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NICEATM Abstracts Published Since 2016

For each abstract, table lists presentation date, authors, title (link to abstract PDF), and presentation venue (link to meeting page on NICEATM site)
Year Presented Authors Title Presentation Venue
2020 Lowit M, Ceger P, Allen D, Arnold E, Choksi N, Daniel A, Hamm J, Judkins D, Kleinstreuer N, Montague B, Sprankle C, Truax J, Odenkirchen E Exploring ways to reduce animal testing in support of the registration of pesticides by the U.S. Environmental Protection Agency SETAC North America
2020 Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N International computational modeling collaborations for predictive toxicology SETAC North America
2020 Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley E, Bell S, Allen D, Kleinstreuer N In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues American Society for Cellular and Computational Toxicology
2020 Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen E, Kleinstreuer N Chemical exploration: identifying bioactivity with the use of structural features American Society for Cellular and Computational Toxicology
2020 Rooney JP, Choksi N, Ceger P, Daniel A, Truax J, Rai R, Kleinstreuer N, Allen D Variability in the rabbit skin irritation assay American Society for Cellular and Computational Toxicology
2020 Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N Collaborative modeling project for prediction acute oral toxicity American Society for Cellular and Computational Toxicology
2020 Abedini J, Bell S, Mansouri K,  McAfee E, Phillips J, Chang X, Karmaus AL, Cook B, Allen D, Casey W, Kleinstreuer N NICEATM computational tools and resources supporting alternative test method development and evaluation American Society for Cellular and Computational Toxicology
2020 Rooney J, Lizarraga L, Yamada T, Allen DBabich MDaniel AFitzpatrick SGarcia-Reyero NGordon JHakkinen PKarmaus AKleinstreuer NMatheson JMumtaz MRua DRuiz P Scarano LVolarath PPatlewicz ICCVAM Read-Across Workgroup: towards guiding principles for read-across applications American Society for Cellular and Computational Toxicology
2020 Borba J, Braga R, Alves V, Muratov E, Kleinstreuer N,  Tropsha A, Andrade C Pred-Skin: a web portal for accurate prediction of human skin sensitizers American Society for Cellular and Computational Toxicology
2020 Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D Testing of agrochemical formulations using in vitro and ex vivo eye irritation test methods American Society for Cellular and Computational Toxicology
2020 Bell S, Abedini J, Ceger P, Karmaus A, Daniel A, Choksi N, Rooney J, Allen D, Kleinstreuer N Providing insight into chemical activity through data curation and assay annotation American Society for Cellular and Computational Toxicology
2020 Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M Human reference database for skin sensitization American Society for Cellular and Computational Toxicology
2020 Foster C, J Wignall, S Kovach, J Trgovcich, A Varghese, J Rochester, M Stout and NC Kleinstreuer Automated applications of ontologies to standardize developmental toxicology study extraction Society for Birth Defects Research and Prevention
2020 Chang X, A Lumen, J Palmer, U Lee, P Ceger, B Donley, S Bell, D Allen, W Casey and NC Kleinstreuer In vitro to in vivo extrapolation for developmental toxicity potency of valproate analogues Society for Birth Defects Research and Prevention
2020 Kleinstreuer N Establishing international test guidelines for skin sensitization: predictive capacity and applicability domain of nonanimal defined dpproaches Society of Toxicology
2020 Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley B, Bell S, Allen DG, Casey W, Kleinstreuer NC In vitro to in vivo extrapolation for developmental toxicity potency of valproate analogues Society of Toxicology
2020 Kleinstreuer N Computational crowdsourcing: leveraging global expertise to predict toxicity Society of Toxicology
2020 Rooney JP, Choksi N, Rai R, Allen DG, Kleinstreuer NC, Casey W Variability in the rabbit skin irritation assay Society of Toxicology
2020 Casey W Modernizing the NTP carcinogenicity testing program Society of Toxicology
2020 Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Allen DG, Casey W, Kleinstreuer NC Collaborative modeling project for predicting acute oral toxicity Society of Toxicology
2020 Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen DG Developing a defined approach for eye irritation testing Society of Toxicology
2020 Strickland J, Allen DG, Api A, Gordon J, Kleinstreuer NC, Ko H-S, Matheson J, Thierse H-J, Truax J, Herzler M Classification of human reference data for skin sensitization Society of Toxicology
2020 Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC NICEATM computational tools and resources supporting alternative test method development and evaluation Society of Toxicology
2019 Bell S, Choksi N, Ceger P, Daniel A, Karmaus A, Abedini J, Allen D, Casey W, Kleinstreuer N Good decisions require good data: creating curated and structured resources for toxicology American Society for Cellular and Computational Toxicology
2019 Kleinstreuer N The march toward big data in toxicology: striking a balance between machine learning
and mechanistic modeling
American Society for Cellular and Computational Toxicology
2019 Bell S, Phillips J, Chang X, Rai R, Karmaus A, Hermes F, Mansouri K, Allen D, Casey W, Kleinstreuer N Facilitating chemical evaluation and data exploration with the Integrated Chemical Environment American Society for Cellular and Computational Toxicology
2019 Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Allen D, Casey W, Kleinstreuer N Collaborative modeling project for predicting acute oral toxicity American Society for Cellular and Computational Toxicology
2019 Hamm J, Behl M, Ceger P, Haendel M, Marvel S, Maull E, Muriana A, Reif D, Tanguay R, Thessen A, Truong L, Vallant M, Walker N, Ryan K The National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology: SEAZIT Teratology Society
2019 Ceger P, Bell S, Choksi N, Hamm J, Daniel A, Allen D, Kleinstreuer N Application of a controlled vocabulary to curated databases of in vivo developmental toxicity data Teratology Society
2019 Choksi N, Clippinger AJ, Gehen S, Corvaro M, Ng S, Kolle SN, van Cott A, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D Defined approach for detection of eye irritants and corrosives for pesticide formulations Society of Toxicology
2019 Kleinstreuer NC Current and future opportunities for U.S. regulatory application of developmental toxicity NAMs Society of Toxicology
2019 Mansouri K International collaboration to build predictive models for acute oral toxicity Society of Toxicology
2019 Kleinstreuer NC Derivation of a dataset for modeling acute oral toxicity and variability assessment of in vivo LD50 data Society of Toxicology
2019 Lebrun SJ, Choksi N, Daniel A, Allen D, Casey W Prevalidation of the OptiSafe ocular irritation assay for the detection of ocular corrosives Society of Toxicology
2019 Kleinstreuer NC IVIVE tools for risk assessment Society of Toxicology
2019 Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Karmaus AL, Mansouri K, McAfee E, Rai R, Allen DG, Casey WM, Kleinstreuer NC The Integrated Chemical Environment: tools and data to support toxicity assessments Society of Toxicology
2019 Karmaus AL, Bell SM, Allen DG, Casey WM, Kleinstreuer NC Adding context to Tox21/ToxCast data: linking in vitro assays to toxicity outcomes Society of Toxicology
2019 Allen DG, Clippinger A, Morefield S, Casey WM, Ghosh C, Goode J, Brown J Using the monocyte activation test for medical devices Society of Toxicology
2019 Mumtaz M, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus AL, Matheson J, Ruiz P, Scarano L, Kleinstreuer NC, Patlewicz G Exploring current read-across applications and needs among U.S. federal agencies Society of Toxicology
2019 Chang X, Mansouri K, Hermes F, Phillips J, Bell SM, Allen DG , Casey WM, Kleinstreuer NC  An open-source, generalized workflow for IVIVE analysis Society of Toxicology
2018 Bell S, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Mansouri K, Rai R, Allen D, Casey W, Kleinstreuer N User-friendly toxicology tools from ICE workflows FutureTox IV
2018 Ceger P, Hamm J, Allen D, Maull E, Casey W Zebrafish ontologies for toxicological screening FutureTox IV
2018 Chang X, Bell S, Rai R, Phillips J, Mansouri K, Allen D, Casey W, Kleinstreuer N An open-source IVIVE workflow integrating in vitro data, QSAR models, and reverse dosimetry FutureTox IV
2018 Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I,  Williams AJ, Judson RS Virtual screening of chemicals for estrogen and androgen activities FutureTox IV
2018 Mansouri K International computational collaborations to solve toxicology problems EuroQSAR 2018
2018 Karmaus A, Mansouri K, Fitzpatrick J, Patlewicz G, Allen D, Casey W, Kleinstreuer N Collaboration to develop predictive models for acute oral systemic toxicity American Society for Cellular and Computational Toxicology
2018 Allen D, Choksi N, Gehen S, Casey W, Clippinger A Public-private partnerships to advance in vitro eye irritation testing methods and approaches American Society for Cellular and Computational Toxicology
2018 Bell S, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Mansouri K, Rai R, Allen D, Casey W, Kleinstreuer N User-friendly toxicology tools from ICE workflows American Society for Cellular and Computational Toxicology
2018 Chang X, Bell S, Rai R, Phillips J, Mansouri K, Allen D, Casey W, Kleinstreuer N An open-source IVIVE workflow integrating in vitro data, QSAR models, and reverse dosimetry American Society for Cellular and Computational Toxicology
2018 Mansouri K, Cariello N, Korotcov A, Tkachenko V, Casey W, Kleinstreuer N, Allen D, Grulke C,  Williams AJ Open source QSAR models for pKa prediction using multiple machine learning approaches American Society for Cellular and Computational Toxicology
2018 Strickland J, Gordon J, Hettick J, Law B,  Petersen EJ, Solomotis N, Truax J, Uhl R, Yourick J, Allen D, Kleinstreuer N Phase 1 validation of the electrophilic allergen screening assay American Society for Cellular and Computational Toxicology
2018 Bell S, Ceger P, Allen D, Kleinstreuer N Open, accessible toxicity testing data for chemical evaluation OpenTox USA 2018
2018 Ceger P, Hamm J, Allen D, Maull E, Casey W Zebrafish ontologies for toxicological screening OpenTox USA 2018
2018 Ryan KR, Hsieh JH, Parham F, Shapiro A, Sipes N, Collins B, Maull E, Paules RS, Walker N, Behl M Strategies and advancements to evaluate developmental neurotoxicity at the National Toxicology Program Teratology Society
2018 Palmer JA, Burrier RE, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer NC A human pluripotent stem cell-based assay accurately predicts the developmental toxicity potency for a series of valproate analogues Teratology Society
2018 Beekhuijzen M, Kleinstreuer NC Teratology Society and European Teratology Society Exchange Lecture: Are We Ready for Alternative Testing? Teratology Society
2018 Wynder J, Ovesen J, Maier A, Judson R, Kleinstreuer N, Krishnan M Evaluating the applicability of read-across tools and high-throughput screening data for food relevant chemicals Society of Toxicology
2018 Haggard DE, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul Friedman K Evaluating perturbation of in vitro steroidogenesis using a high-throughput H295R assay Society of Toxicology
2018 Kleinstreuer N More than skin deep: when alternative approaches outperform animal tests Society of Toxicology
2018 Shah I, Harrill J, Setzer RW, Haggard D, Karmaus A, Martin MT, Thomas RS Predicting chemical mechanisms-of-action using high-throughput transcriptomic data Society of Toxicology
2018 Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I, Williams AJ, Judson R Virtual screening of chemicals for estrogen and androgen activities Society of Toxicology
2018 Bell SM, Burgoon LD, Phillips J, Ceger P, Karmaus A, Allen D, Casey W, Kleinstreuer N ICE tools for aligning assay endpoints to adverse outcome pathways Society of Toxicology
2018 Casey W A roadmap to establishing new approaches for toxicity testing: improving human relevance and reducing animal use Society of Toxicology
2018 Karmaus A, Fitzpatrick J, Allen D, Patlewicz G, Kleinstreuer N, Casey W Variability of LD50 values from rat oral acute toxicity studies: implications for alternative model development Society of Toxicology
2018 Fitzpatrick J, Pradeep P, Karmaus A, Patlewicz G Using chemical and biological descriptors to develop predictive models for rat acute oral toxicity Society of Toxicology
2018 Kleinstreuer N Current and future opportunities for U.S. regulatory application of read-across Society of Toxicology
2018 Ono A, Watanabe S, Sugawara t, Wakabayashi K, Tahara Y, Horle N, Fujimoto K, Kusakari K, Kurokawa Y, Sozu T, Nakayama T, Kusao T, Kawakami T, Kojima K, Kojima H, Richmond J, Kleinstreuer N, Bae-Hwa K, Yamamoto Y, Fujita M, Kasahara T A multi-centre validation study of amino acid derivative reactivity assay (ADRA): a novel in chemico alternative test method for skin sensitization Society of Toxicology
2018 Palmer J, Smith A, Burrier R, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer N Valproate analogue developmental toxicity potency in a human pluripotent stem cell-based assay is concordant with in vivo potency Society of Toxicology
2018 Hamm J, Ceger P, Chang X, Maull E, Mahapatra D, Knuth M, Lingerfelt M, Ekins S, Xia M, Kullman SW Evaluation of FXR-active chemicals identified from Tox21 screening Society of Toxicology
2018 Choksi N, Daniel A, Lebrun S, Nguyen M, DeGeorge G, Willoughby JA, Casey W, Allen D Performance of the OptiSafe ocular irritation assay in a three-laboratory validation study Society of Toxicology
2017 Bell S, Burgoon L, Phillips J, Ceger P, Allen D, Casey W, Kleinstreuer N A new tool for aligning assay endpoints to adverse outcome pathways American Society for Cellular and Computational Toxicology
2017 Karmaus A, Allen D, Kleinstreuer N, Casey W Characterizing variability across rat oral acute toxicity studies: implications for alternative model evaluation American Society for Cellular and Computational Toxicology
2017 Chang X, Zang Q, Bell S, Allen D, Casey W, Kleinstreuer N An open-source IVIVE workflow integrating QSAR and PK models American Society for Cellular and Computational Toxicology
2017 Fitzpatrick J, Karmaus A, Patlewicz G Development of an acute oral toxicity dataset to facilitate assessment of existing QSARs and development of new models American Society for Cellular and Computational Toxicology
2017 Allen D, Wilson D, Hotchkiss J, Morefield S, Casey W, Clippinger A Integrating alternative approaches to replace animals in inhalation toxicity testing Tenth World Congress
2017 Fitzpatrick J, Karmaus A, Patlewicz G Development of an acute oral toxicity dataset to facilitate assessment of existing QSARs and development of new models Tenth World Congress
2017 Strickland J, Karmaus AL, Chang X, Paris M, Allen D, Kleinstreuer N, Casey W Correlation of in vitro cytotoxicity and acute toxicity Tenth World Congress
2017 Kleinstreuer N In vitro insights into chemical carcinogenesis Tenth World Congress
2017 Kleinstreuer N A strategy to ensure relevant science for regulatory acceptance and industry adoption Tenth World Congress
2017 Karmaus AL, Allen D, Kleinstreuer NC, Casey W Characterizing the variability of LD50 values in acute toxicity studies: implications for alternative methods development Tenth World Congress
2017 Chang X, Zang Q, Bell S, Allen D, Casey W, Kleinstreuer N An open-source IVIVE workflow integrating QSAR and PK models Tenth World Congress
2017 Bell S, Burgoon L, Phillips J, Allen D, Casey W, Kleinstreuer N A new tool for aligning assay endpoints to adverse outcome pathways Tenth World Congress
2017 Hamm J, Ceger P, Boyles R, Reif D, Burgoon L, Haendel M, Walker N, Maull EA Implementation of zebrafish ontologies for toxicology screening Tenth World Congress
2017 Miller M, Goodson WH, Lowe L, Manjili MH, Kleinstreuer N, Bisson WH Integrating the low-dose mixture hypothesis of carcinogenesis into the future of cancer research Society of Toxicology
2017 Mansouri K, Kleinstreuer N, Watt E, Harris J, Judson R CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity Society of Toxicology
2017 Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Xia M Androgen receptor agonist identification and characterization by screening the Tox21 10K compound library Society of Toxicology
2017 Bone A, Xia M, Sakamuru S, Huang R, Houtman R, van Beuningen R, Watt E, Kleinstreuer N, Judson R, Houck K Identification of androgen receptor antagonists using Tox21 qHTS data and the MARCoNI assay Society of Toxicology
2017 Lowit A, Schlosser C, Myska A, Patlewicz G, Paris M, Karmaus A, Strickland J, Allen D, Kleinstreuer N, Casey W Replacing animals for acute systemic toxicity testing: a U.S. strategy and roadmap Society of Toxicology
2017 Strickland J, Zang Q, Paris M, Lehmann DM, Bell S, Allen D, Matheson J, Jacobs A, Casey W, Kleinstreuer N Prediction of skin sensitization potency using machine learning approaches Society of Toxicology
2017 Bell S, Phillips J, Sedykh A, Sprankle C, Morefield S, Allen D, Casey W, Kleinstreuer N An Integrated Chemical Environment to support 21st century toxicology Society of Toxicology
2017 Kleinstreuer N Pathway-based models to predict developmental and reproductive toxicologies Society of Toxicology
2017 Ceger P, Choksi N, Hamm J, Truax J, Daniel A, Allen D, Sutherland V, McIntyre B, Foster P, Maull E, Casey W Development of a curated database of in vivo developmental toxicity data Society of Toxicology
2017 Kleinstreuer N, Strickland J, Zuang V, Lowit A, Matheson J, Allen D, Casey W, Whelan M Evaluating defined approaches to testing and assessment of skin sensitization potential Society of Toxicology
2017 Hamm J, Ceger P, Maull E, Padilla S, Perkins E, Planchart A, Stedman D, Tal T, Tanguay R, Volz D, Baker G, Stout M, Walker N SEAZIT: the National Toxicology Program's systematic evaluation of the application of zebrafish in toxicology Society of Toxicology
2017 Boyd WA, Pirone JR, Shaw MP, Kleinstreuer NC, Martin MT, Rashid A, Fostel JM, Thayer KA Identification of environmental chemicals with potential roles in obesity and diabetes using animal studies from U.S. EPA and NTP toxicological databases Society of Toxicology
2017 Chang X, Bell SM, Pirone JR, Allen D, Casey W, Kleinstreuer N Open-source workflows for in vitro to in vivo extrapolation Society of Toxicology
2016 Chang X, Pirone J, Bell SM, Allen D, Casey W, Kleinstreuer N An open-source workflow for in vitro to in vivo extrapolation American Society for Cellular and Computational Toxicology
2016 Kleinstreuer N, Ceger P, Allen D, Browne P, Houck K, Martin M, Thomas R, Dix D, Casey W, Judson R Development and validation of a computational model for androgen receptor activity American Society for Cellular and Computational Toxicology
2016 Casey W Strategy for implementing the vision of toxicity testing in the 21st century American Society for Cellular and Computational Toxicology
2016 Strickland J, Zang Q, Paris M, Lehmann DM, Bell S, Allen D, Matheson J, Jacobs A, Casey W, Kleinstreuer N Prediction of skin sensitization potency using machine learning approaches American Society for Cellular and Computational Toxicology
2016 Zang Q, Allen D, Casey W, Judson R, Kleinstreuer N QSAR modeling to predict androgen receptor pathway activity Society of Toxicology
2016 Allen D Integrating alternative methods within a regulatory framework and the impact of AOPs in designing an integrated testing strategy to replace repeat exposure inhalation toxicity Society of Toxicology
2016 Jaworska J, Natsch A, Ryan C, Strickland J, Ashikaga T, Miyazawa M Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment – a decision support system for quantitative weight of evidence and adaptive testing strategy Society of Toxicology
2016 Strickland J, Zang Q, Paris M, Lehmann DM, Kleinstreuer N, Allen D, Choksi N, Matheson J, Jacobs A, Lowit A, Casey W Multivariate models for prediction of human skin sensitization hazard Society of Toxicology
2016 Chang X, Kleinstreuer N, Ceger P, Choksi N, Hsieh J-H, Wetmore BA, Ferguson S, DeVito MJ, Allen D, Casey W In vitro to in vivo extrapolation for estrogenic activity of environmental chemicals Society of Toxicology
2016 Kleinstreuer N Skin sensitization testing strategy evaluation Society of Toxicology
2016 Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W Development and application of a reference database for androgen receptor activity Society of Toxicology
2016 Paris M, Strickland J, Allen D, Casey W Retrospective analysis of acute toxicity tests for pesticides Society of Toxicology
2016 Yang C, Casey W, Choksi N, Ceger P, Kleinstreuer N, Allen D, Dharshan P, Bittner G An in vitro test method for screening potential androgenic agonists and antagonists in MDA-kb2 cells Society of Toxicology