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Presentations at SOT 2021

Annual Meeting of the Society of Toxicology
Online March 12-26, 2021

View meeting information on the SOT website


Continuing Education Courses

CE11: Establishing Confidence in Organ-on-a-Chip Systems for Toxicity Testing: Lung-on-a-Chip as an Example

Presentation: Implementing New Testing Approaches at the US Food and Drug Administration
Presenter: Fitzpatrick S

Presentation: Organ-on-a-Chip Validation Efforts: Challenges and Lessons Learned
Presenter: Casey W

CE14: Understanding Tox21/ToxCast High-Throughput Screening Data and Applications to Modeling

Presentation: Interpreting the Tox21 Data Analysis Methods Toward a Consensus
Presenter: Karmaus A


NICEATM Presentations

Please note: PDFs of poster presentations are large files (1-2 MB) and may take a few moments to open and load.

Workshop Session: A Future Framework for Application of In Vitro Metabolism and QIVIVE Models to Inform Risk Assessment

Abstract 1033: Toxicokinetic Models for QIVIVE and Consideration of Uncertainty
Presenter: Chang X

Symposium Session: Developmental Toxicity Hazard Assessment without Animals: Pathways and Prospects

Acting NICEATM Director Nicole Kleinstreuer was the session co-chair

Abstract 1066: Automated Approaches to Anchoring Alternatives
Presenter: Kleinstreuer N

Workshop Session: New Approach Methods for Cancer Risk Assessment

Acting NICEATM Director Nicole Kleinstreuer was the session co-chair

Abstract 1196: Incorporating NAMs into the DNTP Carcinogenicity Testing Program
Presenter: Casey W

Poster Session: Ecotoxicology

Abstract 2324/Board P200: Retrospective Evaluation of the Acute Fish Toxicity Test for Pesticide Registration
Authors: Ceger P, Allen DG, Choksi N, Daniel A, Eckel W, Hamm J, Johnson T, Kleinstreuer NC, Lowit M, Sprankle C, Truax J, Odenkirchen E
View Ceger et al poster

Poster Session: Regulation/Policy

Abstract 2341/Board P217: International Regulatory Needs for Acute Toxicity Data
Authors: Strickland J, Daniel AB, Allen DG, Kleinstreuer NC, Haugabrooks E
View Strickland et al poster

Abstract 2345/Board P221: Predicting Oral Acute Toxicity Using the GHS Additivity Equation
Authors: Hamm J, Allen DG, Ceger P, Flint T, Kleinstreuer NC, O'Dell L, Tao JJ, Lowit A
View Hamm et al poster

Poster Session: Computational Toxicology I

Abstract 2541/Board P279: Providing Context for Chemical Effects through Bioactivity and Consumer Use
Authors: Cook B, Abedini JA, Bell S, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC
View Cook et al poster

Abstract 2542/Board P280: NICEATM Computational Tools and Resources Supporting Alternative Test Method Development and Evaluation
Authors: Abedini JA, Bell S, Chang X, Cook BT, Karmaus AL, Mansouri K, Allen DG, Kleinstreuer NC
View Abedini et al poster

Abstract 2543/Board P281: OPERA Models for ADME Properties and Toxicity Endpoints
Authors: Mansouri K, Chang X, Judson R, Williams A, Allen DG, Kleinstreuer NC

Abstract 2561/Board P299: High-Throughput Screening to Predict hERG Inhibition
Authors: Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N

Symposium Session: Opportunities for Human-Induced Pluripotent Stem Cell–Derived Neurons in In Vitro Neurotoxicity Safety Testing

Acting NICEATM Director Nicole Kleinstreuer was a session co-chair

Presentation: The Intersection of Scientific Advances and Regulatory Needs
Presenter: Kleinstreuer N

Poster Session: Computational Toxicology II

Abstract 2791/Board P257: Systematic Evidence Mapping of Research on Environmental Exposures and Cardiovascular Disease
Authors: Krishna S, Beverley B, Walker V, Kleinstreuer N, Rooney A

Poster Session: Alternatives to Mammalian Models I

Abstract 2757/Board P223: Retrospective Analysis of Dermal Absorption Triple Pack Data
Authors: Allen DG, Rooney JP, Kleinstreuer NC, Lowit A, Perron M
View Allen et al poster

Abstract 2760/Board P226: Variability in the Rabbit Skin Irritation Assay
Authors: Rooney JP, Choksi N, Ceger P, Daniel AB, Truax J, Allen DG, Kleinstreuer NC
View Rooney et al poster

Platform Session: Biological Models for In Vitro-In Vivo Extrapolation

Abstract 2958: Updates to the Integrated Chemical Environment: Expanding Tools and Data to Support Toxicity Assessments
Authors: Daniel AB, Abedini JA, Bell S, Chang X, Cook B, Karmaus AL, Hines DE, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC

Workshop Session: Applicability Domains and Future of Nonanimal Tests for Skin Sensitization

Abstract 1283: International Regulatory Progress on Nonanimal Approaches for Skin Sensitization
Author: Kleinstreuer N


ICCVAM Committee Activities

ICCVAM Committee member names are indicated in boldface in author lists.

Roundtable Session: The Future of Uncertainty Factors with In Vitro Studies Using Human Cells

ICCVAM member Suzanne Fitzpatrick (FDA) was a session co-chair.

Poster Session: Computational Toxicology I

Abstract 2554/Board P292: An Expert-Driven Literature Review of “Negative” Reference Chemicals for Developmental Neurotoxicity (DNT) Assay Evaluation
Authors: Martin MM, Baker NC, Boyes WK, Carstens KE, Culbreth ME, Gilbert ME, Harrill JA, Nyffeler J, Padilla S, Paul-Friedman K, Shafer TJ

Poster Session: Risk Assessment

Abstract 2583/Board P321: Surfactants Category: An Integrated Approach to Testing and Assessment (IATA) Including New Approach Methods (NAMs) for Assessing Inhalation Risks under the Toxic Substances Control Act (TSCA)
Authors: Henry TR, Salazar KD, Hayes MP, Kennedy W, Keene AM, Jarabek AM, Price OT, Moors S, Jovanovich L, Rose JL, Tveit A, Tremblay RT, Becker RA, Osman-Sypher S, McMullen PD, Slattery SD, Irwin W, Odin M, Melia J, Sharma M, Clippinger AJ, Stucki A, Stedeford T

Abstract 2593/Board P331: Poorly Soluble, Low Toxicity (PSLT) Polymer Category: An Integrated Approach to Testing and Assessment (IATA) Including New Approach Methods (NAMs) under the Toxic Substances Control Act (TSCA)
Authors: Jarabek AM, Stedeford T, Ladics GS, Price OT, Tveit A, Hayes MP, Tremblay RT, Snyder SA, Salazar KD, Osman-Sypher S, Irwin W, Odin M, Melia J, Carlson-Lynch H, Sharma M, Clippinger AJ, Stucki AO, Henry TR

Symposium Session: Mind the Gap: Finding Practical Ways to Fast-Track the Future of Animal-Free Toxicology Testing

ICCVAM Co-chair Anna Lowit (EPA) was a session co-chair.

Abstract 1134: Recent Progress toward Reducing Animal Use and Adopting New Approach Methods
Presenter: Lowit A

Poster Session: Computational Toxicology II

Abstract 2802/Board P268: OrbiTox: A Translational Discovery Platform for Concerted View and Analysis of Big Data
Authors: Gombar V, Sedykh A, Ross A, Casey W, Shah R

Poster Session: DNA Damage and Repair

Abstract 2804/Board P270: The Genotoxicity of Pyrrolizidine Alkaloids Is Mediated by CYP3A in Metabolically Competent TK6 Cell Lines
Authors: Li X, He X, Chen S, Guo X, Bryant MS, Guo L, Manjanatha MG, Mei N

Abstract 2806/Board P272: Performance of Metabolically Competent HepaRG Cells for Genotoxicity Testing: A Comparison between Three Human Hepatic Cells Using the High-Throughput Micronucleus and Comet Assays
Authors: Guo X, Seo J, Wu Q, Manjanatha MG, Mei N

Poster Session: Alternatives to Mammalian Models I

Abstract 2761/Board P227: Profiling Tox21 Compounds That Activate p53 Signaling after Metabolic Activation
Authors: Ooka M, Zhao J, Huang R, Witt K, Ferguson S, Smith-Roe S, Simeonov A, Xia M

Poster Session: Alternatives to Mammalian Models II

Abstract 2977/Board P115: Toward Automation of High-Throughput Toxicology Assay Image Analysis Using Deep Learning
Authors: Tandon A, Maharana A, Howard B, Ramaiahgari S, Dunlap P, Rice J, Merrick A, DeVito M, Ferguson S, Shah R