Presentations at SOT 2020
59th Annual Meeting of the Society of Toxicology
March 15-19, 2020 - Anaheim, CA, USA
On Monday, March 9, SOT leadership announced that the Annual Meeting would be cancelled. The information below is for reference only.
Continuing Education Courses
Three CE courses that featured topics of potential interest to ICCVAM stakeholders were presented as webinars in April and May 2020.
Introduction to Open-Access Computational Toxicology Tools
Agnes Karmaus, ILS (contractor supporting NICEATM) and NICEATM Acting Director Nicole Kleinstreuer were course co-chairs.
Presentation: Course Introduction: What Do Computational Toxicology Tools Offer?
Presenter: Kleinstreuer N
Presentation: Integrated Chemical Environment
Presenter: Bell S
An Introduction to New Approach Methodologies (NAMs) and Understanding Their Potential to Support Regulatory Decisions
ICCVAM member Suzanne Fitzpatrick (FDA) was a course co-chair.
In Vitro Approaches to Assess the Toxicity of Inhaled Substances
ICCVAM co-chair Emily Reinke (DoD) was a course co-chair.
Presentation: Regulatory Landscape and Key Considerations for Establishing Inhalation Reference Data
Presenter: Allen D
Exhibitor-hosted Sessions
20 Years of ICCVAM: Thinking Back and Looking Forward
Sponsored by the National Institute of Environmental Health Sciences
NICEATM Presentations
Please note: PDFs of poster presentations are large files (1-2 MB) and may take a few moments to open and load.
Workshop Session: Applicability Domains and Future of Nonanimals Tests for Skin Sensitization
Presentation: Establishing International Test Guidelines for Skin Sensitization: Predictive Capacity and Applicability Domain of Nonanimal-Defined Approaches
Presenter: Kleinstreuer N
Poster Session: Developmental and Juvenile Toxicology
Abstract Number 1612: In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Valproate Analogues
Authors: Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley B, Bell S, Allen DG, Casey W, Kleinstreuer NC
Chang et al poster
Roundtable Session: Mechanistic Read-Across of Chemical Toxicants Based on Big Data
SACATM member Hao Zhu (Rutgers University) was the session chair
Presentation: Computational Crowdsourcing: Leveraging Global Expertise to Predict Toxicity
Presenter: Kleinstreuer N
Poster Session: Alternatives to Mammalian Models II
Abstract Number 1415: Variability in the Rabbit Skin Irritation Assay
Authors: Rooney JP, Choksi N, Rai R, Allen DG, Kleinstreuer NC, Casey W
Rooney et al poster
Workshop Session: Human-Relevant Carcinogenicity Testing: Tools for Cancer Assessment in 2020 and Beyond
NICEATM Deputy Director Nicole Kleinstreuer was the session chair
Presentation: Modernizing the NTP Carcinogenicity Testing Program
Presenter: Casey W
Poster Session: Computational Toxicology I
Abstract Number 2060: Collaborative Modeling Project for Predicting Acute Oral Toxicity
Authors: Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Allen DG, Casey W, Kleinstreuer NC
Mansouri et al poster
Poster Session: Regulation/Policy
Abstract Number 2198: Developing a Defined Approach for Eye Irritation Testing
Authors: Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen DG
Choksi et al poster
Poster Session: Autoimmunity/Hypersensitivity
Abstract Number 1872: Classification of Human Reference Data for Skin Sensitization
Authors: Strickland J, Allen DG, Api A, Gordon J, Kleinstreuer NC, Ko H-S, Matheson J, Thierse H-J, Truax J, Herzler M
Strickland et al poster
Poster Session: Computational Toxicology II
Abstract Number 2976: NICEATM Computational Tools and Resources Supporting Alternative Test Method Development and Evaluation
Authors: Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC
Bell et al poster
ICCVAM Committee Activities
ICCVAM Committee member names are indicated in boldface in author lists.
Poster Session: Risk Assessment Methods I
Abstract Number 1539: Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling in Regulatory Risk Assessment for Pesticides
Authors: Tan C, Lowit A, Embry M
Poster Session: Safety Evaluation of Nonpharmaceutical Products
Abstract Number 1668: Glyphosate Safety Assessment Through Ames Test
Authors: Kaldhone P, Yan J, Chen T, Manjanatha M
Abstract Number 1679: Toxicological Evaluation of Acrylonitrile Butdiene Styrene (ABS) 3D Printer Emissions
Authors: Farcas MT, Stefaniak AB, McKinney W, Knepp AK, Bowers L, Mandler WK, Kashon M, Battelli L, Stueckle TA, Orandle M, Winn A, Friend SA, Jackson SR, Qi C, Hammond DR, Mercer R, LeBeouf R, Burns D, Ranpara A, Thomas TA, Matheson J, Castranova V, Qian Y
Poster Session: Neurotoxicity: Developmental
Abstract Number 1461: Zebrafish Larval Locomotor Activity is Depressed by Lack of Swim Bladder Inflation or Dimethyl Sulfoxide
Authors: Hill BN, Hunter DL, Padilla S
Poster Session: Alternatives to Mammalian Models II
Abstract Number 1417: Using a Measurement Science Approach to Increase Confidence in the EASA Skin Sensitization Assay
Authors: Gordon JD, Uhl R, Toman B, Elliot J, Petersen E
Poster Session: Regulation/Policy
Abstract Number 2200: Rethinking Carcinogenicity Assessment for Agrochemicals
Authors: Hilton GM, Akerman G, Baldassari J, Battalora M, Buesen R, Clippinger AJ, Geter D, Lowit A, Melching-Kollmuss S, Kormos T, Papineni S, Peffer RC, Williamson Riffle B, Ryan N, Visconti N, Wolf DC
Poster Session: Endocrine Toxicology
Abstract Number 1889: In Vitro Bioassay and Screening Model for Pre- and Post-Distribution for Chicago-Area Treated Waters
Authors: Medlock Kakaley E, Cardon M, Evans N, Bradley P, Iwanowicz L, Gray E, Hartig P, Wilson V
Workshop Session: In Vitro Microphysiological Systems: Developing Tools to Evaluate Immunotoxicity of Drug Candidates
Abstract Number 2485: In Vitro Microphysiological Systems: Advancing Regulatory Science Through Innovation
Author: Fitzpatrick S
Poster Session: Biological Modeling
Abstract Number 2949: Advantage of Read-Across and Pharmacokinetics Modeling for the Exposure Assessment of Persistent Organic Pollutants
Authors: Ruiz P, Boone S, Mumtaz MM
Poster Session: Cardiovascular Toxicology/Hemodynamics
Abstract Number 3102: Weighted Gene Coregulation Network Analysis (WGCNA) to Decipher Temporal Dynamics in Cardiotoxicity
Authors: Rahman A, Svoboda D, Bushel PR, Berridge BR, Auerbach SS
Abstract Number 3131: Predicting Putative Cardiotoxic Chemicals Using Tox21 qHTS Data
Authors: Krishna S, Berridge BR, Kleinstreuer N
Poster Session: Mixtures
Abstract Number 2820: Joint Toxicity Assessment of Perfluoroalkyl Substances (PFAS) Mixtures
Authors: Mumtaz MM, Pohl HR
Poster Session: Late-breaking III - Exposure, Risk, Safety Assessment
Abstract Number 3393: In Silico and In Vitro Analysis of 4-4'-Methylenedianiline Replacements
Authors: Adams VH, Reinke EN, Holden LA, LaScala JJ
Adams et al poster
Ancillary Meetings
Alternatives for Acute Toxicity Testing: Updates and Planned Activities
Stakeholders will present updates on ongoing efforts toward the development, evaluation, and implementation of new approach methodologies for acute toxicity testing. Scientists from government, industry, and nongovernmental organizations will provide brief presentations in the areas of acute oral and inhalation toxicity, skin and eye irritation, and skin sensitization followed by an opportunity for open discussion.