and pyridine as synthetic flavoring substances for use in food. We are taking this action because, despite FDA’s scientific analysis and determination that these substances do not pose a risk to public health under the conditions of their intended use, the petitioners provided data demonstrating that these additives induce cancer in laboratory animals, and, as a result of this finding in animals, FDA cannot as a matter of law maintain the listing of these synthetic flavoring substances in the food additive regulations. Because of evidence that benzophenone causes cancer in animals, FDA also is amending the food additive regulations to no longer provide for the use of benzophenone as a plasticizer in rubber articles intended for repeated use in contact with food. FDA is denying as moot the portions of the petition proposing that the food additive regulations be amended to no longer authorize the use of styrene as a synthetic flavoring substance because this use has been permanently and completely abandoned. In addition, FDA is declining to act on the petitioners’ request to issue a regulation to prohibit the use of these synthetic flavoring substances in food because that issue is not the proper subject of a food additive petition. NTP Information Cited NTP. Benzophenone (119-61-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/119-61-9. NTP. Methyleugenol (93-15-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/93-15-2. NTP. beta-Myrcene (123-35-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/123-35-3. NTP. Pulegone (89-82-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/89-82-7. NTP. Pyridine (110-86-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/110-86-1.
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119–61–9 140–88–5 93–15–2 123–35–3 89–82–7110–86–1100–42–5 |
| 2018 | EPA |
The Safer Affordable Fuel-Efficient (SAFE) Vehicles Rule for Model Years 2021-2026 Passenger Cars and Light TrucksThe National Highway Traffic Safety Administration (NHTSA) and the Environmental Protection Agency (EPA) are proposing the “Safer Affordable Fuel-Efficient (SAFE) Vehicles Rule for Model Years 2021-2026 Passenger Cars and Light Trucks” (SAFE Vehicles Rule). The SAFE Vehicles Rule, if finalized, would amend certain existing Corporate Average Fuel Economy (CAFE) and tailpipe carbon dioxide emissions standards for passenger cars and light trucks and establish new standards, all covering model years 2021 through 2026. More specifically, NHTSA is proposing new CAFE standards for model years 2022 through 2026 and amending its 2021 model year CAFE standards because they are no longer maximum feasible standards, and EPA is proposing to amend its carbon dioxide emissions standards for model years 2021 through 2025 because they are no longer appropriate and reasonable in addition to establishing new standards for model year 2026. The preferred alternative is to retain the model year 2020 standards (specifically, the footprint target curves for passenger cars and light trucks) for both programs through model year 2026, but comment is sought on a range of alternatives discussed throughout this document. Compared to maintaining the post-2020 standards set forth in 2012, current estimates indicate that the proposed SAFE Vehicles Rule would save over 500 billion dollars in societal costs and reduce highway fatalities by 12,700 lives (over the lifetimes of vehicles through MY 2029). U.S. fuel consumption would increase by about half a million barrels per day (2-3 percent of total daily consumption, according to the Energy Information Administration) and would impact the global climate by 3/1000th of one degree Celsius by 2100, also when compared to the standards set forth in 2012. NTP Information Cited
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106-99-0 |
| 2018 | OEHHA |
Notice of Adoption of Cancer Inhalation Unit Risk and Slope Factors and Cancer Oral Slope Factor for Tert-Butyl AcetateThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting a new cancer inhalation unit risk factor (IUR) for tert-butyl acetate (TBAc). IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. NTP Information Cited
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75-65-0 |
| 2018 | OEHHA |
Announcement of Publication of Public Health Goals and Availability of Technical Support Document for Cis- and Trans-1,2-Dichloroethylene in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of updated Public Health Goals (PHGs) for cis- and trans-1,2-dichloroethylene (cis-/trans-1,2-DCE) in drinking water. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California. The technical support document, available for download below, presents an update of the cis- and trans-1,2-DCE PHGs. The updated PHGs are 13 parts per billion (ppb) for cis-1,2-DCE based on kidney effects and 50 ppb for trans-1,2-DCE based on immune system effects. NTP Information Cited
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156-60-5 |
| 2018 | EPA |
Review of the Dust-Lead Hazard Standards and the Definition of Lead-Based PaintAddressing childhood lead exposure is a priority for EPA. As part of EPA's efforts to reduce childhood lead exposure, EPA evaluated the current dust-lead hazard standards (DLHS) and the definition of lead-based paint (LBP). Based on this evaluation, EPA is proposing to lower the DLHS from 40 μg/ft2 and 250 μg/ft2 to 10 μg/ft2 and 100 μg/ft2 on floors and window sills, respectively. EPA is proposing no changes to the current definition of LBP due to insufficient information to support such a change. NTP Information Cited
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N/A |
| 2018 | OEHHA |
Authoritative Bodies Tracking TableStatus of chemicals considered by OEHHA for addition to the Proposition 65 list under the authoritative bodies mechanism. NTP Information Cited NTP Technical Report on the Toxicology and Carcinogenesis Studies of Trim VX in Wistar HAN [Crl:WI (Han)] Rats and B6C3F1/N Mice (Inhalation Studies) NTP (2016). https://ntp.niehs.nih.gov/go/tr591abs.
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7440-48-4 TRIMVX 50-32-8 |
| 2018 | EPA |
Asbestos; Significant New Use RuleUnder the Toxic Substances Control Act (TSCA), EPA is proposing a significant new use rule (SNUR) for asbestos as defined under the Asbestos Hazard Emergency Response Act. The proposed significant new use of asbestos (including as part of an article) in manufacturing (including importing) or processing for certain uses identified by EPA as no longer ongoing. The Agency has found no information indicating that the following uses are ongoing, and therefore, the following uses are subject to this proposed SNUR: Adhesives, sealants, and roof and non-roof coatings; arc chutes; beater-add gaskets; extruded sealant tape and other tape; filler for acetylene cylinders; high-grade electrical paper; millboard; missile liner; pipeline wrap; reinforced plastics; roofing felt; separators in fuel cells and batteries; vinyl-asbestos floor tile; and any other building material (other than cement). NTP Information Cited
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1332-21-4 |
| 2018 | OEHHA |
Chemical Listed Effective May 25, 2018 as Known to the State of California to Cause Cancer: TRIM® VXEffective May 25, 2018, the Office of Environmental Health Hazard Assessment (OEHHA) is adding TRIM® VX to the list of chemicals known to the State of California to cause cancer for purposes of Proposition 65. The listing of TRIM® VX is based on formal identification by the National Toxicology Program (NTP), an authoritative body, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306. The documentation supporting OEHHA’s determination that the criteria for administrative listing have been satisfied for TRIM® VX is included in the “Notice of Intent to List: TRIM® VX” posted on OEHHA’s website and published in the January 26, 2018 issue of the California Regulatory Notice Register (Register 2018, No. 4-Z). The publication of the notice initiated a public comment period that closed on February 26, 2018. OEHHA received two public comments on TRIM® VX. The comments and OEHHA’s responses are posted with the Notice of Intent to List. NTP Information Cited
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TRIMVX |
| 2018 | OEHHA |
AcrylamideAcrylamide is on the Proposition 65 list of chemicals known to the state to cause cancer or reproductive toxicity (such as birth defects and other reproductive harm). Acrylamide is formed in some baked, fried and roasted foods. It is also present in tobacco smoke. Smokers are exposed to particularly high levels of acrylamide. Acrylamide is a carcinogen. It was added to the Proposition 65 list in 1990 because studies showed it produced cancer in laboratory rats and mice. In February 2011, acrylamide was added to the Proposition 65 list as causing reproductive and developmental effects because, in studies of laboratory animals, acrylamide affected the growth of offspring exposed in the womb and caused genetic damage that resulted in the death of mouse and rat embryos. Plant-based foods that are rich in carbohydrates can form acrylamide when baked, fried or roasted – whether they are cooked at home, in restaurants or by commercial food processors and manufacturers. French fries, potato chips, other fried and baked snack foods, coffee, roasted grain-based coffee substitutes, roasted asparagus, canned sweet potatoes and pumpkin, canned black olives, roasted nuts, prune juice, breakfast cereals, crackers, cookies, breads, and toast all may contain varying amounts of acrylamide. Foods that have been boiled or steamed do not contain acrylamide. The U.S. Food and Drug Administration (FDA) and other health and scientific organizations continue to study the health effects of acrylamide in food. The FDA has not advised people at this time to stop eating products that contain acrylamide. The FDA does advise people to quit smoking. NTP Information Cited National Toxicology Program. (NTP, 2018). Acrylamide.https://www.niehs.nih.gov/health/topics/agents/acrylamide/index.cfm. National Toxicology Program. (NTP, 2013). Fact sheet on Acrylamide. https://www.niehs.nih.gov/health/assets/docs_a_e/acrylamide_508.pdf.
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79-06-1 |
| 2018 | OEHHA |
Notice of Amendment to Section 25705 no Significant Risk Level for Vinylidene ChlorideOn May 9, 2018, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, No Significant Risk Level (NSRL) for the chemical vinylidene chloride. The regulation will be effective on July 1, 2018. This regulation establishes a No Significant Risk Level of 0.88 micrograms per day for vinylidene chloride for purposes of Proposition 65. NTP Information Cited
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75-35-4 |
| 2018 | OEHHA |
Announcement of Publication of Public Health Goals and Availability of Technical Support Document for Nitrate and Nitrite in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of updated Public Health Goals (PHGs) for nitrate and nitrite in drinking water. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California. The technical support document, presents an update of the nitrate and nitrite PHGs. A review of the scientific literature published since the development of the original nitrate and nitrite PHGs in 1997 has identified no new information to support changing the current PHGs of 45 parts per million (ppm) for nitrate and 3 ppm for nitrite. Nitrate and nitrite can also be expressed in terms of their concentrations as nitrogen. When expressed as nitrogen, 45 ppm nitrate is equivalent to 10 ppm nitrogen. The PHG of 3 ppm for nitrite is 1 ppm when expressed as nitrogen. The PHGs for nitrate and nitrite expressed as nitrogen have not changed. The combined nitrate/nitrite PHG of 10 ppm (as nitrogen), which accounts for the additive toxicity of nitrate and nitrite, also remains unchanged. It does not replace the individual values, and the maximum contribution from nitrite should not exceed 1 ppm nitrite-nitrogen. These PHGs protect against the occurrence of infant methemoglobinemia, a blood disorder that results in decreased oxygen distribution to tissues, as well as other effects, such as liver toxicity, that have been shown to occur at higher levels of exposure and in the general population. NTP Information Cited National Toxicology Program (NTP). 2001. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 495. https://ntp.niehs.nih.gov/go/tr495abs NTP (National Toxicology Program). 2014. Report on Carcinogens, Thirteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc
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7632-00-0 |
| 2018 | OEHHA |
Notice of Adoption of Reference Exposure Levels for Ethylene Glycol Mono-N-Butyl EtherThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting revised Reference Exposure Levels (RELs) for Ethylene Glycol mono-n-Butyl Ether (EGBE) (CAS No. 111-76-2) for use in the Air Toxics Hot Spots program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to EGBE in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposure. NTP Information Cited
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111-76-2 |
| 2018 | OEHHA |
Current Proposition 65 No Significant Risk Levels (NSRLs) Maximum Allowable Dose Levels (MADLs)Safe harbor levels, which include No Significant Risk Levels (NSRLs) for cancer-causing chemicals and Maximum Allowable Dose Levels (MADLs) for chemicals causing reproductive toxicity, have been established for many of the chemicals listed under Proposition 65. Exposure levels and discharges to drinking water sources that are below the safe harbor levels are exempt from the requirements of Proposition 65. In some instances, enforcement actions may have resulted in negotiated exposure levels relative to specific settlement agreements. NTP Information Cited Gold L, Slone T, Backman G, Eisenberg S, DaCosta M, Wong M, Manley N, and Ames B (1990). Third chronological supplement to the Carcinogenic Potency Database: Standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environmental Health Perspectives 84: 215-285. https://ehp.niehs.nih.gov/doi/abs/10.1289/ehp.9084215. National Toxicology Program (NTP, 1987). Toxicology and Carcinogenesis Studies of Chlorendic Acid in F344 Rats and B6C3F1 Mice (Feed Studies). NTP Technical Report Series No. 304. N1H Publication No. 87-2560, US Department of Health and Human Services (DHEW), NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr304abs. National Toxicology Program (NTP, 1991). Chemical Status Report. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/msr. National Toxicology Program (NTP, 1986). Toxicology and Carcinogenesis Studies of C.l. Basic Red 9 Monohydrochloride in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP Technical Report Series No. 196. NIH Publication No. 86-2541. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr196abs. National Toxicology Program (NTP, 1982). Toxicology and Carcinogenesis Studies of D & C Red 9 in F344/N Rats and B6C3F1 Mice (Feed Study). NTP Technical Report Series No. 225. NIH Publication No. 82-1781. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr225abs. National Cancer Institute (NCI, 1980). Bioassay of 4,4'-0xydianiline for Possible Carcinogenicity. Carcinogenesis Technical Report Series No. 205. NIH Publication No. 80-1761. US Department of Health and Human Services, NCI Carcinogenesis Testing Program, and National Toxicology Program. https://ntp.niehs.nih.gov/go/tr205abs. National Toxicology Program (NTP, 1986). Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Technical Report Series No. 257. NIH Publication No. 87-2513. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr257abs. National Toxicology Program (NTP, 1986). Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-chloro-2-methyl-propene) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Technical Report Series No. 316. NIH Publication No. 86 2572. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr316abs. National Toxicology Program (NTP, 1986). Toxicology and Carcinogenesis Studies of HC Blue 1 in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP Technical Report Series; No. 271. NTIS Publication No. PB 86-114683. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr271abs. National Toxicology Program (NTP, 1989). Toxicology and Carcinogenesis Studies of Hexachloroethane in F344/N Rats (Gavage Studies). NTP Technical Report Series No. 361. NTIS Publication No. 89-2816. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr361abs.
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115-28-6 569-61-9 5160-02-1 101-80-4 101-90-6513-37-12784-94-3 67-72-1 |
| 2018 | OEHHA |
Amendment to Section 25705 No Significant Risk Level - Glyphosate April 10, 2018On April 6, 2018, the Office of Administrative Law approved an amendment of Title 27, California Code of Regulations, section 25705, No Significant Risk Level (NSRL) for the chemical glyphosate. The regulation will be effective on July 1, 2018. This regulation establishes a NSRL of 1100 micrograms per day for glyphosate. NTP Information Cited
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1071-83-6 |
| 2018 | CDC |
NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings: Proposed Additions to the NIOSH Hazardous Drug List 2018The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) announces the availability for public comment on the drugs proposed for placement on the NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2018 (List), as well as the NIOSH Policy and Procedures for Developing the NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings. NTP Information Cited
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N/A |
| 2018 | OEHHA |
Notice of Proposed Rulemaking Title 27, California Code of Regulations Amendment to Section 25705 Specific Regulatory Levels Posing No Significant Risk: Bromodichloroacetic AcidNotice is hereby given that the Office of Environmental Health Hazard Assessment (OEHHA) proposes to adopt a Proposition 65 No Significant Risk Level (NSRL) of 0.95 micrograms per day for bromodichloroacetic acid, by amending Title 27, California Code of Regulations, section 25705(b). NTP Information Cited
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7113-14-7 |
| 2018 | OEHHA |
Notice of Intent to List: TRIM VXThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list TRIM VX as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism. NTP Information Cited
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N/A |
| 2017 | USDA |
Information Collection; Qualified Products Lists for Fire Chemicals for Wildland Fire ManagementIn accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension with no revision of a currently approved information collection, Qualified Products Lists for Fire Chemicals for Wildland Fire Management. NTP Information Cited
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N/A |
| 2017 | CPSC |
Prohibition of Children’s Toys and Child Care Articles Containing Specified PhthalatesThe United States Consumer Product Safety Commission (Commission or CPSC) issues this final rule prohibiting children’s toys and child care articles that contain concentrations of more than 0.1 percent of diisononyl phthalate (DINP), diisobutyl phthalate (DIBP), di-n-pentyl phthalate (DPENP), di-n-hexyl phthalate (DHEXP), and dicyclohexyl phthalate (DCHP). Section 108 of the Consumer Product Safety Improvement Act of 2008 (CPSIA) established permanent and interim prohibitions on the sale of certain consumer products containing specific phthalates. That provision also directed the CPSC to convene a Chronic Hazard Advisory Panel (CHAP) to study the effects on children’s health of all phthalates and phthalate alternatives as used in children’s toys and child care articles and to provide recommendations to the Commission regarding whether any phthalates or phthalate alternatives, other than those already permanently prohibited, should be prohibited. The CPSIA requires the Commission to promulgate a final rule after receiving the final CHAP report. This rule fulfills that requirement. NTP Information Cited
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117-81-7 |
| 2017 | OEHHA |
Announcement of the Carcinogen Identification Committee Meeting Scheduled for November 2, 2017 and Availability of Hazard Identification Materials for CoumarinThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The Carcinogen Identification Committee (CIC) advises and assists OEHHA in compiling the list of chemicals known to the state to cause cancer as required by Health and Safety Code section 25249.8. The Committee serves as the state’s qualified experts for determining whether a chemical has been clearly shown through scientifically valid testing according to generally accepted principles to cause cancer. NTP Information Cited NTP (1993b). National Toxicology Program, U.S. Department of Health and Human Services. Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). National Toxicology Program Technical Report Series No. 423. https://ntp.niehs.nih.gov/go/tr423abs. NTP (1997). National Toxicology Program, U.S. Department of Health and Human Services. Effect of Dietary Restriction on Toxicology and Carcinogenesis Studies in F344/N Rats and B6C3F1 Mice. National Toxicology Program Technical Report Series No. 460. https://ntp.niehs.nih.gov/go/tr460abs. NTP (1999a). Rats: Fischer F344 (for study years 1984-1994). Historical Controls Database, National Toxicology Program, from https://ntp.niehs.nih.gov/go/historical_controls. NTP (1999b). Mice: B6C3F1 (for study years 1984-1994). Historical Controls Database, National Toxicology Program, from https://ntp.niehs.nih.gov/go/historical_controls.
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91-64-5 |
| 2017 | OEHHA |
Chemical Listed Effective July 7, 2017 as Known to the State of California to Cause Cancer: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]Effective July 7, 2017, OEHHA is adding pentabromodiphenyl ether mixture [DE-71 (technical grade)] to the list of chemicals known to the state to cause cancer for purposes of Proposition 65, under the "authoritative bodies" mechanism. NTP Information Cited
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32534-81-9 |
| 2017 | OEHHA |
Notice of Amendment to Section 25705, No Significant Risk Level for StyreneOn May 4, 2017, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, No Significant Risk Level (NSRL) for the chemical styrene. The regulation will be effective on July 1, 2017. This regulation establishes a No Significant Risk Level of 27 micrograms per day for styrene for purposes of Proposition 65. NTP Information Cited
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100-42-5 |
| 2017 | OEHHA |
Notice of Intent to List Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list pentabromodiphenyl ether mixture [DE-71 (technical grade)] as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism. NTP Information Cited
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32534-81-9 |
| 2017 | CDC |
Proposed Data Collection Submitted for Public Comment and RecommendationsThe Centers for Disease Control and Prevention (CDC), as part of its continuing efforts to reduce public burden and maximize the utility of government information, invites the general public and other Federal agencies to take this opportunity to comment on proposed and/or continuing information collections, as required by the Paperwork Reduction Act of 1995. This notice invites comment on ``Childhood Blood Lead Surveillance (CBLS) and Adult Blood Lead Epidemiology and Surveillance (ABLES).'' The National Center for Environmental Health (NCEH) is leading a new three-year information collection request (ICR) that covers two CDC information collections, one for childhood blood lead surveillance by NCEH and another for adult blood lead surveillance by the National Institute for Occupational Safety and Health (NIOSH). CDC requests an annual time burden of 1,120 burden hours for both collections. NTP Information Cited
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7439-92-1 |
| 2017 | OEHHA |
Amendment to Section 25805, Maximum Allowable Dose Level (Oral) for Ethylene Glycol (Ingested)On April 4, 2017, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25805, Maximum Allowable Dose Level (MADL) for the chemical ethylene glycol (ingested). The regulation will be effective on July 1, 2017. This regulation establishes a MADL of 8,700 (oral) micrograms per day for ethylene glycol (ingested). NTP Information Cited
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7439-92-1 |
| 2017 | EPA |
Tetrabromobisphenol A (TBBPA); TSCA Section 21 PetitionThis document provides the reasons for EPA's response to a petition it received under the Toxic Substances Control Act (TSCA). The TSCA section 21 petition was received from Earthjustice, Natural Resources Defense Council, Toxic-Free Future, Safer Chemicals, Healthy Families, BlueGreen Alliance, and Environmental Health Strategy Center on December 13, 2016. The petitioners requested that EPA issue an order under TSCA section 4, requiring that testing be conducted by manufacturers (which includes importers) and processors on tetrabromobisphenol A (``TBBPA'') (CAS No. 79-94-7). After careful consideration, EPA denied the TSCA section 21 petition for the reasons discussed in this document. NTP Information Cited
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| 2017 | EPA |
Oxytetracycline; Pesticide Tolerances for Emergency ExemptionsThis regulation establishes a time-limited tolerance for residues of oxytetracycline in or on fruit, citrus, group 10-10. This action is in response to EPA's granting of an emergency exemption under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizing use of the pesticide in citrus production. This regulation establishes a maximum permissible level for residues of oxytetracycline in or on the commodities in this crop group. The time-limited tolerance expires on December 31, 2019. NTP Information Cited
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79-57-2 |
| 2017 | EPA |
Isoamyl Acetate; Exemption from the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of isoamyl acetate (CAS Reg. No. 123-92-2) when used as an inert ingredient (buffering agent) in pesticide formulations applied to growing crops and raw agricultural commodities after harvest. The Technology Sciences Group on behalf of the Jeneil Biosurfactant Company submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. NTP Information Cited
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123-92-2 |
| 2017 | EPA |
Fluoride Chemicals in Drinking Water; TSCA Section 21 Petition; Reasons for Agency ResponseThis document announces the availability of EPA's response to a petition it received on November 23, 2016, under section 21 of the Toxic Substances Control Act (TSCA). The TSCA section 21 petition was received from the Fluoride Action Network, Food & Water Watch, Organic Consumers Association, the American Academy of Environmental Medicine, the International Academy of Oral Medicine and Toxicology, and other individual petitioners. The TSCA section 21 petition requested that EPA exercise its authority under TSCA section 6 to ``prohibit the purposeful addition of fluoridation chemicals to U.S. water supplies.'' After careful consideration, EPA has denied the TSCA section 21 petition for the reasons discussed in this document. NTP Information Cited
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7681-49-4 |
| 2017 | OEHHA |
Notice of Adoption of Reference Exposure Levels for Carbonyl SulfideThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for carbonyl sulfide (COS) for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to COS in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposure. NTP Information Cited
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| 2017 | EPA |
Trichloroethylene (TCE); Regulation of Use in Vapor Degreasing Under TSCA Section 6(a)As required under section 6(b)(4) of the Toxic Substances Control Act (TSCA), EPA is proposing to establish a process for conducting risk evaluations to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment, without consideration of costs or other non-risk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation, under the conditions of use. Risk evaluation is the second step, after Prioritization, in a new process of existing chemical substance review and management established under recent amendments to TSCA. This proposed rule identifies the steps of a risk evaluation process including scope, hazard assessment, exposure assessment, risk characterization, and finally a risk determination. EPA is proposing that this process be used for the first ten chemical substances to be evaluated from the 2014 update of the TSCA Work Plan for Chemical Assessments, chemical substances designated as High-Priority Substances during the prioritization process, and those chemical substances for which EPA has initiated a risk evaluation in response to manufacturer requests. The proposed rule also includes the required ‘‘form and criteria’’ applicable to such manufacturer requests. NTP Information Cited National Toxicology Program (NTP). 2015b. OHAT risk of bias tool. https://ntp.niehs.nih.gov/go/riskbias.
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| 2017 | EPA |
Procedures for Chemical Risk Evaluation Under the Amended Toxic Substances Control ActAs required under section 6(b)(4) of the Toxic Substances Control Act (TSCA), EPA is proposing to establish a process for conducting risk evaluations to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment, without consideration of costs or other non-risk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation, under the conditions of use. Risk evaluation is the second step, after Prioritization, in a new process of existing chemical substance review and management established under recent amendments to TSCA. This proposed rule identifies the steps of a risk evaluation process including scope, hazard assessment, exposure assessment, risk characterization, and finally a risk determination. EPA is proposing that this process be used for the first ten chemical substances to be evaluated from the 2014 update of the TSCA Work Plan for Chemical Assessments, chemical substances designated as High- Priority Substances during the prioritization process, and those chemical substances for which EPA has initiated a risk evaluation in response to manufacturer requests. The proposed rule also includes the required "form and criteria'' applicable to such manufacturer requests. NTP Information Cited National Toxicology Program (NTP). 2015b. OHAT risk of bias tool. https://ntp.niehs.nih.gov/go/riskbias.
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| 2017 | EPA |
National Primary Drinking Water Regulations; Announcement of the Results of EPA’s Review of Existing Drinking Water Standards and Request for Public Comment and/or Information on Related IssuesThe Safe Drinking Water Act (SDWA) requires the U.S. Environmental Protection Agency (EPA) to conduct a review every six years of existing national primary drinking water regulations (NPDWRs) and determine which, if any, need to be revised. The purpose of the review, called the Six- Year Review, is to evaluate current information for regulated contaminants to determine if there is new information on health effects, treatment technologies, analytical methods, occurrence and exposure, implementation and/or other factors that provides a health or technical basis to support a regulatory revision that will improve or strengthen public health protection. EPA has completed a detailed review of 76 NPDWRs and at this time has determined that eight NPDWRs are candidates for regulatory revision. The eight NPDWRs are included in the Stage 1 and the Stage 2 Disinfectants and Disinfection Byproducts Rules, the Surface Water Treatment Rule, the Interim Enhanced Surface Water Treatment Rule and the Long Term 1 Enhanced Surface Water Treatment Rule. EPA requests comments on the eight NPDWRs identified as candidates for revision and will consider comments and data as it proceeds with determining whether further action is needed. In addition, as part of this Six-Year Review, EPA identified 12 other NPDWRs that were or continue to be addressed in recently completed, ongoing or pending regulatory actions. EPA thus excluded those 12 NPDWRs from detailed review. This document is not a final regulatory decision, but rather the initiation of a process that will involve more detailed analyses of factors relevant to deciding whether a rulemaking to revise an NPDWR should be initiated. NTP Information Cited National Toxicology Program (NTP). 2007. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 537. https://ntp.niehs.nih.gov/go/tr537abs National Toxicology Program (NTP). 2014. NTP Technical Report on the Toxicology Studies of Bromodichloroacetic Acid in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 583. https://ntp.niehs.nih.gov/go/tr583abs National Toxicology Program (NTP). 2016. NTP research report on systematic literature review on the effects of fluoride on learning and memory in animal studies. Research Triangle Park, NC: National Toxicology Program. Research Report 1. https://doi.org/10.22427/NTP-RR-1.
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7775-09-9 631-64-1 5589-96-8 71133-14-7 7681-49-4 |
| 2017 | EPA |
Trichloroethylene (TCE); Regulation of Use in Vapor Degreasing Under TSCA Section 6(a)Trichloroethylene (TCE) is a volatile organic compound widely used in industrial and commercial processes and has some limited uses in consumer and commercial products. EPA identified significant health risks associated with TCE use in vapor degreasing and EPA’s proposed determination is that these risks are unreasonable risks. To address these unreasonable risks, EPA is proposing under section 6 of the Toxic Substances Control Act (TSCA) to prohibit the manufacture (including import), processing, and distribution in commerce of TCE for use in vapor degreasing; to prohibit commercial use of TCE in vapor degreasing; to require manufacturers, processors, and distributors, except for retailers of TCE for any use, to provide downstream notification of these prohibitions throughout the supply chain; and to require limited recordkeeping. NTP Information Cited
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79-01-6 |
| 2017 | EPA |
Granting Petitions to Add n-Propyl Bromide to the List of Hazardous Air PollutantsThe Environmental Protection Agency (EPA) is publishing a draft notice of the rationale for granting petitions to add n-propyl bromide (nPB), also known as 1-bromopropane (1–BP), (Chemical Abstract Service No. 106–94–5) to the list of hazardous air pollutants (HAP) contained in section 112(b)(1) of the Clean Air Act (CAA). The Halogenated Solvents Industry Alliance (HSIA) and New York State Department of Environmental Conservation (NYSDEC) submitted petitions requesting that nPB be added to the list of HAP. In response to the EPA requests for additional data, HSIA subsequently supplemented its petition. Petitions to add a substance to the list of HAP are permitted under the CAA section 112(b)(3). Based on the EPA’s evaluation of the petitioners’ showing concerning potential hazards, emissions, and atmospheric dispersion modeling that provided estimates of ambient concentrations of nPB, the EPA has determined that there is adequate evidence to support a determination that emissions and ambient concentrations of nPB may reasonably be anticipated to cause adverse health effects. NTP Information Cited
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106-94-5 |
| 2017 | NAS |
New Report Calls for Use of Emerging Scientific Data to Better Assess Public Health RisksRecent scientific and technological advances have the potential to improve assessment of public health risks posed by chemicals, yet questions remain how best to integrate the findings from the new tools and methods into risk assessment. A new National Academies of Sciences, Engineering, and Medicine report recommends approaches for using 21st century science to evaluate the many factors that lead to health risks and disease, laying the groundwork for a new direction in risk assessment that acknowledges the complexity of disease causation. NTP Information Cited
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| 2016 | EPA |
Trichloroethylene; Regulation of Certain Uses Under TSCATrichloroethylene (TCE) is a volatile organic compound widely used in industrial and commercial processes and has some limited uses in consumer and commercial products. EPA identified significant health risks associated with TCE use in aerosol degreasing and for spot cleaning in dry cleaning facilities. EPA has preliminarily determined that these risks are unreasonable risks. To address these unreasonable risks, EPA is proposing under section 6 of the Toxic Substances Control Act (TSCA) to prohibit the manufacture, processing, and distribution in commerce of TCE for use in aerosol degreasing and for use in spot cleaning in dry cleaning facilities; to prohibit commercial use of TCE for aerosol degreasing and for spot cleaning in dry cleaning facilities; to require manufacturers, processors, and distributors, except for retailers of TCE for any use, to provide downstream notification of these prohibitions throughout the supply chain; and to require limited record keeping. NTP Information Cited NTP (National Toxicology Program). 2014. Report on Carcinogens, Thirteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc
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79-34-5 |
| 2016 | EPA |
Formaldehyde Emission Standards for Composite Wood ProductsEPA is issuing a final rule to implement the Formaldehyde Standards for Composite Wood Products Act, which added Title VI to the Toxic Substances Control Act (TSCA). The purpose of TSCA Title VI is to reduce formaldehyde emissions from composite wood products, which will reduce exposures to formaldehyde and result in benefits from avoided adverse health effects. This final rule includes formaldehyde emission standards applicable to hardwood plywood, medium-density fiberboard, and particleboard, and finished goods containing these products, that are sold, supplied, offered for sale, or manufactured (including imported) in the United States. This final rule includes provisions relating to, among other things, laminated products, products made with no-added formaldehyde resins or ultra low-emitting formaldehyde resins, testing requirements, product labeling, chain of custody documentation and other recordkeeping requirements, enforcement, import certification, and product inventory sell-through provisions, including a product stockpiling prohibition. This final rule also establishes a third-party certification program for hardwood plywood, medium-density fiberboard, and particleboard and includes procedures for the accreditation of third-party certifiers and general requirements for accreditation bodies and third-party certifiers. NTP Information Cited NTP (National Toxicology Program). 2014. Report on Carcinogens, Thirteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc
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50-0-0 |
| 2016 | OEHHA |
Chemical Listed Effective October 21, 2016 as Known to the State of California to Cause Cancer: Pentachlorophenol and By-Products of its Synthesis (Complex Mixture)Effective October 21, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding pentachlorophenol and by-products of its synthesis (complex mixture) to the list of chemicals known to the state to cause cancer for purposes of Proposition 65. NTP Information Cited
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87-86-5 |
| 2016 | OEHHA |
Final Technical Support Document on Updated Public Health Goal for Antimony in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of the updated Public Health Goal (PHG) for antimony in drinking water. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California. NTP Information Cited
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123-31-9 28300-74-5 |
| 2016 | VA |
Diseases Associated with Exposure to Contaminants in the Water Supply at Camp LejeuneThe Department of Veterans Affairs (VA) proposes to amend its adjudication regulations relating to presumptive service connection to add certain diseases associated with contaminants present in the base water supply at U.S. Marine Corps Base Camp Lejeune (Camp Lejeune), North Carolina, from August 1, 1953 to December 31, 1987. The chemical compounds involved have been associated by various scientific organizations with the development of certain diseases. This proposed rule would establish that veterans, former reservists, and former National Guard members, who served at Camp Lejeune for no less than 30 days (consecutive or nonconsecutive) during this period, and who have been diagnosed with any of eight associated diseases, are presumed to have a service-connected disability for purposes of entitlement to VA benefits. In addition, VA proposes to establish a presumption that these individuals were disabled during the relevant period of service, thus establishing active military service for benefit purposes. Under this proposed presumption, affected former reservists and National Guard members would have veteran status for purposes of entitlement to some VA benefits. This proposed amendment would implement a decision by the Secretary of Veterans Affairs that service connection on a presumptive basis is warranted for claimants who served at Camp Lejeune during the relevant period and for the requisite amount of time and later develop certain diseases. The Secretary’s decision is supported by the conclusions of internationally recognized scientific authorities that strong evidence exists establishing a relationship between exposure to certain volatile organic compounds (VOCs) that were in the water at Camp Lejeune and later development of certain disabilities. NTP Information Cited
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79-01-6 |
| 2016 | HUD |
Requirements for Notification, Evaluation and Reduction of Lead-Based Paint Hazards in Federally Owned Residential Property and Housing Receiving Federal Assistance; Response to Elevated Blood Lead LevelsThis proposed rule would amend HUD’s lead-based paint regulations on reducing blood lead levels in children under age 6 who reside in federally-owned or -assisted pre-1978 housing and formally adopt the revised definition of ‘‘elevated blood lead levels’’ in children under the age of 6 in accordance with guidance of the Centers for Disease Control and Prevention (CDC), and establish more comprehensive testing and evaluation procedures for the housing where such children reside. In 2012, the CDC issued guidance revising its definition of elevated blood lead level in children under age 6 to be a blood lead level based on the distribution of blood lead levels in the national population. Since CDC’s revision of its definition, HUD has applied the revised definition to funds awarded under its Lead-Based Paint Hazard Control grant program and its Lead Hazard Reduction Demonstration grant program, and has updated its Guidelines for the Evaluation and Control of Lead-Based Paint Hazards in Housing to reflect this definition. CDC is continuing to consider, with respect to evolution of scientific and medical understanding, how best to identify childhood blood lead levels for which environmental interventions are recommended. Through this rule, HUD formally adopts through regulation the CDC’s approach to the definition of ‘‘elevated blood lead levels’’ in children under the age of 6 and addresses the additional elements of the CDC guidance pertaining to assisted housing. NTP Information Cited
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7439-92-1 |
| 2016 | OEHHA |
1-Bromopropane Listed Effective August 5, 2016, as Known to the State of California to Cause CancerEffective August 5, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding 1-bromopropane (CAS No. 106-94-5) to the list of chemicals known to the state to cause cancer for purposes of Proposition 65. NTP Information Cited
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106-94-5 |
| 2016 | OEHHA |
Bromodichloroacetic Acid Listed Effective July 29, 2016 as Known to the State of California to Cause CancerEffective July 29, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding bromodichloroacetic acid (CAS No. 71133-14-7) to the list of chemicals known to the state to cause cancer for purposes of Proposition 65. NTP Information Cited
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71133-14-7 |
| 2016 | DOE |
Chronic Beryllium Disease PreventionThe Department of Energy (DOE or the Department) is proposing to amend its current chronic beryllium disease prevention program regulation. The proposed amendments would improve and strengthen the current provisions and continue to be applicable to DOE Federal and contractor employees who are, were, or potentially were exposed to beryllium at DOE sites. NTP Information Cited
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7440-41-7 |
| 2016 | OEHHA |
Notice of Intent to List Bromodichloroacetic AcidThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemical bromodichloroacetic acid as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. NTP Information Cited
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71133-14-7 |
| 2016 | OEHHA |
Styrene Listed Effective April 22, 2016 As Known To The State Of California To Cause CancerEffective April 22, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding styrene (CAS No. 100-42-5) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of styrene is based on formal identification by the National Toxicology Program (NTP), an authoritative body, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306. NTP Information Cited
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100-42-5 |
| 2016 | OEHHA |
Proposed Amendment to Section 25705, Specific Regulatory Levels Posing No Significant Risk: StyreneThe listing of styrene is based on formal identification by the National Toxicology Program (NTP), an authoritative body, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306. NTP Information Cited
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100-42-5 |
| 2016 | OEHHA |
Notice Of Emergency Action To Amend Section 25603.3 Title 27, California Code Of Regulations Warnings For Exposures To Bisphenol A From Canned And Bottled Foods And BeveragesOn May 11, 2015, Bisphenol A (BPA) was added to the Proposition 65 list of chemicals known to the state to cause reproductive toxicity based on the female reproductive endpoint. Female reproductive toxicity occurs when a chemical damages any aspect of the female reproductive system. BPA is commonly used in certain linings of metal cans and lids of glass bottles containing food and beverages. Under Proposition 65, one year after the listing, beginning May 11, 2016, warnings are required for all exposures to BPA unless the person causing the exposure can show that the exposure when multiplied by 1,000 times has no observable effect. NTP Information Cited
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80-05-7 |
| 2016 | OEHHA |
Notice Of Proposed Rulemaking, Amendment To Section 25805, Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity - Ethylene Glycol (Ingested)OEHHA reviewed the studies identified in the NTP-CERHR Monograph that provide the basis for the listing, and conducted a literature search for any other relevant studies or reports published after the NTP-CERHR review was completed. Additional relevant studies were identified and reviewed by OEHHA. This is discussed in more detail in the initial statement of reasons for this proposed regulatory amendment. NTP Information Cited
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107-21-1 |
| 2016 | EPA |
Diflubenzuron; Pesticide TolerancesThis regulation establishes tolerances for residues of diflubenzuron in or on multiple commodities which are identified and discussed later in this document. Interregional Research Project Number 4 (IR–4) requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). NTP Information Cited
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106-47-8 |
| 2016 | EPA |
Benzyl acetate; Exemption From the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of benzyl acetate (CAS Reg. No. 140–11–4), when used as an inert ingredient (solvent) in pesticide formulations applied to growing crops only under 40 CFR 180.920. Technology Sciences Group, on behalf of the Huntsman Corporation, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of benzyl acetate. NTP Information Cited
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140-11-4 |
| 2015 | EPA |
Addition of 1-Bromopropane; Community Right-to-Know Toxic Chemical Release ReportingThe Environmental Protection Agency (EPA) is adding 1-bromopropane to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. 1-Bromopropane has been classified by the National Toxicology Program in their 13th Report on Carcinogens as ‘‘reasonably anticipated to be a human carcinogen.’’ The EPA has determined that 1-bromopropane meets the EPCRA section 313(d)(2)(B) criteria because it can reasonably be anticipated to cause cancer in humans. NTP Information Cited
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106–94–5 |
| 2015 | OEHHA |
Notice of Intent to List Pentachlorophenol and By-Products of Its Synthesis (Complex Mixture)The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list “pentachlorophenol and by-products of its synthesis (complex mixture)” as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. NTP Information Cited
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87-86-5 |
| 2015 | EPA |
Ethylene Glycol Monobutyl Ether; Community Right-To-Know Toxic Chemical Release ReportingEnvironmental Protection Agency (EPA) is denying a petition to remove ethylene glycol monobutyl ether (EGBE) from the category Certain Glycol Ethers under the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. EPA has reviewed the available data on this chemical and has determined that EGBE does not meet the deletion criterion of EPCRA section 313(d)(3). Specifically, EPA is denying this petition because EPA’s review of the petition and available information resulted in the conclusion that EGBE meets the listing criterion of EPCRA section 313(d)(2)(B) due to its potential to cause serious or irreversible chronic health effects in humans, specifically, liver toxicity and concerns for hematological effects. NTP Information Cited National Toxicology Program (NTP). 2000. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 447. https://ntp.niehs.nih.gov/go/tr447abs National Toxicology Program (NTP). 1993. NTP Technical Report on the Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, and 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 26. https://ntp.niehs.nih.gov/go/tox26abs
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98-01-1 98-00-0 110-00-9 |
| 2015 | OEHHA |
Prioritization: Chemicals for Consultation by the Developmental and Reproductive Toxicant Identification CommitteeThis notice announces the beginning of a 45-day public comment period on the five chemicals listed below. These chemicals will be discussed at the November 9, 2015 meeting of the Proposition 65 Developmental and Reproductive Toxicant Identification Committee (DARTIC). The five chemicals are: • Nickel • Pentachlorophenol • Perfluorooctanoic acid (PFOA) • Perfluorooctane sulfonate (PFOS) • Tetrachloroethylene NTP Information Cited
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7440-02-0 |
| 2015 | OEHHA |
Availability of Hazard Identification Materials For Nitrapyrin And Dilaminotoluenes. "Dilaminotoluene (Mixed)" And Nitrapyrin Are Under Review For Possible DelistingOEHHA is referring nitrapyrin and dilaminotoluene (mixed) to the Carcinogen Identification Committee (CIC), the state’s qualified experts for carcinogenicity determinations under Proposition 65, for review. NTP Information Cited National Toxicology Program (NTP). 1989. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CASRN 87-86-5) in B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 349. https://ntp.niehs.nih.gov/go/tr349abs National Cancer Institute (NCI). 1978. NCI Technical Report on the Bioassay of 2,5-Toluenediamine Sulfate (CASRN 6369-59-1) for Possible Carcinogenicity . Bethesda, MA: National Cancer Institute. Technical Report 126. https://ntp.niehs.nih.gov/go/tr126abs
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95-80-7 6369-59-1 |
| 2015 | OSHA |
Occupational Exposure to Beryllium and Beryllium CompoundsThe Occupational Safety and Health Administration (OSHA) proposes to amend its existing exposure limits for occupational exposure in general industry to beryllium and beryllium compounds and promulgate a substance-specific standard for general industry regulating occupational exposure to beryllium and beryllium compounds. This document proposes a new permissible exposure limit (PEL), as well as ancillary provisions for employee protection such as methods for controlling exposure, respiratory protection, medical surveillance, hazard communication, and recordkeeping. In addition, OSHA seeks comment on a number of alternatives, including a lower PEL, that could affect construction and maritime, as well as general industry. NTP Information Cited National Toxicology Program (NTP). 1999. NTP Report on Carcinogens Background Document for Beryllium and Beryllium Compounds. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/be_no_appendices_508.pdf
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14807-96-6 7440-41-7 |
| 2015 | OEHHA |
Notice of Intent to List Furfuryl AlcoholThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list furfuryl alcohol as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986 NTP Information Cited National Toxicology Program (NTP). 1999. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Furfuryl Alcohol (CARN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 482. https://ntp.niehs.nih.gov/go/tr482abs National Toxicology Program (NTP). 1993. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344/N Rats and B6C3F1 Mice(Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 402. https://ntp.niehs.nih.gov/go/tr402abs
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98-01-1 98-00-0 110-00-9 |
| 2015 | OEHHA |
Petition to AmendPursuant to California Government Code section 11340.6, petitioners Mateel Environmental Justice Foundation, Californians for Alternatives to Toxics, Ecological Rights Foundation and Center for Environmental Health petition the California Office of Environmental Health Hazard Assessment to amend CCR, title 27, section 27001(b) to add glyphosate, malathion, tetrachlorvinphos and parathion to the chemicals listed under that section as known to the State to cause cancer. NTP Information Cited
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56-38-2 |
| 2015 | OEHHA |
Notice of Intent to List: 1-BromopropaneThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list 1-bromopropane as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. NTP Information Cited
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109-94-5 |
| 2015 | OEHHA |
Chemical Listed Effective June 19, 2015 as Known to the State of California to Cause Reproductive Toxicity: Ethylene Glycol (Ingested)Effective June 19, 2015, the Office of Environmental Health Hazard Assessment (OEHHA) is adding ethylene glycol (ingested) (CAS No. 107-21-1) to the list of chemicals known to the state to cause reproductive toxicity for purposes of Proposition 65. NTP Information Cited
|
107-21-1 |
| 2015 | NRDC |
NRDC, Others Petition FDA to Ban Eight Carcinogenic Flavorings in FoodEight synthetic flavorings—which may be found in ice cream, baked goods, candy and beverages—are known to cause cancer in lab animals, and should be banned by the U.S. Food and Drug Administration, a coalition of leading health groups said in a petition filed with the agency today. NTP Information Cited National Toxicology Program (NTP). 2000. NTP Report on Carcinogens Background Document for Methyleugenol. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/me_no_appendices_508.pdf National Toxicology Program (NTP). 2000. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 491. https://ntp.niehs.nih.gov/go/tr491abs National Toxicology Program (NTP). 2010. NTP Technical Report on the Toxicology and Carcinogenesis Studies of beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 557. https://ntp.niehs.nih.gov/go/tr557abs National Toxicology Program (NTP). 2011. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Pulegone (CARN 89-82-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 563. https://ntp.niehs.nih.gov/go/tr563abs National Toxicology Program (NTP). 2000. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 470. https://ntp.niehs.nih.gov/go/tr470abs NTP (National Toxicology Program). 2014. Styrene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/styrene.pdf National Toxicology Program (NTP). 2008. NTP Report on Carcinogens Background Document for Styrene. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf National Toxicology Program (NTP). 2000. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Hexadienal (CASRN 142-83-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 509. https://ntp.niehs.nih.gov/go/tr509abs
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119-61-9 140-88-5 93-15-2 123-35-3 89-82-7110-86-1100-42-5 142-83-6 |
| 2015 | ATSDR |
Toxicological Profile for FormaldehydeThe ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. NTP Information Cited NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc NTP (National Toxicology Program). 2005. Cadmium and Cadmium Compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cadmium.pdf NTP (National Toxicology Program). 2005. Chromium Hexavalent Compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
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NA |
| 2015 | FDA |
Safety and Effectiveness of Health Care Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use; Proposed Amendment of the Tentative Final Monograph; Reopening of Administrative RecordThe Food and Drug Administration (FDA) is issuing this proposed rule to amend the 1994 tentative final monograph or proposed rule (the 1994 TFM) for over-the-counter (OTC) antiseptic drug products. In this proposed rule, we are proposing to establish conditions under which OTC antiseptic products intended for use by health care professionals in a hospital setting or other health care situations outside the hospital are generally recognized as safe and effective. In the 1994 TFM, certain antiseptic active ingredients were proposed as being generally recognized as safe for use in health care settings based on safety data evaluated by FDA as part of its ongoing review of OTC antiseptic drug products. However, in light of more recent scientific developments, we are now proposing that additional safety data are necessary to support the safety of antiseptic active ingredients for these uses. We also are proposing that all health care antiseptic active ingredients have in vitro data characterizing the ingredient’s antimicrobial properties and in vivo clinical simulation studies showing that specified log reductions in the amount of certain bacteria are achieved using the ingredient. NTP Information Cited
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121-54-0 51-79-6 64-17-5 136-77-6 |
| 2015 | OEHHA |
Hazard Identification Materials for Consideration of the Female Reproductive Toxicity of Bisphenol ABisphenol A (BPA) will be considered for listing at the next meeting of the Developmental and Reproductive Toxicant Identification Committee (DARTIC) scheduled for May 7, 2015 in Sacramento. At this meeting,, the DARTIC will consider whether BPA "has been clearly shown through scientifically valid testing according to generally accepted principles to cause female reproductive toxicity". NTP Information Cited National Toxicology Program (NTP). 2008. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
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80-05-7 |
| 2015 | OEHHA |
Meeting Synopsis and Slide Presentation for the Carcinogen Identification Committee Meeting Held on November 19,2014The Office of Environmental Health Hazard Assessment (OEHHA) convened a meeting of the Proposition 65 Carcinogen Identification Committee (CIC) on November 19, 2014, at the California Environmental Protection Agency Headquarters Building in Sacramento, California. The Committee considered whether or not dibenzanthracenes (as a chemical group), dibenz[a,c]anthracene, dibenz[a,j]anthracene, and N-nitrosomethyl-n-alkylamines with alkyl chain lengths of 3 through 12 and 14 carbons should be listed under Proposition 65 as known to the state to cause cancer. NTP Information Cited
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53-70-3 |
| 2015 | EPA |
Addition of 1-Bromopropane; Community Right-To-Know Toxic Chemical Release ReportingThe Environmental Protection Agency (EPA) is proposing to add 1-bromopropane to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. 1-Bromopropance has been classified by the National Toxicology Program in their 13th Report on Carcinogens as “reasonably anticipated to be human carcinogen.” EPA believes that 1-bromopropane meets the EPCRA section 313(d)(2)(B) criteria because it can reasonably be anticipated to cause cancer in humans. Based on a review of the available production and use information, 1-bromopropane is expected to be manufactured, processed, or otherwise used in quantities that would exceed the EPCRA section 313 reporting thresholds. NTP Information Cited National Toxicology Program (NTP). 2013. Report on Carcinogens. Monograph on 1-Bromopropane. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf NTP (National Toxicology Program). 2014. 1-Bromopropane. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromopropane.pdf
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109-94-5 |
| 2015 | OEHHA |
Chemical Listed Effective March 27, 2015 as Known to the State of California to Cause Cancer: Beta-MyrceneEffective March 27, 2015,the Office of Environmental Health Hazard Assessment (OEHHA) is adding beta-myrcene(CAS No. 123-35-3)to the list of chemicals known to the state to cause cancer for purposes of Proposition 65 NTP Information Cited
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123-35-3 |
| 2015 | OEHHA |
Notice of Intent to List: StyreneThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list styrene as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. NTP Information Cited
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100-42-5 |
| 2015 | EPA |
Toluene Diisocyanates (TDI) and Related Compounds; Significant New Use RuleUnder the Toxic Substance Control Act (TSCA), EPA is proposing significant new use rule (SNUR) for 2,4- toluene diisocyanate, 2,6-toluene diisocyanate, toluene diisocyanate unspecified isomers (these three chemical substances are hereafter referred to as toluene diisocyanates or TDI) and related compounds as identified in this proposed rule. The proposed significant new use is any use in a consumer product, with a proposed exception for use of certain chemical substances in coatings, elastomers, adhesives, binders, and sealants that results in less than or equal to 0.1 percent by weight of TDI in a consumer product. In addition, EPA is also proposing that the general SNUR article exemption for persons who import or process these chemical substances as part of an article would not apply." "Persons subject to the SNUR would be required to notify EPA at least 90 days before commencing any manufacturing or processing. The required notification would provide EPA with the opportunity to evaluate the intended use and, if necessary based on the information available at that time, an opportunity to protect against potential unreasonable risks, if any, from that activity before it occurs." NTP Information Cited
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9019-85-6 9017-01-0 26747-90-0 26603-40-7 26603-40-791-08-7584-84-9 26471-62-5 |
| 2015 | OEHHA |
Notice of Proposed Rulemaking and Announcement of Public Hearing Title 27, California Code of Regulations Proposed Adoption of Section 25205 Proposition 65 Lead Agency WebsiteThis regulation would establish the framework for a website operated by OEHHA that would provide supplemental information to the public about potential exposures to Proposition 65 listed chemicals. NTP Information Cited
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N/A |
| 2014 | ATSDR |
Prohibition of Children’s Toys and Child Care Articles Containing Specific PhthalatesSection 108 of the Consumer Product Safety Improvement Act of 2008 (CPSIA), requires the United States Consumer Product Safety Commission (Commission or CPSC) to convene a Chronic Hazard Advisory Panel (CHAP) to study the effects on children’s health of all phthalates and phthalate alternatives as used in children’s toys and child care articles and to provide recommendations to the Commission regarding whether any phthalates or phthalate alternatives other than those already permanently prohibited should be prohibited. The CPSIA requires the Commission to promulgate a final rule after receiving the final CHAP report. The Commission is proposing this rule pursuant to section 108(b) of the CPSIA. The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), § 104(i)(3),[42 U.S.C. 9604(i)(3)], directs the ATSDR administrator to prepare Toxicological Profiles of priority hazardous substances and, as necessary, to revise and publish each updated toxicological profile. NTP Information Cited NTP, 1982. Carcinogenesis bioassay of di(2-ethylhexyl) adipate (CAS No. 103-23-1) in F344 rats and B6C3F1 mice (feed study). National Toxicology Program (NTP), Research Triangle Park, NC. NTP technical report series No. 212. https://ntp.niehs.nih.gov/go/tr212. NTP, 1989. Developmental Toxicity of Dimethyl Phthalate (CAS No. 131-11-3) Administered to CD Rats on Gestational Days 6 Through 15. National Toxicology Program. NTP Study: TER88066. January 9, 1989. https://ntp.niehs.nih.gov/go/ter88066abs. NTP, 1997. Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies. Environmental Health Perspectives 105 (Suppl 1), 199–395. https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.97105s1199. NTP, 2000. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Butyl Phthalate (DBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf. NTP, 2002. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf. NTP, 2003a. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate (BBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4487. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf. NTP, 2003b. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. April 2003. NIH publication no. 03-4485. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/didp/didp_monograph_final.pdf. NTP, 2003c. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isononyl Phthalate (DINP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4484. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dinp/dinp_monograph_final.pdf. NTP, 2003d. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Hexyl Phthalate (DnHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4489. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf. NTP, 2006. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. November 2006. NIH publication no. 06-4476. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf. NTP, 2000. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Butyl Phthalate (DBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf. NTP, 2003a. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate (BBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4487. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf. NTP, 2003c. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isononyl Phthalate (DINP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4484. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/didp/didp_monograph_final.pdf. NTP, 2003d. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Hexyl Phthalate (DnHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4489. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf. NTP, 2003e. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Octyl Phthalate (DnOP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. NIH publication no. 03-4488. May 2003. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnop/dnop_monograph_final.pdf. NTP, 2004. Diethylhexylphthalate: Multigenerational reproductive assessment by continuous breeding when Diethylhexylphthalate (CAS 117-81-7) was administered to SpragueDawley rats in the diet. National Toxicology Program (NTP), Research Triangle Park, NC. NTP Study no. RACB98004. https://ntp.niehs.nih.gov/publications/abstracts/repro/racb98004/index.html. NTP, 2006. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. November 2006. NIH publication no. 06-4476. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf. NTP, 2003b. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. April 2003. NIH publication no. 03-4485. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/didp/didp_monograph_final.pdf.
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| 2014 | OEHHA |
OEHHA Presentation on a PBPK Model of Blood Lead and Worker ExposureThe Office of Environmental Health Hazard Assessment (OEHHA) has developed a PBPK (physiologically based pharmacokinetic) model describing the relationship between airborne lead and blood levels in workers and released it in October 2013. The model was developed at the request of the California Department of Public Health (CDPH) and is being used to understand workplace exposures. NTP Information Cited NTP (2011) ‘Lead and lead compounds Report on Carcinogens’, Twelfth Edition, National Toxicology program, department of health and human services https://ntp.niehs.nih.gov/go/roc12.
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7439-92-1 |
| 2014 | EPA |
National Emissions Standards for Hazardous Air Pollutants: Primary Aluminum Reduction PlantsThis action supplements our proposed amendments to the national emission standards for hazardous air pollutants (NESHAP) for the Primary Aluminum Production source category published in the Federal Register on December 6, 2011. In that action, the Environmental Protection Agency (EPA) proposed amendments based on the initial residual risk and technology reviews (RTR) for this source category, and also proposed certain emission limits reflecting performance of Maximum Achievable Control Technology (MACT). Today’s action reflects a revised technology review and a revised residual risk analysis for the Primary Aluminum Production source category and proposes new and revised emission standards based on those analyses, newly obtained emissions test data, and comments we received in response to the 2011 proposal, including certain revisions to the technology-based standards reflecting performance of MACT. This action also proposes new compliance requirements to meet the revised standards. This action, if adopted, will provide improved environmental protection regarding potential emissions of hazardous air pollutant (HAP) emissions from primary aluminum production facilities. NTP Information Cited
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| 2014 | FDA |
Information Collection; Qualified Products Lists for Fire Chemicals for Wild Land Fire ManagementIn accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension with no revision of a currently approved information collection, Qualified Products Lists for Fire Chemicals for Wild Land Fire Management. NTP Information Cited NTP (National Toxicology Program). Report on Carcinogens, Twelfth Edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc.
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| 2014 | OEHHA |
Request for Relevant Information on the Carcinogenic Hazards of DiaminotoluenesIn order to clarify the scope of the listing, OEHHA is referring diaminotoluene (mixed) to the CIC for a determination as to whether the chemical should continue to be included on the list of chemicals known to the state to cause cancer pursuant to Title 27, Cal. Code of Regs., section 25306 (j). NTP Information Cited National Toxicology Program, NTP Technical Report on the Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures in B6C3F1 Mice, NTP TR 349, NIH Publication No. 89-2804, March, 1989. https://ntp.niehs.nih.gov/go/tr349.
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2687-25-4 95-70-5 823-40-5 496-72-0 108-71-4 |
| 2014 | EPA |
National Emission Standards for Hazardous Air Pollutants: Ferroalloys ProductionThis action supplements our proposed amendments to the national emission standards for hazardous air pollutants (NESHAP) for the Ferroalloys Production source category published in the Federal Register on November 23, 2011. In that action, the Environmental Protection Agency (EPA) proposed amendments based on the initial technology and residual risk reviews for this source category. Today’s action presents a revised technology review and a revised residual risk review for the Ferroalloys Production source category and proposes revisions to the standards based on those reviews. This action also proposes new compliance requirements to meet the revised standards. This action would result in significant environmental improvements through the reduction of fugitive manganese emissions and through more stringent emission limits for several processes. NTP Information Cited NTP (National Toxicology Program). Report on Carcinogens, Twelfth Edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc.
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| 2014 | OSHA |
Chemical Management and Permissible Exposure Limits (PELs); Proposed RuleOSHA is reviewing its overall approach to managing chemical exposures in the workplace and seeks stakeholder input about more effective and efficient approaches that addresses challenges found with the current regulatory approach. This review involves considering issues related to updating permissible exposure limits (PELs), as well as examining other strategies that could be implemented to address workplace conditions where workers are exposed to chemicals. The notice details the role of past court decisions on the Agency’s current approach to chemical management for the purpose of informing stakeholders of the legal framework in which the Agency must operate. It then describes possible modifications of existing processes, along with potential new sources of data and alternative approaches the Agency may consider. The Agency is particularly interested in information about how it may take advantage of newer approaches, given its legal requirements. This RFI is concerned primarily with chemicals that cause adverse health effects from long-term occupational exposure, and is not related to activities being conducted under Executive Order 13650, Improving Chemical Facility Safety and Security. NTP Information Cited National Toxicology Program (NTP). (2013). High Throughput Screening Initiative. Retrieved from: https://ntp.niehs.nih.gov/go/28213.
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| 2014 | FDA |
Revocation of General Safety Test Regulations that are Duplicative of Requirements in Biological License ApplicationsThe Food and Drug Administration (FDA) is proposing to amend the biologics regulations by removing the general safety test (GST) requirements for biological products. FDA is proposing this action because the existing codified GST regulations are duplicative of requirements that are also specified in biologics licenses, or are no longer necessary or appropriate to help ensure the safety, purity, and potency of licensed biological products. FDA is taking this action as part of its retrospective review of its regulations to promote improvement and innovation, in response to an Executive order. NTP Information Cited
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| 2014 | EPA |
Fragrance Components; Proposed Exemption from the Requirement of a ToleranceThis document proposes to establishes an exemption from the requirement of a tolerance for residues of various fragrance component substances (when used as inert ingredients) in antimicrobial pesticide formulations for use on food contact surfaces in public eating places, dairy processing equipment, and food processing equipment and utensils NTP Information Cited
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75-07-0 64-19-7 107-92-6 71-36-3 5392-40-5106-22-9150-84-5 23726-92-3 112-31-2 65405-70-1 334-48-5 112-30-1 106-72-9 20407-84-5 452-79-1 106-24-1 105-87-3 111-71-7 111-14-8 111-70-6 66-25-1 142-62-1 111-27-3 828-96-1 3681-71-8 142.92-7 111-27-3 143-07-7 112-54-9 112-53-8 5989-27-5 127-42-4 1191-16-8 110-41-8 124-25-4 544-63-8 141-12-8 124-19-6 112-05-0 143-08-8 124-13-0 124-07-2 111-87-5 57-10-3 79-09-4 57-11-4 7774-82-5 5435-64-3 112-44-7 112-42-5 110-62-3 109-52-4 |
| 2014 | OEHHA |
Comments Received on the Notice of Intent to List for Ethylene GlycolThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemical ethylene glycol (EG) as known to the state to cause reproductive toxicity (developmental endpoint) under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism NTP Information Cited
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107-21-1 |
| 2014 | OEHHA |
Notice of Adoption of Reference Exposure Levels for BenzeneThe Office of Environmental Health Hazard Assessment (OEHHA) is adopting new and revised Reference Exposure Levels (RELs) for benzene. NTP Information Cited National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of benzene (CASRN 71-43-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 289. https://ntp.niehs.nih.gov/go/tr289.
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71-43-2 |
| 2014 | OEHHA |
Chemical Listed Effective May 2, 2014 as Known to the State of California to Cause Cancer: N,N-dimethyl-p-toluidineEffective May 2, 2014, the Office of Environmental Health Hazard Assessment (OEHHA) is adding N,N-dimethyl-p-toluidine to the list of chemicals known to the State to cause cancer for purposes of Proposition 65. NTP Information Cited
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99-97-8 |
| 2014 | EPA |
Control of Air Pollution from Motor Vehicles: Tier 3 Motor Vehicle Emission and Fuel StandardsThis action establishes more stringent vehicle emissions standards and will reduce the sulfur content of gasoline beginning in 2017, as part of a systems approach to addressing the impacts of motor vehicles and fuels on air quality and public health. The gasoline sulfur standard will make emission control systems more effective for both existing and new vehicles, and will enable more stringent vehicle emissions standards. The vehicle standards will reduce both tailpipe and evaporative emissions from passenger cars, light-duty trucks, medium-duty passenger vehicles, and some heavy-duty vehicles. This will result in significant reductions in pollutants such as ozone, particulate matter, and air toxics across the country and help state and local agencies in their efforts to attain and maintain health-based National Ambient Air Quality Standards. Motor vehicles are an important source of exposure to air pollution both regionally and near roads. These vehicle standards are intended to harmonize with California's Low Emission Vehicle program, thus creating a federal vehicle emissions program that will allow automakers to sell the same vehicles in all 50 states. The vehicle standards will be implemented over the same timeframe as the greenhouse gas/fuel efficiency standards for light-duty vehicles (promulgated by EPA and the National Highway Safety Administration in 2012), as part of a comprehensive approach toward regulating emissions from motor vehicles. NTP Information Cited NTP (National Toxicology Program). Benzene. Report on Carcinogens, Twelfth Edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf.
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71-43-2 106-99-0 75-07-0 91-20-3 50-00-0 |
| 2014 | OEHHA |
Intent to List: Ethylene GlycolThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemical ethylene glycol (EG) as known to the state to cause reproductive toxicity (developmental endpoint) under the Safe Drinking Water and Toxic Enforcement Act of 1986.1 This action is being proposed under the authoritative bodies listing mechanism. NTP Information Cited
|
107–21–1 |
| 2014 | EPA |
Diflubenzuron; Pesticide TolerancesThis regulation establishes tolerances for residues of diflubenzuron (N-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluorobenzimide) in or on fruit, citrus, group 10-10 and citrus, oil. Chemtura Corporation, requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). NTP Information Cited National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351.
|
20265-96-7 |
| 2013 | FDA |
Safety and Effectiveness of Consumer Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use; Proposed Amendment of the Tentative Final Monograph; Reopening of Administrative Record.The Food and Drug Administration (FDA) is issuing this proposed rule to amend the 1994 tentative final monograph or proposed rule (the 1994 TFM) for over-the-counter (OTC) antiseptic drug products. In this proposed rule, we are proposing to establish conditions under which OTC consumer antiseptic products intended for use with water (referred to throughout as consumer antiseptic washes) are generally recognized as safe and effective. In the 1994 TFM, certain antiseptic active ingredients were proposed as being safe for antiseptic handwash use by consumers based on safety data evaluated by FDA as part of our ongoing review of OTC antiseptic drug products. However, in light of more recent scientific developments and changes in the use patterns of these products we are now proposing that additional safety data are necessary to support the safety of antiseptic active ingredients for this use. We also are proposing that all consumer antiseptic wash active ingredients have data that demonstrate a clinical benefit from the use of these consumer antiseptic wash products compared to nonantibacterial soap and water. NTP Information Cited
|
136-77-6 |
| 2013 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption; Acacia (Gum Arabic)The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the expanded safe use of acacia (gum arabic) in foods. This action is in response to a petition filed by Nexira. NTP Information Cited
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|
| 2013 | EPA |
Addition of ortho-Nitrotoluene; Community Right-to-Know Toxic Chemical Release ReportingEPA is adding ortho-nitrotoluene (o-nitrotoluene) to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. o-Nitrotoluene has been classified by the National Toxicology Program in its 12th Report on Carcinogens as “reasonably anticipated to be a human carcinogen.” EPA has determined that o-nitrotoluene meets the EPCRA section 313(d)(2)(B) criteria because it can reasonably be anticipated to cause cancer in humans. NTP Information Cited
|
88-72-2 |
| 2013 | CDC |
World Trade Center Health Program; Addition of Prostate Cancer to the List of WTC-Related Health Conditions.On May 2, 2013, the Administrator of the World Trade Center (WTC) Health Program received a petition (Petition 002) requesting the addition of prostate cancer to the List of WTC-Related Health Conditions (List) covered in the WTC Health Program. In this final rule, the Administrator adds malignant neoplasm of the prostate (prostate cancer) to the List in the WTC Health Program regulations. NTP Information Cited
|
NA |
| 2013 | OSHA |
Occupational Exposure to Respirable Crystalline SilicaThe Occupational Safety and Health Administration (OSHA) proposes to amend its existing standards for occupational exposure to respirable crystalline silica. The basis for issuance of this proposal is a preliminary determination by the Assistant Secretary of Labor for Occupational Safety and Health that employees exposed to respirable crystalline silica face a significant risk to their health at the current permissible exposure limits and that promulgating these proposed standards will substantially reduce that risk. This document proposes a new permissible exposure limit, calculated as an 8-hour time-weighted average, of 50 micrograms of respirable crystalline silica per cubic meter of air (50 μg/m3). OSHA also proposes other ancillary provisions for employee protection such as preferred methods for controlling exposure, respiratory protection, medical surveillance, hazard communication, and recordkeeping. OSHA is proposing two separate regulatory texts—one for general industry and maritime, and the other for construction—in order to tailor requirements to the circumstances found in these sectors. NTP Information Cited
|
None assigned |
| 2013 | CDC |
World Trade Center Health Program; Addition of Prostate Cancer to the List of WTC-Related Health ConditionsOn May 2, 2013, the Administrator of the World Trade Center (WTC) Health Program received a petition (Petition 002) requesting the addition of prostate cancer to the List of WTC-Related Health Conditions (List) covered in the WTC Health Program. The Administrator has determined to publish a proposed rule adding malignant neoplasm of the prostate (prostate cancer) to the List in the WTC Health Program regulations. NTP Information Cited NTP (National Toxicology Program). 2011. Arsenic and Inorganic Arsenic Compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/arsenic.pdf NTP (National Toxicology Program). 2011. Arsenic. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cadmium.pdf
|
7440-38-2 7440-43-9 |
| 2013 | EPA |
Formaldehyde Emissions Standards for Composite Wood ProductsEPA is proposing new requirements under the Formaldehyde Standards for Composite Wood Products Act, or Title VI of the Toxic Substances Control Act (TSCA). These proposed requirements are designed to implement the statutory formaldehyde emission standards for hardwood plywood, medium-density fiberboard, and particle board sold, supplied, offered for sale, or manufactured (including imported) in the United States. As directed by the statute, this proposal includes provisions relating to, among other things, laminated products, products made with no-added formaldehyde resins or ultra low-emitting formaldehyde resins, testing requirements, product labeling, chain of custody documentation and other recordkeeping requirements, enforcement, and product inventory sell-through provisions, including a product stockpiling prohibition. The composite wood product formaldehyde emission standards contained in TSCA Title VI are identical to the emission standards currently in place in California. This regulatory proposal implements these emissions standards and is designed to ensure compliance with the TSCA Title VI formaldehyde emission standards while aligning, where practical, with the regulatory requirements in California. NTP Information Cited NTP (National Toxicology Program). 2011. Formaldehyde. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf
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50-00-0 |
| 2013 | EPA |
Formaldehyde; Third-Party Certification Framework for the Formaldehyde Standards for Composite Wood ProductsThe Formaldehyde Standards for Composite Wood Products Act (Title VI of the Toxic Substances Control Act (TSCA)) establishes formaldehyde emission standards for hardwood plywood, particle board, and medium-density fiberboard (composite wood products) and directs EPA to promulgate implementing regulations by January 1, 2013. Pursuant to the requirements of TSCA Title VI, EPA is proposing a framework for a TSCA Title VI Third-Party Certification Program for composite wood products. Under the framework, third-party certifiers (TPCs) would be accredited by EPA-recognized accreditation bodies (ABs) so that TPCs may certify composite wood product panel producers under TSCA Title VI. This proposed rule identifies the roles and responsibilities of the TPCs and ABs involved, as well as the criteria for participation in the TSCA Title VI Third-Party Certification Program. The Agency is proposing the TSCA Title VI Third-Party Certification Program framework prior to the rest of the TSCA Title VI implementing regulations in order to allow interested parties an opportunity to comment and to begin identifying the business practices and infrastructure that may need to be modified or developed in order to effectively participate in the program. NTP Information Cited
|
50-00-0 |
| 2013 | EPA |
Guar Hydroxypropyltrimethylammonium Chloride; Exemption From the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of guar hydroxypropyltrimethylammonium chloride (CAS Reg. No. 71329-50-5) when used as an inert ingredient (thickener/drift reduction agent) in pesticide formulations applied to growing crops. SciReg. Inc., on behalf of Rhodia Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of guar hydroxypropyltrimethylammonium chloride. NTP Information Cited
|
9000-30-0 |
| 2013 | EPA |
Control of Air Pollution From Motor Vehicles: Tier 3 Motor Vehicle Emission and Fuel StandardsThis action would establish more stringent vehicle emissions standards and reduce the sulfur content of gasoline beginning in 2017, as part of a systems approach to addressing the impacts of motor vehicles and fuels on air quality and public health. The proposed gasoline sulfur standard would make emission control systems more effective for both existing and new vehicles, and would enable more stringent vehicle emissions standards. The proposed vehicle standards would reduce both tailpipe and evaporative emissions from passenger cars, light-duty trucks, medium-duty passenger vehicles, and some heavy-duty vehicles. This would result in significant reductions in pollutants such as ozone, particulate matter, and air toxics across the country and help state and local agencies in their efforts to attain and maintain health-based National Ambient Air Quality Standards. Motor vehicles are an important source of exposure to air pollution both regionally and near roads. These proposed vehicle standards are intended to harmonize with California's Low Emission Vehicle program, thus creating a federal vehicle emissions program that would allow automakers to sell the same vehicles in all 50 states. The proposed vehicle standards would be implemented over the same timeframe as the greenhouse gas/fuel efficiency standards for light-duty vehicles, as part of a comprehensive approach toward regulating emissions from motor vehicles. NTP Information Cited
|
50-00-0 71-43-2 75-07-0 91-20-3 106-99-0 |
| 2013 | OEHHA |
Chemical Delisted Effective April 19, 2013 as Known to the State of California to Cause Reproductive Toxicity: Bisphenol A (BPA)Effective April 19, 2013, the Office of Environmental Health Hazard Assessment (OEHHA) is removing bisphenol A (BPA) (CAS No. 80-05-7) from the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of Proposition 65.1 The chemical was added to the list on April 11, 2013 based on reproductive endpoints (developmental toxicity). NTP Information Cited National Toxicology Program (NTP). 2008. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
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80-05-7 |
| 2013 | CDC |
World Trade Center Health Program; Certification of Breast Cancer in WTC Responders and Survivors Exposed to PCBsOn September 12, 2012, HHS published a final rule in the Federal Register adding certain types of cancer to the List of World Trade Center (WTC)-Related Health Conditions (List) established in the WTC Health Program regulation. Breast cancer was included on the List, although only individuals experiencing nighttime sleep disruption as a result of response and cleanup activities involving shiftwork are currently considered to have experienced exposure relevant for certification. A recent publication in The Lancet Oncology by the International Agency for Research on Cancer (IARC) concludes that there is limited evidence that polychlorinated biphenyls (PCBs) cause breast cancer in humans. As described below, the WTC Program Administrator (Administrator) has found that PCBs were present in WTC dust in the New York City disaster area and, accordingly, the Program will now certify breast cancer in eligible WTC responders and survivors who were exposed to either shiftwork/nighttime sleep disruption or PCBs as a result of the 9/11 attacks. NTP Information Cited
|
1336-36-3 |
| 2013 | EPA |
Addition of ortho-Nitrotoluene; Community Right-to-Know Toxic Chemical Release ReportingEPA is proposing to add ortho-nitrotoluene (o-nitrotoluene) to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. o-Nitrotoluene has been classified by the National Toxicology Program in their 12th Report on Carcinogens as “reasonably anticipated to be a human carcinogen.” EPA believes that o-nitrotoluene meets the EPCRA section 313(d)(2)(B) criteria because it can reasonably be anticipated to cause cancer in humans. Based on a review of the available production and use information, o-nitrotoluene is expected to be manufactured, processed, or otherwise used in quantities that would exceed the EPCRA section 313 reporting thresholds. NTP Information Cited
|
88-72-2 |
| 2012 | EPA |
2017 and Later Model Year Light-Duty Vehicle Greenhouse Gas Emissions and Corporate Average Fuel Economy StandardsEPA and NHTSA, on behalf of the Department of Transportation, are issuing final rules to further reduce greenhouse gas emissions and improve fuel economy for light-duty vehicles for model years 2017 and beyond. On May 21, 2010, President Obama issued a Presidential Memorandum requesting that NHTSA and EPA develop through notice and comment rulemaking a coordinated National Program to improve fuel economy and reduce greenhouse gas emissions of light-duty vehicles for model years 2017-2025, building on the success of the first phase of the National Program for these vehicles for model years 2012-2016. This final rule, consistent with the President's request, responds to the country's critical need to address global climate change and to reduce oil consumption. NHTSA is finalizing Corporate Average Fuel Economy standards for model years 2017-2021 and issuing augural standards for model years 2022-2025 under the Energy Policy and Conservation Act, as amended by the Energy Independence and Security Act. NHTSA will set final standards for model years 2022-2025 in a future rulemaking. EPA is finalizing greenhouse gas emissions standards for model years 2017-2025 under the Clean Air Act. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, and represent the continuation of a harmonized and consistent National Program. Under the National Program automobile manufacturers will be able to continue building a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices that are available today. EPA is also finalizing minor changes to the regulations applicable to model years 2012-2016, with respect to air conditioner performance, nitrous oxides measurement, off-cycle technology credits, and police and emergency vehicles. NTP Information Cited National Toxicology Program (NTP). 2012. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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75-07-0 91-20-3 71-43-2 106-99-0 50-00-0 |
| 2012 | CDC |
World Trade Center Health Program; Addition of Certain Types of Cancer to the List of WTC-Related Health ConditionsTitle I of the James Zadroga 9/11 Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) to establish the World Trade Center (WTC) Health Program. The WTC Health Program, which is administered by the Director of the National Institute for Occupational Safety and Health (NIOSH), within the Centers for Disease Control and Prevention (CDC), provides medical monitoring and treatment to eligible firefighters and related personnel, law enforcement officers, and rescue, recovery, and cleanup workers who responded to the September 11, 2001, terrorist attacks in New York City, at the Pentagon, and in Shanksville, Pennsylvania, and to eligible survivors of the New York City attacks. In accordance with WTC Health Program regulations, which establish procedures for adding a new condition to the list of covered health conditions, this final rule adds to the List of WTC-Related Health Conditions the types of cancer proposed for inclusion by the notice of proposed rulemaking. NTP Information Cited
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NA |
| 2012 | OEHHA |
Added to List of Chemicals Known to the State to Cause Cancer: Isopyrazam and 3,3',4,4'-TetrachloroazobenzeneEffective July 24, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding two chemicals, isopyrazam (CAS No. 881685-58-1) and 3,3’,4,4’‑tetrachloroazobenzene (CAS No. 14047-09-7), to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (commonly known as Proposition 651) NTP Information Cited National Toxicology Program (NTP). 1998. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (CASRN 14047-09-7) to F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 65.
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14047-09-7 |
| 2012 | CPSC |
Proposed Statement of Policy on Animal TestingThe Consumer Product Safety Commission (CPSC or Commission) proposes to codify its statement of policy on animal testing, as amended, which was previously published in the Federal Register. The amended statement of policy on animal testing is intended for manufacturers of products subject to the Federal Hazardous Substances Act (FHSA) to find alternatives to animal testing and reduce the number of animal tests under the FHSA. NTP Information Cited ICCVAM Authorization Act of 2000
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NA |
| 2012 | CDC |
World Trade Center Health Program; Addition of Certain Types of Cancer to the List of WTC-Related Health ConditionsTitle I of the James Zadroga 9/11 Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) to establish the World Trade Center (WTC) Health Program. The WTC Health Program, which is administered by the Director of the National Institute for Occupational Safety and Health (NIOSH), within the Centers for Disease Control and Prevention (CDC), provides medical monitoring and treatment to eligible firefighters and related personnel, law enforcement officers, and rescue, recovery, and cleanup workers who responded to the September 11, 2001, terrorist attacks in New York City, at the Pentagon, and in Shanksville, Pennsylvania, and to eligible survivors of the New York City attacks. In accordance with our regulations, which establish procedures for adding a new condition to the list of health conditions covered by the WTC Health Program, this proposed rule would add certain types of cancer to the List of WTC-Related Health Conditions. NTP Information Cited National Toxicology Program (NTP). 2012. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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7740-38-2 75-01-4 |
| 2012 | EPA |
Sixty-Ninth Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for CommentsThe Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 69th Report to the EPA Administrator on April 5, 2012. In the 69th ITC Report, which is included with this notice, the ITC is adding a category of cadmium compounds including any chemical that contains cadmium as part of that chemical's structure, 6 non-phthalate plasticizers, 25 phosphate ester flame retardants, 2 other flame retardants, 9 chemicals to which children living near hazardous waste sites may be exposed, and a category of 69 diisocyanates and related compounds (including 14 Action Plan chemicals and 55 related compounds) to the TSCA Priority Testing List. In addition, the ITC is removing 103 cadmium compounds and 14 High Production Volume (HPV) Challenge Program orphan chemicals from the Priority Testing List during this reporting period (June to November 2011). The ITC is adding the category of cadmium compounds and removing 103 cadmium compounds to provide a more comprehensive approach to assessing cadmium compounds' safety. NTP Information Cited National Toxicology Program (NTP). 2012. Tris(1,3-Dichloro-2-propyl) Phosphate (13674-87-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: National Toxicology Program.
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13674-84-5 |
| 2012 | EPA |
Integrated Risk Information System (IRIS); Announcement of 2012 ProgramThe U.S. Environmental Protection Agency (EPA) is announcing the IRIS 2012 agenda and requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including assessments that EPA is starting this year. NTP Information Cited National Toxicology Program (NTP). 2012. NTP Monograph on Health Effects of Low-Level Lead. Research Triangle Park, NC: National Toxicology Program.
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7439-92-1 |
| 2012 | FDA |
Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Established ListThe Food and Drug Administration (FDA) is establishing a list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke (the established HPHC list) as required by the Federal Food, Drug, and Cosmetic Act (the FD&C Act). NTP Information Cited National Toxicology Program (NTP). 2012. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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N/A |
| 2012 | EPA |
Benzidine-Based Chemical Substances; Di-n-pentyl phthalate (DnPP); and Alkanes, C12–13, Chloro; Proposed Significant New Use RulesUnder the Toxic Substances Control Act (TSCA), EPA is proposing: To add nine benzidine-based chemical substances to the Significant New Use Rule (SNUR) on benzidine-based chemical substances; a SNUR for di-n-pentyl phthalate (DnPP) (1,2-benzenedicarboxylic acid, 1,2-dipentyl ester) (CAS No. 131-18-0); and a SNUR for alkanes, C12–13, chloro (CAS No. 71011-12-6). In the case of the benzidine-based chemical substances, EPA is also proposing to make inapplicable the exemption relating to persons that import or process substances as part of an article. If finalized, this rule would require persons who intend to manufacture, import, or process these chemical substances for an activity that is designated as a significant new use to notify EPA at least 90 days before commencing that activity. The required notification would provide EPA with the opportunity to evaluate activities associated with a significant new use and an opportunity to protect against potential unreasonable risks, if any, from exposure to the chemical substance. NTP Information Cited National Toxicology Program (NTP). 2012. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate (BBP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Octyl Phthalate (DnOP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isononyl Phthalate (DINP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. Testing Status of Di-n-pentylphthalate (131-18-0). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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92-87-5 131-18-0 |
| 2012 | OSHA |
Hazard CommunicationIn this final rule, OSHA is modifying its Hazard Communication Standard (HCS) to conform to the United Nations' Globally Harmonized System of Classification and Labelling of Chemicals (GHS). OSHA has determined that the modifications will significantly reduce costs and burdens while also improving the quality and consistency of information provided to employers and employees regarding chemical hazards and associated protective measures. Consistent with the requirements of Executive Order 13563, which calls for assessment and, where appropriate, modification and improvement of existing rules, the Agency has concluded this improved information will enhance the effectiveness of the HCS in ensuring that employees are apprised of the chemical hazards to which they may be exposed, and in reducing the incidence of chemical-related occupational illnesses and injuries. The modifications to the standard include revised criteria for classification of chemical hazards; revised labeling provisions that include requirements for use of standardized signal words, pictograms, hazard statements, and precautionary statements; a specified format for safety data sheets; and related revisions to definitions of terms used in the standard, and requirements for employee training on labels and safety data sheets. OSHA is also modifying provisions of other standards, including standards for flammable and combustible liquids, process safety management, and most substance-specific health standards, to ensure consistency with the modified HCS requirements. The consequences of these modifications will be to improve safety, to facilitate global harmonization of standards, and to produce hundreds of millions of dollars in annual savings. NTP Information Cited
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NA |
| 2012 | FDA |
International Conference on Harmonisation; Final Recommendation for the Revision of the Permitted Daily Exposure for the Solvent Cumene According to the Maintenance Procedures for the Guidance Q3C Impurities: Residual Solvents; AvailabilityThe Food and Drug Administration (FDA) is announcing the availability of a final recommendation for the revision of the permitted daily exposure (PDE) for the solvent cumene according to the maintenance procedures for the guidance for industry entitled “Q3C Impurities: Residual Solvents.” The recommendation was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). NTP Information Cited National Toxicology Program (NTP). 1996. Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138) (CASRN 3296-90-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-452.
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98-82-8 |
| 2012 | EPA |
National Emission Standards for Hazardous Air Pollutants From Coal- and Oil-Fired Electric Utility Steam Generating Units and Standards of Performance for Fossil-Fuel-Fired Electric Utility, Industrial-Commercial-Institutional, and Small Industrial-Commercial-Institutional Steam Generating UnitsOn May 3, 2011, under authority of Clean Air Act (CAA) sections 111 and 112, the EPA proposed both national emission standards for hazardous air pollutants (NESHAP) from coal- and oil-fired electric utility steam generating units (EGUs) and standards of performance for fossil-fuel-fired electric utility, industrial-commercial-institutional, and small industrial-commercial-institutional steam generating units (76 FR 24976). After consideration of public comments, the EPA is finalizing these rules in this action. NTP Information Cited National Toxicology Program (NTP). 1996. Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CASRN 12035-72-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-453. National Toxicology Program (NTP). 1996. Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-454.
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10101-97-0 12035-72-2 |
| 2011 | DEA |
Schedules of Controlled Substances: Placement of Carisoprodol Into Schedule IVWith the issuance of this final rule, the Administrator of the Drug Enforcement Administration (DEA) places the substance carisoprodol, including its salts, isomers, and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible, into Schedule IV of the Controlled Substances Act (CSA). This action is pursuant to the CSA which requires that such actions be made on the record after opportunity for a hearing. NTP Information Cited
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78-44-4 |
| 2011 | DOT |
2017 and Later Model Year Light-Duty Vehicle Greenhouse Gas Emissions and Corporate Average Fuel Economy StandardsEPA and NHTSA, on behalf of the Department of Transportation, are issuing this joint proposal to further reduce greenhouse gas emissions and improve fuel economy for light-duty vehicles for model years 2017-2025. This proposal extends the National Program beyond the greenhouse gas and corporate average fuel economy standards set for model years 2012-2016. On May 21, 2010, President Obama issued a Presidential Memorandum requesting that NHTSA and EPA develop through notice and comment rulemaking a coordinated National Program to reduce greenhouse gas emissions of light-duty vehicles for model years 2017-2025. This proposal, consistent with the President's request, responds to the country's critical need to address global climate change and to reduce oil consumption. NHTSA is proposing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended by the Energy Independence and Security Act, and EPA is proposing greenhouse gas emissions standards under the Clean Air Act. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, and represent a continued harmonized and consistent National Program. Under the National Program for model years 2017-2025, automobile manufacturers would be able to continue building a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices. EPA is also proposing a minor change to the regulations applicable to MY 2012-2016, with respect to air conditioner performance and measurement of nitrous oxides. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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71-43-2 106-99-0 75-07-0 91-20-3 |
| 2011 | EPA |
National Emissions Standards for Hazardous Air Pollutants: Ferroalloys ProductionThe EPA is proposing amendments to the national emissions standards for hazardous air pollutants for Ferroalloys Production to address the results of the residual risk and technology review that the EPA is required to conduct under the Clean Air Act. These proposed amendments include revisions to particulate matter standards for electric arc furnaces, metal oxygen refining processes, and crushing and screening operations. The amendments also add emission limits for hydrochloric acid, mercury, polycyclic aromatic hydrocarbons, and formaldehyde from electric arc furnaces. Furthermore, the amendments expand and revise the requirements to control fugitive emissions from furnace operations and casting. Other proposed requirements related to testing, monitoring, notification, recordkeeping, and reporting are included. We are also proposing to revise provisions addressing periods of startup, shutdown, and malfunction to ensure that the rules are consistent with a recent court decision. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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NA |
| 2011 | EPA |
Testing of Certain High Production Volume Chemicals; Third Group of ChemicalsEPA is promulgating this final rule under section 4(a)(1)(B) of the Toxic Substances Control Act (TSCA) to require manufacturers, importers, and processors to conduct testing to obtain screening level data for health and environmental effects and chemical fate for 15 high production volume (HPV) chemical substances listed in this final rule. This test data is needed in order to help EPA to determine whether these 15 HPV chemical substances pose a risk to human health and/or environmental safety. Based on comments received by EPA on the proposed rule for this final rule, EPA has determined that only 15 of the 29 HPV chemical substances proposed for testing meet the criteria for testing at this time. NTP Information Cited
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NA |
| 2011 | EPA |
Certain High Production Volume Chemicals; Test Rule and Significant New Use Rule; Fourth Group of ChemicalsEPA is proposing to issue a test rule under Toxic Substances Control Act (TSCA) section 4(a)(1)(B) to require manufacturers and processors of 23 high production volume (HPV) chemical substances to develop screening-level health, environmental, and fate data based on the potential for substantial exposures of workers and consumers to these chemicals. EPA is also proposing to issue simultaneously a significant new use rule (SNUR) for another 22 HPV chemical substances under TSCA section 5(a)(2). The SNUR would require persons to file a significant new use notice (SNUN) with EPA prior to manufacturing, importing, or processing any of these chemical substances for use in a consumer product or for any use, or combination of uses, that is reasonably likely to expose 1,000 or more workers at a single corporate entity. The required notification would provide EPA with the opportunity to evaluate the intended use and, if necessary, to prohibit or limit that activity before it occurs. EPA is also soliciting comment on a number of issues with regard to both the test rule and the SNUR. NTP Information Cited National Toxicology Program (NTP). 2003. Test Method Protocol for the BALB/c 3T3 Neutral Red Uptake Cytotoxicity Test, a Test for Basal Cytotoxicity for an in vitro Validation Study—Phase III. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. Test Method Protocol for the NHK Neutral Red Uptake Cytotoxicity Test, a Test for Basal Cytotoxicity for an in vitro Validation Study—Phase III. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. National Toxicology Program (NTP). 2003. Test Method Protocol for Solubility Determination, in vitro Cytotoxicity Validation Study—Phase III. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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NA |
| 2011 | USDA |
Information Collection; Qualified Products List for Water Enhancers (Gels) for Wildland FirefightingIn accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension (without revision) of a currently approved information collection, Qualified Products List for Water Enhancers (Gels) for Wildland Firefighting. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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NA |
| 2011 | USDA |
Information Collection; Qualified Products List for Long-Term Retardant for Wildland FirefightingIn accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension (with contact revision) of a currently approved information collection, Qualified Products List for Long-Term Retardant For Wildland Firefighting. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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N/A |
| 2011 | DOT , EPA |
Greenhouse Gas Emissions Standards and Fuel Efficiency Standards for Medium- and Heavy-Duty Engines and VehiclesEPA and NHTSA, on behalf of the Department of Transportation, are each finalizing rules to establish a comprehensive Heavy-Duty National Program that will reduce greenhouse gas emissions and fuel consumption for on-road heavy-duty vehicles, responding to the President's directive on May 21, 2010, to take coordinated steps to produce a new generation of clean vehicles. NHTSA's final fuel consumption standards and EPA's final carbon dioxide (CO2) emissions standards are tailored to each of three regulatory categories of heavy-duty vehicles: Combination Tractors; Heavy-duty Pickup Trucks and Vans; and Vocational Vehicles. The rules include separate standards for the engines that power combination tractors and vocational vehicles. Certain rules are exclusive to the EPA program. These include EPA's final hydrofluorocarbon standards to control leakage from air conditioning systems in combination tractors, and pickup trucks and vans. These also include EPA's final nitrous oxide (N2O) and methane (CH4) emissions standards that apply to all heavy-duty engines, pickup trucks and vans. EPA's final greenhouse gas emission standards under the Clean Air Act will begin with model year 2014. NHTSA's final fuel consumption standards under the Energy Independence and Security Act of 2007 will be voluntary in model years 2014 and 2015, becoming mandatory with model year 2016 for most regulatory categories. Commercial trailers are not regulated in this phase of the Heavy-Duty National Program. The agencies estimate that the combined standards will reduce CO2 emissions by approximately 270 million metric tons and save 530 million barrels of oil over the life of vehicles sold during the 2014 through 2018 model years, providing over $7 billion in net societal benefits, and $49 billion in net societal benefits when private fuel savings are considered. EPA is also finalizing provisions allowing light-duty vehicle manufacturers to use CO2 credits to meet the light-duty vehicle N2O and CH4 standards, technical amendments to the fuel economy provisions for light-duty vehicles, and a technical amendment to the criteria pollutant emissions requirements for certain switch locomotives. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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71-43-2 106-99-0 75-07-0 91-20-3 |
| 2011 | USDA |
Information Collection; Qualified Products List for Class A Foams for Wildland FirefightingIn accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension (without revision) of a currently approved information collection, Qualified Products List for Class A Foams for Wildland Firefighting. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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NA |
| 2011 | EPA |
Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Request for CommentsThe Food and Drug Administration (FDA) is requesting comments, including scientific and other information, concerning the harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke. This information will assist the Agency in establishing a list of HPHCs in tobacco products and tobacco smoke (the HPHC list). NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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N/A |
| 2011 | OEHHA |
OEHHA Adopts First-in-the-Nation Public Health Goal For Hexavalent Chromium in Drinking WaterThe California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) today published the nation’s first public health goal (PHG) for hexavalent chromium in drinking water. Hexavalent Chromium in Drinking Water Fact Sheet. The final PHG for hexavalent chromium, also known as chromium 6, is set at 0.02 parts per billion (ppb), which is the same level as the draft that was released for public comment in December 2010. “This final public health goal is the culmination of years of study and research on the health effects of this chemical,” said Dr. George Alexeeff, OEHHA’s Acting Director. “As the nation’s first official goal for this contaminant, it will be an important tool that the Department of Public Health will use to develop a regulatory standard that will protect Californians from the health risks of chromium 6 in drinking water.” NTP Information Cited National Toxicology Program (NTP). 2008. Technical Report on the Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) in F344/N Rats and B6C3F1 Mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-546. https://ntp.niehs.nih.gov/go/tr546abs
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7789-12-0 |
| 2011 | EPA |
Carboxymethyl Guar Gum Sodium Salt and Carboxymethyl-Hydroxypropyl Guar; Exemption From the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of carboxymethyl guar gum sodium salt (CAS Reg. No. 39346-76-4) and carboxymethyl-hydroxypropyl guar (CAS Reg. No. 68130-15-4); when used as an inert ingredient (thicker/drift reduction agent) in pesticide formulations applied to growing crops. SciReg Inc., on behalf of Rhodia Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of carboxymethyl guar gum sodium salt and carboxymethyl-hydroxypropyl guar. NTP Information Cited National Toxicology Program (NTP). 1982. Carcinogenesis Bioassay of Guar Gum (CASRN 9000-30-0) in F344 Rats and B6C3F1 Mice (Feed Study). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-229.
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9000-30-0 |
| 2011 | EPA |
Testing of Bisphenol ABisphenol A (BPA) (Chemical Abstracts Service Registry Number (CASRN) 80-05-7), a high production volume (HPV) chemical, is a reproductive, developmental, and systemic toxicant in animal studies and is weakly estrogenic. EPA is providing this ANPRM to request comment on requiring toxicity testing to determine the potential for BPA to cause adverse effects, including endocrine-related effects, in environmental organisms at low concentrations. EPA is also seeking comment on requiring environmental testing consisting of sampling and monitoring for BPA in surface water, ground water, drinking water, soil, sediment, sludge, and landfill leachate in the vicinity of expected BPA releases to determine whether environmental organisms may currently be exposed to concentrations of BPA in the environment that are at or above levels of concern for adverse effects, including endocrine-related effects. This ANPRM is directed only toward the environmental presence and environmental effects of BPA. EPA is working with the Department of Health and Human Services (HHS) on potential human health issues, but is not considering any additional testing specifically in regard to human health issues at this time. NTP Information Cited National Toxicology Program (NTP). 1982. Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-215.
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80-05-7 |
| 2011 | DOT |
Hazardous Materials: Revision to the List of Hazardous Substances and Reportable QuantitiesPHMSA amends the Hazardous Materials Regulations by removing saccharin and its salts from the list of hazardous substances and reportable quantities. The Comprehensive Environmental Response, Compensation and Liability Act, requires PHMSA to list and regulate all hazardous substances designated by statute or by the U.S. Environmental Protection Agency (EPA). EPA recently removed saccharin and its salts from their list of hazardous substances through notice and comment rulemaking. This final rule simply harmonizes the lists to better enable shippers and carriers to identify the affected hazardous substances, comply with all applicable regulatory requirements, and make required notifications if the release of a hazardous substance occurs. NTP Information Cited
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81-07-2 |
| 2011 | EPA |
Diethylene Glycol MonoEthyl Ether (DEGEE); Exemption From the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of Diethylene Glycol MonoEthyl Ether (DEGEE) when used as an inert ingredient as a solvent, stabilizer and/or antifreeze within pesticide formulations/products, for preharvest use on growing crops and raw agricultural commodities, without limitation. Huntsman, Dow AgroSciences L.L.C., Nufarm Americas Inc., BASF, Stepan Company, Loveland Products Inc., and Rhodia Inc. submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of DEGEE on growing crops and raw agricultural commodities. NTP Information Cited National Toxicology Program (NTP). 1993. Toxicology and Carcinogenesis Studies of Ethylene Glycol (CASRN 107-21-1) in B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-413.
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107-21-1 |
| 2011 | FDA |
Labeling and Effectiveness Testing; Sunscreen Drug Products for Over-the-Counter Human UseThe Food and Drug Administration (FDA) is issuing this document to address labeling and effectiveness testing for certain over-the-counter (OTC) sunscreen products containing specified active ingredients and marketed without approved applications. This document addresses labeling and effectiveness testing issues raised by the nearly 2,900 submissions that we received in response to the sunscreen proposed rule of August 27, 2007 (2007 proposed rule). The document also identifies specific claims that render a product that is subject to this rule misbranded or would not be allowed on any OTC sunscreen product marketed without an approved application. The document does not address issues related to sunscreen active ingredients or certain other issues regarding the GRASE determination for sunscreen products. The document requires OTC sunscreen products to comply with the content and format requirements for OTC drug labeling contained in the 1999 Drug Facts final rule (published in the Federal Register of March 17, 1999, by lifting the delay of implementation date for that rule that we published on September 3, 2004). NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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N/A |
| 2011 | EPA |
Ethylene Glycol; Exemption from the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of ethylene glycol (CAS Reg. No. 107-21-1) when used as a pesticide inert ingredient as a solvent, stabilizer and/or antifreeze within pesticide formulations/products without limitation. Huntsman, et. al, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of ethylene glycol. Also, this regulation establishes an exemption from the requirement of a tolerance for residues of ethylene glycol (CAS Reg. No. 107-21-1) when used as an inert ingredient as an encapsulating agent for pesticides being applied post-harvest as residual, and crack and crevice sprays in and around food and nonfood areas of residential and nonresidential structures, including food handling establishments, with no limit. The Sumitomo Chemical Company submitted a petition to EPA under FFDCA, requesting an establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of ethylene glycol. NTP Information Cited National Toxicology Program (NTP). 1978. Bioassay of Nitrofen (1836-75-5) for Possible Carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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109-86-4 110-80-5 111-76-2 |
| 2011 | DOD |
Defense Federal Acquisition Regulation Supplement; Minimizing the Use of Materials Containing Hexavalent Chromium (DFARS Case 2009–D004)DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to implement the requirements for minimizing the use of materials containing hexavalent chromium in items acquired by DoD (deliverables and construction materials hereafter referred to as deliverables). Hexavalent chromium is a chemical that has been used in numerous DoD weapons systems and platforms due to its corrosion protection properties. However, hexavalent chromium is a known carcinogen. This rule codifies a DoD policy for addressing the serious human health and environmental risks related to the use of hexavalent chromium. The rule prohibits the delivery of items containing more than 0.1 percent by weight hexavalent chromium in any homogeneous material under DoD contracts unless there is no acceptable alternative to the use of hexavalent chromium. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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N/A |
| 2011 | OEHHA |
Chemicals Listed Effective May 3, 2011 as Known to the State of California to Cause Cancer: Malonaldehyde, Sodium SaltThe Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding four chemicals -- androstenedione (CAS No. 63-05-8), dibromoacetonitrile (CAS No. 3252-43-5), hexachlorobutadiene (CAS No. 87-68-3), and malonaldehyde, sodium salt (CAS No. 24382-04-5) -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of the four chemicals is effective May 3, 2011. NTP Information Cited
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24382-04-5 |
| 2011 | OEHHA |
Chemicals Listed Effective May 3, 2011 as Known to the State of California to Cause Cancer: AndrostenedioneThe Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding four chemicals -- androstenedione (CAS No. 63-05-8), dibromoacetonitrile (CAS No. 3252-43-5), hexachlorobutadiene (CAS No. 87-68-3), and malonaldehyde, sodium salt (CAS No. 24382-04-5) -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of the four chemicals is effective May 3, 2011. NTP Information Cited
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63-05-8 |
| 2011 | OEHHA |
Chemicals Listed Effective May 3, 2011 as Known to the State of California to Cause Cancer: DibromoacetonitrileThe Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding four chemicals -- androstenedione (CAS No. 63-05-8), dibromoacetonitrile (CAS No. 3252-43-5), hexachlorobutadiene (CAS No. 87-68-3), and malonaldehyde, sodium salt (CAS No. 24382-04-5) -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of the four chemicals is effective May 3, 2011. NTP Information Cited National Toxicology Program (NTP). 1988. Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CASRN 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-331. National Toxicology Program (NTP). 2010. Toxicology and Carcinogenesis Studies of Androstenedione (CASRN 63-05-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-560. National Toxicology Program (NTP). 2010. Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-544.
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3252-43-5 |
| 2011 | EPA |
National Emission Standards for Hazardous Air Pollutants From Coal- and Oil-Fired Electric Utility Steam Generating Units and Standards of Performance for Fossil-Fuel-Fired Electric Utility, Industrial-Commercial-Institutional, and Small Industrial-Commercial-Institutional Steam Generating UnitsThe United States (U.S.) Environmental Protection Agency (EPA or Agency) is proposing national emission standards for hazardous air pollutants (NESHAP) from coal- and oil-fired electric utility steam generating units (EGUs) under Clean Air Act (CAA or the Act) section 112(d) and proposing revised new source performance standards (NSPS) for fossil-fuel-fired EGUs under CAA section 111(b). The proposed NESHAP would protect air quality and promote public health by reducing emissions of the hazardous air pollutants (HAP) listed in CAA section 112(b). In addition, these proposed amendments to the NSPS are in response to a voluntary remand of a final rule. We also are proposing several minor amendments, technical clarifications, and corrections to existing NSPS provisions for fossil-fuel-fired EGUs and large and small industrial-commercial-institutional steam generating units. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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75-07-0 71-43-2 |
| 2011 | EPA |
Sodium Ferric Ethylenediaminetetraacetate; Exemption From the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of sodium ferric ethylenediaminetetraacetate (EDTA) in or on all food commodities when applied as a molluscicide and used in accordance with good agricultural practices. W. Neudorff GmbH KG submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of sodium ferric EDTA under the FFDCA. NTP Information Cited National Toxicology Program (NTP). 1977. Bioassay of Trisodium Ethylenediaminetetraacetate Trihydrate (EDTA) (CASRN 150-38-9) for Possible Carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-011.
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178949–82–1 |
| 2011 | OEHHA |
Chemical Listed Effective February 25, 2011 as Known to the State of California to Cause Reproductive Toxicity: Acrylamide (CAS No. 79-06-1)The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding acrylamide (CAS No. 79-06-1) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of acrylamide is effective February 25, 2011. Acrylamide is being listed as a chemical known to the State of California to cause developmental and male reproductive toxicity. NTP Information Cited National Toxicology Program (NTP). 2011. Report on Carcinogens, Twelfth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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79-06-1 |
| 2011 | EPA |
Agency Information Collection Activities; Proposed Collections; Toxic Chemical Release Reporting; Request for Comments on Proposed Renewal of Form R and Form A, Including Minor Form Revisions and the Ratio-Based Burden MethodologyIn compliance with the Paperwork Reduction Act (PRA)(44 U.S.C. 3501 et seq.), EPA is planning to submit a request to renew an existing approved Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR is scheduled to expire on July 31, 2011. The ICR Supporting Statement, which is summarized below and also posted in the docket, along with a technical document titled ‘‘Revising TRI Burden to Ratio-Based Methodology,’’ describes the nature of the information collection (including proposed form changes) and its estimated burden and cost. Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below. NTP Information Cited
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N/A |
| 2011 | EPA |
(S,S)-Ethylenediamine Disuccinic Acid Trisodium Salt; Exemption From the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of (S,S)-Ethylenediamine Disuccinic Acid Trisodium Salt (CAS Reg. No. 178949–82–1) when used as an inert ingredient (sequestrant or chelating agent) in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest under EPA regulations. Innospec Limited submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of (S,S)-ethylenediamine disuccinic acid trisodium salt. NTP Information Cited National Toxicology Program (NTP). 1977. Bioassay of Trisodium Ethylenediaminetetraacetate Trihydrate (EDTA) (CASRN 150-38-9) for Possible Carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-011.
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178949–82–1 |
| 2011 | OEHHA |
Chemical Listed Effective January 7, 2011 as Known to the State of California to Cause Cancer: 4-Methylimidazole4-Methylimidazole meets the criteria for listing as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code Section 25249.5 et seq.), more commonly known as Proposition 65, via the authoritative bodies mechanism. The regulatory requirements for listing by this mechanism are set forth in Title NTP Information Cited National Toxicology Program (NTP). 2007. Toxicology and Carcinogenesis Studies of 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-535.
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822-36-6 |
| 2010 | OEHHA |
Announcement of Publication of the Final Public Health Goals for Benzo(A)Pyrene, Methoxychlor, and TCDD (Dioxin) In Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final technical support documents for the Public Health Goals (PHGs) for benzo(a)pyrene, methoxychlor, and TCDD (dioxin) in drinking water. The PHG for benzo(a)pyrene is established at 0.007 parts per billion (ppb), based on carcinogenic effects in rats and mice. The PHG for methoxychlor is established at 0.09 ppb, based on effects in male offspring of female mice treated with methoxychlor during pregnancy. The PHG for TCDD is established at 0.00005 parts per trillion (ppt), based on tumors in multiple sites in female rats. NTP Information Cited National Toxicology Program (NTP). 1982. NTP Technical Report on the Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster Mice. Research Triangle Park, NC: National Toxicology Program. Technical Report 201. https://ntp.niehs.nih.gov/go/tr201abs
National Toxicology Program (NTP). 1982. NTP Technical Report on the Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study). Research Triangle Park, NC: National Toxicology Program. Technical Report 209. https://ntp.niehs.nih.gov/go/tr209abs NTP (National Toxicology Program). (1984). Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation. Board of Scientific Counselors. National Toxicology Program, U.S. DHHS, Public Health Service, Research Triangle Park, NC. https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/archives/1984/august/bsc_minutes19840816_508.pdf NTP (National Toxicology Program). 2000. Report on Carcinogens, Ninth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc National Toxicology Program (NTP). 2006. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Study). Research Triangle Park, NC: National Toxicology Program. Technical Report 521. https://ntp.niehs.nih.gov/go/tr521abs NTP (National Toxicology Program), NIEHS (National Institute of Environmental Health Sciences). (1989). Symposium on Significance of Foci of Cellular Alteration in the Rat Liver. Toxicol Pathol 17:557-735. https://pubmed.ncbi.nlm.nih.gov/2629097/
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| 2010 | EPA |
Hazardous Waste Management System; Identification and Listing of Hazardous Waste; Removal of Saccharin and Its Salts From the Lists of Hazardous Constituents, Hazardous Wastes, and Hazardous SubstancesThe Environmental Protection Agency (EPA or the Agency) is proposing to amend its regulations under the Resource Conservation and Recovery Act (RCRA) to remove saccharin and its salts from the lists of hazardous constituents and commercial chemical products, which are hazardous wastes when discarded or intended to be discarded. EPA is also proposing to amend the regulations under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) to remove saccharin and its salts from the list of hazardous substances. This proposed rule is in response to a petition submitted to EPA by the Calorie Control Council (CCC), to remove saccharin and its salts from the above lists. EPA is proposing to grant CCC's petition based on a review of the evaluations conducted by key public health agencies concerning the carcinogenic and other potential toxicological effects of saccharin and its salts, as well as EPA’s own assessment of the waste generation and management information for saccharin and its salts, which demonstrate that saccharin and its salts do not meet the criteria in the hazardous waste regulations for remaining on EPA's lists of hazardous constituents, hazardous wastes, and hazardous substances. NTP Information Cited National Toxicology Program (NTP). 1999. NTP Report on Carcinogens Background Document for Saccharin (CASRN 81-07-2). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf
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81-07-2 |
| 2010 | EPA |
Addition of National Toxicology Program (NTP) Carcinogens; Community Right-to-Know Toxic Chemical Release ReportingEPA is proposing to add sixteen (16) chemicals to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act of 1990. NTP Information Cited NTP (National Toxicology Program). 2005. 1-Amino-2,4-dibromoanthraquinone. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminodibromoanthraquinone.pdf NTP (National Toxicology Program). 2005. 2,2-bis(Bromomethyl)-1,3-propanediol. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bis_bromomethyl_propanediol.pdf NTP (National Toxicology Program). 2005. Furan. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/furan.pdf NTP (National Toxicology Program). 2005. Glycidol. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/glycidol.pdf NTP (National Toxicology Program). 2005. Isoprene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf NTP (National Toxicology Program). 2005. Methyleugenol. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methyleugenol.pdf
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81-49-2 3296-90-0 110-00-9 556-52-5 78-79-593-15-242397-64-8 42397-65-9 7496-02-8 57835-92-4 91-23-6 75-52-5 77-09-8 116-14-3 509-14-8 75-02-5 |
| 2010 | FDA |
Food Additives; Bisphenol A; AvailabilityThe Food and Drug Administration (FDA) announces the availability of five documents related to FDA’s continuing assessment of Bisphenol A (BPA) and solicits public comments on the four documents prepared by FDA’s Center for Food Safety and Applied Nutrition (CFSAN). These documents do not represent an agency opinion or position on BPA, on which an interim update was recently provided. (See https:// NTP Information Cited National Toxicology Program (NTP). 2008. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
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80-05-7 |
| 2010 | OEHHA |
Bromochloroacetic Acid (CAS No. 5589-96-8), Cumene (CAS No. 98-82-8) and Diclofop-Methyl (CAS No. 51338-27-3) Listed as Known to the State to Cause CancerThe Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding Bromochloroacetic acid (CAS No. 5589-96-8), Cumene (CAS No. 98-82-8) and Diclofop-methyl (CAS No. 51338-27-3) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of bromochloroacetic acid, cumene and diclofop-methyl is effective April 6, 2010. NTP Information Cited National Toxicology Program (NTP). 2009. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 542. https://ntp.niehs.nih.gov/go/tr542abs
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5589-96-8 98-82-8 |
| 2010 | EPA |
Testing of Certain High Production Volume Chemicals; Third Group of ChemicalsEPA is proposing a test rule under section 4(a)(1)(B) of the Toxic Substances Control Act (TSCA) that would require manufacturers, importers, and processors of certain high production volume (HPV) chemicals to conduct testing to obtain screening level data for health and environmental effects and chemical fate. NTP Information Cited NTP (National Toxicology Program). 2005. Acetaldehyde. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf NTP (National Toxicology Program). 2005. Benzene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf NTP (National Toxicology Program). 2005. 1,3-Butadiene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf NTP (National Toxicology Program). 2005. Alcoholic Beverage Consumption. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/alcoholicbeverageconsumption.pdf NTP (National Toxicology Program). 2005. Naphthalene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/naphthalene.pdf
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75-07-0 71-43-2 106-99-0 91-20-3 |
| 2009 | EPA |
Public Availability of Identities of Inert Ingredients in PesticidesIn response to two petitions seeking disclosure of selected inert ingredients on pesticide labels, based on hazard, EPA is initiating rulemaking to increase public availability of the identities of the inert ingredients in pesticide products. This action would assist consumers and users of pesticides in making informed decisions and reduce the presence of potentially hazardous ingredients in pesticides. NTP Information Cited National Toxicology Program (NTP). 2009. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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NA |
| 2009 | EPA |
Lead; Amendment to the Opt-out and Recordkeeping Provisions in the Renovation, Repair, and Painting ProgramEPA proposes several revisions to the Lead Renovation, Repair, and Painting Program (RRP) rule that published in the Federal Register on April 22, 2008. The rule establishes accreditation, training, certification, and recordkeeping requirements, as well as work practice standards on persons performing renovations for compensation in most pre-1978 housing and child-occupied facilities. In this document, EPA proposes eliminating the ‘‘opt-out’’ provision that currently exempts a renovation firm from the training and work practice requirements of the rule where the firm obtains a certification from the owner of a residence he or she occupies that no child under age 6 or pregnant women resides in the home and the home is not a child- occupied facility. EPA also proposes requiring renovation firms to provide a copy of the records demonstrating compliance with the training and work practice requirements of the RRP rule to the owner and, if different, the occupant of the building being renovated or the operator of the child-occupied facility. NTP Information Cited National Toxicology Program (NTP). 2009. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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7439-92-1 |
| 2009 | OSHA |
Hazard CommunicationOSHA proposes to modify its existing Hazard Communication Standard (HCS) to conform with the United Nations’ (UN) Globally Harmonized System of Classification and Labeling of Chemicals (GHS). OSHA has preliminarily determined that the proposed modifications will improve the quality and consistency of information provided to employers and employees regarding chemical hazards and associated protective measures. The Agency anticipates this improved information will enhance the effectiveness of the HCS in ensuring that employees are apprised of the chemical hazards to which they may be exposed, and in reducing the incidence of chemical-related occupational illnesses and injuries. NTP Information Cited National Toxicology Program (NTP). 2009. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
|
NA |
| 2009 | EPA |
Proposed Rulemaking To Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy StandardsEPA and NHTSA are issuing this joint proposal to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint proposed rulemaking is consistent with the National Fuel Efficiency Policy announced by President Obama on May 19, 2009, responding to the country’s critical need to address global climate change and to reduce oil consumption. EPA is proposing greenhouse gas emissions standards under the Clean Air Act, and NHTSA is proposing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, covering model years 2012 through 2016, and represent a harmonized and consistent National Program. Under the National Program, automobile manufacturers would be able to build a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices. NTP Information Cited National Toxicology Program (NTP). 2009. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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71-43-2 106-99-0 75-07-0 91-20-3 |
| 2009 | NIOSH |
Request for Information on 1-BromopropaneThe National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) intends to evaluate the scientific data on the brominated organic solvent, 1-Bromopropane (1–BP, CAS # 106–94–5, also known as n-propyl bromide), and develop appropriate communication documents, such as a Current Intelligence Bulletin, Criteria Document and/or other informational products, and establish a Recommended Exposure Limit (REL) for 1–BP. NIOSH is requesting information on the following: (1) published and unpublished reports and findings from in vitro and in vivo toxicity studies with 1–BP, (2) information on possible health effects observed in workers exposed to 1–BP, (3) information on workplaces and products in which 1–BP can be found, (4) description of work tasks and scenarios with a potential for exposure to 1–BP, (5) workplace exposure data, and (6) information on control measures (e.g., engineering controls, work practices, personal protective equipment) that are being used in workplaces where potential exposures to 1–BP occur. NTP Information Cited National Toxicology Program (NTP). 2011. 1-Bromopropane (CASRN 106-94-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-564.
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106-94-5 |
| 2009 | OEHHA |
Announcement of Publication of The Final Public Health Goal For 1,2,3-Trichloropropane In Drinking WaterOffice of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent 1,2,3-trichloropropane in drinking water. This document establishes a PHG for 1,2,3-trichloropropane of 0.0007 parts per billion, versus the current Notification Level of 0.005 ppb, set in 2005. The PHG is based on an updated cancer potency calculation. NTP Information Cited National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of 1,2-dibromo-3-chloropropane (CASRN 96-12-8) in F344/N rats and B6C3F1 mice (inhalation studies). TR-206.
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96-18-4 |
| 2009 | EPA |
Amine Salts of Alkyl (C8-C24) Benzenesulfonic Acid (Dimethylaminopropylamine, Isopropylamine, Mono-, Di-, and Triethanolamine); Exemption from the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethylaminopropylamine, isopropylamine, mono-, di-, and triethanolamine) when used as an inert ingredient in pesticide formulations applied to growing crops and applied to animals. The Joint Inerts Task Force, Cluster Support Team Number 8, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethyl aminopropylamine, isopropylamine, mono-, di, and triethanolamine). NTP Information Cited
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111-42-2 |
| 2009 | OEHHA |
Announcement of Publication of the Final Public Health Goal for Trichloroethylene in Drinking WaterOEHHA within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent trichloroethylene in drinking water. This document increases the PHG for trichloroethylene to 1.7 parts per billion, versus 0.8 ppb in the original PHG published in 1999. The PHG is based on the same cancer endpoint with an updated potency calculation. NTP Information Cited National Toxicology Program (NTP). 1988. Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-273. National Toxicology Program (NTP). 1990. Carcinogenesis Studies of Trichloroethylene (without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-243.
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79-01-6 |
| 2009 | EPA |
Residues of Silver in Foods from Food Contact Surface Sanitizing Solutions; Exemption from the Requirement of a ToleranceThis regulation amends the exemption from the requirement of a tolerance for residues of silver (excludes silver salts) in or on all foods when applied or used in public eating places, dairy processing equipment, and food processing equipment. ETO H2O, Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act requesting to establish concentration limits for silver in end-use solutions eligible for tolerance exemption. The regulation being established will exempt all foods from the requirement of a tolerance for residues of silver resulting from contact with surfaces treated with solutions in which the end-use concentration of silver is not to exceed 50 parts per million (ppm). NTP Information Cited National Toxicology Program (NTP). 2002. Developmental Toxicity Evaluation for Silver Acetate (CASRN 563-63-3) Administered by Gavage to Sprague-Dawley Rats on Gestational Days 6-19. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TER20001.
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NA |
| 2009 | EPA |
Regulation of Fuels and Fuel Additives: Changes to Renewable Fuel Standard ProgramUnder the Clean Air Act, as amended by Sections 201, 202, and 210 of the Energy Independence and Security Act of 2007, the Environmental Protection Agency is required to promulgate regulations implementing changes to the Renewable Fuel Standard program. NTP Information Cited National Toxicology Program (NTP). 2009. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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75-07-0 71-43-2 106-99-0 64-17-5 91-20-3 |
| 2009 | OEHHA |
Announcement of Publication of The Final Public Health Goals for Lead, Oxamyl and Pentachlorophenol In Drinking WaterA revised Public Health Goal (PHG) of 0.3 parts per billion (ppb) is hereby established for pentachlorophenol (PCP) in drinking water, based on carcinogenicity. The earlier PHG for PCP of 0.4 ppb, developed in 1997, is based on the same rodent carcinogenicity data and a cancer potency value identical to that used in this revised PHG. NTP Information Cited National Toxicology Program (NTP). 1989. Toxicology and Carcinogenesis Studies of Two Pentachlorophenol (CASRN 87-86-5) Technical-Grade Mixtures in B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-349. National Toxicology Program (NTP). 1999. Toxicology and Carcinogenesis Studies of Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-483.
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87-86-5 |
| 2009 | OEHHA |
Announcement of Publication of The Final Public Health Goals for Lead, Oxamyl and Pentachlorophenol In Drinking WaterThe purpose of this document is to review and evaluate the new data since 1997 regarding the toxicity of lead that are relevant to the estimation of a public health-protective level in drinking water, and establish any necessary changes in the previous risk assessment based on the new findings. This document is centered on updating the earlier OEHHA assessments for drinking water (OEHHA, 1997a, 2007). NTP Information Cited National Toxicology Program (NTP). 2009. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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|
| 2008 | EPA |
Diflubenzuron; Pesticide Tolerances for Emergency ExemptionsThis regulation establishes time-limited tolerances for combined residues of diflubenzuron and its metabolites p-chlorophenylurea and p-chloroaniline in or on alfalfa, forage and alfalfa, hay. This action is in response to EPAs granting of an emergency exemption under section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizing use of the pesticide on alfalfa and mixed grass/alfalfa fields. This regulation establishes a maximum permissible level for residues of diflubenzuron and its metabolites p-chlorophenylurea and p-chloroaniline, in these food commodities. The time-limited tolerances expire and are revoked on December 31, 2011. NTP Information Cited
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20265-96-7 |
| 2008 | EPA |
Inert Ingredient: Exemption from the Requirement of a Tolerance for (S,S)Ethylenediaminedisuccinic AcidThis regulation establishes an exemption from the requirement of a tolerance for residues of (S,S)Ethylenediaminedisuccinic Acid (CAS Reg. No. 20846-91-7) ((S,S)EDDS) when used as an inert ingredient sequestrant or chelating agent in pesticide formulations applied to growing crops only under 40 CFR 180.920. Associated Octel Company, Limited, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of (S,S)Ethylenediaminedisuccinic acid. NTP Information Cited
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CAS No. 150-38-9 |
| 2008 | EPA |
National Ambient Air Quality Standards for LeadBased on its review of the air quality criteria and national ambient air quality standards (NAAQS) for lead (Pb), EPA is making revisions to the primary and secondary NAAQS for Pb to provide requisite protection of public health and welfare, respectively. With regard to the primary standard, EPA is revising the level to 0.15 μg/m3. EPA is retaining the current indicator of Pb in total suspended particles (Pb-TSP). EPA is revising the averaging time to a rolling 3-month period with a maximum (not-to-be-exceeded) form, evaluated over a 3-year period. EPA is revising the secondary standard to be identical in all respects to the revised primary standard. NTP Information Cited NTP (National Toxicology Program). 2005. Lead and Lead Compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lead.pdf
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NA |
| 2008 | EPA |
Sixty-Third Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for CommentsThe Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 63rd Report to the Administrator of the EPA on October 7, 2008. In the 63rd ITC report, which is included with this notice, the ITC is revising the TSCA section 4(e) Priority Testing List by removing 1 tungsten compound and 1 High Production Volume (HPV) Challenge Program orphan chemical. NTP Information Cited
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10213-10-2 |
| 2008 | EPA |
Control of Emissions From Nonroad Spark-Ignition Engines and EquipmentWe are setting emission standards for new non-road spark-ignition engines that will substantially reduce emissions from these engines. The exhaust emission standards apply starting in 2010 for new marine spark-ignition engines, including first-time EPA standards for stern-drive and inboard engines. The exhaust emission standards apply starting in 2011 and 2012 for different sizes of new land-based, spark-ignition engines at or below 19 kilowatts (kW). These small engines are used primarily in lawn and garden applications. We are also adopting evaporative emission standards for vessels and equipment using any of these engines. In addition, we are making other minor amendments to our regulations. NTP Information Cited NTP (National Toxicology Program). 2005. 1,3-Butadiene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf
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71-43-2 106-99-0 75-07-0 91-20-3 |
| 2008 | EPA |
Dichlorvos (DDVP); Order Denying NRDCs Objections and Requests for HearingIn this order, EPA denies objections to, and requests for hearing on, a prior order denying a petition requesting that EPA revoke all pesticide tolerances for dichlorvos under section 408(d) of the Federal Food, Drug, and Cosmetic Act. The objections and hearing requests were filed on February 1, 2008, by the Natural Resources Defense Council (NRDC). The Original petition was also filed by NRDC. NTP Information Cited
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62-73-7 |
| 2008 | EPA |
Control of Emissions of Air Pollution from Locomotive Engines and Marine Compression-Ignition Engines Less than 30 Liters per Cylinder; RepublicationEPA is adopting a comprehensive program to dramatically reduce pollution from locomotives and marine diesel engines. The controls will apply to all types of locomotives, including line-haul, switch, and passenger, and all types of marine diesel engines below 30 liters per cylinder displacement, including commercial and recreational, propulsion and auxiliary. The near-term emission standards for newly-built engines will phase in starting in 2009. The near-term program also includes new emission limits for existing locomotives and marine diesel engines that apply when they are remanufactured, and take effect as soon as certified remanufacture systems are available, as early as 2008. The long-term emissions standards for newly-built locomotives and marine diesel engines are based on the application of high-efficiency catalytic after-treatment technology. These standards begin to take effect in 2015 for locomotives and in 2014 for marine diesel engines. We estimate particulate matter (PM) reductions of 90 percent and nitrogen oxides (NOX) reductions of 80 percent from engines meeting these standards, compared to engines meeting the current standards. NTP Information Cited NTP (National Toxicology Program). 2005. Naphthalene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/naphthalene.pdf NTP (National Toxicology Program). 2005. Benzene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf NTP (National Toxicology Program). 2005. 1,3-Butadiene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf NTP (National Toxicology Program). 2005. Acetaldehyde. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf
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91-20-3 71-43-2 106-99-0 75-07-0 |
| 2008 | OEHHA |
Chemical Listed Effective June 17, 2008 as Known to the State of California to Cause Cancer, Dibromoacetic acid (CAS No. 631-64-1)The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding dibromoacetic acid (CAS No. 631-64-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of dibromoacetic acid is effective June 17, 2008. Toxicological endpoints: Reproductive Toxicity and Cancer NTP Information Cited
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631-64-1 |
| 2008 | EPA |
Sixty-Second Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for CommentsThe Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its sixty-second report to the Administrator of EPA on April 17, 2008. In the 62nd ITC Report, which is included with this notice, the ITC is revising the TSCA section 4(e) Priority Testing List by removing four tungsten compounds and four cresols. NTP Information Cited
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1314-35-8 10213-10-2 |
| 2008 | CPSC |
Standard for the Flammability of Residential Upholstered FurnitureThe United States Consumer Product Safety Commission (Commission or CPSC) is proposing flammability standards for residential upholstered furniture under the Flammable Fabrics Act (FFA). The proposal would establish performance requirements and certification and labeling requirements for upholstered furniture. Manufacturers of upholstered furniture would choose one of two possible methods of compliance: They could use cover materials that are sufficiently smolder resistant to meet a cigarette ignition performance test; or they could place fire barriers that meet smoldering and open flame resistance tests between the cover fabric and interior filling materials. Manufacturers of upholstered furniture would be required to certify compliance with the standard and to comply with certain recordkeeping requirements as specified in the proposal. NTP Information Cited
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NA |
| 2008 | OEHHA |
Final Public Health Goal for Copper in Drinking WaterThis Public Health Goal (PHG) technical support document provides information on health effects from copper in drinking water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime. NTP Information Cited
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7758-99-8 |
| 2007 | OEHHA |
Final Public Health Goal for Water Soluble Polychlorinated Biphenyls (PCBs) Expected to be Found in Drinking WaterThis Public Health Goal (PHG) technical support document provides information on health effects from Water Soluble Polychlorinated Biphenyls Expected to be Found in Drinking Water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime. NTP Information Cited
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| 2007 | OEHHA |
Chemical Listed Effective September 28, 2007 as Known to the State of California to Cause Cancer: anthraquinone(CAS No. 84-65-1)The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding anthraquinone (CAS No. 84-65-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of anthraquinone is effective September 28, 2007. Anthraquinone (CAS No. 84-65-1) is being listed as a chemical known to the State of California to cause cancer. The listing of this chemical is based on formal identification by an authoritative body (i.e., the National Toxicology Program (NTP)), that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the authoritative bodies mechanism can be found in Title 22, Cal. Code of Regs., section 12306. Toxicological endpoint: cancer NTP Information Cited National Toxicology Program (NTP). 2005. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 494. https://ntp.niehs.nih.gov/go/tr494abs NTP (National Toxicology Program). 2005. Anthraquinone. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminoanthraquinone.pdf
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84-65-1 |
| 2007 | ATSDR |
Intent To Develop Two Interaction ProfilesThis notice announces the intent of ATSDR to develop two interaction profiles. NTP Information Cited National Toxicology Program (NTP). 1999. NTP Report on Carcinogens Background Document for 2,3, 7,8-Tetrachlorodibenzo-p-Dioxin (TCDD). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf National Toxicology Program (NTP). 1979. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2N,4,4N,5,5N-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 529. https://ntp.niehs.nih.gov/go/tr529abs National Cancer Institute (NCI). 1979. NCI Technical Report on the Bioassay of Fenthion (CASRN 55-38-9) for Possible Carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 103. https://ntp.niehs.nih.gov/go/tr103abs National Cancer Institute (NCI). 1979. NCI Technical Report on the Bioassay of Malathion (CASRN 121-75-5) for Possible Carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 192. https://ntp.niehs.nih.gov/go/tr192abs National Cancer Institute (NCI). 1978. NCI Technical Report on the Bioassay of Aroclor 1254 (CASRN 27323-18-8) for Possible Carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 38. https://ntp.niehs.nih.gov/go/tr38abs National Cancer Institute (NCI). 1979. NCI Technical Report on the Bioassay of Dibenzo p-dioxin (CASRN 262-12-4) for Possible Carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 122. https://ntp.niehs.nih.gov/go/tr122abs National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-butyl Phthalate (DBP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isononyl Phthalate (DINP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dinp/dinp_monograph_final.pdf National Toxicology Program (NTP). 2006. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-(2-ethylhexyl) Phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-hexyl Phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isodecyl Phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/didp/didp_monograph_final.pdf National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-octyl Phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnop/dnop_monograph_final.pdf
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| 2007 | OEHHA |
Announcement of Publication of the Final Public Health Goal for Glyphosate in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for glyphosate, which is an update of the PHG published in 1997. NTP Information Cited
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1071-83-6 |
| 2007 | EPA |
Protection of Stratospheric Ozone: Listing of Substitutes for Ozone-Depleting Substances-n-Propyl Bromide in Solvent CleaningThe Environmental Protection Agency (EPA) determines that n-propyl bromide (nPB) is an acceptable substitute for methyl chloroform and chlorofluorocarbon (CFC)-113 in the solvent cleaning sector under the Significant New Alternatives Policy (SNAP) program under section 612 of the Clean Air Act. The SNAP program reviews alternatives to Class I and Class II ozone depleting substances and approves use of alternatives which do not present a substantially greater risk to public health and the environment than the substance they replace or than other available substitutes. NTP Information Cited NTP, 2003. Results of 13-week Inhalation Testing by the National Toxicology Program. https://ntp.niehs.nih.gov/go/717271 National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf
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| 2007 | OEHHA |
Chemical Listed Effective April 20, 2007 as Known to the State of California to Cause Reproductive Toxicity: di-isodecyl phthalate (DIDP)The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding di-isodecyl phthalate (DIDP) (CAS No. 68515-49-1 and 26761-40-0) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of di-isodecyl phthalate (DIDP) is effective April 20, 2007. NTP Information Cited National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-isodecyl Phthalate (DIDP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/didp/didp_monograph_final.pdf
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68515-49-1 26761-40-0 |
| 2006 | OEHHA |
Final Public Health Goal for N-Nitrosodimethylamine and Cadmium in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for N-nitrosodimethylamine and cadmium. NTP Information Cited National Toxicology Program (NTP). 1999. Report on Carcinogens, Ninth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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| 2006 | OEHHA |
Chemicals Delisted Effective December 8, 2006 from the List of Chemicals Known to the State of California to Cause Cancer, isosafrole, 5-nitro-o-anisidine, tris(aziridinyl)-p-benzoquinoneThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is removing isosafrole [CAS No. 120-58-1], 5-nitro-o-anisidine [CAS No. 99-59-2], and tris(aziridinyl)-p-benzoquinone (triaziquone) [CAS No. 68-76-8] from the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The delisting of the three chemicals is effective December 8, 2006. 5-Nitro-o-anisidine was removed from the NTP Sixth Annual Report on Carcinogens as a substance reasonably anticipated to be a human carcinogen in 1991, when NTP concluded there was insufficient evidence of carcinogenicity. NTP Information Cited National Toxicology Program (NTP). 2004. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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99-59-2 |
| 2006 | EPA |
Diflubenzuron; Pesticide TolerancesThis regulation establishes tolerances for combined residues of diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline in or on brassica, leafy greens subgroup 5B, turnip greens, peanut, peanut hay, peanut oil, barley grain, barley hay, barley straw, oat grain, oat forage, oat hay, oat straw, wheat grain, wheat forage, wheat hay, wheat straw, aspirated grain fractions, and pummelo. The Interregional Research Project #4 requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA). NTP Information Cited National Toxicology Program (NTP). 1989. Toxicology and Carcinogenesis Studies of Para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-351.
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35367-38-5 150-68-5 106-47-8 |
| 2006 | EPA |
Export Notification; Change to Reporting RequirementsEPA is promulgating amendments to the Toxic Substances Control Act (TSCA) section 12(b) export notification regulations at subpart D of 40 CFR part 707. One amendment changes the current annual notification requirement to a one-time requirement for exporters of chemical substances or mixtures (hereinafter referred to as "chemicals") for which certain actions have been taken under TSCA. Relatedly, for the same TSCA actions, EPA is changing the current requirement that the Agency notify foreign governments annually after the Agency's receipt of export notifications from exporters to a requirement that the Agency notify foreign governments once after it receives the first export notification from an exporter. EPA is also promulgating de minimis concentration levels below which notification will not be required for the export of any chemical for which export notification under TSCA section 12(b) is otherwise required, promulgating other minor amendments (to update the EPA addresses to which export notifications must be sent, to indicate that a single export notification may refer to more than one section of TSCA where the exported chemical is the subject of multiple TSCA actions, and to correct an error in 40 CFR 799.19 that currently omits mentioning multi-chemical test rules as being among those final TSCA section 4 actions that trigger export notification), and clarifying exporters' and EPA's obligations where an export notification- triggering action is taken with respect to a chemical previously or currently subject to export notification due to the existence of a previous triggering action. NTP Information Cited National Toxicology Program (NTP). 2004. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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| 2006 | EPA |
Eucalyptus Oil; Exemption from the Requirement of a ToleranceThis regulation establishes an exemption from the requirement of a tolerance for residues of eucalyptus oil on honey and honeycomb when applied at 2 g or less eucalyptus oil per hive to suppress varroa mites. Brushy Mountain Bee farm, c/o IR-4 Project submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of eucalyptus oil in honey and honeycomb. NTP Information Cited National Toxicology Program (NTP). Accessed 2022-07-27. 1,8-Cineole (470-82-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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470-82-6 |
| 2006 | FDA |
Skin Bleaching Drug Products For Over-the-Counter Human Use; Proposed RuleThe Food and Drug Administration is issuing a notice of proposed rulemaking that would establish that over-the-counter (OTC) skin bleaching drug products are not generally recognized as safe and effective (GRASE) and are misbranded. FDA is also withdrawing the previous proposed rule on skin bleaching drug products for OTC human use, which was issued in the form of a tentative final monograph (TFM). FDA is issuing this proposed rule after considering new data and information on the safety of hydroquinone, the only active ingredient that had been proposed for inclusion in a monograph for these products. This proposal is part of FDA's ongoing review of OTC drug products. Further, upon issuance of a final rule, FDA intends to consider all skin bleaching drug products, whether currently marketed on a prescription or OTC basis, to be new drugs requiring an approved new drug application (NDA) for continued marketing. NTP Information Cited National Toxicology Program (NTP). 1989. Technical Report of the Toxicology and Carcinogenesis Studies of Hydroquinone in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-366.
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123-31-9 and 497-76-7 |
| 2006 | MSHA |
Diesel Particulate Matter Exposure of Underground Metal and Nonmetal MinersThis final rule revises the May 20, 2006 effective date of the diesel particulate matter (DPM) final concentration limit of 160 micrograms of total carbon (TC) per cubic meter of air (160TC ug/m3) promulgated in the 2001 final rule "Diesel Particulate Matter Exposure of Underground Metal and Nonmetal Miners," and published in the Federal Register on January 19, 2001 (66 FR 5706) and amended on September 19, 2005 (70 FR 55019). NTP Information Cited National Toxicology Program (NTP). 2002. Report on Carcinogens, Tenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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| 2006 | EPA |
Ethylene Oxide Emissions Standards for Sterilization FacilitiesThis action finalizes our decision not to revise the Ethylene Oxide Emission Standards for Sterilization Facilities, originally promulgated on December 6, 1994. Within 8 years of promulgating these standards, the Clean Air Act directs us to assess the risk and to promulgate more stringent standards if necessary to protect public health with an ample margin of safety and to prevent adverse environmental effects. Also, within 8 years of promulgating the national emission standards, the Clean Air Act requires us to review and revise the standards as necessary, taking into account developments in practices, processes, and control technologies. Today¿s action reflects our findings that after conducting these risk and technology reviews, no additional control requirements are warranted. NTP Information Cited National Toxicology Program (NTP). 2002. Report on Carcinogens, Tenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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| 2006 | EPA |
Testing of Certain High Production Volume ChemicalsEPA is promulgating a final rule under the Toxic Substances Control Act that requires manufacturers (including importers) and processors of 17 high production volume chemicals to conduct acute toxicity, repeat dose toxicity, developmental and reproductive toxicity, genetic toxicity (gene mutations and chromosomal aberrations), ecotoxicity (in fish, Daphnia, and algae), and environmental fate (including 5 tests for physical chemical properties and biodegradation) testing. NTP Information Cited National Toxicology Program (NTP). 1989. Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CASRN 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-365.
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78-11-5 |
| 2006 | EPA |
Ethylenediaminetetraacetic Acid Chemicals: Exemptions from the Requirement of a ToleranceThe Agency is proposing to establish 16 new and amend three existing exemptions from the requirement of a tolerance for residues of various ethylenediaminetetraacetic acid (EDTA) chemicals in or on raw agricultural commodities when used as inert ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA). This regulation eliminates the need to establish a maximum permissible level for residues of these EDTA chemicals. NTP Information Cited National Toxicology Program (NTP). 1977. Bioassay of Trisodium Ethylenediaminetetraacetate Trihydrate (EDTA) (CASRN 150-38-9) for Possible Carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-11.
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150-38-9 |
| 2006 | OEHHA |
Announcement of Publication of the Final Technical Support Documents for the Public Health Goal and Responses to Comments for Six Chemicals in Drinking WaterIn accordance with Health and Safety Code Section 116293 (SB1822, Sher, Statutes of 2002), the Office of Environmental Health Hazard Assessment (OEHHA) hereby publishes the final Public Health Goal (PHG) for cis/trans-1,2-dichloroethylene, 1,1,1-trichloroethane, 1,1,2-trichloroethane, radium-226 and 228, strontium-90, and tritium in drinking water. OEHHA has completed technical support documents that provide the scientific basis for the PHGs. NTP Information Cited National Toxicology Program (NTP). 2002. Toxicity Studies of Trans-1,2-Dichloroethylene (CASRN 156-60-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-55. National Toxicology Program (NTP). 1987. Developmental Toxicity Evaluation of 1,1,1-Trichloroethane (CASRN 71-55-6) Administered to CD Rats. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. T0151. National Toxicology Program (NTP). 1987. Developmental Toxicity Evaluation of 1,1,1-T.richloroethane Administered in Drinking Water to CD Rats. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. T0179. National Toxicology Program (NTP). 2000. Technical Report on the Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55-6) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-41.
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156-60-5 |
| 2006 | OEHHA |
Announcement of Publication of the Final Technical Support Documents for the Public Health Goal and Responses to Comments for Six Chemicals in Drinking WaterIn accordance with Health and Safety Code Section 116293 (SB1822, Sher, Statutes of 2002), the Office of Environmental Health Hazard Assessment (OEHHA) hereby publishes the final Public Health Goal (PHG) for cis/trans-1,2-dichloroethylene, 1,1,1-trichloroethane, 1,1,2-trichloroethane, radium-226 and 228, strontium-90, and tritium in drinking water. OEHHA has completed technical support documents that provide the scientific basis for the PHGs. NTP Information Cited NTP (1996). Technical report on renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats. Toxicity Report Series. TOX-45 NTP (2000). Technical report on the toxicity studies of 1,1,1-trichloroethane (CAS No. 71-55-6) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. TOX-41
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71-55-6 |
| 2006 | OSHA |
Occupational Exposure to Hexavalent ChromiumThe Occupational Safety and Health Administration (OSHA) is amending the existing standard which limits occupational exposure to hexavalent chromium (Cr(VI)). OSHA has determined based upon the best evidence currently available that at the current permissible exposure limit (PEL) for Cr(VI), workers face a significant risk to material impairment of their health. NTP Information Cited National Toxicology Program (NTP). 1980. Report on Carcinogens, First Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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18540-29-9 |
| 2006 | EPA |
National Primary Drinking Water Regulations: Stage 2 Disinfectants and Disinfection Byproducts RuleThe Environmental Protection Agency (EPA) is promulgating today's final rule, the Stage 2 Disinfectants and Disinfection Byproducts Rule (DBPR), to provide for increased protection against the potential risks for cancer and reproductive and developmental health effects associated with disinfection byproducts (DBPs). NTP Information Cited National Toxicology Program (NTP). 1987. Toxicity and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-321. https://ntp.niehs.nih.gov/go/tr321abs National Toxicology Program (NTP). 2004. Toxicology and Carcinogenesis Studies of Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)—Draft Abstract. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-517. https://ntp.niehs.nih.gov/go/tr517abs National Toxicology Program (NTP). 2005. Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies)—Draft Abstract. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-532. https://ntp.niehs.nih.gov/go/tr532abs National Toxicology Program (NTP). 2005. Dibromoacetic Acid (631-64-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
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75-27-4 7775-09-9 and 631-64-1 |
| 2005 | EPA |
National Perchloroethylene Air Emission Standards for Dry Cleaning FacilitiesEPA is proposing revised standards to limit emissions of perchloroethylene (PCE) from existing and new dry cleaning facilities. NTP Information Cited
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127-18-4 |
| 2005 | EPA |
List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category ListEPA is amending the list of hazardous air pollutants contained in section 112 of the Clean Air Act by removing the compound methyl ethyl ketone (MEK) (2-Butanone) (CAS No. 78-93-3). This action is being taken in response to a petition submitted by the Ketones Panel of the American Chemistry Council (formerly the Chemical Manufacturers Association) on behalf of MEK producers and consumers to delete MEK from the HAP list. Petitions to remove a substance from the HAP list are permitted under section 112 of the CAA. NTP Information Cited
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78-93-3 108-10-1 |
| 2005 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption; Synthetic Fatty AlcoholsThe Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of n-octanol (n-octyl alcohol) produced by a new manufacturing process, the hydrodimerization of 1,3-butadiene. This action is in response to a petition filed by Kuraray International Corp. NTP Information Cited
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106-99-0 |
| 2005 | OEHHA |
Chemicals Listed Effective December 2, 2005 as Known to the State of California to Cause Reproductive Toxicity: butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3)The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of the three phthalates is effective December 2, 2005 Toxicological endpoint: cancer. Toxicological endpoints: Developmental toxicity, Female reproductive toxicity, and Male reproductive toxicity NTP Information Cited National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Butyl Phthalate (DBP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf National Toxicology Program (NTP). 2003. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Hexyl Phthalate (DnHP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf
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85-68-7 84-74-2 84-75-3 |
| 2005 | OEHHA |
Chemicals Listed Effective August 19, 2005 as Known to the State of California to Cause Cancer: estrogens, steroidalThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding estrogens, steroidal to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of estrogens, steroidal is effective August 19, 2005. NTP Information Cited
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Steroidal Estrogens (as a class) |
| 2005 | MSHA |
Asbestos Exposure LimitMSHA is proposing to revise their existing health standards for asbestos exposure at metal and nonmetal mines, surface coal mines, and surface areas of underground coal mines. The proposed rule would reduce the full-shift permissible exposure limit and the excursion limit for airborne asbestos fibers, and make several nonsubstantive changes to add clarity to the standard. Exposure to asbestos has been associated with lung and other cancers, mesotheliomas, and asbestosis. This proposed rule would help assure that fewer miners who work in an environment where asbestos is present would suffer material impairment of health or functional capacity over their working lifetime. NTP Information Cited
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1332-21-4 |
| 2005 | MSHA |
Diesel Particulate Matter Exposure of Underground Metal and Nonmetal MinersIn this final rule: MSHA revises the existing standards addressing diesel particulate matter (DPM) exposure in underground metal and nonmetal (M/NM) mines; changes the interim concentration limit measured by total carbon to a comparable permissible exposure limit measured by elemental carbon, which renders a more accurate DPM exposure measurement; increases flexibility of compliance for mine operators by requiring longstanding hierarchy of controls for its other exposure-based health standards at M/NM mines, but retains the prohibition on rotation of miners for compliance; requires MSHA to consider economic as well as technological feasibility in determining if operators qualify for an extension of time in which to meet the final DPM limit; deletes the requirement for a control plan; and makes conforming changes to existing provisions concerning compliance determinations, environmental monitoring and recordkeeping. NTP Information Cited NTP (National Toxicology Program). 2002. Report on Carcinogens, Tenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc NTP (National Toxicology Program). 2002. Diesel Exhaust Particulates. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dieselexhaustparticulates.pdf
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| 2005 | OEHHA |
Chemicals Listed Effective May 27, 2005 and May 31, 2005 as known to the State of California to Cause Cancer or Reproductive ToxicityThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 2-bromopropane (2-BP) (CAS No. 75-26-3)...to the list of chemicals known to the state to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of... 2-bromopropane (2-BP) is effective May 31, 2005. Toxicological endpoint: Female reproductive and male reproductive toxicity NTP Information Cited
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75-26-3 |
| 2005 | OEHHA |
Chemicals Listed Effective May 20, 2005 as Known to the State of California to Cause Cancer: Cobalt sulfate, DiazoaminobenzeneThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding cobalt sulfate (CAS No. 10124-43-3) and diazoaminobenzene (CAS No. 136-35-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of cobalt sulfate and diazoaminobenzene is effective May 20, 2005. Toxicological Endpoint: cancer NTP Information Cited
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10124-43-3 |
| 2005 | OEHHA |
Chemicals Listed Effective May 20, 2005 as Known to the State of California to Cause Cancer: Cobalt sulfate, DiazoaminobenzeneThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding cobalt sulfate (CAS No. 10124-43-3) and diazoaminobenzene (CAS No. 136-35-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of cobalt sulfate and diazoaminobenzene is effective May 20, 2005. Toxicological Endpoint: cancer NTP Information Cited NTP (National Toxicology Program). 2005. Diazoaminobenzene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diazoaminobenzene.pdf
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc
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136-35-6 |
| 2005 | EPA |
Isophorone; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on FoodThis notice announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of a certain pesticide chemical in or on various food commodities. NTP Information Cited
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78-59-1 |
| 2005 | OSHA |
Notice of Availability of the Regulatory Flexibility Act Review of the Occupational Health Standard for Ethylene OxideThe Occupational Safety and Health Administration (OSHA) has conducted a review of its Ethylene Oxide (EtO) Standard pursuant to section 610 of the Regulatory Flexibility Act and section 5 of Executive Order 12866 on Regulatory Planning and Review. NTP Information Cited
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75-21-8 |
| 2005 | FDA |
Food Additives Permitted for Direct Addition to Food for HumanConsumption; Acacia (Gum Arabic)The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of acacia (gum arabic) as a thickener, emulsifier, or stabilizer in alcoholic beverages at a maximum use level of 20 percent. This action is in response to a petition filed by Kerry, Inc. NTP Information Cited
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9000-01-5 |
| 2005 | OEHHA |
Chemical Listed Effective February 11, 2005 as Known to the State of California to Cause Cancer: Vanadium PentoxideThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding vanadium pentoxide (orthorhombic crystalline form) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of the chemical is effective February 11, 2005. Toxicological Endpoint: Cancer NTP Information Cited
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1314-63-1 |
| 2005 | CPSC |
Standard for the Flammability (Open Flame) of Mattresses and Mattress/Foundation Sets; Notice of Proposed RulemakingThe Commission is proposing a flammability standard under the authority of the Flammable Fabrics Act that would address open flame ignition of mattresses and mattress and foundation sets ("mattresses/sets"). NTP Information Cited
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| 2005 | FDA |
Guidance for Industry: Labeling for Topically Applied Cosmetic Products Containing Alpha Hydroxy Acids as Ingredients; AvailabilityThe Food and Drug Administration (FDA) is announcing the availability of a guidance document entitled "Guidance for Industry: Labeling for Topically Applied Cosmetic Products Containing Alpha Hydroxy Acids as Ingredients." The guidance recommends content for a labeling statement for cosmetic products containing alpha hydroxy acids (AHAs) as ingredients. NTP Information Cited
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79-14-1 and 69-72-7 |
| 2004 | OEHHA |
Chemical Listed Effective December 7, 2004 as known to the State of California to Cause Reproductive Toxicity: 1-Bromopropane (1-BP)The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 1-bromopropane (1-BP) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of the chemical is effective December 7, 2004. Toxicological Endpoint: Developmental, female reproductive and male reproductive toxicity NTP Information Cited
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106-94-5 |
| 2004 | OEHHA |
Chemical Listed Effective December 3, 2004 as known to the State of California to Cause Cancer: RiddelliineThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding riddelliine to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of riddelliine is effective December 3, 2004. Toxicological Endpoint: Cancer NTP Information Cited
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23246-96-0 |
| 2004 | EPA |
List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category List; Petition To Delist of Ethylene Glycol Monobutyl EtherThe EPA is amending the list of hazardous air pollutants contained in section 112(b)(1) of the Clean Air Act by removing the compound ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)(CAS No. 111-76-2) from the group of glycol ethers. NTP Information Cited
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111-76-2 |
| 2004 | OSHA |
Occupational Exposure to Hexavalent ChromiumOSHA proposes to amend its existing standard for employee exposure to hexavalent chromium (Cr(VI)). The basis for issuance of this proposal is a preliminary determination by the Assistant Secretary that employees exposed to Cr(VI) face a significant risk to their health at the current permissible exposure limit and that promulgating this proposed standard will substantially reduce that risk. NTP Information Cited
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13765-19-0 7778-50-9 |
| 2004 | EPA |
National Emission Standards forHazardous Air Pollutants for Industrial, Commercial, and Institutional Boilers and Process HeatersThe EPA is promulgating national emission standards for hazardous air pollutants for industrial, commercial, and institutional boilers and process heaters and has identified industrial, commercial, and institutional boilers and process heaters as major sources of hazardous air pollutants. NTP Information Cited
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7782-50-5 7681-52-9 10599-90-3 |
| 2004 | OEHHA |
Chemicals Listed Effective July 9, 2004 as Known to the State of California to Cause Cancer: aristolochic acids and herbal remedies containing plant species of the genus AristolochiaThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding aristolochic acids and herbal remedies containing plant species of the genus Aristolochia to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of "aristolochic acids and herbal remedies containing plant species of the genus Aristolochia is effective July 9, 2004. Toxicological Endpoint: Cancer NTP Information Cited
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Aristolochia |
| 2004 | Treasury |
Removal of Requirement To Disclose Saccharin in the Labeling of Wine, Distilled Spirits, and Malt BeveragesAmends the Alcohol and Tobacco Tax and Trade Bureau's labeling regulations to remove the requirement for bottlers of wine, distilled spirits, and malt beverages to show a warning on products containing saccharin. The regulatory amendments in this document reflect the National Toxicology Program's revised findings about saccharin and the removal of the statutory requirement for the warning. NTP Information Cited
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81-07-2 |
| 2004 | OEHHA |
Chemicals Listed Effective June 11, 2004 as Known to the State of California to Cause Cancer: propylene glycol mono-t-butyl ether; 3,3'-dimethylbenzidine (DMB)-based dyes metabolized to 3,3'-dimethylbenzidine; 3,3'-dimethoxybenzidine-based dyes metabolized to 3,3'-dimethoxybenzidineThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 3,3'-dimethoxybenzidine-(DMOB)based dyes metabolized to 3,3'-dimethoxybenzidine, 3,3'-dimethylbenzidine- (DMB)based dyes metabolized to 3,3'-dimethylbenzidine, ethylbenzene, propylene glycol mono-t-butyl ether, and thiouracil to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of these chemicals is effective June 11, 2004. Toxicological Endpoint: Cancer NTP Information Cited National Toxicology Program (NTP). 2004. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in Male NBR Rats (Inhalation Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 515. https://ntp.niehs.nih.gov/go/tr515abs NTP (National Toxicology Program). 2002. 3,3′-Dimethylbenzidine and Dyes Metabolized to 3,3′-Dimethylbenzidine. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylbenzidineanddyes.pdf NTP (National Toxicology Program). 2002. 3,3′-Dimethoxybenzidine and Dyes Metabolized to 3,3′-Dimethoxybenzidine. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethoxybenzidineanddyes.pdf
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57018-52-7 |
| 2004 | FDA |
Furan in Food, Thermal Treatment; Request for Data and InformationThe FDA is requesting the submission of data and information on furan, a heat treatment related byproduct that has been detected in certain thermally treated foods. NTP Information Cited
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110-00-9 |
| 2004 | OEHHA |
Chemical Listed Effective May 7, 2004 as known to the State of California to Cause Cancer: Nickel CompoundsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding nickel compounds to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of nickel compounds is effective May 7, 2004. Toxicological Endpoint: Cancer NTP Information Cited
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Nickel compounds |
| 2004 | OEHHA |
Announcement of Publication of the Final Public Health Goal for Arsenic in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goal (PHG) for arsenic. NTP Information Cited
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121-19-7 |
| 2004 | EPA |
National Emission Standards for Hazardous Air Pollutants: Proposed Standards for Hazardous Air Pollutants for Hazardous Waste CombustorsThe EPA proposes national emission standards for hazardous air pollutants (HAPs) for hazardous waste combustors (HWCs). These proposed standards will, when final, implement section 112(d) of the Clean Air Act by requiring HWCs to meet HAP emission standards reflecting the application of the maximum achievable control technology. NTP Information Cited
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1313-99-1 12035-72-2 10101-97-0 1746-01-6 |
| 2004 | FDA |
Final Rule Declaring DietarySupplements Containing Ephedrine Alkaloids Adulterated Because They Present an Unreasonable RiskFinal Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated Because They Present an Unreasonable Risk NTP Information Cited
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134-72-5 |
| 2004 | EPA |
Fifty-Third Report of the TSCAInteragency Testing Committee to theAdministrator of the EnvironmentalProtection Agency; Receipt of Reportand Request for CommentsThe Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its Fifty-Third Report to the Administrator of the EPA on December 2, 2003 revising the Priority Testing List by adding 3 pyridinamines and 20 tungsten compounds requesting that EPA add the 3 pyridinamines and 20 tungsten compounds to the TSCA section 8(a) Preliminary Assessment Information Reporting (PAIR) rule and soliciting voluntary use, exposure, and effects information for 3 pyridinamines, 20 tungsten compounds, and 43 vanadium compounds through its Voluntary Information Submissions Innovative Online Network. NTP Information Cited
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1314-35-8 |
| 2003 | EPA |
List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category ListThe EPA proposes to amend the list of hazardous air pollutants contained in section 112(b)(1) of the Clean Air Act by removing ethylene glycol monobutyl ether from the group of glycol ethers. NTP Information Cited
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111-76-2 |
| 2003 | OEHHA |
Chemical Listed Effective November 14, 2003 as Known to the State of California to Cause Cancer: Fumonisin B1The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding fumonisin B1 to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of fumonisin B1 is effective November 14, 2003 Toxicological Endpoint: Cancer NTP Information Cited
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116355-83-0 |
| 2003 | FDA |
International Conference on Harmonisation; Final Recommendations on the Revision of the Permitted Daily Exposures for Two Solvents, N-Methylpyrrolidone and Tetrahydrofuran, According to the Maintenance Procedures for the Guidance Q3C Impurities: Residual Solvents; AvailabilityThe Food and Drug Administration (FDA) is announcing final recommendations to revise the permitted daily exposures (PDEs) for two solvents, n-methylpyrrolidone (NMP) and tetrahydrofuran (THF), according to the maintenance procedures for the guidance for industry entitled “Q3C Impurities: Residual Solvents.” The final recommendations were reached under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). NTP Information Cited
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7772-99-8 |
| 2003 | OEHHA |
Announcement of Publication of the Final Technical Support Documents for Public Health Goals for 11 Chemicals in Drinking WaterThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water. NTP Information Cited National Toxicology Program (NTP). 1990c. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Tremolite (CASRN 14567-73-8) in F344/N Rats (Feed Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 277. https://ntp.niehs.nih.gov/go/tr277abs
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12172-73-5 12001-29-5 12001-28-4 12001-29-5 12172-73-514567-73-81332-21-4 103-23-1 108-90-7 106-93-4 10326-27-9 |
| 2003 | EPA |
National Primary Drinking Water Regulations: Stage 2 Disinfectants and Disinfection Byproducts RuleThe EPA is proposing maximum contaminant level goals (MCLGs) for chloroform, monochloroacetic acid and trichloroacetic acid;National Primary Drinking Water Regulations for total trihalomethanes and haloacetic acids; and revisions to the reduced monitoring requirements for bromates. NTP Information Cited
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79-11-8 75-25-2 75-27-4 |
| 2003 | OEHHA |
Chemical Listed Effective March 14, 2003 as Known to the State of California to Cause Cancer: Strong Inorganic Acid Mists Containing Sulfuric AcidThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding strong inorganic acid mists containing sulfuric acid to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of strong inorganic acid mists containing sulfuric acid is effective March 14, 2003. Toxicological Endpoint: Cancer NTP Information Cited
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7664-93-9 (Mists containing) |
| 2003 | FDA |
New Animal Drugs: Phenylbutazone; Extralabel Animal Drug Use; Order of ProhibitionThe FDA is prohibiting the extralabel use of phenylbutazone animal and human drugs in female dairy cattle 20 months of age or older. The extralabel use presents a risk to the public health. NTP Information Cited
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50-33-9 |
| 2002 | EPA |
Sucrose Octanoate Esters; Exemption from the Requirement of a ToleranceThe EPA has established an exemption from the tolerance requirements pursuant to FFDCA 408(c) and 9(d) for residues of certain Sucrose Octanoate Esters (SOEs) in or on all food commodities when applied/used in accordance with good agricultural practices. NTP Information Cited
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124-07-2 |
| 2002 | EPA |
Indirect Food Additives: PolymersThe EPA is soliciting public comment on whether a preliminary determination that nine contaminants do not meet all three Safe Drinking Water Act requirements is appropriate, and thus no National Primary Drinking Water Regulations (NPDWR) should be considered for these contaminants. NTP Information Cited
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91-20-3 87-68-3 |
| 2002 | OEHHA |
Chemical Listed Effective May 17, 2002 as Known to the State of California to Cause Cancer: PyridineThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding pyridine to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of pyridine is effective May 17, 2002. Toxicological Endpoint: Cancer NTP Information Cited
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110-86-1 |
| 2002 | EPA |
Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on FoodEPA announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of a certain pesticide chemical in or on various food commodities. NTP Information Cited
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7681-49-4 |
| 2002 | OEHHA |
Chemical Listed Effective April 19, 2002 as Known to the State of California to Cause Cancer: NaphthaleneThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding naphthalene to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of naphthalene is effective April 19, 2002. Toxicological Endpoint: Cancer NTP Information Cited
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91-20-3 |
| 2002 | EPA |
Indirect Food Additives: PolymersEPA intends to reclassify eight inert ingredients from List 2, Potentially Toxic Inerts/High Priority for Testing to List 1 Inerts of Toxicological Concern. One of the criteria for being considered a List 1 inert ingredient is to be characterized by the NTP as an animal carcinogen in at least one species and sex. NTP Information Cited
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100-41-4 106-88-7 149-30-4 120-32-1 85-68-7111-42-275-52-5 111-76-2 |
| 2002 | EPA |
Diflubenzuron; Pesticide ToleranceThis regulation establishes a tolerance for combined residues of diflubenzuron and its metabolites 4-chloroaniline and 4-chlorophenylurea in or on pear. IR-4 requested this tolerance under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act (FQPA) of 1996. NTP Information Cited
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20265-96-7 |
| 2001 | OEHHA |
Chemical Listed Effective November 16, 2001 as Known to the State of California to Cause Cancer: MethyleugenolThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding the chemical methyleugenol to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemical is listed effective November 16, 2001. Toxicological Endpoint: Cancer NTP Information Cited
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93-15-2 |
| 2001 | EPA |
National Advisory Committee for Acute Exposure Guidelines Levels (AEGLs) for Hazardous Substances; Proposed AEGL Values.The EPA is proposing AEGLs for 18 chemicals to provide Federal, State, and local agencies with threshold short-term exposure limits for the public to hazardous, airborne chemicals. NTP Information Cited
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509-14-8 127-18-4 |
| 2001 | OEHHA |
Chemicals Delisted Effective April 6, 2001 as Known to the State to Cause CancerThe California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). As the lead agency, OEHHA is removing saccharin from the list of chemicals known to the state to cause cancer, for purposes of Proposition 65. Saccharin [CAS No. 81-07-2] was originally added to the Proposition 65 list on October 1, 1989. This chemical was added to the Proposition 65 list as a result of the issuance of a judicial decision enforcing Labor Code Section 6382(b)(1) and (d) which are incorporated by reference as Proposition 65 listing provisions pursuant to Health and Safety Code Section 25249.8(b). Labor Code Section 6382(b)(1) requires inclusion of substances listed as human or animal carcinogens by the International Agency for Research on Cancer (IARC). Labor Code Section 6382(d) requires the inclusion of chemicals identified as carcinogens or potential carcinogens by IARC or the National Toxicology Program (NTP). Saccharin was identified by IARC and NTP as causing cancer. NTP Information Cited National Toxicology Program (NTP, 2000). Report on Carcinogens, Ninth Edition: Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC.
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81-07-2 |
| 2001 | OEHHA |
Chemicals Listed Effective February 23, 2001 as Known to the State to Cause Cancer or Reproductive Toxicity: 13 chemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding thirteen chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective February 27, 2001. Ethoprop, indium phosphide, lynestrenol, norethynodrel, and propachlor are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer. NTP Information Cited
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22398-80-7 |
| 2001 | MSHA |
Diesel Particulate Matter Exposure of Underground Coal MinersThe Department of Labor is establishing new health standards for underground coal mines that use equipment powered by diesel engines. High concentrations of diesel particulate matter (DPM) increases the risk of serious health hazards in underground mines. NTP Information Cited
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| 2001 | EPA |
Control of Air Pollution from New Motor Vehicles: Heavy-Duty Engine and Vehicle Standards and Highway Diesel Fuel Sulfur Control Requirements.The EPA is setting new diesel exhaust emission standards for heavy-duty highway engines to protect the public's health. Health studies indicate potential hazards that appear to be related to acute and chronic exposure. NTP Information Cited
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| 2001 | EPA |
Lead and Lead Compounds: Lowering of Reporting ThresholdsThe EPA is lowering the reporting thresholds for lead and lead compounds which are subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act and section 6607 of the Pollution Prevention Act. NTP Information Cited
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| 2000 | OEHHA |
Chemicals Listed Effective December 22, 2000 as Known to the State of California to Cause Cancer or Reproductive Toxicity: Bromoethane, and 4 othersThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding five chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective December 22, 2000. Bromoethane and isoxaflutole are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer. NTP Information Cited
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74-96-4 |
| 2000 | FDA |
Vinclozolin; Pesticide TolerancesThe FDA is amending the food additive regulations to provide for the safe use of hydrogenated butadiene/acrylonitrile copolymers intended for contact with food in repeated use applications. Although the additive itself has not been shown to cause cancer, it has been found to contain residual amounts of acrylonitrile and butadiene, carcinogenic impurities resulting from the manufacture of the additive. NTP Information Cited
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106-99-0 |
| 2000 | OSHA |
Occupational Exposure to 4,4'Methylenedianiline (MDA)OSHA is promulgating new standards regulating exposure to MDA. NTP Information Cited
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13552-44-8 |
| 2000 | EPA |
Vinclozolin; Pesticide TolerancesThe EPA has established tolerances for combined residues of vinclozolin and its metabolites containing the 3,5-dichloroaniline moiety in or on specific raw agricultural commodities. NTP Information Cited
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20265-96-7 |
| 2000 | OEHHA |
Chemicals Listed Effective June 2, 2000 as Known to the State to Cause Cancer: Chloroprene, Cobalt sulfate heptahydrate, and FenoxycarbThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer. NTP Information Cited
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126-99-8 |
| 2000 | OEHHA |
Chemicals Listed Effective June 2, 2000 as Known to the State to Cause Cancer: Chloroprene, Cobalt sulfate heptahydrate, and FenoxycarbThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer. NTP Information Cited
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10026-24-1 |
| 2000 | EPA |
Diflubenzuron; Pesticide TolerancesThe EPA has received a pesticide petition for establishing a tolerance for residues of diflubenzuron in or on the raw agricultural commodity rangeland grass at 6.0 ppm. P-Chloroaniline (PCA) is a metabolite of diflubenzuron. NTP Information Cited
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20265-96-7 |
| 2000 | OSHA |
Air ContaminantsOSHA notice providing index to Jan. 19, 1989 final rule and list of references relied upon for health effects evaluations in rule. NTP Information Cited
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78-87-5 127-18-4 140-88-5 26471-62-5 75-09-275-35-479-01-6 |
| 2000 | EPA |
Notice of Filing a Pesticide Petition to Establish a Tolerance for Certain Pesticide Chemicals in or on Food.The FDA is amending the food additive regulations to provide for the safe use of ethylene-norbornene copolymers as articles or components of articles in contact with dry food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of benzene, a carcinogenic impurity resulting from the manufacture of the additive. NTP Information Cited
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71-43-2 |
| 2000 | EPA |
1,3-Dichloropropene: Proposed Determination to Terminate Special ReviewThe EPA proposed to terminate the Special Review of 1,3-Dichloropropene (1,3-D). The EPA has determined that the benefits associated with the continued use of 1,3-D under the recently revised terms and conditions of 1,3-D's reregistration outweigh the risks. NTP Information Cited
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542-75-6 |
| 1999 | FDA |
Diflubenzuron; Pesticide TolerancesThe FDA is amending the food additive regulations to provide for the safe use of 4,5-dichloro-1,2-dithiol-3-one as a slimicide in the manufacture of food-contact paper and paperboard. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of tetrachloroethylene, a carcinogenic impurity resulting from the manufacture of the additive NTP Information Cited
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127-18-4 |
| 1999 | EPA |
Diflubenzuron; Pesticide TolerancesThe EPA established tolerances for residues of the insecticide diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline in/on rice grain at 0.02 ppm and rice straw at 0.8 ppm. NTP Information Cited
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20265-96-7 |
| 1999 | EPA |
Acetonitrile: Community Right-to-Know Toxic Chemical Release ReportingThe EPA is denying a petition to remove acetonitrile from the list of chemicals subject to the reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) and section 6607 of the Pollution Prevention Act of 1990 (PPA). NTP Information Cited
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75-05-8 |
| 1999 | FDA |
Diflubenzuron; Pesticide TolerancesThe FDA is issuing a final rule establishing that the over-the-counter stimulant laxative ingredients danthron and phenolphthalein are not generally recognized as safe and effective and are misbranded. NTP Information Cited
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| 1999 | EPA |
Update on the Status of the Superfund Substance-Specific Applied Research ProgramThis Notice provides the status of ATSDR's Superfund mandated Substance-Specific Applied Research Program (SSARP). To date, 188 priority data needs have been identified for the 50 priority hazardous substances frequently found at waste sites. NTP Information Cited
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| 1998 | FDA |
Indirect Food Additives: Adjuvants, Production Aids, and SanitizersThe FDA is amending the food additive regulations to provide for the safe use of 2,9-dichloro-5,12-dihydroquinone[2,3-b]acridine-7,14-dione (C.I. Pigment Red 202) as a colorant for polymers used in contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of para-chloroaniline, a carcinogenic impurity resulting from the manufacture of the additive. NTP Information Cited
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| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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88-72-2 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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612-83-9 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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21739-91-3 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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598-55-0 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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77-09-8 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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20265-96-7 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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389-08-2 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
|
842-07-9 |
| 1998 | OEHHA |
Notice to Interested Parties Chemicals Listed Effective May 15, 1998 as Known to the State to Cause Cancer or Reproductive Toxicity: 28 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer NTP Information Cited
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599-79-1 |
| 1998 | EPA |
Diflubenzuron; Temporary Pesticide ToleranceThis regulation establishes a temporary tolerance for residues of the insecticide diflubenzuron and metabolites convertible to p-chloroaniline (PCA) expressed as diflubenzuron on rice grain at 0.01 ppm. NTP Information Cited
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20265-96-7 |
| 1998 | EPA |
Organobromine Production Wastes; Identification and Listing of Hazardous Waste; Land Disposal Restrictions; Listing of CERCLA Hazardous Substances, Reportable QuantitiesEPA is adding tribromophenol and wastes generated from its production to its list of CERCLA hazardous substances. EPA used structure activity relationship (SAR) analysis information in support of its listing of tribromophenol. NTP Information Cited
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88-06-2 106-93-4 107-06-2 |
| 1997 | FDA |
Laxative Drug Products for Over-the-Counter Human Use: Proposed Amendment to the Tentative Final MonographAs part of its ongoing review of OTC drug products, the FDA is proposing to amend the tentative final monograph for over-the-counter laxative drug products by reclassifying phenolphthalein from Category I (generally recognized as safe and effective) to Category II (not generally recognized as safe and effective). NTP Information Cited
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77-09-8 |
| 1997 | OEHHA |
Chemicals Listed Effective August 26, 1997 as Known to the State to Cause Cancer or Reproductive Toxicity: 16 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 18 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective August 26, 1997. Toxicological Endpoint: Cancer NTP Information Cited
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2429-74-5 |
| 1997 | OEHHA |
Chemicals Listed Effective August 26, 1997 as Known to the State to Cause Cancer or Reproductive Toxicity: 16 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 18 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective August 26, 1997. Toxicological Endpoint: Cancer NTP Information Cited
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81-49-2 |
| 1997 | OEHHA |
Chemicals Listed Effective August 26, 1997 as Known to the State to Cause Cancer or Reproductive Toxicity: 16 ChemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 18 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective August 26, 1997. Toxicological Endpoint: Cancer NTP Information Cited
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28407-37-6 |
| 1997 | OSHA |
Supplement to California State Plan; ApprovalOSHA approves, subject to certain conditions, the California Hazard Communication Standard, including Proposition 65 -- the California Safe Drinking Water and Toxic Enforcement Act. NTP Information Cited
|
N/A |
| 1997 | EPA |
Addition of Dioxin and Dioxin-Like Compounds; Modification of Polychlorinated Biphenyls Listing; Toxic Chemical Release Reporting; Community Right-to-KnowThe EPA is proposing to add a chemical category that includes dioxin and 27 dioxin-like compounds to the list of toxic chemicals subject to the reporting requirements under EPCRA. NTP Information Cited
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| 1997 | OEHHA |
Chemicals Listed Effective May 1, 1997 as Known to the State to Cause Cancer or Reproductive Toxicity: 9 chemicalsThe Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added nine chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). These chemicals are listed effective May 1, 1997. Toxicological Endpoint: Cancer NTP Information Cited National Toxicology Program (NTP). 1995a. Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 461. https://ntp.niehs.nih.gov/go/tr461abs
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75-52-5 116-14-3 |
| 1997 | EPA |
Indirect Food Additives: Adhesives and Components of Coatings; Adjuvants, Production Aids and SanitizersFinal Rule: The FDA is amending the food additive regulations to provide for the safe use of 2,2-ethylidenebis(4,6-di-tert-butylphenyl)fluorophosphonite as an antioxidant in adhesives and in the preparation of polymers intended for contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of methylene chloride, which is a carcinogenic impurity resulting from the manufacture of the additive. NTP Information Cited
|
75-09-2 |
| 1997 | EPA |
Supplement to California State Plan; ApprovalEPA is denying a petition to remove the barium compounds category from the list of chemicals subject to reporting requirements under the Community Right-to-Know Act and the Pollution Prevention Act. The EPA concluded that barium ion can become available from the barium compounds subject to the reporting, and that barium ion can reasonably be anticipated to cause chronic toxicity. NTP Information Cited
|
10326-27-9 |
| 1996 | FDA |
Indirect Food Additives: Adjuvants, Production Aids, and SanitizersFinal Rule: The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of 1,2-benzisothiazolin-3-one as a biocide in rubber latex for use in the manufacture of rubber articles intended for repeated use in contact with food. In its evaluation of the safety of this additive, the FDA has reviewed the safety of the additive itself and that of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzo-p-dioxins impurities resulting from the manufacturing process. NTP Information Cited
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| 1996 | EPA |
Guidelines for Reproduction Toxicity Risk AssessmentNotice: The EPA has made available the final Guidelines for Reproductive Toxicity Risk Assessment. The Guidelines include protocols designed to determine the potential of a test substance to produce reproductive toxicity in laboratory animals. NTP Information Cited
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| 1996 | EPA |
Food Additives Permitted for Direct Addition to Food for Human Consumption: OlestraThe EPA is promulgating a new use rule which requires persons to notify the EPA at least 90 days before commencing the manufacture, import, or processing of certain (22) benzidine-based chemical substances for significant new use as described in this rule. NTP Information Cited
|
16071-86-6 2602-46-2 1937-37-7 |
| 1996 | FDA |
Indirect Food Additives: PolymersThe Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of a copolymer of ethyl acrylate, methyl methacrylate, and methacrylamide in combination with melamine-formaldehyde resin as a coating for polyethylene phthalate films intended for use in contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of unreacted ethyl acrylate, which is a carcinogenic impurity resulting from the manufacture of the additive. NTP Information Cited
|
140-88-5 |
| 1996 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption: OlestraThe Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of phosphorylated tall oil fatty acids as pigment dispersants in polymeric films intended for use in contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of dimethyl hydrogen phosphite, which is a carcinogenic impurity resulting from the manufacture of the additive. NTP Information Cited
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| 1996 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption: OlestraThe Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of polyaryletherketone resins as a basic resin for use in food-contact materials. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of methylene chloride, which is a carcinogenic impurity resulting from the manufacture of the additive. NTP Information Cited
|
75-09-2 |
| 1996 | EPA |
Food Additives Permitted for Direct Addition to Food for Human Consumption: OlestraEPA is proposing a test rule under section 4(a) of the Toxic Substances Control Act to require manufacturers and processors of 21 hazardous air pollutants (HAPs) to test these substances for certain health effects. NTP Information Cited
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| 1996 | EPA |
Proposed Guidelines for Carcinogen Risk AssessmentThe EPA announced the publication of the new "Proposed Guidelines for Carcinogen Risk Assessment" which replaces the 1986 guidelines. NTP Information Cited
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| 1996 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption: OlestraThe FDA is amending the food additive regulations to provide for the safe use of sucrose esterified with medium and long chain fatty acids (olestra) as a replacement for fats and oils. NTP Information Cited
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| 1995 | EPA |
Dichlorvos; Notice of Preliminary Determination to Cancel Certain Registrations and Draft Notice of Intent to CancelEPA's issued this Notice to inform the public that the Agency has, after reviewing additional study date, reassessed the potential adverse effects and the benefits associated with the use of pesticide products containing dichlorvos. The Agency has preliminarily determined that, unless the terms and conditions of registration are modified as proposed in this Notice, the risks from the use of dichlorvos outweigh the benefits of their continued use. NTP Information Cited
|
62-73-7 |
| 1995 | EPA |
Diethyl Phthalate; Toxic Chemical Release Reporting: Community Right-to-KnowEPA is proposing to delete diethyl phthalate (DEP) from the list of chemicals subject to reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 and section 6607 of the Pollution Prevention Act of 1990. NTP Information Cited
|
84-66-2 |
| 1995 | EPA |
Benzidine-Based Chemical Substances; Proposed Significant New Uses of Certain Chemical SubstancesThe EPA is proposing a significant new use rule under section 5(a)(2) of TSCA which would require persons to notify EPA at least 90 days before commencing the manufacture, import, or processing of benzidine-based chemical substances. The EPA believes that benzidine-based chemical substances may be hazardous to human health and that the proposed rule will protect against potentially adverse exposure. NTP Information Cited
|
16071-86-6 2602-46-2 1937-37-7 |
| 1995 | EPA |
Thirty-Sixth Report of the TSCA ITC; Revision of Priority Testing ListThe ITC is revising its Priority Testing List including the removal of butyraldehyde; sulfonyl bis(4-chlorobenzene); 2-propenoic acid,2-cyanoethyl ester; and dipropylene glycol from the List as a result of NTP testing. NTP Information Cited
|
123-72-8 25265-71-8 80-07-9 7085-85-0 |
| 1995 | EPA |
Proposal to delist di-(2-ethylhexyl) adipate from the reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 and section 6607 of the Pollution Prevention Act of1990 NTP Information Cited
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103-23-1 |
| 1995 | EPA |
Food Additives Permitted for Direct Addition to Food for Human Consumption; Acesulfame PotassiumThe EPA proposes to establish a tolerance for residues of the insecticide dimethoate in or on the raw agricultural commodities blueberries and asparagus (see Federal Register July 5, 1995, p. 34945) NTP Information Cited
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60-51-5 |
| 1995 | EPA |
Reportable Quantity AdjustmentsThe EPA has taken final action on reportable quantities (RQs) for hazardous substances under the Comprehensive Environmental Response, Compensation, and Liability Act. The person in charge of a facility or vessel from which a hazardous substance is released in excess of its RQs must notify appropriate authorities, who can then evaluate whether a response is needed. NTP Information Cited
|
111-42-2 |
| 1995 | EPA |
Diflubenzuron: Pesticide TolerancesThe EPA established tolerances for residues of the insecticide diflubenzuron in or on raw agricultural commodities. Para-chloroaniline (PCA) is a metabolite of diflubenzuron. NTP Information Cited
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20265-96-7 |
| 1995 | EPA |
Monosodium Methanearsonate and Disodium Methanearsonate: Toxic Chemical Release Reporting; Community Right-to-KnowEPA is denying a petition to delist monosodium methanearsonate and disodium methanearsonate from the reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986. NTP Information Cited
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| 1995 | EPA |
Test Rule; Office of Water Chemicals Proposed Withdrawal of Certain Testing RequirementsThe EPA is proposing to withdraw certain testing requirements for two chemical substances listed in the Office of Water chemicals test rule. This proposal includes the withdrawal of the 90-day subchronic testing requirements for 1,1,2,2-tetrachloroethane. NTP Information Cited
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79-34-5 |
| 1995 | FDA |
Gastroenterology-Urology Devices; Effective Date of the Requirement for Premarket Approval of the Implanted Mechanical/Hydraulic Urinary Continence DeviceThe FDA is proposing to require the filing of a premarket approval application for a medical device. The Agency is also summarizing its proposed findings regarding the degree of risk of illness or injury designed to be eliminated or reduced. NTP Information Cited
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13552-44-8 |
| 1995 | EPA |
Food and Feed Additive Regulations for d-Limonene, Dihydro-5-Pentyl-2(3H)-Furanone, and Dihydro-5-Heptyl-2(3H)-FuranoneEPA proposes to establish food/feed additive regulations for residues of the insecticide d-limonene when used as an active ingredient in insect-repellent tablecloths and in insect repellent strips used in food/feed-handling establishments. NTP Information Cited
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5989-27-5 |
| 1995 | EPA |
Acephate, Triadimefon, Iprodione, and Imazalil; Revocation of Food Additive RegulationsEPA is proposing to revoke food additive regulations for five pesticides which EPA has determined "induce cancer" within the meaning of the Delaney clause of section 409 of the Federal Food, Drug and Cosmetic Act (FFDCA). After a full evaluation of all the data and supporting information regarding animal carcinogenicity, the EPA has concluded that exposure to triadimefon results in the induction of hepatocellular adenomas in NMRI mice. Hepatocellular adenomas are considered to be evidence of cancer because hepatocellular adenomas can progress to hepatocellular carcinomas. NTP Information Cited
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| 1994 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption; Acesulfame PotassiumMethylene chloride is used as a solvent in the initial step in the manufacturing process of acesulfame potassium and may be present as an impurity in the additive. The FDA used risk assessment procedures to estimate the upper-bound limit of risk presented by methylene chloride. NTP Information Cited
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75-09-2 |
| 1994 | EPA |
Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-KnowEPA is taking this action pursuant to its authority to add to the list those chemicals and chemical categories that meet the EPCRA section 313(d)(2) criteria for addition to the list of toxic chemicals. NTP Information Cited
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108171-27-3 |
| 1994 | OSHA |
Respiratory ProtectionOSHA is proposing to modify its existing standards on respiratory protection so that employers will provide effective protection for employees who wear respirators. agents include saccharin and di-2-ethylhexyl phthalate (DEHP). NTP Information Cited
|
117-81-7 |
| 1994 | EPA |
Asbestos Worker Protection; Asbestos-Containing Materials in Schools; Proposed AmendmentThe proposed rule would generally extend the coverage provided under the 1986 OSHA Asbestos Standard for Construction to State and local government employees who are not covered by OSHA- or EPA-approved State plans. It also proposes to extend coverage provided under the OSHA Asbestos Standard for General Industry for automotive brake and clutch repair. NTP Information Cited
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12001-28-4 12172-73-5 14567-73-8 12001-29-5 |
| 1994 | EPA |
Drinking Water; National Primary Drinking Water Regulations: Disinfectants and Disinfection ByproductsIncludes establishment of maximum residual disinfectant level goals (MRDLGs) for chlorine, chloramines, and chlorine dioxide and maximum contaminant level goals (MCLGs) for bromodichloromethane, dibromochloromethane, and bromoform. NTP Information Cited
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75-25-2 75-27-4 124-48-1 CHLORWATERMX |
| 1994 | FDA |
Secondary Direct Food Additives Permitted in Food for Human Consumption: Cellulose TriacetateAmendment of food additive regulations to provide for the safe use of cellulose triacetate as an immobilizing agent for lactase for use in reducing the lactose content of milk. NTP Information Cited
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75-09-2 |
| 1994 | EPA |
Thirty-Fourth Report of the TSCA Interagency Testing Committee to the Administrator: Receipt of Report and Request for CommentsReceipt of report of the TSCA Interagency Testing Committee to the Administrator. The ITC revised the Priority Testing List including the removal of eight chemicals from the List. NTP Information Cited
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135-88-6 |
| 1994 | EPA |
Pesticides; Proposed Rule Revoking Certain Food RegulationsRevocation of certain food additive regulations for several pesticides which EPA has determined "induce cancer" within the meaning of the Delaney Clause of section 409 of the Federal Food, Drug and Cosmetic Act. NTP Information Cited
|
75-21-8 |
| 1994 | EPA |
Fuels and Fuel Additives Registration RegulationsEstablishment of new requirements for the registration of designated fuels and fuel additives as authorized by sections of the Clean Air Act. NTP Information Cited
|
110-54-3 |
| 1994 | EPA |
Dicofol; Revocation of Food Additive ToleranceRevocation of the food additive tolerance for residues of the pesticide dicofol in or on dried tea. NTP Information Cited
|
115-32-2 |
| 1994 | EPA |
d_Limonene; Tolerance ExemptionExemption from the requirement of a tolerance be established for residues of d-limonene when used as an inert ingredient in pesticide formulations applied to growing crops or raw agricultural commodities after harvest. NTP Information Cited
|
5989-27-5 |
| 1994 | FDA |
Oral Health Care Drug Products for Over-the-Counter Human Use; Tentative Final Monograph for Oral Antiseptic Drug ProductsNotification of proposed rulemaking in the form of a tentative final monograph that would establish conditions under which over-the-counter oral antiseptic drug products are generally recognized as safe and effective and not misbranded. NTP Information Cited
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121-54-0 |
| 1994 | OSHA |
Hazard CommunicationRequirement of employers to establish hazard communication programs to transmit information on the hazards of chemicals to their employees by means of labels on containers, material safety data sheets, and training programs. NTP Information Cited
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N/A |
| 1994 | FDA |
Food Additives Permitted for Direct Addition to Food for Human Consumption; Dimethyl DicarbonateAmendment to the food additive regulations to provide for the safe use of dimethyl dicarbonate as a yeast inhibitor in dealcoholized and low alcohol wines, Jan 26, 1993, and in ready-to-drink tea beverages. NTP Information Cited
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598-55-0 |
| 1994 | EPA |
Cold, Cough, Allergy, Bronchodilator, and Antiasthmatic Drug Products for Over-the Counter Human Use; Amendment of Final Monograph of OTC Antihistamine Drug ProductsEstablishment of conditions under which over-the-counter antihistamine drug products are generally recognized as safe and effective and not misbranded. Dec. 9, 1992. Amendment of final rule to include doxylamine succinate. NTP Information Cited
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469-21-6 91-84-9 |
| 1994 | FDA |
Indirect Food Additives: Adjuvants, Production Aids, and SanitizersAmendment of food additive regulations to provide for the safe use of 3,5-di-tert-butyl-4-hydroxyhydrocinnamic acid triester with 1,3,5-tris(2-hydroxyethyl)-s-triazine-2,4,6-(1H,3H,5H)-trione as an antioxidant for polyester elastomers in contact with dry food and rubber articles intended for repeated use in contact with food. NTP Information Cited
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140-88-5 |
| 1994 | EPA |
Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-KnowAddition of 313 chemicals and chemical categories to the list of toxic chemicals required to be reported on under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 and section 6607 of the Pollution Prevention Act of 1990. NTP Information Cited
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115-28-6 57-41-0 28407-37-6 6459-94-5 101-90-6563-47-320325-40-0 612-82-8 |
| 1993 | EPA |
Drinking Water Maximum Contaminant Level Goal; FluorideAnnouncement of decision not to revise the maximum contaminant level goal (MCLG) for fluoride after consideration of recent reports concerning the health effects of fluoride. NTP Information Cited
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7681-49-4 |
| 1993 | EPA |
Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Significant New Use RuleFinal Rule: Addition of 21 chemicals and 2 chemical categories to the list of toxic chemicals under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA). NTP Information Cited
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64-18-6 |
| 1993 | EPA |
Pesticide Tolerances for DicambaEstablishment of a tolerance for the combined residues of the herbicide dicamba and its 5-hydroxy metabolite. NTP Information Cited
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33857-26-0 |
| 1993 | EPA |
Acetophenone, Phenol, N,N-Dimethylaniline, Ethyl Acetate, and 2,6-Dimethylphenol; Proposed Test Rule, Notice of Opportunity to Initiate Negotiations for TSCA Section 4 Testing Consent AgreementsProposed Rule: Proposed test rule under section 4(a) of the Toxic Substances Control Act (TSCA) that would require manufacturers and processors of five chemicals, acetophenone, phenol, n, n-dimethylaniline, ethyl acetate, and 2,6-dimethylphenol, to conduct testing for certain chemical fate, health and environmental effects. NTP Information Cited
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121-69-7 |
| 1993 | EPA |
Significant New Uses of Certain Acrylate EstersProposed a significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act for all acrylate esters falling within the definition proposed in this rule (acrylate substances). NTP Information Cited
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140-88-5 |
| 1993 | EPA |
Dichlorvos: Revocation of Food Additive ToleranceRevocation of the food additive regulation for residues of the pesticide dichlorvos in or on packaged or bagged non perishable processed food. NTP Information Cited
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62-73-7 |
| 1993 | EPA |
Pesticide Tolerance for DimethoateEstablishment of a tolerance for residues of the insecticide dimethoate in or on raw Brussels sprouts. NTP Information Cited
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60-51-5 |
| 1993 | EPA |
Revocation of Food Additive Regulations for Benomyl, Mancozeb, Phosmet, and TrifluralinRevocation of certain food additive regulations for four pesticides, benomyl, mancozeb, phosmet, and trifluralin, which were included in a 1989 petition. NTP Information Cited
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96-45-7 |
| 1993 | EPA |
C.I. Pigment Violet #23 (Carbazole Violet), C.I. Pigment Blue #15, C.I. Pigment Green #7, and FD & C Red No. 40; Tolerance ExemptionsExemption from the requirement of a tolerance be established for residues of C.I. Pigment Violet #23, C.I. Pigment Blue #15, C.I. Pigment Green #7 and FD Red No. 40 when used as inert ingredients in pesticide formulations applied to growing crops only. NTP Information Cited
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147-14-8 1328-53-6 |
| 1993 | FDA |
Pesticide Tolerance and Animal Feed Additive Regulation for Fluoride CompoundsTentative Final Rule: Tentative affirmation that gelatin is generally recognized as safe (GRAS) for use as a direct human food ingredient. NTP Information Cited
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87-86-5 |
| 1993 | EPA |
Pesticide Tolerance and Animal Feed Additive Regulation for Fluoride CompoundsEstablishment of a 3-year time-limited tolerance for residues of cryolite and/or synthetic cryolite. NTP Information Cited
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7681-49-4 |
| 1993 | EPA |
National Ambient Air Quality Standards For Ozone.Announcement that revisions of the national ambient air quality standards for ozone are not appropriate at this time. NTP Information Cited
|
10028-15-6 |
| 1992 | CPSC |
Dioxin-containing WastesIssued guidelines specifying criteria for determining when any customary or reasonably foreseeable use of an art material can result in chronic hazard. NTP Information Cited
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| 1992 | OSHA |
Occupational Exposure to CadmiumOSHA publishes a new standard for occupational exposure to cadmium. NTP Information Cited
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| 1992 | EPA |
Chemicals: Toxic Chemical Release Reporting; Community Right-To-Know; Proposed Significant New Use RuleThe EPA is partially granting a petition submitted by the Governor of New York to add 80 chemicals and 2 chemical categories to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-To-Know Act by proposing to add 68 chemicals and 2 chemical categories. NTP Information Cited
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1338-23-4 108-46-3 80-62-6 630-20-6 303-34-4148-82-3 |
| 1992 | FDA |
Indirect Food Additives: Paper and Paperboard ComponentsThe FDA is amending the food additive regulations to provide for the safe use of ethyl acrylate in the manufacture of paper and paperboard intended for use in contact with food. NTP Information Cited
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140-88-5 |
| 1992 | EPA |
Drinking Water: National Primary Drinking Water Regulations-Synthetic Organic Chemicals and Inorganic Chemicals; National Primary Drinking Water Regulations ImplementationEPA is promulgating maximum contaminant level goals and National Primary Drinking Water Regulations for 18 synthetic organic and 5 inorganic chemicals. NTP Information Cited
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117-81-7 103-23-1 |
| 1992 | EPA |
Thirtieth Report of the Interagency Testing Committee: Request for Comments Regarding Priority Testing List of ChemicalsThe Priority Testing List was revised by adding one chemical group, the siloxanes, and four chloralkyl phosphates. NTP Information Cited
|
80-07-9 |
| 1992 | OSHA |
Air ContaminantsHealth Effects of Substances to be Regulated NTP Information Cited
|
74-96-4 75-35-4 78-87-5 98-01-1 79-01-6127-18-4106-87-6 96-18-4 117-81-7 75-05-8 75-56-9 80-62-6 87-86-5 26471-62-5 106-92-3 |
| 1992 | OSHA |
Occupational Exposure to Methylene ChlorideNotice of informal public hearings concerning OSHA's proposal to modify the existing provisions for controlling employee exposure to methylene chloride. NTP Information Cited
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75-09-2 |
| 1992 | EPA |
Ethylene Bisdithiocarbamates: Notice of Intent to Cancel; Conclusion of Special ReviewThe EPA concludes the Special Review and risk/benefit analysis of EBDCs and announces the intent to cancel registrations and to deny applications for registration for all pesticide products containing EBDCs as an active ingredient unless the registrations/applications comply with the terms and conditions of registration set forth in this Notice. The Agency has determined that use will result in unreasonable adverse effects to humans or the environment. NTP Information Cited
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96-45-7 |
| 1992 | FDA |
Indirect Food Additives: PolymersThe FDA is amending the food additive regulations to provide for the safe use of polyestercarbonate resin. NTP Information Cited
|
75-09-2 |
| 1992 | EPA |
Aryl Phosphate Base Stocks; Proposed Test Rule Including Reporting and Record-keeping RequirementsEPA proposes that manufacturers, importers and processors of chemical substances in the category of aryl phosphate base stocks be required, under section 4 of the Toxic Substances Control Act to conduct testing. NTP Information Cited
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1330-78-5 |
| 1991 | FDA |
Topical Acne Drug Products for Over-The Counter Human Use; Amendment of Tentative Final MonographProposed Rule: Amendment to final monograph for over-the counter topical acne products. This amendment reclassifies the topical acne active ingredient benzoyl peroxide to a "more-data-needed" category. NTP Information Cited
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INIT/PROM |
| 1990 | EPA |
Identification and Listing of Hazardous Waste; Wood PreservingThe EPA is amending its regulations under the Resource Conservation and Recovery Act by listing as hazardous three categories of wastes from wood preserving operations. NTP Information Cited
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87-86-5 |
| 1990 | EPA |
Pesticide Tolerances for OxytetracyclineThis document proposes that tolerances be established for residues of the pesticide oxytetracycline in or on the raw agricultural commodities cherries and tomatoes. NTP Information Cited
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2058-46-0 |
| 1990 | EPA |
National Primary and Secondary Drinking Water Regulations; Synthetic Organic Chemicals and InorganicChemicalsEPA is proposing maximum contaminant level goals and National Primary Drinking Water Regulations for organic and inorganic chemicals. NTP Information Cited
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75-09-2 77-47-4 1746-01-6 117-81-7 85-68-7103-23-1 |
| 1990 | FDA |
General and Plastic Surgery Devices; Effective Date of Requirement for Premarket Approval of Silicone Gel-filled Breast Prosthesis.FDA is proposing to require the filing of a premarket approval application for the silicone gel-filled breast prosthesis. NTP Information Cited
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N/A |
| 1990 | FDA |
Urethane in Alcoholic Beverages; Research and Survey ReportsThe FDA announced the availability of research and survey reports on urethane in alcoholic beverages. NTP Information Cited
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51-79-6 |
| 1990 | EPA |
Chrome Antimony Titanium Buff Rutile; Toxic Chemical Release Reporting; Community Right-to-KnowEPA is denying a petition to exempt Chrome Antimony Titanium Buff Rutile from reporting under the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) NTP Information Cited
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N/A |
| 1990 | EPA |
National Primary and Secondary Drinking Water Regulations; FluorideEPA is soliciting information that has a bearing on the current standards for fluoride in drinking water. NTP Information Cited
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7681-49-4 |
| 1989 | EPA |
Ethylene Bisdthiocarbamate (EBDC) PesticidesEPA Notice of Preliminary Determination to propose cancellation of certain registrations of EBDC products and propose modifications of registrations not cancelled. NTP Information Cited
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96-45-7 |
| 1989 | EPA |
Inert Ingredients in PesticidesEPA notice for revision of lists of inert ingredients of toxicological concern. NTP Information Cited
|
103-23-1 |
| 1989 | FDA |
4,4'-DiphenylmethanediamineFDA final rule amending food additive regulations to allow use of polyamide-imide resins in articles which come into contact with food. NTP Information Cited
|
|
| 1989 | EPA |
Methyl Ethyl Ketoxime (96-29-7)EPA final rule under TSCA 4 to require testing for oncogenicity, mutagenicity, developmental toxicity, reproductive toxicity, neurotoxicity, and pharmacokinetics. NTP Information Cited
|
96-29-7 |
| 1989 | MSHA |
LeadMSHA proposed rule to revise standards for air quality and chemical substances in mines. NTP Information Cited
|
1317-36-8 1314-87-0 |
| 1989 | EPA |
Reportable Quantities: 1,4-dioxane, 2-ethoxyethanol, ethylene oxide, 2-nitropropane, perchloroethylene, and saccharin.EPA final rule adjusting the reportable quantities (RQ) of these six substances; hazardous substance releases in quantities equal to or greater than their RQ's must be reported to the National Response Center. NTP Information Cited
|
75-21-8 110-80-5 79-46-9 123-91-1 81-07-2 |
| 1989 | EPA |
AsbestosEPA final rule under TSCA 6 to prohibit future manufacture, importation, processing, and distribution in commerce of asbestos in almost all products. NTP Information Cited
|
12001-29-5 |
| 1989 | EPA |
Reportable quantities: Methyl Isocyanate (624-83-9), Aluminum Thiosulfate, and 258 other substancesEPA final rule retaining statutory RQ for MIC, delisting ammonium thiosulfate, and adjusting the RQ's of 258 hazardous substances. NTP Information Cited
|
624-83-9 |
| 1989 | FDA |
Methylene Chloride (75-09-2)FDA final rule banning use of methylene chloride as an ingredient of cosmetic products. NTP Information Cited
|
75-09-2 |
| 1989 | EPA |
Drinking WaterEPA proposed rule on maximum contaminant level goals and National Primary Drinking Water Regulations for 30 synthetic organic chemicals and 8 inorganic chemicals. NTP Information Cited
|
78-87-5 100-42-5 87-86-5 108-90-7 12001-29-5127-18-41330-20-7 |
| 1989 | EPA |
Copper Phthalocyanine PigmentsEPA proposed rule to exempt Pigments Blue 15, Green 7, and Green 36 from SARA 313 release reporting requirements. NTP Information Cited
|
147-14-8 1328-53-6 |
| 1989 | OSHA |
4,4'-Methylenedianiline (13552-44-8)OSHA proposed rule to establish an 8-hour time-weighted average (TWA) of 10ppb, a short-term exposure limit (STEL) of 100PPB, and associated provisions. NTP Information Cited
|
13552-44-8 |
| 1989 | OSHA |
Methylene Chloride (75-09-2)OSHA agenda notice to planned NPRM setting new standard for occupational exposure. NTP Information Cited
|
75-09-2 |
| 1989 | EPA |
Dinitrobenzenes, Allyl Alcohol, Diethylamine, 2,3-Dichloropropene, Isosafrole, Creosote, Dinitrotoluene, ToluenediisocyanateEPA proposed rule to add these chemicals to list of chemicals for which release reporting is required under SARA Section 313. NTP Information Cited
|
121-14-2 26471-62-5 109-89-7 8021-39-4 |
| 1989 | EPA |
Glycol EthersEPA final rule on enforceable testing consent order. NTP Information Cited
|
109-86-4 110-80-5 111-76-2 |
| 1989 | EPA |
CaptanEPA notice of intent to cancel registrations. NTP Information Cited
|
133-06-2 |
| 1989 | OSHA |
Air ContaminantsOSHA final rule amending the air contaminants standard, including new table of Permissible Exposure Limits (PEL). NTP Information Cited
|
127-18-4 75-56-9 |
| 1988 | EPA |
Hazardous Waste Management SystemEPA proposed rule to amend RCRA regulations to list as hazardous 4 additional wastes from wood preserving and surface protection processes. NTP Information Cited
|
87-86-5 |
| 1988 | FDA |
Dimethyl DicarbonateFDA final rule amending food additive regulations to allow use as yeast inhibitor in wines. NTP Information Cited
|
598-55-0 |
| 1988 | EPA |
Methyl Ethyl KetoximeEPA proposed rule to require testing under TSCA Section 4. NTP Information Cited
|
78-93-3 |
| 1988 | EPA |
2-MercaptobenzothiazoleEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
149-30-4 |
| 1988 | EPA |
Certain Chemicals in Anilines CategoryEPA notice of termination of rulemaking because there is no basis for finding of unreasonable risk of injury to health or the environment. NTP Information Cited
|
89-63-4 |
| 1988 | EPA |
Aniline & 7 Substituted AnilinesEPA final rule regarding enforceable testing consent orders under TSCA. NTP Information Cited
|
106-47-8 100-01-6 20265-96-7 |
| 1988 | FDA |
D& C Red No. 36FDA final rule permanently listing D Red No. 36 for general use except in eye area. NTP Information Cited
|
5160-02-1 |
| 1988 | EPA |
BenzeneEPA proposed rule on setting NESHAP applicable to benzene equipment leaks, ethylbenzene/styrene and maleic anhydride process vents, benzene storage vessels, and coke byproduct recovery plants. NTP Information Cited
|
71-43-2 |
| 1988 | FDA |
D& C Red No. 8 and D& C Red No. 9FDA notice of denial of petition for listing for use in ingested lip products and in externally applied drugs and cosmetics. NTP Information Cited
|
5160-02-1 |
| 1988 | EPA |
MelamineEPA proposed rule to delete melamine from list of toxic chemicals for which toxic chemical release reporting is required under SARA Section 313. NTP Information Cited
|
108-78-1 |
| 1988 | EPA |
RCRA Hazardous Waste IdentificationEPA notice regarding strategy for setting compound-specific dilution/attenuation factors in the Toxicity Characteristic used by waste generators to determine whether their solid wastes are hazardous. NTP Information Cited
|
75-09-2 106-46-7 110-86-1 |
| 1988 | EPA |
NaphthaleneEPA notice of assessment results under Clean Air Act, concluding that the health data base is insufficient to warrant regulation under the CAA. NTP Information Cited
|
91-20-3 |
| 1988 | EPA |
IsopropanolEPA proposed rule to require testing under TSCA Section 4. NTP Information Cited
|
67-63-0 |
| 1988 | EPA |
Diethylene Glycol Butyl Ether and Diethylene Glycol Butyl Ether AcetateEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
112-34-5 |
| 1988 | EPA |
DichlorvosEPA notice of initiation of special review of determine whether registration should be cancelled or otherwise amended in light of carcinogenic and other health effects. NTP Information Cited
|
62-73-7 |
| 1988 | EPA |
Commercial HexaneEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
110-54-3 |
| 1987 | FDA |
Cancer-Causing Residues in Edible Products of Food-Producing AnimalsFDA final rule on procedures and criteria to ensure absence of such residues in animals to which drugs, food additives, or color additives have been administered. NTP Information Cited
|
|
| 1987 | EPA |
Polyamine-epichlorohydrinFDA final rule amending food additive regulations concerning paper and paperboard components. NTP Information Cited
|
107-06-2 |
| 1987 | EPA |
CPSC statement of enforcement policy for household products containing methylene chloride. NTP Information Cited
|
75-09-2 |
| 1987 | OSHA |
BenzeneOSHA final rule revising existing occupational standard to reduce PEL (Permissible Exposure Limit) from 10 ppm to 8-hr TWA (time weighted average) of 1 ppm and short-term exposure limit of 5 ppm. NTP Information Cited
|
71-43-2 |
| 1987 | EPA |
2-EthylhexanolEPA final rule to require a 2-year oncogenicity bioassay under TSCA Section 4. NTP Information Cited
|
104-76-7 |
| 1987 | EPA |
Butyl Benzyl PhthalateEPA proposed rule to delete this chemical from SARA Section 313 list of chemicals for which release reporting is required. NTP Information Cited
|
85-68-7 |
| 1987 | EPA |
Ethylene Bisdithiocarbamate (EBDC)EPA notice of initiation of special review to determine whether regulatory action is required. NTP Information Cited
|
96-45-7 |
| 1987 | EPA |
1,2,4,5-TetrachlorobenzeneEPA final rule modifying the test substance purity requirements under TSCA Section 4. NTP Information Cited
|
95-94-3 |
| 1987 | EPA |
8 Volatile Synthetic Organic Chemicals (VOC's)EPA final rule for National Primary Drinking Water Regulations setting maximum contaminant levels and monitoring requirements for 8 VOC's under the Safe Drinking Water Act (SDWA). NTP Information Cited
|
106-46-7 |
| 1987 | EPA |
Drinking WaterEPA notice of 7 substituted contaminants on SDWA list of 83 contaminants. NTP Information Cited
|
100-41-4 106-93-4 |
| 1987 | EPA |
FluoroalkenesEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
75-38-7 |
| 1987 | EPA |
Polyhalogenated Dibenzo-p-dioxins and Dibenzofurans (HDD and HDF)EPA final rule under TSCA to require testing for certain chemicals for HDD/HDF contamination. NTP Information Cited
|
1163-19-5 |
| 1987 | EPA |
11-Aminoundecanoic AcidEPA final rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
2432-99-7 |
| 1987 | FDA |
Indirect Food AdditivesFDA final rule allowing use of an additive to paper products which come into contact with food, although the additive may contain minute amounts of methylene chloride as a byproduct of its production. NTP Information Cited
|
75-09-2 |
| 1987 | EPA |
CyclohexaneEPA proposed rule on test standards and requirements under TSCA Section 4. NTP Information Cited
|
110-82-7 |
| 1987 | EPA |
2,4,5-TrichlorophenolEPA notice of intent to cancel registration as active ingredient for all uses. NTP Information Cited
|
1746-01-6 |
| 1987 | EPA |
P-DichlorobenzeneEPA proposed rule to regulate p-dichlorobenzene as a probable human carcinogen under the Safe Drinking Water Act by amending the Maximum Contaminant Level Goal (MCLG). NTP Information Cited
|
106-46-7 |
| 1987 | EPA |
8 Polybrominated Biphenyls (PBB's) and TrisEPA final rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
67774-32-7 |
| 1987 | EPA |
PentachlorophenolEPA notice of decision to cancel registrations for all products containing pentachlorophenol for all non-wood uses except pulp/paper mill, oil well operations, and cooling tower uses. NTP Information Cited
|
87-86-5 |
| 1986 | EPA |
2-EthylhexanolEPA proposed rule on testing under TSCA Section 4. NTP Information Cited
|
104-76-7 |
| 1986 | FDA |
D& C Red No. 8 and No. 9FDA final rule permanently listing D Red No. 8 and No. 9 as color additives for use in lip products & externally applied drugs and cosmetics. NTP Information Cited
|
5160-02-1 |
| 1986 | OSHA |
Methylene ChlorideOSHA ANPR to revise occupational health exposure standards. NTP Information Cited
|
75-09-2 |
| 1986 | FDA |
FD& C Yellow No. 6FDA final rule permanently listing FD Yellow No. 6 for use in food, drugs, and cosmetics. NTP Information Cited
|
2783-94-0 |
| 1986 | EPA |
2-Ethylhexanoic AcidEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
149-57-5 |
| 1986 | EPA |
1,3-DichloropropeneEPA notice of special review of pesticides containing 1,3-dichloropropene. NTP Information Cited
|
542-75-6 |
| 1986 | OSHA |
1,3-ButadieneOSHA ANPR to reduce occupational exposure. NTP Information Cited
|
106-99-0 |
| 1986 | EPA |
Nickel Subsulfide and Nickel CarbonylEPA notice of determination that no Federal regulation is warranted at this time under CAA. NTP Information Cited
|
10101-97-0 1313-99-1 12035-72-2 |
| 1986 | EPA |
Guidelines for Assessing Health Risks of Environmental PollutantsEPA issuance of guidelines for carcinogen risk assessment, mutagenicity risk assessment, health risk assessment of chemical mixtures, and health assessment of suspect developmental toxicants. NTP Information Cited
|
|
| 1986 | EPA |
Bisphenol AEPA final rule to require a 90-day inhalation subchronic toxicity study with particular emphasis on pulmonary effects, under TSCA Section 4. NTP Information Cited
|
80-05-7 |
| 1986 | EPA |
Dioxin-containing wastesEPA denial of petition to amend rule listing certain dioxin-containing wastes as acute hazardous wastes. NTP Information Cited
|
57653-85-7 |
| 1986 | EPA |
1,2-DichloropropaneEPA final rule to require testing under TSCS Section 4. NTP Information Cited
|
78-87-5 |
| 1986 | EPA |
PentachloroethaneEPA final rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
76-01-7 |
| 1986 | EPA |
1,1-DichloroethyleneEPA proposed rule to require testing under TSCA Section 4. NTP Information Cited
|
75-35-4 |
| 1986 | FDA |
Listing of D& C Orange No. 17 for Use in Externally Applied Drugs and CosmeticsFDA final rule permanently listing D Orange No. 17 as a color additive for use in externally applied drugs and cosmetics. NTP Information Cited
|
|
| 1986 | EPA |
11-Aminoundecanoic AcidEPA proposed rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
2432-99-7 |
| 1986 | EPA |
ToluenediaminesEPA notice of termination of investigation of occupational exposure in light of evidence of carcinogenicity. NTP Information Cited
|
95-80-7 |
| 1986 | EPA |
Chlorinated BenzenesEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
106-46-7 95-50-1 95-94-3 |
| 1986 | EPA |
8 Polybrominated Biphenyls (PBB's) and TrisEPA proposed rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
67774-32-7 |
| 1986 | OSHA |
Asbestos, Tremolite, Anthrophyllite, and ActinoliteOSHA final rule amending standard for occupational exposure and establishing a PEL. NTP Information Cited
|
12001-28-4 14567-73-8 12172-73-5 |
| 1986 | EPA |
Methylcyclopentane and Commercial HexaneEPA proposed rule to require testing under TSCA Section 4. NTP Information Cited
|
110-54-3 96-37-7 |
| 1986 | EPA |
CresolsEPA final rule to require testing under TSCA Section 4. NTP Information Cited
|
1319-77-3 |
| 1986 | OSHA |
1,3-ButadieneOSHA notice responding to EPA referral under TSCA Section 9 and announcing preliminary conclusion that current PEL should be revised. NTP Information Cited
|
106-99-0 |
| 1986 | EPA |
PentachloroethaneEPA proposed rule promulgating a significant new use rule under TSCA Section 5. (Final rule published 9/9/86.) NTP Information Cited
|
76-01-7 |
| 1986 | EPA |
PerchloroethyleneEPA correction of previous FR notice to assess perchloroethylene as a potentially toxic air pollutant under the Clean Air Act Section 112. NTP Information Cited
|
127-18-4 |
| 1986 | EPA |
FormamideEPA notice of decision not to require further testing under TSCA Section 4, pursuant to federal district court ruling that EPA, in lieu of a negotiated testing agreement, require testing or give reasons for not requiring testing. NTP Information Cited
|
75-12-7 |
| 1986 | OSHA |
4,4'-Methylenedianiline (MDA)OSHA notice responding to EPA referral of MDA under TSCA Section 9 and announcing determination that the risk described by EPA may be eliminated or reduced by a workplace standard. NTP Information Cited
|
13552-44-8 |
| 1986 | USDA |
Irradiation of PorkUSDA final rule to permit gamma radiation to control Trichinella Spiralis. NTP Information Cited
|
|
| 1985 | EPA |
HydroquinoneEPA proposed rule on testing standards for hydroquinone. NTP Information Cited
|
123-31-9 |
| 1985 | EPA |
PerchloroethyleneEPA notice of assessment of perc as a potentially toxic air pollutant and intent to list under CAA Section 112. NTP Information Cited
|
127-18-4 |
| 1985 | EPA |
TrichloroethyleneEPA notice of assessment of TCE as a potentially toxic air pollutant and intent to list under CAA Section 112. (This rule was clarified on 3/5/86.) NTP Information Cited
|
79-01-6 |
| 1985 | EPA |
HydroquinoneEPA final rule requiring testing under TSCA Section 4. NTP Information Cited
|
123-31-9 |
| 1985 | FDA |
Methylene ChlorideFDA proposed rule to ban use in cosmetic products. NTP Information Cited
|
75-09-2 |
| 1985 | OSHA |
BenzeneOSHA proposed rule on occupational exposure to benzene to reduce PEL from 10 ppm to 8-hr TWA to 1 ppm to reduce risk of leukemia and other adverse health consequences. NTP Information Cited
|
71-43-2 |
| 1985 | EPA |
Hazardous Waste Management SystemEPA proposed rule to list used oil as hazardous waste. NTP Information Cited
|
127-18-4 |
| 1985 | EPA |
Propylene OxideEPA final rule to require testing for developmental toxicity under TSCA Section 4. NTP Information Cited
|
75-56-9 |
| 1985 | EPA |
Synthetic Organic Chemicals, Inorganic Chemicals, and MicroorganismsEPA proposed rule to establish Recommended Maximum Contaminant Levels as part of the National Primary Drinking Water Regulation under the Safe Drinking Water Act. NTP Information Cited
|
1330-20-7 108-88-3 106-46-7 78-87-5 1746-01-687-86-595-50-1 106-93-4 108-90-7 12001-28-4 12001-29-5 12172-73-5 14567-73-8 |
| 1985 | EPA |
Volatile Synthetic Organic ChemicalsEPA notice of new evidence and requests for comment on new NTP report on tetrachloroethylene. NTP Information Cited
|
127-18-4 |
| 1985 | EPA |
PentabromoethylbenzeneEPA proposed rule on testing under TSCA Section 4. NTP Information Cited
|
85-22-3 |
| 1985 | EPA |
Volatile Synthetic Organic ChemicalsEPA final rule promulgating National Primary Drinking Water regulations. NTP Information Cited
|
106-46-7 127-18-4 |
| 1985 | EPA |
2-MercaptobenzothiazoleEPA proposed rule requiring testing under TSCA Section 4. NTP Information Cited
|
149-30-4 |
| 1985 | EPA |
FluoroalkenesEPA proposed rule requiring testing. NTP Information Cited
|
75-38-7 |
| 1985 | FDA |
Cinnamyl AnthranilateFDA final rule prohibiting use in human food. NTP Information Cited
|
87-29-6 |
| 1985 | EPA |
Methylene ChlorideEPA ANPR announcing initiation of comprehensive regulatory investigation. NTP Information Cited
|
75-09-2 |
| 1985 | EPA |
1,3-ButadieneEPA notice of intent to list under CAA Section 112 as a potentially toxic air pollutant. NTP Information Cited
|
106-99-0 |
| 1985 | EPA |
1,3-ButadieneEPA referral to OSHA under TSCA Section 9. NTP Information Cited
|
106-99-0 |
| 1985 | EPA |
Dioxin-containing wastesEPA tentative denial of petition to amend the rule listing certain dioxin-containing wastes as acute hazardous wastes. NTP Information Cited
|
57653-85-7 |
| 1985 | EPA |
HexachlorocyclopentadieneEPA notice of intent not to regulate and solicitation of information. NTP Information Cited
|
77-47-4 |
| 1985 | EPA |
ChloropreneEPA notice of intent not to regulate and solicitation of information. NTP Information Cited
|
126-99-8 |
| 1985 | EPA |
Benzyl Butyl PhthalateEPA proposed test rule. NTP Information Cited
|
85-68-7 |
| 1985 | FDA |
Certain Color AdditivesFDA final rule postponing closing dates for provisional listing of certain color additives to allow uninterrupted use while scientific evaluation continues. NTP Information Cited
|
5160-02-1 |
| 1985 | EPA |
Chlorinated BenzenesEPA notice of intent not to regulate chlorinated benzenes under CAA. NTP Information Cited
|
106-46-7 |
| 1985 | EPA |
ManganeseEPA decision not to regulate manganese under CAA. NTP Information Cited
|
10034-96-5 |
| 1985 | FDA |
Irradiation of FoodFDA final rule to permit gamma radiation of pork to control Trichinella Spiralis, citing NTP study which concluded that histopathological data did not show a carcinogenic response. NTP Information Cited
|
|
| 1985 | EPA |
4,4-MethylenedianilineEPA notice of decision to refer to OSHA under TSCA Section 9. NTP Information Cited
|
13552-44-8 |
| 1985 | FDA |
Certain Color AdditivesFDA proposed rule to postpone closing dates on provisional listing of certain color additives. NTP Information Cited
|
5160-02-1 |
| 1985 | FDA |
Irradiation of FoodFDA final rule to permit irradiation of dry or dehydrated enzyme preparations. NTP Information Cited
|
|
| 1985 | EPA |
Methyl ChloroformEPA notice of assessment as a potentially toxic air pollutant and determination that regulation under CAA is not warranted. NTP Information Cited
|
71-55-6 |
| 1985 | EPA |
DiethylenetriamineEPA final rule on testing requirements under TSCA Section 4. NTP Information Cited
|
111-40-0 |
| 1985 | EPA |
2-Ethylhexanoic AcidEPA proposed rule on testing under TSCA Section 4. NTP Information Cited
|
104-76-7 |
| 1985 | EPA |
Bisphenol AEPA proposed rule on testing under TSCA Section 4. NTP Information Cited
|
80-05-7 |
| 1985 | EPA |
CyromazineEPA notice of determination to issue conditional registration under FIFRA. NTP Information Cited
|
108-78-1 |
| 1985 | EPA |
Methylene ChlorideEPA notice of initiation of accelerated review under TSCA Section 4. NTP Information Cited
|
75-09-2 |
| 1985 | FDA |
Irradiation of FoodFDA final rule to permit irradiation of additional herbs, spices, and vegetable seasonings. NTP Information Cited
|
N/A |
| 1985 | EPA |
Dioxin-containing WastesEPA final rule listing certain dioxin-containing wastes as acute hazardous wastes. NTP Information Cited
|
57653-85-7 |
| 1984 | EPA |
Certain Polyamino Chemical SubstancesEPA proposed rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
13552-44-8 |
| 1984 | EPA |
[(Dinitrophenyl)Azo]-[2,4-Diamino-5-Methoxybenzene] Derivatives; Proposed Determination of Significant New UsesEPA proposed rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited
|
|
| 1984 | EPA |
1,1,1-TrichloroethaneEPA final rule identifying specific chemical substance and mixture testing requirements. NTP Information Cited
|
71-55-6 |
| 1984 | OSHA |
Ethylene OxideOSHA final standard on occupational PEL. NTP Information Cited
|
75-21-8 |
| 1984 | EPA |
DichloromethaneEPA proposed rule to withdraw testing requirements under TSCA. Evaluation of data indicates dichloromethane does not present unreasonable risks. NTP Information Cited
|
75-09-2 |
| 1984 | EPA |
NitrobenzeneEPA proposed rule to withdraw testing requirements under TSCA. Ongoing government and manufacturers' tests are expected to meet all testing. NTP Information Cited
|
98-95-3 |
| 1984 | EPA |
Volatile Synthetic Organic ChemicalsEPA proposed rule for National Primary Drinking Water Regulations establishing Recommended Maximum Contaminant Levels for several VOC's. NTP Information Cited
|
106-46-7 79-01-6 71-55-6 75-35-4 |
| 1984 | EPA |
FluoroalkenesEPA notice of proposed decision to adopt a negotiated testing program in lieu of required testing. NTP Information Cited
|
75-35-4 |
| 1984 | EPA |
Bis(2-Ethylhexyl) TerephthalateEPA notice of decision to adopt negotiated testing program. NTP Information Cited
|
104-76-7 4376-20-9 |
| 1984 | EPA |
TolueneEPA notice of decision not to regulate under CAA based on studies showing toluene not to pose a significant risk to public health. This decision is not relevant to regulation of toluene as a VOC under the air quality standards for ozone. NTP Information Cited
|
108-88-3 |
| 1984 | EPA |
FormaldehydeEPA ANPR announcing decision that TSCA Section 4f priority consideration is applicable in 2 exposure categories, and initiating a regulatory investigation. NTP Information Cited
|
50-00-0 |
| 1984 | EPA |
Calcium, Cobalt, and Lead NapthenatesEPA notice of determination not to require testing. NTP Information Cited
|
10124-43-3 61789-51-3 |
| 1984 | EPA |
1,3-ButadieneEPA ANPR and invitation to submit data on controlling exposures, following recent bioassays establishing carcinogenicity. NTP Information Cited
|
106-99-0 |
| 1984 | EPA |
CyromazineEPA proposed temporary feed additive regulation. NTP Information Cited
|
108-78-1 |
| 1984 | EPA |
CyromazineEPA proposed rule to establish feed additive regulation setting temporary maximum permissible residue level in poultry feed. NTP Information Cited
|
108-78-1 |
| 1984 | EPA |
CyromazineEPA notice of proposed conditional registration under FIFRA for temporary period. NTP Information Cited
|
108-78-1 |
| 1984 | EPA |
IsophoroneEPA notice of decision to adopt negotiated testing program. NTP Information Cited
|
78-59-1 |
| 1984 | EPA |
|
78-87-5 |
| 1984 | EPA |
1,2-Butylene OxideEPA notice of determination not to require testing. NTP Information Cited
|
106-88-7 |
| 1984 | EPA |
Certain Alkyl EpoxidesEPA ANPR on testing under TSCA NTP Information Cited
|
7320-37-8 |
| 1984 | EPA |
HydroquinoneEPA Proposed test rule under TSCA Section 4. NTP Information Cited
|
123-31-9 |
| 1984 | EPA |
Ethylene OxideEPA notice of determination not to require testing. NTP Information Cited
|
75-21-8 |
| 1984 | EPA |
AnilinesEPA ANPR to require health and environmental effects testing. NTP Information Cited
|
20265-96-7 |
| 1983 | EPA |
Hexafluoropropylene OxideEPA proposed test rule under TSCA Section 4. NTP Information Cited
|
428-59-1 |
| 1983 | EPA |
CyromazineEPA issuance of emergency exemptions for use of an unregistered pesticide. NTP Information Cited
|
108-78-1 |
| 1983 | EPA |
Chlorinated BenzenesEPA proposed rule to withdraw most testing requirements. NTP Information Cited
|
120-82-1 108-90-7 608-93-5 95-50-1 |
| 1983 | OSHA |
Hazard CommunicationOSHA final rule setting final occupational safety and health standard requiring hazard assessment and communication to employees of chemical hazard information. NTP Information Cited
|
N/A |
| 1983 | EPA |
FormaldehydeEPA notice of reconsideration as to whether TSCA Section 4f priority consideration is appropriate. NTP Information Cited
|
50-00-0 |
| 1983 | EPA |
Bis(2-Ethylhexyl)Terephthalate; Response to the Interagency Testing CommitteeEPA notice that it is not initiating TSCA Section 4 test requirement rulemaking because ongoing tests are expected to provide sufficient information to predict toxicity. NTP Information Cited
|
104-76-7 4376-20-9 |
| 1983 | EPA |
TrisEPA notice that it is not initiating TSCA Section 4A test requirement rulemaking because ongoing tests are expected to provide sufficient information to predict toxicity. NTP Information Cited
|
78-42-2 |
| 1983 | OSHA |
AsbestosOSHA emergency temporary standard to reduce occupational PEL. NTP Information Cited
|
12001-28-4 12001-29-5 12172-73-5 14567-73-8 1332-21-4 |
| 1983 | OSHA |
Ethylene DibromideOSHA NPRM to revise current occupational exposure standard to reduce PEL, restrict dermal exposure, etc. NTP Information Cited
|
106-93-4 |
| 1983 | EPA |
4,4-MethylenedianilineEPA ANPR of EPA/OSHA joint initiation of regulatory action under TSCA and OSHA Act. NTP Information Cited
|
13552-44-8 |
| 1983 | EPA |
4,4-MethylenedianilineEPA notice that it is not initiating a TSCA Section 4A health effects test rule because recent NTP study shows MDA to be carcinogenic in rats and mice. NTP Information Cited
|
13552-44-8 |
| 1983 | EPA |
FormamideEPA notice of determination not to require additional health effects testing. NTP Information Cited
|
75-12-7 |
| 1983 | EPA |
IsophoroneEPA notice that it is not initiating TSCA Section 4A test requirements because of adequate ongoing tests. NTP Information Cited
|
78-59-1 |
| 1982 | EPA |
AcetonitrileEPA notice that testing by NTP and manufacturers is adequate and further testing under TSCA Section 4 is not warranted. NTP Information Cited
|
75-05-8 |
| 1982 | EPA |
PyridineEPA notice that testing under TSCA Section 4 is not warranted. NTP Information Cited
|
110-86-1 |
| 1982 | EPA |
HexachlorocyclopentadieneEPA notice that testing under TSCA Section 4 is not warranted. NTP Information Cited
|
77-47-4 |
| 1982 | EPA |
XylenesEPA notice that testing under TSCA Section 4 is not warranted. NTP Information Cited
|
1330-20-7 |
| 1982 | EPA |
TolueneEPA notice that a test rule under TSCA Section 4 is unnecessary because information from current and planned testing will be sufficient. NTP Information Cited
|
108-88-3 |
| 1982 | EPA |
AsbestosEPA final rule requiring schools to identify friable asbestos-containing building materials, to maintain records, and to notify employees and PTA's. NTP Information Cited
|
12001-28-4 12001-29-5 14567-73-8 1332-21-4 12172-73-5 |
| 1982 | FDA |
Carcinogenic Chemicals in Food and Color AdditivesFDA ANPR on setting a policy for regulating use of food and color additives containing carcinogens. NTP Information Cited
|
|
| 1982 | CPSC |
Urea Formaldehyde Foam InsulationCPSC final rule banning UF foam insulation in residences and schools. NTP Information Cited
|
50-00-0 |
| 1982 | EPA |
Chlorinated ParaffinsEPA notice that testing under TSCA Section 4 is not being required because currently planned testing is sufficient. NTP Information Cited
|
108171-27-3 108171-26-2 |
| 1981 | EPA |
Benzidine, o-Tolidine, o-DianisidineEPA notice that testing under TSCA Section 4 is not required due to adequacy of current testing programs of NTP and other federal agencies. NTP Information Cited
|
92-87-5 119-93-7 |
| 1981 | EPA |
Alkyl Phthalate and Benzyl Butyle PhthalateEPA notice of preliminary decision not to require testing under TSCA, following receipt of CMA testing proposal. NTP Information Cited
|
85-68-7 |
| 1981 | CPSC |
Urea Formaldehyde Foam InsulationCPSC proposed rule to ban manufacture or sale in the US. NTP Information Cited
|
50-00-0 |
| 1980 | EPA |
AsbestosEPA proposed rule to require schools to identify friable asbestos-containing materials and to notify employees and PTAs. NTP Information Cited
|
1332-21-4 |
| 1980 | EPA |
Chloromethane and Chlorinated BenzenesEPA proposed rule to require testing under TSCA Section 4. NTP Information Cited
|
106-46-7 |