ICCVAM Communities of Practice Webinar 2021

Non-animal Approaches for Mixtures Assessment

January 26, 2021

Slides and video from the webinar are available below.

ICCVAM promotes the development and validation of toxicity testing methods that protect human health and the environment while replacing reducing, or refining animal use. ICCVAM also provides guidance to test method developers and facilitates collaborations that promote the development of new test methods. This webinar, organized on behalf of ICCVAM by NICEATM, discussed new approach methodologies for assessing exposure to and potential hazards associated with chemical mixtures. 

While most available toxicity data are for single chemicals, humans are often exposed to chemicals as mixtures. Assessing the safety of a mixture is a complex process that requires consideration of both the toxicity of each chemical component of the mixture and the potential for interaction among the components to affect toxicity of the overall mixture. Additionally, most alternative methods and approaches used for assessing chemical safety are developed and evaluated using single chemicals. This can result in lack of clarity about whether a method is appropriate to use for assessing toxicity of a particular mixture. In this webinar, three presentations featuring speakers from U.S. federal research and regulatory agencies described key insights and ongoing activities.

View Federal Register notice announcing the webinar (January 11, 2021) – View notice as webpage

Presentations

• Applying In Vitro Approaches to Understand Complex Mixtures in Assessing Botanical Safety
  Cynthia Rider, Ph.D., Division of the NTP, National Institute of Environmental Health Sciences
• Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology
  Patricia Ruiz, Ph.D., Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry
• Mining Potential Chemical Co-exposures from Consumer Product Purchasing and Ingredient Data
  Kristin Isaacs, Ph.D., Office of Research and Development, U.S. Environmental Protection Agency

Run time of video is approximately 2 hours.