On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/niceatm-wc13

NICEATM and ICCVAM Presentations at WC13

13th World Congress on Alternatives and Animal Use in the Life Sciences
August 31-September 4, 2025 – Rio de Janeiro, Brazil

Visit the meeting website

Oral Presentations

Session 20: Artificial Intelligence to Reduce and Replace Animal Testing

Abstract 187: From Data to Decisions: AIs Role in Modern Toxicology
Presenter: Nicole Kleinstreuer, NIH

Session 84: Transitioning to Animal-Free Chemical Safety Assessment

Abstract 493: Integrating New Approach Methods to Inform Chemical Safety Evaluation at the US EPA
Presenter: Alison Harrill, EPA

Session 125: Ending 100 Years of Suffering: Regulatory Assessment of Acute Oral Toxicity Without Using Animals

Abstract 101: The CATMoS Model: An In Silico Tool for Predicting Acute Oral Toxicity
Presenter: Kamel Mansouri, NIEHS/NICEATM

Session 127: Regulatory Frameworks for Complex Endpoints

Abstract 607: Advancing Defined Approaches for Developmental Neurotoxicity Using the Integrated Testing and Assessment Framework Template
Presenter: Helena Hogberg, NIEHS/NICEATM

Session 126: One Health, Many Models: Computational Approaches for Systemic Toxicities

Abstract 102: Assessing the Utility of the Collaborative Acute Toxicity Modeling Suite (CATMoS) from Ecological Risk Assessment to Human Health Hazard
Presenter: Kamel Mansouri, NIEHS/NICEATM

Session 79: Using New Approach Methods (NAMs) to Derive Point-of-departures (PoD) for Next Generation Risk Assessment (NGRA) of Skin Sensitizers: Towards Regulatory Implementation

Abstract 92: Integrating NAMs for Quantitative Skin Sensitization Potency Assessment into Regulatory Frameworks: Experience from the Work in OECD TG 497
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)

Session 33: Generative AI for Drug Safety and Toxicology

Nicole Kleinstreuer, NIH, was session co-chair.

Abstract 87: Elucidation of Adverse Outcome Pathways for Compound-Induced Developmental Neurotoxicity Using Knowledge Graphs
Presenter: Ricardo Scheufen Tieghi, NIEHS/NICEATM; University of North Carolina – Chapel Hill

Session 75: Update to OECD Guidance Document 34 on the Validation of Test Methods and Defined Approaches

Alison Harrill, EPA, was session co-chair.

Session 13: The Journey Towards Animal-free Systemic Toxicity Assessment for Cosmetics

Abstract 149: Opportunities to Build Confidence in Use of NAMs for Systemic Toxicity
Presenter: Alison Harrill, EPA

Session 143: Sailing the Seas of Validation: Challenges Encountered to Chart the Course Ahead

Abstract 155: Validation Powerlifting: Strengthening Confidence in NAMs with Flexibility and Fitness (for Purpose)
Presenter: Amber Daniel, Inotiv (contractor supporting NICEATM)

Session 78: Unveiling Chemical Similarity in Computational Toxicology: Navigating Supervised and Unsupervised Approaches

Kamel Mansouri, NIEHS/NICEATM, was session co-chair.

Abstract 100: Understanding the Concept of Similarity and Its Applications to Toxicological Research and Risk Assessment
Presenter: Kamel Mansouri, NIEHS/NICEATM

Session 62: One Science: The Continuum of New Approach Methodologies from Research to Regulation

Nicole Kleinstreuer, NIH, was session co-chair.

Abstract 287: Validation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs)
Presenter: Margaret Ochocinska, NIH

Session 113: Overcoming Barriers to Regulatory Uptake of Next Generation Risk Assessment

Abstract 747: Translating Experience into Progress: Advancing Regulatory Acceptance of NGRA
Presenter: Warren Casey, NIEHS

Session 29: Building Confidence and Transparency into Validation Management and Peer Review

Emily Reinke, Inotiv (contractor supporting NICEATM), was session co-chair.

Abstract 91: Ensuring Transparency and Rigor in the Peer Review of New Approach Methods for Skin Sensitization Assessment
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)

Session 15: Regulatory Experience Using a Weight of Evidence Approach to Reducing Testing on Animals

Abstract 103: Utilization of Non-Animal Approaches to Support Pesticide Assessments in the United States
Presenter: Monique Perron, EPA

Session 138: Moving Forward Towards the Application of New Approach Methodologies for the Environmental Risk Assessment of Chemicals

Helena Hogberg, NIEHS/NICEATM, was session co-chair.

Session 107: Accelerating Science to Policy Transfer of Animal Alternatives for Human and Environmental Safety Assessment: Lessons Learned and Ways Forward

Abstract 746: Leveraging Strategic Funding and Public-Private Partnerships to Establish Confidence in NAMs for Biomedical Research and Regulatory Testing
Presenter: Warren Casey, NIEHS

Closing Keynote: Computational Intelligence and Biological Relevance: Innovating for a Safer Future
Presenter: Nicole Kleinstreuer, NIH

Poster Presentations

Human Health - Replacement

Abstract 286: Understanding the Range of Phenotypic Responses for the Embryonic Zebrafish Developmental Toxicity Assay
Authors: Hill B, Hamm J, Hsieh JH, Knapp B, Reinke E, Hogberg H, Ryan K - View Hill et al. poster

Abstract 288: Web Application to Classify and Subcategorize Skin Sensitizers Using Human Data
Authors: Unnikrishnan A, To K, Herzler M, Germolec D, Reinke E, Kleinstreuer N - View Unnikrishnan, To, et al. poster

Abstract 297: Physiologically Based Pharmacokinetic (PBPK) Modeling Approach to Quantify Chemical Distribution in Brain and Adipose Compartments
Authors: Unnikrishnan A, Chang X, Kreutz A, LaPratt T, Hogberg H, Sluka JP, Wambaugh J, Li D, Linakis M, Reinke E, Kleinstreuer N - View Unnikrishnan, Chang et al. poster

Abstract 304: Development of TTC Values for Inhalable Substances
Authors: Londenberg A, Api AM, Boislève F, Bowden AM, Collins S, Joshi K, Moustakasb H, Muldoon J, Patlewicz G, Zocher M, Singal M, Sadekar N, Escher S

Abstract 508: SARA-ICE: A Self-contained Model for Predicting a Human Relevant Point-of-Departure for Skin Sensitization
Authors: Reinke E, Reynolds E, Reynolds J, Gilmour N, Marco B, Maxwell G, Kleinstreuer N

Environmental Health - Replacement

Abstract 90: Integrating Structure-based Chemical Taxonomies to Focus Queries of NAMs Data
Authors: Hull V, LaPratt T, Reinke E, Kleinstreuer N - View Hull, LaPratt et al. poster

Abstract 609: Automating the Generation of QSAR Prediction Reporting Format Reports Using OPERA Models and KNIME
Authors: Rangananth D, Moreira-Filho JT, Mansouri K, Kleinstreuer N

Abstract 706: Enhancing a Curated High-Throughput Screening Pipeline to Improve Toxicological Interpretations of In Vitro Data
Authors: Hull V, Hill B, Unnikrishnan A, Reinke E, Kleinstreuer N, Hogberg H - View Hull, Hill et al. poster