Workshop: Advancing Quantitative Analysis in Human Health Assessments through Probabilistic Methods
Monday, October 7, 2024 – 9:00 a.m.-5:00 p.m.
Tuesday, October 8, 2024 – 9:00 a.m.-3:30 p.m.
U.S. Environmental Protection Agency, Research Triangle Park, NC and online
Register to attend in person: deadline Tuesday, September 24
Register to view webcast: available through the end of the workshop
Agenda (updated August 21)
Those planning to attend in person are invited to submit abstracts for the poster session. Abstracts will be accepted either until Friday, September 13 or until 40 abstracts have been received. Abstracts should describe projects or activities relevant to workshop agenda topics. EPA will contact submitters to confirm poster acceptance and to provide logistical details about the presentation.
The EPA Office of Research and Development, in conjunction with NICEATM, is convening a workshop to facilitate discussion of probabilistic methods in human health risk assessment. This workshop will provide examples of application of probabilistic methods in chemical risk assessments, highlight ongoing research, and discuss the needs and challenges for the regular use of these methods.
The National Academies of Sciences, Engineering, and Medicine recently recommended consideration of how and when traditional deterministic approaches for human health risk assessment (i.e., toxicity value point estimates) can be transitioned towards probabilistic methods for deriving risk-specific doses. This workshop will highlight past examples where probabilistic methods were implemented to derive chemical-specific toxicity values, provide insight into the current state of the research surrounding probabilistic methods in chemical risk assessments, and discuss the future directions for implementing these probabilistic methods in human health assessments.
Broken into four subtopics, the agenda will feature sessions on:
- Probabilistic exposure
- Toxicokinetics
- Benchmark dose modeling
- Toxicity value determination
Throughout these sessions interdisciplinary panels comprising subject matter experts from government, industry, academia, and NGOs will conduct panel discussions to evaluate the proposed methods and provide suggestions for how the transition might be implemented. Workshop participants can expect to gain a greater understanding of probabilistic methods within the context of human health assessments while helping to guide discussion for how these methods may ultimately be implemented.
Attendee Information
The workshop will be held in person at EPA in Research Triangle Park, NC, and will also be webcast. Register using the appropriate links above. In-person attendees should register by Tuesday, September 24; view information for visitors to EPA. When arriving, attendees should state that they are attending the “Workshop: Advancing the Science of Health Assessments Through Probabilistic Methods.” Visitors over the age of 18 must show an official photo ID for entrance into the facility, a Federal ID (smartcard/PIV card), or Military ID. Visitors who are not federal employees will receive a visitors badge.
For general information about workshop registration or attendance, please contact Catherine Sprankle at [email protected]. Individuals with disabilities who need accommodation to participate in this event should contact Amanda Persad at [email protected]. Requests should be made at least five business days in advance of the event. Visitors with questions specific to the EPA site should also contact Dr. Persad.