Presentations at SOT 2023
Annual Meeting of the Society of Toxicology
March 19-23, 2023 – Nashville, TN, USA
View meeting information on the SOT website
Continuing Education Courses: Sunday, March 19
A Training on the OECD Guidance for Characterizing, Validating, and Reporting Physiologically Based Kinetic Models
8:15 a.m.-12:00 noon
Cecilia Tan (ICCVAM representative, EPA) is course chair.
Presentation: An International Effort to Promote the Regulatory Use of PBK Models: Introduction to the OECD PBK Guidance
Author: Tan C
Presentation: Hands-On Model Evaluation
Author: Tan C
In Vitro to In Vivo Extrapolation Strategy and Guidance across Organ System Toxicities
1:15-5:00 p.m.
NICEATM staff scientist Helena Hogberg-Durdock is course co-chair.
Presentation: Developing a Developmental Neurotoxicity Battery for Organophosphorus Flame Retardant-Induced Toxicity for Human Health Risk Assessment
Author: Hogberg-Durdock H
Exhibitor-Hosted Session: Tuesday, March 21
ICCVAM Progress on Advancing Alternatives: Five Years into the Strategic Roadmap
4:30-5:30 p.m. – Room 101A
Presented by National Institute of Environmental Health Sciences
NICEATM Presentations
NICEATM group member names are indicated in boldface in author lists.
Monday, March 20
Poster Session: Alternatives to Mammalian Models I
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3015/Poster P116: Development and Validation of Enzyme-Based CYP26A1 Inhibition Assay in a High-Throughput Screening Platform
Authors: Sakamuru S, Ma D, Pierro JD, Baker NC, Kleinstreuer N, Cali JJ, Knudsen TB, Xia M
Poster Session: Cardiovascular Toxicology/Hemodynamics
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3161/Poster P270: In Vitro Assessment of Environmental Chemical Hazards on Cardiovascular Diseases
Authors: Ramaiahgari S, Krishna S, Kleinstreuer N, Liu J, Auerbach SS, Beverly B, Merrick BA, Berridge BR
Poster Session: Regulation/Policy
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3175/Poster P290: An Informatics Approach to Inform a Class-Based Analysis of Health Effects Associated with Exposure to Organohalogen Flame Retardants
Authors: Rooney AA, Mansouri K, Bevington C, Hatlelid K, Helmick K, Blain R, Hannani A, Tracy W, Peppriell A, Cooney G, Sibrizzi C, Taylor K, Shipkowski K, Walker V
Abstract 3177/Poster P292: Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency
Authors: Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer NC, Ko H, Matheson J, Thierse H, Truax J, Vanselow J, Strickland J
Abstract 3181/Poster P296: Evaluating New Chemicals in the US under the Toxic Substances Control Act: Application of New Approach Methods to Evaluate Eye Irritation
Authors: Beardslee RA, Salazar KD, van der Zalm A, Camacho IA, Brunner R, Raabe H, Allen D, Daniel A, Kleinstreuer NC, O'Dell L, Clippinger A, Scarano L, Lowit A
Symposium Session: AI Buzz or Bliss: Case Studies for Successful Applications of Artificial Intelligence in Predictive Toxicology
9:15 a.m.-12:00 noon – Karl Dean Ballroom B1
Abstract 1016: Computational Crowdsourcing to Understand and Address Regulatory Needs: Case Studies for Prioritization of Environmental Chemicals Using AI/ML Approach
Author: Kleinstreuer N
Workshop Session: Understanding the Concept of Similarity and Its Applications to Toxicological Research and Risk Assessment
9:15 a.m.-12:00 noon – Room 207B
Kamel Mansouri (NIEHS/NICEATM) is session chair.
Presentation: Introduction
Author: Mansouri K
Abstract 1053: Applications of Class-Based Approaches in Risk Assessment and Toxicological Research
Author: Mansouri K
Poster Session: Ocular Toxicology
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 3137/Poster P245: Three-Phase Testing of Agrochemical Formulations: Developing a Defined Approach for Eye Irritation Potential
Authors: Daniel AB, van der Zalm AJ, Clippinger AJ, Kleinstreuer NC, Allen DG
Poster Session: Biotransformation/Cytochrome P450
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 3271/Poster P390: Mechanistic Insights from Profiling Chemical-Mediated Transcription Factor Transactivation with the Integration of Cytochrome P450 Metabolism
Authors: Medvedev A, Karmaus AL, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer NC, Casey W
Workshop Session: Establishing Scientific Confidence in New Approach Methods: A Modern Framework
1:45-4:30 p.m. – Room 202
Abstract 1094: Human Biological Relevance: Topical Toxicity Case Studies
Author: Kleinstreuer N
Poster Session: Computational Toxicology I
2:30-4:15 p.m. – Tox Expo Hall C
Agnes Karmaus (Inotiv, contractor supporting NICEATM) is session chair.
Abstract 3064/Poster P169: OPERA Models Supporting Regulatory Needs
Authors: Mansouri K, Martin T, Chang X, Williams A, Kleinstreuer N
Abstract 3068/Poster P173: Interpretable Chemical Grouping Using an Automated KNIME Workflow
Authors: Moreira Filho J, Conway M, Schmitt C, Kleinstreuer N, Mansouri K
Abstract 3089/Poster P194: DASS App: A Web Application for Applying Defined Approaches for Skin Sensitization to Predict Hazard and Potency Categorization
Authors: To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer NC
Tuesday, March 21
Poster Session: Computational Toxicology II
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3669/Poster P154: Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity
Authors: Chang X, Reinke EN, Daniel AB, Allen DG, Mumtaz MM, Kleinstreuer NC
Abstract 3670/Poster P155: Integrating Population Enzyme Variability into Physiologically Based Kinetic Models of Parent Chemicals and Metabolites
Authors: Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JC, Erickson J, Combs P, Ferguson S, Kleinstreuer NC, Mansouri K
Abstract 3695/Poster P180: Annotations for ToxCast and Tox21 High-Throughput Screening Assays: Facilitating Assay Interpretation and Data Use
Authors: Karmaus AL, Borrel A, Feshuk M, Harrill A, Wittwehr C, Kleinstreuer NC
Symposium Session: Achieving Successful Reproducibility for Next-Generation Toxicological Methods
1:00-2:30 p.m. – Room 202
Agnes Karmaus (Inotiv, contractor supporting NICEATM) is session chair.
Abstract 1139: Leveraging In Vivo Variability to Assess Performance of Predictive Models and the Role of Reanalysis to Build Confidence via Consensus
Authors: Karmaus AL
Poster Session: Alternatives to Mammalian Models II
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3624/Poster P106: Validation of the Electrophilic Allergen Screening Assay (EASA) to Detect Substances That Impact the Initial Key Event in the Adverse Outcome Pathway for Skin Sensitization
Authors: Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Allen DG, Kleinstreuer NC, Strickland J
Abstract 3627/Poster P109: Application of Defined Approaches for Skin Sensitization for Chemicals of Federal Agency Interest
Authors: Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec D
Abstract 3634/Poster P116: Peer Review Report of the EpiSensA Skin Sensitization Assay
Authors: Reinke EN, Corsini E, Ono A, Fukuyama T, Ashikaga T, Gerberick GF
Abstract 3643/Poster P125: Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions
Authors: Wittwehr C, Chang X, Bisson W, Edwards SW, Ferguson S, Harrill A, Hogberg HT, Karmaus AL, Batista-Leite S, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O'Brien JM, Reinke EN, Schmitt C, Tucker NN, Virvilis V
Poster Session: Bioinformatics
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3740/Poster P226: Applying In Silico Toxicity Models across the Tox21 Chemical Universe
Authors: Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NC
Abstract 3742/Poster P228: ChemMaps.com V2: Exploring the Environmental Chemical Universe
Authors: Borrel A, Unnikrishnan A, Allen DG, Kleinstreuer NC
Abstract 3744/Poster P230: Integrated Chemical Environment: An Advanced Platform Aiding NAM-Based Chemical Assessments
Authors: Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel AB, Cooper S, Phillips J, McAfee E, Allen DG, Casey W, Kleinstreuer NC
Poster Session: Neurotoxicity: General
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 4009/Poster P504: The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19
Authors: Hogberg-Durdock H, Lam A, Elan O, Shahbaz MA, Clerbaux L, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M
Platform Session: Mixtures Toxicology
3:00-4:30 p.m. – Room 205
Abstract 2039: Mapping a Path to Disease: Quantifying the Risk of Exposure to Environmental Chemical Mixtures via a Common Molecular Target Using a Geospatial Modeling Approach
Authors: Eccles KM, Karmaus AL, Kleinstreuer NC, Parham F, Wambaugh JF, Messier KP
Workshop Session: Computational Visualization Tools for Communicating Large, Complex Data
3:00-4:30 p.m. – Room 202
Kim To (Inotiv, contractor supporting NICEATM) is session co-chair.
Wednesday, March 22
Workshop Session: Shedding Light on Population Variability and Susceptibility: New Approach Methods to Inform Risk Assessment
8:00-10:45 a.m. – Karl Dean Ballroom A1
NICEATM staff scientist Helena Hogberg-Durdock is session chair.
Presentation: Introduction
Author: Hogberg-Durdock H
Poster Session: Biological Modeling
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 4326/Poster P191: Risk-Based, Geospatially Informed Prioritization of Potentially Cardiotoxic Chemicals
Authors: Krishna S, Chang X, Eccles KM, Messier K, Kleinstreuer NC
Poster Session: Skin and Dermal Toxicity
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 4449/Poster P322: Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro
Authors: Salminen AT, Davis KJ, Felton RP, Nischal N, VonTungeln LS, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho L
Abstract 4454/Poster P327: The Skin Allergy Risk Assessment-Integrated Chemical Environment (SARA-ICE) Model for UN GHS Classification: An Evaluation and Application in Case Studies
Authors: Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke E, Germolec D, Truax J, Allen D, Maxwell G, Kleinstreuer N
Symposium Session: Toxicology 2.0: Moving from Reductionist to Holistic Paradigms
1:30-4:15 p.m. – Room 205
Abstract 1240: The Central Role of Computational Toxicology in Toxicology 2.0
Authors: Kleinstreuer NC
ICCVAM Committee Activities
ICCVAM Committee member names are indicated in boldface in author lists.
Monday, March 20
Poster Session: Alternatives to Mammalian Models I
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3005/Poster P106: Lessons Learned in Establishing a Reliable and Low-Cost Assay for Urea Production in Human Primary Hepatocytes Cultured in a Liver Chip for the Study of Drug Hepatotoxicity
Authors: Shi Q, Ren L, Papineau KS, Sauld J, Kulkarni G, Ewart L, Avigan M, Mendrick DL, JJ Hawes, Schnackenberg LK
Abstract 3010/Poster P111: Adaptive versus Toxicological Responses: Reversibility for DILI with 3D Hepatocyte Transcriptomics
Authors: Ferguson SS, Lavrich K, Ramaiahgari S, Auerbach S, Phadke D, Balik-Meisner M, Shah R, Roberts G, Gorospe J, Sparrow B, DeVito M, Paules RS, Alex M
Poster Session: Cardiovascular Toxicology/Hemodynamics
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3150/Poster P259: Inhalation of Emissions Generated by 3D Print with Polycarbonate Plastic: Cardiovascular Effects
Authors: Krajnak K, Farcas M, McKinney W, Waugh S, Mandler W, Matheson J, Thomas T, Qian Y
Poster Session: Regulation/Policy
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3175/Poster P290: An Informatics Approach to Inform a Class-Based Analysis of Health Effects Associated with Exposure to Organohalogen Flame Retardants
Authors: Rooney AA, Mansouri K, Bevington C, Hatlelid K, Helmick K, Blain R, Hannani A, Tracy W, Peppriell A, Cooney G, Sibrizzi C, Taylor K, Shipkowski K, Walker V
Abstract 3177/Poster P292: Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency
Authors: Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer NC, Ko H, Matheson J, Thierse H, Truax J, Vanselow J, Strickland J
Abstract 3178/Poster P293: Evaluating New Chemicals in the US under the Toxic Substances Control Act (TSCA): A Human Health Risk Assessment Approach for Mixed Metal Oxides (MMOs) in Cathode Active Materials (CAMs) Used in Electric Vehicle (EV) Batteries
Authors: Salazar KD, Beardslee RA, Scarano L, Lowit A
Abstract 3181/Poster P296: Evaluating New Chemicals in the US under the Toxic Substances Control Act: Application of New Approach Methods to Evaluate Eye Irritation
Authors: Beardslee RA, Salazar KD, van der Zalm A, Camacho IA, Brunner R, Raabe H, Allen D, Daniel A, Kleinstreuer NC, O'Dell L, Clippinger A, Scarano L, Lowit A
Poster Session: DNA Damage and Repair
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 3226/Poster P343: Evaluation of Newly Developed 14 Human TK6-Derived Cell Lines That Individually Express a Human Cytochrome P450 for Toxicity Studies
Authors: Mei N, Li X, Le Y, Guo X, Manjanatha MG, Chen S, Guo L
Abstract 3229/Poster P346: Actein Contributes to Black Cohosh Extract-Induced Genotoxicity in Human TK6 Cells
Authors: Le Y, Li S, Chen S, Ning K, Guo X, Wu C, Manjanatha M, Mei N
Poster Session: Biotransformation/Cytochrome P450
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 3271/Poster P390: Mechanistic Insights from Profiling Chemical-Mediated Transcription Factor Transactivation with the Integration of Cytochrome P450 Metabolism
Authors: Medvedev A, Karmaus AL, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer NC, Casey W
Exhibitor-Hosted Session: Are We on the Same Page? Regulatory Acceptance of NAMs in Human Health Safety Testing of Agrochemicals and Industrial Chemicals
12 noon-1:00 p.m. – Room 101D – Presented by LabCorp
Monique Perron (ICCVAM workgroup member, EPA) is a member of the presenting panel.
Roundtable Session: Evaluating and Rethinking the Use of Dogs in Agrochemical Evaluation and Registration
12:10-1:30 p.m. – Room 207B
Cecilia Tan (ICCVAM representative, EPA) will moderate the panel discussion.
Roundtable Session: A Transformative Vision for an ’Omics-Based Regulatory Chemical Testing Paradigm
12:10-1:30 p.m. – Karl Dean Ballroom A1
Presentation: A US EPA Regulatory Perspective to Molecular Points of Departure
Author: Lowit A
Symposium Session: Playing with Fire: Human Exposure, Health Risks, and Safer Design of Flame Retardants
1:45-4:30 p.m. – Karl Dean Ballroom A1
Presentation: Introduction
Author: Hatlelid K
Workshop Session: Establishing Scientific Confidence in New Approach Methods: A Modern Framework
1:45-4:30 p.m. – Room 202
Abstract 1098: Practical Steps to Putting the Scientific Confidence Framework into Regulatory Use
Author: Lowit A
Poster Session: Computational Toxicology I
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3063/Poster P168: Machine Learning Models for Rat Multigeneration Reproductive Toxicity Prediction
Authors: Liu J, Guo W, Dong F, Aungst J, Fitzpatrick S, Patterson TA, Hong H
Abstract 3086/Poster P191: MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulation Tools
Authors: Groff LK, Hagan B, Patlewicz G, Shah I
Poster Session: Risk Assessment I
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3279/Poster P400: Environmental Metal Mixtures Exposure Prevalence in Pregnant Women in the United States
Authors: Ruiz P, Cheng P, Desai S, Shin M, Jarrett JM, Ward CD, Shim Y
Abstract 3280/Poster P401: Real-Life Environmental Exposures and Neurodegenerative Diseases
Authors: Jameshenry N, Pulido H, Ruiz P, Mumtaz M
Abstract 3289/Poster P410: Development of a Database to Derive Inhalation TTC Values for Airborne Compounds
Authors: Schwartz-Zocher M, Api AM, Joshi K, Giusti A, Rose J, Collins S, Patlewicz G, Bowden AM, Boisleve F, Singal M, Sadekar N, Escher SE
Abstract 3298/Poster P419: Assessing Audiology Studies for Various Ototoxic Substances
Authors: Bradley M, Zarus G, Ruiz P, Eichwald J
Tuesday, March 21
Poster Session: Computational Toxicology II
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 3669/Poster P154: Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity
Authors: Chang X, Reinke EN, Daniel AB, Allen DG, Mumtaz MM, Kleinstreuer NC
Poster Session: Molecular Toxicology
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 4207/Poster P717: Optimizing Circadian Transcriptional Machinery Output to Augment Cellular Resiliency in Operationally Extreme Environments
Authors: Cox C, Hussain S, Kemp M
Workshop Session: Establishing Confidence in New Approach Methods for Human Health Risk Assessment: Recent Examples of Context of Use
11:00 a.m.-12:30 p.m. – Karl Dean Ballroom A1
Suzanne Fitzpatrick (ICCVAM principal agency representative, FDA) is session chair
Presentation: What Are Regulators Looking For?
Author: Fitzpatrick S
Platform Session: Enhancing Toxicology with Machine Learning
1:00-2:15 p.m. – Room 201
Abstract 2033: Deriving Benchmark Dose from the Deep-Learning Prediction Scores of High-Throughput Toxicology Images
Authors: Tandon A, Howard BE, Mav D, Balik-Meisner M, Ramaiaghari S, Ferguson S, Shah R, Merrick BA
Poster Session: Alternatives to Mammalian Models II
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3620/Poster P102: Evaluating Acrylamide Toxicokinetics in an In Vitro Integrated Organ Platform
Authors: McKim JM, Austin D, Sprando RL, Mattes W, Fitzpatrick S
Abstract 3624/Poster P106: Validation of the Electrophilic Allergen Screening Assay (EASA) to Detect Substances That Impact the Initial Key Event in the Adverse Outcome Pathway for Skin Sensitization
Authors: Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Allen DG, Kleinstreuer NC, Strickland J
Abstract 3625/Poster P117: Analysis of Reproducibility and Robustness of PhysioMimix™ T12, a Proximal Renal Tubule Microphysiological System for Studies of Pharmacokinetics and Toxicological Assessment of Drugs and Chemicals
Authors: Sakolish C, Moyer H, Ferguson SS, Chiu WA, Rusyn I
Abstract 3626/Poster P108: A Novel Approach to Investigate the Molecular Interaction between Inhaled Contaminants and the Human Lung Surfactant System
Authors: Mayville B, Coyle J, Sayes C, Hussain S
Poster Session: Alternatives to Mammalian Models III
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3656/Poster P140: Reproducibility and Robustness of PhysioMimix LC12, a Liver Microphysiological System, under Varying Culture Conditions and Cell Type Combinations
Authors: Lim AY, Kato Y, Sakolish C, Hardwick RN, Ferguson SS, Rusyn I
Abstract 3664/Poster P148: Comparative Analysis of Tox21 In Vitro Assay Readouts from Three Major Data-Cleaning Pipelines
Authors: Sedykh A, Kidd B, Gombar V, Shah R, Casey W
Poster Session: Neurotoxicity: Developmental I
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3966/Poster P460: High-Throughput Phenotypic Profiling Approach for the Screening and Prioritization of Potential Developmental Neurotoxicity Hazard
Authors: Culbreth M, Byrd G, Harris F, Willis C, Carstens K, Harrill JA
Poster Session: Bioinformatics
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3744/Poster P230: Integrated Chemical Environment: An Advanced Platform Aiding NAM-Based Chemical Assessments
Authors: Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel AB, Cooper S, Phillips J, McAfee E, Allen DG, Casey W, Kleinstreuer NC
Poster Session: Neurotoxicity: Developmental II
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 3986/Poster P480: Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity
Authors: Carstens K, Freudenrich T, Wallace K, Choo S, Carpenter A, Patlewicz G, Richard A, Wetmore B, Paul Friedman K, Shafer T
Poster Session: Neurotoxicity: General
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 4009/Poster P504: The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19
Authors: Hogberg-Durdock H, Lam A, Elan O, Shahbaz MA, Clerbaux L, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M
Wednesday, March 22
Workshop Session: Shedding Light on Population Variability and Susceptibility: New Approach Methods to Inform Risk Assessment
9:00-10:45 a.m. – Karl Dean Ballroom A1
Abstract 1207: Diversity Outbred Mice That Mimic Human Heterozygosity and Are Highly Genetically Diverse
Author: Harrill A
Poster Session: Biological Modeling
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 4321/Poster P186: Utilizing a Pharmacokinetic Model for Evaluating Exposures to PFOA: Various Dosing Considerations Aimed at Simulating Site-Specific Exposures to Drinking Water
Authors: Welsh C, Sautner J, Siwakoti R, Compton J, Kowalski P, Goodwin B, Somers TS, Ruiz P, Fisher J
Poster Session: Mixtures
9:00-10:45 a.m. – Tox Expo Hall C
Abstract 4494/Poster P369: Mixtures Risk Assessment of Volatile Organic Chemicals through Multiple Target Organ Evaluation
Authors: Mumtaz MM, Young A, Mellard D, Pohl H, Przybyla J, Langmann D
Poster Session: Kidney
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 4288/Poster P152: An In Vitro 3D Model of the Human Renal Proximal Tubule for Nephrotoxicity Screening Studies
Authors: Pearson AT, Travlos GS, Ferguson SS
Poster Session: PFAS II
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 4369/Poster P236: Biological Response Similarity Analyses and Hierarchical Clustering of Aqueous Film-Forming Foams (AFFF) and Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) Using In Vitro Hepatocyte Transcriptomics
Authors: Mauge-Lewis KA, Ramaiahgari S, Roberts G, Waidyanatha S, Fenton S, Phadke D, Balik-Meisner M, Ferguson S, Gorospe J, Sparrow B
Poster Session: Emerging Technologies
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 4437/Poster P309: Pulmonary Evaluation of Whole-Body Inhalation Exposure of Polycarbonate (PC) Filament 3D Printer Emissions in Rats
Authors: Farcas MT, McKinney W, Mandler W, Knapp A, Service S, Battelli L, Friend SA, Leboul R, Thomas TA, Matheson JA, Qian Y
Poster Session: Skin and Dermal Toxicity
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 4449/Poster P322: Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro
Authors: Salminen AT, Davis KJ, Felton RP, Nischal N, VonTungeln LS, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho L
Abstract 4452/Poster P325: Development of Preliminary Candidate Surface Guidelines for Air Force-Relevant Dermal Sensitizers Using New Approach Methodologies
Authors: Keebaugh AJ, Clewell RA, Steele ML, Raabe H, Merrill EA, Chusha YG, Cantrell K, Islas-Robles A, Hillberer A, Mattie DR
Poster Session: Natural Products
10:45 a.m.-12:30 p.m. – Tox Expo Hall C
Abstract 4739/Poster P646: Investigation of Blue Cohosh Extract Compositions and Human Hepatocellular Effects
Authors: Quiroz-Delfi G, Mueller G, Jarmusch AK, Ferguson SS, Rider CK
Roundtable Session: 21st-Century Agrochemical Evaluation: Discussing a New Vision
11:00 a.m.-12:20 p.m. – Room 209
Presentation: Use of NAMs to Meet Regulatory Needs: Scoping Opportunities in a New Paradigm
Author: Perron M
Workshop Session: New Approach Methodologies in the Pharmaceutical Sciences: Novel Strategies Challenging the Traditional Testing Paradigm to Increase Regulatory Confidence
1:30-4:15 p.m. – Karl Dean Ballroom A1
Abstract 1254: Regulatory Perspectives on the Integration of Novel Testing Tools, Such as MPS and CIVM, into Nonclinical Drug Safety Assessment
Author: N Sadrieh
Poster Session: Liver II: In Vitro
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 4274/Poster P137: Unraveling PCB Effects in Differentiated Human Hepatocytes
Authors: Dunlap PE, Rice JR, Ramaiahgari S, Dunnick J, Merrick BA, DeVito MJ, Ferguson SS
Poster Session: Respiratory Toxicology I
2:30-4:15 p.m. – Tox Expo Hall C
Abstract 4583/Poster P473: Weight-of-Evidence Analysis for the Development of a Reference List of Chemical Respiratory Sensitizers
Authors: Carstens K, Freudenrich T, Wallace K, Choo S, Carpenter A, Patlewicz G, Richard A, Wetmore B, Paul Friedman K, Shafer T
Thursday, March 23
Symposium Session: High-Content Imaging: Cell Painting Basics and Emerging Applications to Toxicological Research
8:30-11:15 a.m. – Room 202
Allison Harrill (ICCVAM representative, EPA) is session chair.
Presentation: Introduction
Author: Harrill A
Symposium Session: Refining Inhalation Risk Assessments by Integrating New Approach Methodologies
8:30-11:15 a.m. – Room 207B
Abstract 1268: Introduction to Inhalation Risk Assessment and Initial NAM Considerations
Author: Perron M
Satellite Meetings
21st Century Toxicology: Sneak Preview of Ongoing Relevant Activities
Thursday, March 23, 12 noon-4:00 p.m. CDT - Room 102A
Organized by the Johns Hopkins University Center for Alternatives to Animal Testing and Humane Society International/Animal-free Safety Assessment Collaboration
This satellite meeting is free and open to both SOT attendees and remote viewers: register for more information. Speakers will include ICCVAM members Nicole Kleinstreuer (NIEHS/NICEATM), Suzanne Fitzpatrick (FDA), Nakissa Sadrieh (FDA), and Gino Scarano (EPA).