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Presentations at SOT 2020

59th Annual Meeting of the Society of Toxicology
March 15-19, 2020 - Anaheim, CA, USA


Continuing Education Courses

Introduction to Open-Access Computational Toxicology Tools

Sunday, March 15 – 8:15 a.m.-12 noon

Agnes Karmaus, ILS (contractor supporting NICEATM) and NICEATM Acting Director Nicole Kleinstreuer are course co-chairs.

Presentation: Course Introduction: What Do Computational Toxicology Tools Offer?
Presenter: Kleinstreuer N

Presentation: Integrated Chemical Environment
Presenter: Bell S

An Introduction to New Approach Methodologies (NAMs) and Understanding Their Potential to Support Regulatory Decisions

Sunday, March 15 – 1:15-5:00 p.m.

ICCVAM member Suzanne Fitzpatrick (FDA) is a course co-chair.

In Vitro Approaches to Assess the Toxicity of Inhaled Substances

Sunday, March 15 – 1:15-5:00 p.m.

ICCVAM co-chair Emily Reinke (DoD) is a course co-chair.

Presentation: Regulatory Landscape and Key Considerations for Establishing Inhalation Reference Data
Presenter: Allen D


Exhibitor-hosted Sessions

20 Years of ICCVAM: Thinking Back and Looking Forward

Tuesday, March 17 – 3:00-4:00 p.m. – CC Room 206B
Sponsored by the National Institute of Environmental Health Sciences


NICEATM Presentations

Workshop Session: Applicability Domains and Future of Nonanimals Tests for Skin Sensitization

Monday, March 16 – 8:00-10:45 a.m. – CC Room 204B

Presentation: Establishing International Test Guidelines for Skin Sensitization: Predictive Capacity and Applicability Domain of Nonanimal-Defined Approaches
Presenter: Kleinstreuer N

Poster Session: Developmental and Juvenile Toxicology

Monday, March 16 – 10:45 a.m.-12:30 p.m. – CC Exhibit Hall

Abstract Number 1612/Poster P733: In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Valproate Analogues
Authors: Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley B, Bell S, Allen DG, Casey W, Kleinstreuer NC

Roundtable Session: Mechanistic Read-Across of Chemical Toxicants Based on Big Data

Monday, March 16 – 11:00 a.m.-12:20 p.m. – CC Room 204B

SACATM member Hao Zhu (Rutgers University) is the session chair

Presentation: Computational Crowdsourcing: Leveraging Global Expertise to Predict Toxicity
Presenter: Kleinstreuer N

Poster Session: Alternatives to Mammalian Models II

Monday, March 16 – 2:15-4:30 p.m. – CC Exhibit Hall

Abstract Number 1415/Poster P495: Variability in the Rabbit Skin Irritation Assay
Authors: Rooney JP, Choksi N, Rai R, Allen DG, Kleinstreuer NC, Casey W

Workshop Session: Human-Relevant Carcinogenicity Testing: Tools for Cancer Assessment in 2020 and Beyond

Tuesday, March 17 – 8:00-10:45 a.m. – CC Room 304A

NICEATM Deputy Director Nicole Kleinstreuer is the session chair

Presentation: Modernizing the NTP Carcinogenicity Testing Program
Presenter: Casey W

Poster Session: Computational Toxicology I

Tuesday, March 17 – 9:00-10:45 a.m. – CC Exhibit Hall

Abstract Number 2060/Poster P394: Collaborative Modeling Project for Predicting Acute Oral Toxicity
Authors: Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Allen DG, Casey W, Kleinstreuer NC

Poster Session: Regulation/Policy

Tuesday, March 17 – 9:00-10:45 a.m. – CC Exhibit Hall

Abstract Number 2198/Poster P556: Developing a Defined Approach for Eye Irritation Testing
Authors: Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen DG

Poster Session: Autoimmunity/Hypersensitivity

Tuesday, March 17 – 10:45 a.m.-12:30 p.m. – CC Exhibit Hall

Abstract Number 1872/Poster P170: Classification of Human Reference Data for Skin Sensitization
Authors: Strickland J, Allen DG, Api A, Gordon J, Kleinstreuer NC, Ko H-S, Matheson J, Thierse H-J, Truax J, Herzler M

Poster Session: Computational Toxicology II

Wednesday, March 18 – 2:15-4:30 p.m. – CC Exhibit Hall

Abstract Number 2976/Poster P607: NICEATM Computational Tools and Resources Supporting Alternative Test Method Development and Evaluation
Authors: Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC


ICCVAM Committee Activities

ICCVAM Committee member names are indicated in boldface in author lists.

Poster Session: Risk Assessment Methods I

Monday, March 16 – 9:00-10:45 a.m. – CC Exhibit Hall

Abstract Number 1539/Poster P641: Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling in Regulatory Risk Assessment for Pesticides
Authors: Tan C, Lowit A, Embry M

Poster Session: Safety Evaluation of Nonpharmaceutical Products

Monday, March 16 – 9:00-10:45 a.m. – CC Exhibit Hall

Abstract Number 1668/Poster P812: Glyphosate Safety Assessment Through Ames Test
Authors: Kaldhone P, Yan J, Chen T, Manjanatha M

Abstract Number 1679/Poster P823: Toxicological Evaluation of Acrylonitrile Butdiene Styrene (ABS) 3D Printer Emissions
Authors: Farcas MT, Stefaniak AB, McKinney W, Knepp AK, Bowers L, Mandler WK, Kashon M, Battelli L, Stueckle TA, Orandle M, Winn A, Friend SA, Jackson SR, Qi C, Hammond DR, Mercer R, LeBeouf R, Burns D, Ranpara A, Thomas TA, Matheson J, Castranova V, Qian Y

Poster Session: Neurotoxicity: Developmental

Monday, March 16 – 10:45 a.m.-12:30 p.m. – CC Exhibit Hall

Abstract Number 1461/Poster P556: Zebrafish Larval Locomotor Activity is Depressed by Lack of Swim Bladder Inflation or Dimethyl Sulfoxide
Authors: Hill BN, Hunter DL, Padilla S

Poster Session: Alternatives to Mammalian Models II

Monday, March 16 – 2:15-4:30 p.m. – CC Exhibit Hall

Abstract Number 1417/Poster P497: Using a Measurement Science Approach to Increase Confidence in the EASA Skin Sensitization Assay
Authors: Gordon JD, Uhl R, Toman B, Elliot J, Petersen E

Poster Session: Regulation/Policy

Tuesday, March 17 – 9:00-10:45 a.m. – CC Exhibit Hall

Abstract Number 2200/Poster P558: Rethinking Carcinogenicity Assessment for Agrochemicals
Authors: Hilton GM, Akerman G, Baldassari J, Battalora M, Buesen R, Clippinger AJ, Geter D, Lowit A, Melching-Kollmuss S, Kormos T, Papineni S, Peffer RC, Williamson Riffle B, Ryan N, Visconti N, Wolf DC

Poster Session: Endocrine Toxicology

Tuesday, March 17 – 10:45 a.m.-12:30 p.m. – CC Exhibit Hall

Abstract Number 1889/Poster P188: In Vitro Bioassay and Screening Model for Pre- and Post-Distribution for Chicago-Area Treated Waters
Authors: Medlock Kakaley E, Cardon M, Evans N, Bradley P, Iwanowicz L, Gray E, Hartig P, Wilson V

Workshop Session: In Vitro Microphysiological Systems: Developing Tools to Evaluate Immunotoxicity of Drug Candidates

Wednesday, March 18 – 8:00-10:45 a.m. – CC Room 304A

Abstract Number 2485: In Vitro Microphysiological Systems: Advancing Regulatory Science Through Innovation
Author: Fitzpatrick S

Poster Session: Biological Modeling

Wednesday, March 18 – 9:00-10:45 a.m. – CC Exhibit Hall

Abstract Number 2949/Poster P579: Advantage of Read-Across and Pharmacokinetics Modeling for the Exposure Assessment of Persistent Organic Pollutants
Authors: Ruiz P, Boone S, Mumtaz MM

Poster Session: Cardiovascular Toxicology/Hemodynamics

Wednesday, March 18 – 2:15-4:30 p.m. – CC Exhibit Hall

Abstract Number 3102/Poster P736: Weighted Gene Coregulation Network Analysis (WGCNA) to Decipher Temporal Dynamics in Cardiotoxicity
Authors: Rahman A, Svoboda D, Bushel PR, Berridge BR, Auerbach SS

Abstract Number 3131/Poster P765: Predicting Putative Cardiotoxic Chemicals Using Tox21 qHTS Data
Authors: Krishna S, Berridge BR, Kleinstreuer N

Poster Session: Mixtures

Wednesday, March 18 – 2:15-4:30 p.m. – CC Exhibit Hall

Abstract Number 2820/Poster P437: Joint Toxicity Assessmemt of Perfluoroalkyl Substances (PFAS) Mixtures
Authors: Mumtaz MM, Pohl HR


Ancillary Meetings

Alternatives for Acute Toxicity Testing: Updates and Planned Activities

Tuesday, March 17 – 5:00-6:00 p.m.
California Ballroom A – Hilton Anaheim, 777 W. Convention Way