National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/tbox

Tox21 Toolbox


The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.



NIEHS/NTP Tools

Tox21 Data Visualization - these tools are focused on providing quick, easy-to-use Tox21 qHTS data access, visualization, and clustering.

  • Tox21 Actives – beta version: Access to active versus inactive compounds per assay or over all assays.
    *This tool requires Microsoft Silverlight be installed.Using a Mozilla Firefox or Safari web browser is recommended.
  • Tox21 Curve Browser – beta version: Visualize the concentration-response curves of one or many compounds of interest with the ability to superimpose assay results per compound for easy comparison.
  • Tox21 Activity Profiler – beta version: Prioritize compounds through compound structure and/or Tox21 qHTS data activity clustering visualization. Plots and data are available for download.

Tox21 Data Integration - these tools provide quick correlations between Tox21 compounds and biological and compound feature enrichment based on groupings of Tox21 chemicals by structure or biological activity.

  • Tox21 Correlation Browser: Identify compounds in the Tox21 library that produce similar patterns of activity across the assays or are structurally similar through correlation analysis. All features (from all assays, nuclear receptor assays, cell stress assays, or cell viability assays) are used to identify the assay correlations reported in the browser. These features are beta versions.
    *This tool requires Microsoft Silverlight be installed. Using a Mozilla Firefox or Safari web browser is recommended.
  • Tox21 Enricher – beta version: Load a set of compounds and find any enriched toxicological characteristics in the set of uploaded compounds from many biological data sources such as DrugMatrix®, PubChem, Comparative Toxicogenomics Database, and Leadscope.

DrugMatrix® and ToxFX® - these tools increase the efficiency of the toxicological assessment process.

  • DrugMatrix®: Database contains one of the world’s largest toxicogenomic reference resources ever assembled.
  • ToxFX®: Companion database to Drug Matrix® and contains a reporting system that creates fully annotated reports in minutes.


External Tools

PubChem allows access to large-scale screening data (including but not limited to Tox21 qHTS data), along with the medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells, and biochemical pathways. PubChem is organized as three linked databases within the NCBI's Entrez information retrieval system. These databases are PubChem Substance, PubChem Compound, and PubChem BioAssay.

Tox21 Data Browser – beta version: Access chemical quality control information. This tool was developed by the National Center for Advancing Translational Sciences (NCATS).

EPA hosts a collection of flat files for Tox21 and ToxCast programs as well as the EPA iCSS Dashboard. Files include assay and chemical descriptions, HTS data, and other related files.
 

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.