Short-Term Toxicity Reports
About Technical Reports
Long-term NTP toxicology and carcinogenicity studies usually involve exposing laboratory animals (rats and mice) to a substance for a period of two years. These studies are designed and conducted to characterize and evaluate the toxicologic potential, including carcinogenic activity, of selected substances. Substances selected for NTP toxicology and carcinogenesis studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. Substance selection is not an indicator of a substance's carcinogenic potential.
The methods, results, and conclusions of these studies are published in NTP's Technical Report (TR) series after undergoing peer review. The interpretive conclusions presented in Technical Reports and Abstracts are based only on the results of these NTP studies.
Learn More About NTP Technical Reports
The studies described in the Technical Reports are performed under the direction of NTP and adhere to the following standards:
- Studies are conducted in compliance with NTP laboratory health and safety requirements.
- Studies meet or exceed all applicable federal, state, and local health and safety regulations.
- Animal care and use are in accord and compliance with the Public Health Service Policy on Humane Care and Use of Animals.
- Studies are also conducted in compliance with Food and Drug Administration Good Laboratory Practice Regulations (21 CFR, Part 58).
Abstracts are taken from the technical reports and include a link to the full report at the start of the abstracts. When available, the abstracts also link to supporting pathology tables, survival and growth curves; target organs and tumor incidences; and 2-D structures at the end of each abstract.
Definition of Carcinogenicity Results
For more information, contact the NTP Web Team:
- NTP Web Team
- P.O. Box 12233, MD K2-05 Research Triangle Park, NC 27709
- 984-287-3211
- [email protected] or use our contact form
AIDS Therapeutics Toxicity Studies Program
Infection with human immunodeficiency virus (HIV) causes suppression of the immune system. Infection leads to acquired immunodeficiency syndrome (AIDS) with a broad spectrum of opportunistic infections. Treatment of AIDS generally involves combination therapies of antiretroviral agents with antimicrobial drugs specific for the opportunistic infections.
The National Institute of Environmental Health Sciences (NIEHS), under the AIDS research program, collaborated with other institutes of the NIH, other government agencies, and pharmaceutical companies to evaluate facets of AIDS therapeutics including:
- Reproductive/developmental toxicity
- General toxicity
- Immunotoxicity
- Neurotoxicity
These evaluations included single therapeutic agents or combination therapies when the toxic potential of these substances in animal models was not available or was incomplete. The studies with combination therapies were very important. They were vital because they increased awareness and understanding of interactions between antiretroviral therapies and other drugs/substances that HIV-infected individuals use.
AIDS Publication Abstracts
- Sanders VM, Elwell MR, Heath JE, Collins BJ, Dunnick JK, Rao GN, Prejean D, Lindamood C 3rd, Irwin RD. Induction of thymic lymphoma in mice administered the dideoxynucleoside ddC. Fundam Appl Toxicol. 1995;27(2):263-269.
- Rao GN, Collins BJ, Giles HD, Heath JE, Foley JF, May RD, Buckley LA. Carcinogenicity of 2',3'-dideoxycytidine in mice. Cancer Res. 1996;;56(20):4666-4672.
- Rao GN, Lindamood C 3rd, Heath JE, Farnell DR, Giles HD. Subchronic toxicity of human immunodeficiency virus and tuberculosis combination therapies in B6C3F1 mice. Toxicol Sci. 1998;45(1):113-127.
Other AIDS Information Sites
- Division of Acquired Immune Deficiency Syndrome – National Institute of Allergy and Infectious Diseases
- AIDS Information Resources – The National Library of Medicine
- NIH Office of AIDS Research (OAR) – National Institutes of Health
- CDC National Prevention Information Network – Centers for Disease Control and Prevention
- The Joint United Nations Program on HIV/AIDS
- AIDS Hotlines and Service Organizations
About Toxicity Reports
The NTP Toxicity Report Series (TOX) includes reports about short-term studies. These studies usually involve exposing laboratory animals (rats and mice) for 3 months to evaluate the toxicity, but exposure can be any duration less than one year. Substances selected for short-term studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. The selection of a substance is not an indicator of its carcinogenic potential.
The report abstracts in the NTP Toxicity Report Series include brief descriptions of the findings, but a link to the full report is listed at the end of each abstract. In some cases, the short-term studies for a particular substance may be reported with longer term studies and not included in the TOX report series.
The NTP Toxicity Reports are peer-reviewed by at least two external experts, typically in the fields of toxicology, pathology, or other field applicable to the study. NTP also maintains a list of studies undergoing review.
Learn More About Short-Term Studies
Because short-term study experiments are conducted under a limited set of conditions, relating the findings from short-term studies to human health requires additional information and possibly further testing. Positive short-term study findings mean that a substance is toxic for laboratory animals and that exposure to the substance is potentially hazardous to humans. Negative short-term study results mean that study animals did not have a greater incidence of toxicity than control animals; however, negative results do not necessarily mean that a substance is not toxic.
The studies described in the NTP Toxicity Report Series are performed under the direction of NTP. The short-term studies:
- Comply with NTP laboratory health and safety requirements.
- Meet or exceed all applicable federal, state, and local health and safety regulations.
- Comply with the Public Health Service Policy on Humane Care and Use of Animals.
- Comply with Food and Drug Administration Good Laboratory Practice Regulations (21 CFR, Part 58).
Abstracts are taken from the published reports for the individual studies. A link to the full report is listed at the end of each abstract.
For more information, contact the NTP Web Team:
- NTP Web Team
- P.O. Box 12233, MD K2-05 Research Triangle Park, NC 27709
- 984-287-3211
- [email protected] or use our contact form
About Research Reports
NTP research reports cover research and literature-analysis activities that do not fall under the scope of existing report series.
About Immunotoxicity Reports
NTP has developed a range of techniques and testing regimens for evaluating the potential of environmental and occupational substances to damage the immune system. These materials may include:
- Food additives
- Natural products such as mycotoxins
- Products used in the pharmaceutical, farming, chemical, or consumer product industries
Immunotoxicity tests are designed to evaluate immune function and hypersensitivity. These tests are carried out using rodent models, cultured mammalian cells, and other in vitro methods.
About Genetically Modified Model Reports
Genetically modified model reports evaluate the toxicologic potential, including carcinogenic activity, of selected agents in laboratory animals that have been genetically modified. There are two animal types used:
TG.AC: This mouse model has an alteration of specific tumor suppressor genes that have been shown to be associated with induced tumors in rodents and in human malignancies.
P53 deficient: This mouse model has an alteration of the p53 tumor suppressor gene, which is critical to cell cycle control and DNA repair.
About Developmental & Reproductive Toxicity (DART) Reports
NTP has developed a range of techniques and testing regimes to evaluate the potential of environmental and occupational substances to affect development and damage reproductive systems.
Prenatal developmental toxicity studies identify substances that may pose a risk to the developing fetus if pregnant women are exposed. Regulatory agencies use the results of well-conducted animal studies to help set human exposure guidelines.
We have also developed methods for evaluating the potential toxic effects of exposure to environmental and occupational substances on the reproductive system. These studies are carried out primarily using rodent models.
Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, email us or use our contact form and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.
How to search with filtering and sorting
Search for particular reports by filtering or searching the table. As you type in the search box, the page will filter the table results as you type each letter.
Sort by clicking the up or down arrow in a column header. Click again to reverse the order. If only one arrow is displayed, that column is sorted in the direction of the arrow. Only one column can be sorted at a time.
| Abstract | Full Text | Report Title | Year | Type |
|---|---|---|---|---|
| TOX-107 | PDF (2.83 MB) | Toxicity Study of Stachybotrys chartarum (CASRN 67892-26-6) Administered by Inhalation to B6C3F1/N Mice | 2024 | Short-Term Toxicity |
| TOX-106 | PDF (2.68 MB) | Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice | 2023 | Short-Term Toxicity |
| TOX-105 | PDF (4.16 MB) | Toxicity Studies of Usnea Lichens Containing (+/−)-Usnic Acid (CASRN 125-46-2) Administered in Feed to F344/N Nctr Rats and B6C3F1/Nctr Mice | 2022 | Short-Term Toxicity |
| TOX-104 | PDF (4.58 MB) | Toxicity Studies of (+)-Usnic Acid (CASRN 7562-61-0) Administered in Feed to F344/N Nctr Rats and B6C3F1/Nctr Mice | 2022 | Short-Term Toxicity |
| TOX-103 | PDF (4.65 MB) | Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice | 2022 | Short-Term Toxicity |
| TOX-102 | PDF (2.58 MB) | Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice | 2021 | Short-Term Toxicity |
| TOX-101 | PDF (6.74 MB) | Toxicity Studies of Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered by Nose-only Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice | 2021 | Short-Term Toxicity |
| TOX-100 | PDF (3.27 MB) | Toxicity Studies of Aspergillus fumigatus Administered by Inhalation to B6C3F1/N Mice (Revised) | 2021 | Short-Term Toxicity |
| TOX-99 | PDF (1.07 MB) | Toxicology Studies of A Gum Guggul Extract Formulation Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice | 2020 | Short-Term Toxicity |
| TOX-98 | PDF (2.99 MB) | Toxicity Studies of Acetoin (CASRN 513-86-0) and 2,3-Pentanedione (CASRN 600-14-6) Administered by Inhalation to Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice | 2023 | Short-Term Toxicity |
| TOX-97 | PDF (8.61 MB) | Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised) | 2022 | Short-Term Toxicity |
| TOX-96 | PDF (6.02 MB) | Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised) | 2022 | Short-Term Toxicity |
| TOX-95 | PDF (3.84 MB) | Toxicity Studies of Myristicin (CASRN 607-91-0) Administered to F344/NTac Rats and B6C3F1 Mice | 2019 | Short-Term Toxicity |
| TOX-94 | PDF (2.23 MB) | Toxicity Studies of 1020 Long Multiwalled Carbon Nanotubes (CASRN L-MWNT-1020) Administered by Inhalation to Sprague-Dawley Rats and B6C3F1/N Mice | 2019 | Short-Term Toxicity |
| TOX-93 | PDF (1.59 MB) | Toxicity Studies of Chitosan (CASRN 9012-76-4) Administered in Feed to Sprague-Dawley Rats | 2017 | Short-Term Toxicity |
| TOX-92 | PDF (2.46 MB) | Toxicity Studies of Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice | 2016 | Short-Term Toxicity |
| TOX-91 | PDF (5.27 MB) | Toxicity Studies of Abrasive Blasting Agents Administered by Inhalation to F344/NTac Rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats | 2020 | Short-Term Toxicity |
| TOX-90 | Not yet available | Toxicity Studies of PCN 66/67 Comparison (CASRN PCNCOMPARISN) Administered by Gavage to Harlan Sprague-Dawley Rats - No report issued. | N/A | Short-Term Toxicity |
| TOX-89 | PDF (1.38 MB) | Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice | 2015 | Short-Term Toxicity |
| TOX-88 | PDF (1.58 MB) | Toxicity Studies of p-Toluenesulfonamide Administered in Feed to F344/N Rats, F344/NTac Rats, and B6C3F1/N Mice (CASRN 70-55-3) | 2016 | Short-Term Toxicity |
| TOX-87 | PDF (3.72 MB) | Toxicity Studies of Fullerene C60 (1μm and 50 nm) (CASRN 99685-96-8) Administered by Nose-Only Inhalation to Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice | 2020 | Short-Term Toxicity |
| TOX-86 | PDF (4.57 MB) | Toxicity Studies of Cedarwood Oil (CASRN 8000-27-9) Cedarwood Oil (Virginia) Administered Dermally to F344/N Rats and B6C3F1/N Mice | 2016 | Short-Term Toxicity |
| TOX-85 | PDF (1.66 MB) | Toxicity Studies of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (CASRN 21850-44-2) Administered by Gavage to F344/NTac Rats and B6C3F1/N Mice | 2017 | Short-Term Toxicity |
| TOX-84 | PDF (2.62 MB) | Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8) Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice | 2018 | Short-Term Toxicity |
| TOX-83 | PDF (2.11 MB) | Toxicity Studies of o-Chloropyridine (CASRN 109-09-1) Administered by Dosed-Water to F344/N Rats and B6C3F1 Mice | 2017 | Short-Term Toxicity |
| TOX-82 | PDF (3.26 MB) | Toxicity Studies of Estragole (CASRN 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 2011 | Short-Term Toxicity |
| TOX-81 | PDF (2.81 MB) | Toxicity Studies of alpha-Pinene (CASRN 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice | 2016 | Short-Term Toxicity |
| TOX-80 | PDF (2.01 MB) | Toxicity Studies of Sodium Thioglycolate (CASRN 367-51-1) Administered Dermally to F344/N Rats and B6C3F1/N Mice | 2016 | Short-Term Toxicity |
| TOX-79 | PDF (1.63 MB) | Toxicity Study Report of the Reproductive Dose Range-Finding Study of Genistein (CASRN 446-72-0) Administered in Feed to Sprague-Dawley Rats | 2007 | Short-Term Toxicity |
| TOX-78 | PDF (2.37 MB) | Toxicity Studies of Triethylamine (CASRN 121-44-8) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 2018 | Short-Term Toxicity |
| TOX-77 | PDF (2.19 MB) | Toxicity Studies of Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage to Female Sprague Dawley (Hsd:Sprague Dawley SD) Rats | 2021 | Short-Term Toxicity |
| TOX-76 | PDF (5.81 MB) | Toxicity Studies of 2,4-Decadienal (CASRN 25152-84-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 2011 | Short-Term Toxicity |
| TOX-75 | PDF (1.21 MB) | Toxicity Studies of Dimethylaminopropyl Chloride, Hydrochloride (CASRN 5407-04-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 2007 | Short-Term Toxicity |
| TOX-74 | PDF (7.26 MB) | Toxicity Study Report on the Atmospheric Characterization, Particle Size, Chemical Composition, and Workplace Exposure Assessment of Cellulose Insulation | 2006 | Short-Term Toxicity |
| TOX-73 | PDF (2.34 MB) | Metabolism, Toxicity, and Predicted Carcinogenicity Studies of Diazoaminobenzene (CASRN 136-35-6) Administered Dermally to F344/N Rats and B6C3F1 Mice | 2002 | Short-Term Toxicity |
| TOX-72 | PDF (13.68 MB) | Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice | 2007 | Short-Term Toxicity |
| TOX-71 | PDF (1.31 MB) | Toxicity Studies of Malachite Green Chloride and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) Administered in Feed to F344/N Rats and B6C3F1 Mice | 2004 | Short-Term Toxicity |
| TOX-70 | PDF (3.66 MB) | Toxicity Studies of p-tert-Butylcatechol (CASRN 98-29-3) Administered in Feed to F344/N Rats and B6C3F1 Mice | 2002 | Short-Term Toxicity |
| TOX-69 | PDF (2.53 MB) | Toxicity Studies of Butanal Oxime (CASRN 110-69-0) Administered in Drinking Water and by Gavage to F344/N Rats and B6C3F1 Mice | 2004 | Short-Term Toxicity |
| TOX-67 | PDF (1.62 MB) | Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole (CASRNs 693-98-1 and 822-36-6) Administered in Feed to F344/N Rats and B6C3F1 Mice | 2004 | Short-Term Toxicity |
| TOX-66 | PDF (2.73 MB) | Toxicity Studies of 3,3',4,4'-Tetrachloroazoxybenzene (CASRN 21232-47-3) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1998 | Short-Term Toxicity |
| TOX-65 | PDF (1.74 MB) | Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene (CASRN 14047-09-7) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1998 | Short-Term Toxicity |
| TOX-62 | PDF (1.8 MB) | Toxicity Studies of WY-14,643 (CASRN 50892-23-4) Administered in Feed to Sprague-Dawley Rats, B6C3F1 Mice, and Syrian Hamsters | 2007 | Short-Term Toxicity |
| TOX-61 | PDF (2.12 MB) | Toxicity Studies of Benzophenone (CASRN 119-61-9) Administered in Feed to F344/N Rats and B6C3F1 Mice | 2000 | Short-Term Toxicity |
| TOX-60 | Not yet available | Toxicity Studies of Dibutyl Phthalate - No report issued. | N/A | Short-Term Toxicity |
| TOX-59 | PDF (10.23 MB) | Toxicity and Metabolism Studies of Chloral Hydrate (CASRN 302-17-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1999 | Short-Term Toxicity |
| TOX-58 | PDF (1.53 MB) | Toxicity, Reproductive, and Developmental Studies of 60-Hz Magnetic Fields Administered by Whole Body Exposure to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice | 1996 | Short-Term Toxicity |
| TOX-57 | PDF (2.14 MB) | Toxicity Studies of Benzyltrimethylammonium Chloride (CASRN 56-93-9) Administered by Gavage to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice | 2000 | Short-Term Toxicity |
| TOX-56 | PDF (3.03 MB) | Toxicity Studies of Carisoprodol (CASRN 78-44-4) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 2000 | Short-Term Toxicity |
| TOX-55 | PDF (2.55 MB) | Toxicity Studies of trans-1,2-Dichloroethylene (CASRN 156-60-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice | 2002 | Short-Term Toxicity |
| TOX-54 | PDF (375 KB) | Summary Report on the Metabolism, Disposition and Toxicity of 1,4-Butanediol (CASRN 110-63-4) | 1996 | Short-Term Toxicity |
| TOX-53 | PDF (3.66 MB) | Toxicity Studies of t-Butyl Alcohol (CASRN 75-65-0) Administered in F344/N Rats and B6C3F1 Mice (Inhalation Studies) | 1997 | Short-Term Toxicity |
| TOX-52 | PDF (2.81 MB) | Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol Administered to F344/N Rats and B6C3F1 Mice | 1996 | Short-Term Toxicity |
| TOX-51 | PDF (8.11 MB) | Toxicity Studies of Methyl Ethyl Ketoxime Administered (CASRN 96-29-7) in Drinking Water to F344/N Rats and B6C3F1 Mice | 1999 | Short-Term Toxicity |
| TOX-50 | PDF (1.53 MB) | Toxicity Studies of Cyclohexanone Oxime (CASRN 100-64-1) Administered by Drinking Water to B6C3F1 Mice | 1996 | Short-Term Toxicity |
| TOX-49 | PDF (2.47 MB) | Toxicity Studies of 1,1,2,2-Tetrachloroethane (CASRN 79-34-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice | 2004 | Short-Term Toxicity |
| TOX-48 | PDF (16.13 MB) | Comparative Toxicity Studies of Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN 107-18-6) and Acrolein (CASRN 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | 2006 | Short-Term Toxicity |
| TOX-47 | PDF (2.16 MB) | Toxicity Studies of Methacrylonitrile (CASRN 126-98-7) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 2000 | Short-Term Toxicity |
| TOX-46 | PDF (1.52 MB) | Hepatoxicity Studies of the Liver Carcinogen Methapyrilene Hydrochloride (CASRN 135-23-9) Administered in Feed to Male F344/N Rats | 2000 | Short-Term Toxicity |
| TOX-45 | PDF (1.24 MB) | Renal Toxicity Studies of Selected Halogenated Ethanes Administered by Gavage to F344/N Rats | 1996 | Short-Term Toxicity |
| TOX-44 | PDF (1.53 MB) | Comparative Toxicity and Carcinogenicity Studies of o-Nitrotoluene and o-Toluidine Hydrochloride (CASRNs 88-72-2 and 636-21-5) Administered in Feed to Male F344/N Rats | 1996 | Short-Term Toxicity |
| TOX-43 | PDF (3.47 MB) | Comparative Toxicity Studies of o-, m-, and p-Chloroaniline (CASRNs 95-51-2, 108-42-9, and 106-47-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1998 | Short-Term Toxicity |
| TOX-42 | PDF (1.4 MB) | Toxicity Studies of 1,3-Diphenylguanidine (CASRN 102-06-7) Administered in Feed to F344/N Rats and B6C3F1 Mice | 1995 | Short-Term Toxicity |
| TOX-41 | PDF (2.06 MB) | Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55-6) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice | 2000 | Short-Term Toxicity |
| TOX-40 | PDF (1.73 MB) | Toxicity Studies of beta-Bromo-beta-Nitrostyrene (CASRN 7166-19-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1994 | Short-Term Toxicity |
| TOX-39 | PDF (1.82 MB) | Toxicity Studies of Cadmium Oxide (CASRN 1306-19-0) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 1995 | Short-Term Toxicity |
| TOX-38 | PDF (1.83 MB) | Toxicity Studies of Sodium Selenate and Sodium Selenite (CASRNs 13410-01-0 and 10102-18-8) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice | 1994 | Short-Term Toxicity |
| TOX-37 | PDF (590.69 KB) | Toxicity Studies of Sodium Cyanide, (CASRN 143-33-9) Administered by Dosed Water to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-36 | PDF (4.74 MB) | Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-35 | PDF (10.12 MB) | Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-34 | PDF (838.27 KB) | Toxicity Studies of 1-Nitropyrene (CASRN 5522-43-0) Administered by Inhalation to F344/N Rats | 1996 | Short-Term Toxicity |
| TOX-33 | PDF (9.01 MB) | Toxicity Studies of 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene (CASRN 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-32 | PDF (3.34 MB) | Toxicity Studies of Methylene bis(thiocyanate), (CASRN 6317-18-6) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-31 | PDF (7.18 MB) | Toxicity Studies of Isoprene (CASRN 78-79-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 1995 | Short-Term Toxicity |
| TOX-30 | PDF (2.49 MB) | Toxicity Studies of Dibutyl Phthalate (CASRN 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice | 1995 | Short-Term Toxicity |
| TOX-29 | PDF (5.57 MB) | Toxicity Studies of Cupric Sulfate (CASRN 7758-99-8) Administered in Drinking Water and Feed to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-28 | PDF (820.36 KB) | Toxicity Studies of Tetrachlorophthalic Anhydride (CASRN 117-08-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-27 | PDF (1.59 MB) | Toxicity Studies of Riddelliine (CASRN 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1 Mice. | 1993 | Short-Term Toxicity |
| TOX-26 | PDF (8.2 MB) | Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-25 | PDF (2.22 MB) | Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-24 | PDF (1.27 MB) | Toxicity Studies of 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice | 1993 | Short-Term Toxicity |
| TOX-23 | PDF (6.43 MB) | Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-22 | PDF (1.87 MB) | Toxicity Studies of N,N-Dimethylformamide (CASRN 68-12-2) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-21 | PDF (20.39 MB) | Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-20 | PDF (2.02 MB) | Toxicity Studies of Diethanolamine (CASRN 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-19 | PDF (1.43 MB) | Toxicity Studies of Formic Acid (CASRN 64-18-6) Administered by Inhalation to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-18 | PDF (3.57 MB) | Toxicity Studies of Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) in Dimethyl Phthalate (CASRN 131-11-3) (45:55) | 1993 | Short-Term Toxicity |
| TOX-17 | PDF (1.36 MB) | Toxicity Studies of Black Newsprint Inks Administered Topically to F344/N Rats and C3H Mice | 1992 | Short-Term Toxicity |
| TOX-16 | PDF (1.59 MB) | Toxicity Studies of Glyphosate (CASRN 1071-83-6) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-15 | PDF (726.21 KB) | Toxicity Studies of t-Butyl Perbenzoate (CASRN 614-45-9) Administered by Gavage to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-14 | PDF (1.71 MB) | Toxicity Studies of p-Chloro-a,a,a-Trifluorotoluene (CASRN 98-56-6) Administered in Corn Oil and a-Cyclodextrin to F344/N Rats and B6C3F1 Mice in 14-Day Comparative Gavage Studies | 1992 | Short-Term Toxicity |
| TOX-13 | PDF (1.65 MB) | Toxicity Studies of Trinitrofluorenone (CASRN 129-79-3) Administered by Topical Application and Dosed Feed to F344/N Rats and B6C3F1 Mice | 1992 | Short-Term Toxicity |
| TOX-12 | PDF (240.09 KB) | Toxicity Studies of Castor Oil (CASRN 8001-79-4) in F344/N Rats and B6C3F1 Mice (Dosed Feed Studies) | 1992 | Short-Term Toxicity |
| TOX-11 | PDF (2.11 MB) | Toxicity Studies of Antimony Potassium Tartrate (CASRN 28300-74-5) in F344/N Rats and B6C3F1 Mice (Drinking Water and Intraperitoneal Injection Studies) | 1992 | Short-Term Toxicity |
| TOX-10 | PDF (3.47 MB) | Toxicity Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) | 1992 | Short-Term Toxicity |
| TOX-09 | PDF (6.27 MB) | Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) | 1992 | Short-Term Toxicity |
| TOX-08 | PDF (1.94 MB) | Toxicity Studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 8003-22-3) | 1991 | Short-Term Toxicity |
| TOX-07 | PDF (3.75 MB) | Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3) | 1991 | Short-Term Toxicity |
| TOX-06 | PDF (3.57 MB) | Toxicity Studies of Pentachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 608-93-5) | 1991 | Short-Term Toxicity |
| TOX-05 | PDF (2.65 MB) | Toxicity Studies of Cobalt Sulfate Heptahydrate in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (CASRN 10026-24-1) | 1991 | Short-Term Toxicity |
| TOX-04 | PDF (3.51 MB) | Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2) | 1991 | Short-Term Toxicity |
| TOX-03 | PDF (2.65 MB) | Toxicity Studies of Acetone in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (CASRN 67-64-1) | 1991 | Short-Term Toxicity |
| TOX-02 | PDF (1.95 MB) | Toxicity Studies of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CASRN 110-54-3) | 1991 | Short-Term Toxicity |
| TOX-01 | PDF (322.25 KB) | Toxicity Studies of Hexachloro-1,3-butadiene in B6C3F1 Mice (Feed Studies) (CASRN 87-68-3) | 1991 | Short-Term Toxicity |