https://ntp.niehs.nih.gov/go/804412

NICEATM Abstracts Published Since 2020

For each abstract, table lists presentation date, authors, title (link to abstract PDF), and presentation venue (link to meeting page on NICEATM site)
Year Presented Authors Title Presentation Venue
2024 Chang X In Vitro to In Vivo Extrapolation Application to Promote the Use of NAMs for Assessing Inhalation Toxicity Society of Toxicology
2024 Lane TR, Snyder S, Harris JS, Hamm J, Urbina F, Unnikrishnan A, Borrel A, Karmaus A , Behl M, Hogberg-Durdock H Seizure Predictions Using Adverse Outcome Pathway-Based Fast Interpretable Greedy-Tree Sums Modeling Society of Toxicology
2024 Krishna S, Beverly B, Walker VR, Kleinstreuer NC, Hannani A, Whately H, Trgovcich J, Rochester J, Sprowles J, Miller M, Tracy W, Sibrizzi C, Rooney AA Artificial Intelligence Approaches to Identify and Categorize Health-Relevant Research for Big Questions: Case Study of Cardiovascular Disease and Environmental Exposures Society of Toxicology
2024 Whitehead TM, Strickland J, Conduit GJ, Borrel A, Mucs D, Baskerville-Abraham I Toxicological Data Gap Filling of Ingredients; Comparison of Machine Learning Based Imputation and Traditional QSAR Methods Society of Toxicology
2024 Moreira-Filho J, Ranganath D, Conway M, Waidyanatha S, Collins B, Schmitt C, Kleinstreuer N, Mansouri K Modeling and Visualization (MoVIZ): Democratizing Cheminformatics with a User-friendly Guided Pipeline Society of Toxicology
2024 Hsieh J, Wang Z, Nolte S, Marvel S, Hill B, Hamm J, Roberts G, Schmitt, Ryan K SEAZIT-DIVER: A Web Application for Integrating and Visualizing Inter-laboratory Data on Substance-Induced Developmental Toxicity Phenotypes in Zebrafish Embryos Society of Toxicology
2024 McPherson CA, Combs P, Cushman J, Erickson J, Hsieh J, Hall L, Hogberg HT, Kendricks K, Sills R Integrating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery to Identify Compounds for Future Study Society of Toxicology
2024 Sutherland V, Hogberg HT, Behl M, Hsieh J, Mansouri K, Mehta S, Roberts G, Ryan K, Taylor KW, Walker N, Walker VR, Witchey S, Rooney AA Organophosphate Flame Retardants: A Comprehensive Toxicological Assessment Society of Toxicology
2024 Scheufen Tieghi R, Rath MK, Moreira-Filho JT, Martin H, Beasley J, Hogberg HT, Kleinstreuer N, Muratov E PregPred: A Model to Predict the Developmental Toxicity Potential of Environmental Chemicals and FDA-Approved Drugs and Cosmetics Society of Toxicology
2024 Borrel A Deep-Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms Society of Toxicology
2024 de Aguiar Marciano L, Filipe Costa L, Silva Cardoso N, de Araújo Paula F, Pupin Silvério A, Kleinstreuer N, Martins I Risk Assessment of Exposure to Triazole Fungicides by Human Biomonitoring and Mechanistic Data Society of Toxicology
2024 Hogberg-Durdock H, Hamm J, Borrel A, Karmaus A , Lane T, Unnikrishnan A, Urbina F, Behl M Identifying Seizure-Inducing Biological Targets: A Collaborative Approach Using AOP Networks, In Vitro Assays, and Computational Tools Society of Toxicology
2024 Unnikrishnan A, Chang X, Kreutz A, Hull V, Tedla GE, Hogberg HT, Sluka JP, Wambaugh JF, Allen DG, Kleinstreuer N PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues Society of Toxicology
2024 Tedla G, Borrel A, Karmaus A, Hull V, To KT, Auman JT, Allen DG, Kleinstreuer N Machine learning-based development of cytotoxicity flags within the Tox21/ToxCast assays Society of Toxicology
2024 Sullivan K, Reinke E, Macmillan DS, Raabe H, Germolec D, Allen D, Choi E, Filipovska J, Kleinstreuer N Advancing Flexibility for Defined Approach Guidelines: Developing Performance Standards to Incorporate Alternate Information Sources into the Defined Approach for Skin Sensitization Guideline Society of Toxicology
2024 Reinke EN, LaPratt T, Strickland JA, Germolec D, Truax J, Reynolds J, Reynolds G, Gilmour N, Allen DG, Maxwell G, Kleinstreuer NC Application of the SARA-ICE Skin Sensitization Defined Approach to a Diverse Chemical Set – a Comparative Case Study Society of Toxicology
2024 Oyetade OB, Chang X, Kreutz A, Hsieh JH, Behl M, Sipes N, Allen DG, Hogberg HT OPFR Prioritization using the Developmental Neurotoxicity In Vitro Test Battery: An Update to OECD IATA Case Study Society of Toxicology
2024 Maxwell G, Reynolds J, Gilmour N, Strickland J, Reinke EN, Germolec D, Truax J, Allen DG, Blaylock M, LaPratt T, Reynolds G, Kleinstreuer N Application of Skin Allergy Risk Assessment-Integrated Chemical Environment Defined Approach (SARA-ICE DA) to Assess Skin Sensitization Potency of Isothiazolinone Compounds Society of Toxicology
2024 Kreutz A, Chang X, Lawless M, Shafer TJ, Wambaugh JF, Wetmore BA, Allen DG, Hogberg HT In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models Society of Toxicology
2024 Johnson VJ, Reinke EN, LaPratt TR, Strickland J, To KT, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer NC, Germolec DR Testing of Regulatory-Relevant Chemicals for Skin and Respiratory Sensitization Hazard Society of Toxicology
2024 Hull V, LaPratt TR, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer NC Curating chemical use categories and exposure predictions to inform chemical assessment Society of Toxicology
2024 Hill BN, Reinke EN, Auman JT, Unnikrishnan A, Allen DG, Kleinstreuer NC Incorporating Ontologies into High Throughput Screening Assay Annotations to Increase Data Use and Interpretation Society of Toxicology
2024 Daniel AB, van der Zalm AJ, Raabe HA, Clippinger AJ, Kleinstreuer NC, Allen DG Predicting GHS Hazard Classification for Eye Irritation/Corrosion Potential of Agrochemical Formulations Using Defined Approaches Society of Toxicology
2024 Chang X, Palmer J, Donley E, Reinke E, Allen D, Kleinstreuer N IVIVE to Facilitate Animal-free Risk Assessment of Potential Developmental Toxicants Society of Toxicology
2024 Borrel A, Tedla G, To KT, Hill B, Karmaus AL, Wang A, Luechtefeld T, Reif D, Allen DG, Kleinstreuer NC Modern In Vitro Imputation Modeling and Machine Learning to Predict Chemical Carcinogenicity Society of Toxicology
2024 Allen DG, Hull V, Reinke EN, Daniel AB, To KT, Karmaus AL, Mansouri K, Kleinstreuer NC Curation and Characterization of a Reference Rat Acute Inhalation Toxicity Database Society of Toxicology
2024 Marko S, Allen DG, Hogberg H, Oyetade OB, Kleinstreuer NC, Carder J Opportunities for Encouraging the Consideration of Alternative Methods Society of Toxicology
2023 Borrel A, Unnikrishnan A, Allen D, Kleinstreuer N ChemMaps.com v2.0 - Exploring the Environmental Chemical Universe Southeast Regional Meeting of the American Chemical Society
2023 Borrel A, Unnikrishnan A, Allen D, Kleinstreuer N ChemMaps.com v2.0 - Exploring the Environmental Chemical Universe American Society for Cellular and Computational Toxicology
2023 Borrel A, Karmaus AL, Tedla G, Mansouri K, Luechtefeld T, Lunn R, Wang A, Allen D, Kleinstreuer N Deep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms  American Society for Cellular and Computational Toxicology
2023 Hull V, Reinke EN, Daniel AB, To KT, Karmaus AL, Allen DG, Mansouri K, Kleinstreuer NC Compilation and Standardization of Rat Acute Inhalation Study Data to Support Predictive Modeling American Society for Cellular and Computational Toxicology
2023 Hull V, LaPratt T, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer NC Curating Chemical Use Categories and Exposure Predictions to Inform Chemical Assessment American Society for Cellular and Computational Toxicology
2023 To KT, Strickland J, Reinke E, Borrel A, Truax J, Allen D, Kleinstreuer N Web Application to Predict Skin Sensitization Using Defined Approaches  American Society for Cellular and Computational Toxicology
2023 Herzler M, To KT, Unnikrishnan A, Abedini J, Allen D, Germolec D, Gordon J, Kleinstreuer K, Ko HS, Matheson J, Thierse HJ, Truax J, Vanselow JT, Strickland J Evaluation of Skin Sensitization Classification Rules to Reflect Induction Potency in Humans American Society for Cellular and Computational Toxicology
2023 Unnikrishnan A, Chang X, Hull V, Tedla GE, Hogberg H, Sluka J, Wambaugh J, Allen D, Kleinstreuer N Expanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues American Society for Cellular and Computational Toxicology
2023 Unnikrishnan A, Hull V, Chang X, Borrel A, To K, Karmaus A, Phillips J, McAfee E, Allen D, Kleinstreuer N Facilitating NAM-Based Chemical Assessments with the Integrated Chemical Environment American Society for Cellular and Computational Toxicology
2023 Hogberg H, Behl M, Combs P, Cushman J, Erickson J, Hall L, Hsieh JH, Kendricks D, Kreutz A, Stanko J, Thomas D, Wilson L, Zhang X, Sills R, McPherson C Generating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Daniel A, van der Zalm A, Raabe H, Clippinger AJ, Kleinstreuer N, Allen D Defined Approaches for GHS Categorization to Assess Eye Irritation Potential of Agrochemical Formulations 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Wittwehr C, Chang X, Bisson W, Culbreth M, Edwards SW, Ferguson S, Harrill A, Hogberg H, Karmaus AL, Leite SB, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O'Brien JM, Reinke E, Schmitt C, Tucker NN, Virvilis V Methods2AOP: An International Collaboration Advancing AOP Key Event Descriptions 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Unnikrishnan A, Chang X, Karmaus AL, Hull V, Allen DG, Kleinstreuer NC Expanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel A, Cooper S, Phillips J, McAfee E, Allen DG, Kleinstreuer NC ICE Data and Tools to Advance NAMs 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 To KT, Oyetade O, Allen DG, Harrill A, Kleinstreuer N, Hogberg HT Using NAMs to Address Variability and Susceptibility Across Populations 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer N Web Application to Predict Skin Sensitization Using Defined Approaches 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec D Defined Approaches for Skin Sensitization for Diverse Chemical Sets 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Reinke EN, Daniel AB, Hull VH, To KT, Karmaus AL, Allen DG, Mansouri K, Kleinstreuer NC Development and Curation of an Acute Inhalation Toxicity Database 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Reinke EN, Strickland J, Truax J, To KT, Gulledge T, Johnson VJ, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer NC, Germolec D Evaluating Skin Sensitization Hazard of Diverse Chemicals Using GARDskin  12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Oyetade OB, Karmaus AL, Reinke E, Allen DG, Kleinstreuer N Variability of In Vivo Toxicology Studies: Impact on NAMs 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Maxwell G, Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke EN, Germolec D, Truax J, Allen DG, Kleinstreuer N The SARA-ICE Model for Predicting Skin Sensitizer Potency 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NC Applying In Silico Toxicity Models Across the Tox21 Chemical Universe 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Karmaus AL, Borrel A, Unnikrishnan A, Wittwehr C, Kleinstreuer NC Annotating High-Throughput Screening Assays: Facilitating Interpretation and Data Use 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Karmaus AL, Medvedev A, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer N, Casey W Insights from Profiling Transcription Factor Transactivation with CYP450 Metabolism Integration 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JLCM, Erickson J, Combs P, Ferguson S, Mansouri K, Kleinstreuer N Integrating Enzyme Variability Into PB-K Models of Chemicals and Metabolites 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Hull V, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer N Curating Chemical Use and Exposure Predictions to Contextualize Chemical Hazard 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Hull V, Borrel A, Karmaus AL, Allen DG, Kleinstreuer N Integration of Technological Interference into Curated HTS Data 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer N, Ko H-S, Matheson J, Thierse H-J, Truax J, Vanselow JT, Strickland J Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Elliott J, Gutierrez R, Johnson VJ, Germolec D, Allen DG, Kleinstreuer NC, Strickland J Validation of the Electrophilic Allergen Screening Assay (EASA) 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Daniel A, Kleinstreuer N, Allen D, Blaylock M, Glover K, Goralski T, Kerr C, Tagle D, Williams M, Holmes A A Working Group Supporting Adoption of MPS in Infectious Disease Research 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Chang X, Reinke E, Daniel A, Allen DG, Kleinstreuer N, Mumtaz MM Using In Vitro Data and PBPK Models to Predict Inhalation Toxicity 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Carder J, Allen DG, Hogberg H, Oyetade O, Kleinstreuer N, Marko S Opportunities for Encouraging the Consideration of Alternative Methods 12th World Congress on Alternatives and Animal Use in the Life Sciencess
2023 Borrel A, Karmaus AL, Tedla G, Mansouri K, Luechtefeld T, Lunn R, Wang A, Allen DG, Kleinstreuer N Deep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Borrel A, Unnikrishnan A, Allen DG, Kleinstreuer N ChemMaps.com V2 - Exploring the Environmental Chemical Universe 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023 Kleinstreuer NC Establishing Confidence in NAMs for Developmental and Reproductive Toxicology Society for Birth Defects Research and Prevention
2023 Kleinstreuer NC AI-Assisted Insights into Developmental Disruption Society for Birth Defects Research and Prevention
2023 Beardslee RA, Salazar K, van der Zalm A, Camacho IA, Brunner R, Raabe H, Allen D, Daniel A, Kleinstreuer N, O’Dell L, Clippinger A, Scarano L, Lowit A Evaluating New Chemicals in the U.S. under the Toxic Substances Control Act (TSCA): Application of New Approach Methods (NAMs) to Evaluate Eye Irritation Society of Toxicology
2023 Borrel A, Unnikrishnan A, Fourches D, Allen DG, Kleinstreuer N ChemMaps.com V2 – Exploring the Environmental Chemical Universe Society of Toxicology
2023 Karmaus AL, Borrel A, Feshuk M, Harrill A, Wittwehr C, Kleinstreuer NC Annotations for ToxCast and Tox21 High-Throughput Screening Assays: Facilitating Assay Interpretation and Data Use Society of Toxicology
2023 Wittwehr C, Chang X, Bisson W, Edwards SW, Ferguson S, Harrill A, Hogberg H, Karmaus AL, Leite SB, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O’Brien JM, Reinke E, Schmitt C, Tucker NN, Virvilis V Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions Society of Toxicology
2023 Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel A, Cooper S, Phillips J, McAfee E, Allen DG, Casey W, Kleinstreuer N Integrated Chemical Environment: An Advanced Platform Aiding NAM-based Chemical Assessments Society of Toxicology
2023 To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer NC DASS App: A Web Application for Applying Defined Approaches for Skin Sensitization to Predict Hazard and Potency Categorization Society of Toxicology
2023 Sakamuru S, Ma D, Pierro JD, Baker NC, Kleinstreuer N, Cali JJ, Knudsen TB, Xia M Development and Validation of Enzyme-Based CYP26A1 Inhibition Assay in a High-Throughput Screening Platform Society of Toxicology
2023 Ramaiahgari S, Krishna S, Kleinstreuer N, Liu J, Auerbach SS, Beverly B, Merrick BA, Berridge BR In Vitro Assessment of Environmental Chemical Hazards on Cardiovascular Diseases Society of Toxicology
2023 Rooney AA, Mansouri K, Bevington C, Hatlelid K, Helmick K, Blain R, Hannani A, Tracy W, Peppriell A, Cooney G, Sibrizzi C, Taylor K, Shipkowski K, Walker V An Informatics Approach to Inform a Class-Based Analysis of Health Effects Associated with Exposure to Organohalogen Flame Retardants Society of Toxicology
2023 Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer NC, Ko H, Matheson J, Thierse H, Truax J, Vanselow J, Strickland J Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency Society of Toxicology
2023 Kleinstreuer N Computational Crowdsourcing to Understand and Address Regulatory Needs: Case Studies for Prioritization of Environmental Chemicals Using AI/ML Approach Society of Toxicology
2023 Mansouri K Applications of Class-Based Approaches in Risk Assessment and Toxicological Research Society of Toxicology
2023 Daniel AB, van der Zalm AJ, Clippinger AJ, Kleinstreuer NC, Allen DG Three-Phase Testing of Agrochemical Formulations: Developing a Defined Approach for Eye Irritation Potential Society of Toxicology
2023 Medvedev A, Karmaus AL, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer NC, Casey W Mechanistic Insights from Profiling Chemical-Mediated Transcription Factor Transactivation with the Integration of Cytochrome P450 Metabolism Society of Toxicology
2023 Kleinstreuer N Human Biological Relevance: Topical Toxicity Case Studies Society of Toxicology
2023 Mansouri K, Martin T, Chang X, Williams A, Kleinstreuer N OPERA Models Supporting Regulatory Needs Society of Toxicology
2023 Moreira Filho J, Conway M, Schmitt C, Kleinstreuer N, Mansouri K Interpretable Chemical Grouping Using an Automated KNIME Workflow Society of Toxicology
2023 Chang X, Reinke EN, Daniel AB, Allen DG, Mumtaz MM, Kleinstreuer NC Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity Society of Toxicology
2023 Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JC, Erickson J, Combs P, Ferguson S, Kleinstreuer NC, Mansouri K Integrating Population Enzyme Variability into Physiologically Based Kinetic Models of Parent Chemicals and Metabolites Society of Toxicology
2023 Karmaus AL Leveraging In Vivo Variability to Assess Performance of Predictive Models and the Role of Reanalysis to Build Confidence via Consensus Society of Toxicology
2023 Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Allen DG, Kleinstreuer NC, Strickland J Validation of the Electrophilic Allergen Screening Assay (EASA) to Detect Substances That Impact the Initial Key Event in the Adverse Outcome Pathway for Skin Sensitization Society of Toxicology
2023 Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec D Application of Defined Approaches for Skin Sensitization for Chemicals of Federal Agency Interest Society of Toxicology
2023 Reinke EN, Corsini E, Ono A, Fukuyama T, Ashikaga T, Gerberick GF Peer Review Report of the EpiSensA Skin Sensitization Assay Society of Toxicology
2023 Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NC Applying In Silico Toxicity Models across the Tox21 Chemical Universe Society of Toxicology
2023 Hogberg-Durdock H, Lam A, Elan O, Shahbaz MA, Clerbaux L, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19 Society of Toxicology
2023 Eccles KM, Karmaus AL, Kleinstreuer NC, Parham F, Wambaugh JF, Messier KP Mapping a Path to Disease: Quantifying the Risk of Exposure to Environmental Chemical Mixtures via a Common Molecular Target Using a Geospatial Modeling Approach Society of Toxicology
2023 Krishna S, Chang X, Eccles KM, Messier K, Kleinstreuer NC Risk-Based, Geospatially Informed Prioritization of Potentially Cardiotoxic Chemicals Society of Toxicology
2023 Salminen AT, Davis KJ, Felton RP, Nischal N, VonTungeln LS, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho L Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro Society of Toxicology
2023 Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke E, Germolec D, Truax J, Allen D, Maxwell G, Kleinstreuer N The Skin Allergy Risk Assessment-Integrated Chemical Environment (SARA-ICE) Model for UN GHS Classification: An Evaluation and Application in Case Studies Society of Toxicology
2023 Kleinstreuer NC The Central Role of Computational Toxicology in Toxicology 2.0 Society of Toxicology
2022 Mansouri K, Martin T, Chang X, Allen D, Williams A, Kleinstreuer N OPERA Models to Support Regulatory Needs American Society for Cellular and Computational Toxicology
2022 Hull V, Borrel A, Karmaus AL, To K, Allen D, Kleinstreuer NC Integration of Technological Interference into the Interpretation of Curated High-throughput Screening (cHTS) Data American Society for Cellular and Computational Toxicology
2022 Karmaus AL, Daniel A, Hull V, Reinke E, Medvedev A, Allen D, Kleinstreuer NC, Casey W Investigating the Impact of Cytochrome P450 Metabolism on Chemical-mediated Transcription Factor Transactivation American Society for Cellular and Computational Toxicology
2022 Rogers B, Brown J, Allen D, Casey W, Clippinger A Progress Towards the Replacement of In Vivo Leptospirosis Vaccine Potency Testing in the United States American Society for Cellular and Computational Toxicology
2022 Moreira-Filho JT, Conway M, Schmitt C, Kleinstreuer N, Mansouri K Chemical Grouping Using an Automated KNIME Workflow: An Interpretable Machine Learning Approach American Society for Cellular and Computational Toxicology
2022 Hines D, Cook B, Hull V, Allen D, Dorne JLCM, Erickson J, Combs P, Ferguson S, Kleinstreuer N, Mansouri K Integrating Population Enzyme Variability Into Physiologically-based Kinetic Models of Parent Chemicals and Metabolites American Society for Cellular and Computational Toxicology
2022 Lee S, Li T, Liu Z, Tong W, Mansouri K, Kleinstreuer N Applying Deep Learning Toxicity Models Across the Chemical Universe American Society for Cellular and Computational Toxicology
2022 Strickland J, Abedini J, Allen D, Api AM, Germolec D, Gordon J, Hull V, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, To K, Truax J, Vanselow JT, Herzler M Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency and Support Weight-of-Evidence Assessments American Society for Cellular and Computational Toxicology
2022 Daniel A, Kleinstreuer N, Allen D, Glover K, Goralski T, Gough B, Schurdak M, Sprankle C, Tagle D, Williams M, Holmes A Facilitating Global Connections through the Microphysiological Systems for COVID Research (MPSCoRe) Working Group American Society for Cellular and Computational Toxicology
2022 van der Zalm AJ, Barroso J, Browne P, Casey W, Henry T, Kleinstreuer NC, Lowit A, Perron M, Clippinger AJ A Modern Framework to Establish Scientific Confidence in NAMs American Society for Cellular and Computational Toxicology
2022 Chang X, Palmer J, Donley E, Reinke E, Allen D, Kleinstreuer N In Vitro to In Vivo Extrapolation to Facilitate the Animal-free Risk Assessment of Potential Developmental Toxicants American Society for Cellular and Computational Toxicology
2022 To K, Karmaus A, Hull V, Allen D, Kleinstreuer N Characterizing the Impacts of Assay Design on Cytotoxic Concentration Range American Society for Cellular and Computational Toxicology
2022 Unnikrishnan A, Chang X, To K, Abedini J, Cook B, Hines D, McAfee E, Phillips J, Allen D, Kleinstreuer N ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure Scenarios American Society for Cellular and Computational Toxicology
2022 Bisson W, Mansouri K, Garner S, Arroyave W, Ewens A, Wang A, Jahnke G, Lunn R A Potential Novel Integrative Strategy for Read-Across to Evaluate Large Numbers of Nitro-Polycyclic Aromatic Hydrocarbons (NPAHs) for Cancer Hazard Evaluation American Society for Cellular and Computational Toxicology
2022 Ehrlich D, Krishna S, Kleinstreuer N Data-Driven Derivation of an Adverse Outcome Pathway Linking VEGF and Cardiotoxicity American Society for Cellular and Computational Toxicology
2022 Chang X, Bell S, Abedini J, Allen D, Kleinstreuer N Fit for Purpose Evaluation of In Vitro Assays for IVIVE FutureTox V
2022 Karmaus AL, Ceger P, Rooney J, Bell S, Allen D, Kleinstreuer N Developing In Vitro Assay Annotations to Provide Context and Facilitate Interpretation Toward Toxicological Endpoints FutureTox V
2022 Hines D, Abedini J, Allen D, Kleinstreuer N, Mansouri K Integrating Parameter Uncertainty in PBPK Modeling FutureTox V
2022 Mumtaz M, Chang X, Allen DG, Kleinstreuer N Application of In Vitro to In Vivo Extrapolation (IVIVE) to Informing In Vivo Point of Departure Society of Toxicology
2022 Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, Germolec D, Gehen S, Allen D, Kleinstreuer N Application of Defined Approaches for Skin Sensitization to Agrochemical Products Society of Toxicology
2022 Krishna S, Berridge B, Kleinstreuer NC High-Throughput Screening to Identify Chemical Cardiotoxic Potential Society of Toxicology
2022 Mansouri K, Choksi N, Chang X, Allen D, Kleinstreuer N OPERA Models for ADME Properties Society of Toxicology
2022 Ramaiahgari S, Krishna S, Parham F, Auerbach S, Kleinstreuer N, Beverley B, Merrick A, Berridge B A Comprehensive In Vitro Approach to Assess Environmental Chemical Hazard on Cardiovascular Diseases Society of Toxicology
2022 Ross A, Sedykh A, Gombar V, Kleinstreuer N, Merrick A, Shah R, Casey W OrbiTox: A Computational Translational Discovery Platform for Data Mining and Read-Across Society of Toxicology
2022 Hogberg H Ontogeny of Neurotransmitter Function as an Endpoint for Developmental Neurotoxicity Assessment Society of Toxicology
2022 Hogberg H Assay Gaps in the Developmental Neurotoxicity (DNT) New Approach Methodologies (NAMs) Battery for Human Health Risk Assessment Society of Toxicology
2022 Allen DG, Rooney J, To K, Choksi N, Ceger P, Daniel A, Karmaus AL, Strickland J, Truax J, Casey W, Kleinstreuer N Variability in Reference Test Method Data and the Impact on NAM Evaluations Society of Toxicology
2022 Krishna S, Chang X, Kleinstreuer N Applying IVIVE to Determine Margins of Exposure for Potentially Cardiotoxic Chemicals Society of Toxicology
2022 Karmaus A, Rooney J, Ceger P, Abedini J, Phillips J, Bell S, Allen DG, Kleinstreuer NC Providing Context to In Vitro High-Throughput Screening Data via Annotation and Visualization Tools Society of Toxicology
2022 Abedini J, Cook B, McAfee E, Phillips J, Rooney J, Allen DG, Mansouri K, Kleinstreuer NC ICE Tools to Support Chemical Evaluations Society of Toxicology
2022 Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Choksi N, Daniel A, Hines D, Karmaus AL, McAfee E, Phillips J, Allen DG, Casey W, Kleinstreuer NC Building Confidence in Alternative Methods through ICE Society of Toxicology
2022 Strickland J, To K, Matheson J, Germolec D, Allen DG, Api AM, Gordon J, Ko H, Thierse H, Truax J, Kleinstreuer NC, Herzler M Variability of Human Reference Data for Skin Sensitization Society of Toxicology
2022 Reynolds G, Reynolds J, Gilmour N, Strickland J, Germolec D, Truax J, Maxwell G, Kleinstreuer N Modification of the Skin Allergy Risk Assessment (SARA) Model for GHS Classification and Its Application to Isothiazolinone Case Studies Society of Toxicology
2022 Cook B, Abedini J, Bell S, Rooney J, McAfee E, Phillips J, Allen D, Kleinstreuer N Providing Context for Chemical Effects Through Compound Structure Similarity American Chemical Society 2022 Spring Meeting
2021 Karmaus A, Rooney J, Ceger P, Abedini J, Phillips J, Bell S, Allen D, Kleinstreuer N Annotating and Visualizing In Vitro Data to Gain Context American Society for Cellular and Computational Toxicology
2021 Bishop P, Mansouri K, Allen D, Casey W, Kleinstreuer N Acute Oral Toxicity Predictions for Environmental Risk Assessment American Society for Cellular and Computational Toxicology
2021 Abedini J, Cook B, McAfee E, Phillips J, Bell S, Rooney J, Allen D, Casey W, Kleinstreuer N Utilizing ICE Tools to Expand Chemical Knowledge: Chemical Quest American Society for Cellular and Computational Toxicology
2021 Allen D, Rooney J, Choksi N, Ceger P, Daniel A, Karmaus A, Strickland J, To K, Truax J, Casey W, Kleinstreuer N Establishing Confidence in NAMs: Considering Variability in Reference Test Methods American Society for Cellular and Computational Toxicology
2021 Mansouri K, Chang X, Allen D, Casey W, Kleinstreuer N QSAR Models Supporting Toxicokinetic Modeling and In Vitro to In Vivo Extrapolation American Society for Cellular and Computational Toxicology
2021 Krishna S, Beverley B, Walker V, Kleinstreuer N, Rooney A Systematic Evidence Mapping of Research on Environmental Exposures and Cardiovascular Disease American Society for Cellular and Computational Toxicology
2021 Krishna S, Borrell A, Huang R, Zhao J, Xia M, Kleinstreuer N High-throughput Screening to Predict hERG Inhibition American Society for Cellular and Computational Toxicology
2021 Chang X, Palmer J, Donley E, Allen D, Casey W, Kleinstreuer N In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Selected Tox21 Chemicals American Society for Cellular and Computational Toxicology
2021 Bell S, Ceger P, Fostel J, Holmgren S, Masci AM, Allen D, Casey W, Kleinstreuer N Accelerating Adoption of NAMs with FAIR Principles American Society for Cellular and Computational Toxicology
2021 Strickland J, Truax J, Corvaro M, Settivari R, Henriquez R, McFadden J, Gulledge T, Johnson V, Gehen S, Germolec D, Allen D, Kleinstreuer N Skin Sensitization Testing of Mixtures Without Animals American Society for Cellular and Computational Toxicology
2021 Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Hines D, Karmaus A, McAfee E, Phillips J, Allen D, Casey W, Kleinstreuer N Building Confidence in Alternative Methods Through ICE American Society for Cellular and Computational Toxicology
2021 Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M Compilation and Characterization of a Human Skin Sensitization Data Set American Society for Cellular and Computational Toxicology
2021 Hines D, Bell S, X Chang, K Mansouri, D Allen, W Casey, N Kleinstreuer Computational Support of Pharmacokinetic Models and In Vitro to In Vivo Extrapolation American Society for Cellular and Computational Toxicology
2021 Strickland J, Daniel A, Allen DG, Kleinstreuer N, Haugabrooks E International regulatory needs for acute toxicity data 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Kleinstreuer N Systematic evidence mapping of research on environmental exposures and cardiovascular disease 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Kleinstreuer N High-throughput screening to predict HERG inhibition 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Foster C, Wignall J, Kovach S, Choksi N, Allen D, Trgovcich J, Rochester J, Ceger P, Daniel A, Hamm J, Truax J, Blake B, McIntyre B, Sutherland V, Stout M, Kleinstreuer N Standardizing developmental toxicology study extractions using automated application of ontologies 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Hamm J, Allen DG, Ceger P, Flint T, Lowit A, O'Dell L, Tao J, Kleinstreuer N Performance of the GHS Mixtures Equation for predicting acute oral toxicity 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Sprankle CS, Abedini J, Bell S, Browning L, Daniel A, McAfee E, Phillips J, Allen DG, Kleinstreuer N Effective user support documentation for a toxicological data resource: ICE as a case study 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, Germolec D, Allen DG, Kleinstreuer N Application of defined approaches for skin sensitization to agrochemical products 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Rooney JP, Choksi N, Ceger P, Daniel A, Truax J, Allen DG, Kleinstreuer N Variability in the rabbit skin irritation assay 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Mansouri K OPERA, an open-source and open-data suite of QSAR models 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Ceger P, Allen DG, Choksi N, Daniel A, Eckel W, Hamm J, Harwood E, Johnson T, Kleinstreuer N, Sprankle C, Truax J, Lowit M Retrospective evaluation of the acute fish toxicity test for pesticide registration 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Karmaus AL, Mansouri K, Fitzpatrick J, Strickland J, Patlewicz G, Allen DG, Casey W, Kleinstreuer N Rat acute systemic toxicity testing: evaluating reproducibility and inherent variability 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Kleinstreuer N, Allen DG Developing a defined approach for eye irritation testing 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Allen DG, Rooney JP, Kleinstreuer N, Lowit A, Perron M Retrospective analysis of dermal triple pack data 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Chang X, Lumen A, Palmer J, Mansouri K, Lee UJ, Ceger P, Donley ELR, Bell S, Allen DG, Casey W, Kleinstreuer N In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Bell S, Abedini J, Chang X, Cook B, Hines D, Karmaus AL, McAfee E, Phillips J, Rooney J, Mansouri K, Allen DG, Casey W, Kleinstreuer N Improving alternative method adoption through tools and resources to support community knowledge 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Kleinstreuer N Building an AOP-driven defined approach guideline 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Kleinstreuer N Applying in vitro to in vivo extrapolation to NAM-derived PODs 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Karmaus AL, Hsieh J, Huang R, Shockley K, Paul-Friedman K, Judson R, Casey W, Kleinstreuer N, Sipes N Comparing and interpreting Tox21 data analysis approaches 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Kleinstreuer N A North American regulatory perspective on skin sensitization risk assessment 11th World Congress on Alternatives and Animal Use in the Life Sciences
2021 Chang X, Lumen A, Palmer J, Mansouri K, Lee UJ, Ceger P, Donley B, Bell S, Allen DG, Casey W, Kleinstreuer NC In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues Society for Birth Defects Research and Prevention
2021 Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen D, Kleinstreuer N Chemical exploration: providing biological context for NAMs QSAR 2021
2021 Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N Collaborative modeling project for predicting acute oral toxicity (CATMoS) QSAR 2021
2021 Abedini J, Bell S, Chang X, Choksi N, Cook B, Daniel AB, Hines D, Karmaus AL, Mansouri K, Allen D, Kleinstreuer N NICEATM computational tools and data resources QSAR 2021
2021 Mansouri K, Grulke C, Judson R, Richard A, Williams A, Kleinstreuer N Open-source QSAR-ready chemical structure standardization workflow QSAR 2021
2021 Kleinstreuer N Automated approaches to anchoring alternatives Society of Toxicology
2021 Ceger P, Allen DG, Choksi N, Daniel A, Eckel W, Hamm J, Johnson T, Kleinstreuer NC, Lowit M, Sprankle C, Truax J, Odenkirchen E Retrospective evaluation of the acute fish toxicity test for pesticide registration Society of Toxicology
2021 Strickland J, Daniel AB, Allen DG, Kleinstreuer NC, Haugabrooks E International regulatory needs for acute toxicity data Society of Toxicology
2021 Hamm J, Allen DG, Ceger P, Flint T, Kleinstreuer NC, O'Dell L, Tao JJ, Lowit A Predicting oral acute toxicity using the GHS additivity equation Society of Toxicology
2021 Cook B, Abedini JA, Bell S, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC Providing context for chemical effects through bioactivity and consumer use Society of Toxicology
2021 Abedini JA, Bell S, Chang X, Cook BT, Karmaus AL, Mansouri K, Allen DG, Kleinstreuer NC NICEATM computational tools and resources supporting alternative test method development and evaluation Society of Toxicology
2021 Mansouri K, Chang X, Judson R, Williams A, Allen DG, Kleinstreuer NC OPERA models for ADME properties and toxicity endpoints Society of Toxicology
2021 Allen DG, Rooney JP, Kleinstreuer NC, Lowit A, Perron M Retrospective analysis of dermal absorption triple pack data Society of Toxicology
2021 Rooney JP, Choksi N, Ceger P, Daniel AB, Truax J, Allen DG, Kleinstreuer NC Variability in the rabbit skin irritation assay Society of Toxicology
2021 Daniel AB, Abedini JA, Bell S, Chang X, Cook B, Karmaus AL, Hines DE, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC Updates to the Integrated Chemical Environment: expanding tools and data to support toxicity assessments Society of Toxicology
2021 Kleinstreuer N International regulatory progress on nonanimal approaches for skin sensitization Society of Toxicology
2020 Lowit M, Ceger P, Allen D, Arnold E, Choksi N, Daniel A, Hamm J, Judkins D, Kleinstreuer N, Montague B, Sprankle C, Truax J, Odenkirchen E Exploring ways to reduce animal testing in support of the registration of pesticides by the U.S. Environmental Protection Agency SETAC North America
2020 Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N International computational modeling collaborations for predictive toxicology SETAC North America
2020 Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley E, Bell S, Allen D, Kleinstreuer N In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues American Society for Cellular and Computational Toxicology
2020 Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen E, Kleinstreuer N Chemical exploration: identifying bioactivity with the use of structural features American Society for Cellular and Computational Toxicology
2020 Rooney JP, Choksi N, Ceger P, Daniel A, Truax J, Rai R, Kleinstreuer N, Allen D Variability in the rabbit skin irritation assay American Society for Cellular and Computational Toxicology
2020 Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N Collaborative modeling project for predicting acute oral toxicity (CATMoS) American Society for Cellular and Computational Toxicology
2020 Abedini J, Bell S, Mansouri K, McAfee E, Phillips J, Chang X, Karmaus AL, Cook B, Allen D, Casey W, Kleinstreuer N NICEATM computational tools and resources supporting alternative test method development and evaluation American Society for Cellular and Computational Toxicology
2020 Rooney J, Lizarraga L, Yamada T, Allen D, Babich M, Daniel A, Fitzpatrick S, Garcia-Reyero N, Gordon J, Hakkinen P, Karmaus A, Kleinstreuer N, Matheson J, Mumtaz M, Rua D, Ruiz P, Scarano L, Volarath P, Patlewicz G ICCVAM Read-Across Workgroup: towards guiding principles for read-across applications American Society for Cellular and Computational Toxicology
2020 Borba J, Braga R, Alves V, Muratov E, Kleinstreuer N, Tropsha A, Andrade C Pred-Skin: a web portal for accurate prediction of human skin sensitizers American Society for Cellular and Computational Toxicology
2020 Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D Testing of agrochemical formulations using in vitro and ex vivo eye irritation test methods American Society for Cellular and Computational Toxicology
2020 Bell S, Abedini J, Ceger P, Karmaus A, Daniel A, Choksi N, Rooney J, Allen D, Kleinstreuer N Providing insight into chemical activity through data curation and assay annotation American Society for Cellular and Computational Toxicology
2020 Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M Human reference database for skin sensitization American Society for Cellular and Computational Toxicology
2020 Foster C, Wignall J, Kovach S, Trgovcich J, Varghese A, Rochester J, Stout M, Kleinstreuer NC Automated applications of ontologies to standardize developmental toxicology study extraction Society for Birth Defects Research and Prevention
2020 Chang X, Lumen A, Palmer J, Lee U, Ceger P, Donley B, Bell S, Allen D, Casey W, Kleinstreuer NC In vitro to in vivo extrapolation for developmental toxicity potency of valproate analogues Society for Birth Defects Research and Prevention
2020 Kleinstreuer N Establishing international test guidelines for skin sensitization: predictive capacity and applicability domain of nonanimal defined approaches Society of Toxicology
2020 Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley B, Bell S, Allen DG, Casey W, Kleinstreuer NC In vitro to in vivo extrapolation for developmental toxicity potency of valproate analogues Society of Toxicology
2020 Kleinstreuer N Computational crowdsourcing: leveraging global expertise to predict toxicity Society of Toxicology
2020 Rooney JP, Choksi N, Rai R, Allen DG, Kleinstreuer NC, Casey W Variability in the rabbit skin irritation assay Society of Toxicology
2020 Casey W Modernizing the NTP carcinogenicity testing program Society of Toxicology
2020 Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Allen DG, Casey W, Kleinstreuer NC Collaborative modeling project for predicting acute oral toxicity Society of Toxicology
2020 Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen DG Developing a defined approach for eye irritation testing Society of Toxicology
2020 Strickland J, Allen DG, Api A, Gordon J, Kleinstreuer NC, Ko H-S, Matheson J, Thierse H-J, Truax J, Herzler M Classification of human reference data for skin sensitization Society of Toxicology
2020 Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC NICEATM computational tools and resources supporting alternative test method development and evaluation Society of Toxicology