Past Webinars & Workshops - NICEATM

Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials.

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Listing of all past events
Date	Event	Event Type	Materials
Oct 11, 2023	Workshop - Trust Your Gut: Establishing Confidence in Gastrointestinal Models	Webinars & Workshops - NICEATM	Agenda Meeting Materials Workshop - Trust Your Gut: Establishing Confidence in Gastrointestinal Models Meeting Materials October 11-12, 2023 Meeting Webpage
Oct 06, 2023	Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 3: Evaluating Potential Allergenicity	Webinars & Workshops - NICEATM	Agenda Meeting Materials Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 3: Evaluating Potential Allergenicity Meeting Materials October 6, 2023 Webpage
Sep 20, 2023	Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 2: Microbiome Effects on Toxicity	Webinars & Workshops - NICEATM	Agenda Meeting Materials Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 2: Microbiome Effects on Toxicity Meeting Materials September 20, 2023 Webpage
Sep 18, 2023	Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 1: Absorption and Pharmacokinetics	Webinars & Workshops - NICEATM	Agenda Meeting Materials Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 1: Absorption and Pharmacokinetics Meeting Materials September 18, 2023 Webpage
May 31, 2023	Workshop: From Research to Readiness: Advancing Research and Regulatory Acceptance of Microphysiological Systems for Infectious Disease Applications	Webinars & Workshops - NICEATM	Meeting Webpage
Oct 26, 2022	Symposium Webinar: Using New Approach Methodologies to Address Variability and Susceptibility Across Populations	NICEATM	Meeting Webpage
Mar 09, 2022	Webinar: Opportunities and New Approaches for Quantitative Risk Assessment	Webinars & Workshops - NICEATM	Meeting Webpage
Sep 30, 2020	Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing	NICEATM	Agenda Final Documents Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing Final Documents September 30, 2020 Abstracts for all presentations Publications developed from the symposium: Lowe et al. 2021. Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies. https://doi.org/10.1016/j.yrtph.2021.105073. Tan et al. 2021. Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment. https://doi.org/10.1016/j.yrtph.2021.105070 Presentations Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing Presentations September 30, 2020 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials.
Oct 30, 2019	Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Lethality	NICEATM	Agenda Final Documents Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Lethality Final Documents October 30-31, 2019 Workshop report (ALTEX)
Oct 25, 2018	Webinar Series on the Utility of Zebrafish Models for Toxicology	Webinars & Workshops - NICEATM	Presentations Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations October 25, 2018 Robert Tanguay, Ph.D., Distinguished Professor of Molecular Toxicology, Department of Environmental and Molecular Toxicology, Oregon State University Presentation: AHR Gene Duplication
Oct 16, 2018	Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond	Webinars & Workshops - NICEATM	Meeting Website
Sep 27, 2018	Webinar Series on the Utility of Zebrafish Models for Toxicology	Webinars & Workshops - NICEATM	Presentations Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations September 27, 2018 Michael Carvan, Ph.D., Shaw Professor, School of Freshwater Sciences, University of Wisconsin-Milwaukee Presentation: Transgenerational Inheritance
Sep 18, 2018	Workshop: The Monocyte Activation Test for Pyrogen Testing of Medical Devices	Webinars & Workshops - NICEATM	Meeting Webpage
Apr 11, 2018	Workshop: Predictive Models for Acute Oral Systemic Toxicity	Webinars & Workshops - NICEATM	Agenda Final Documents Workshop: Predictive Models for Acute Oral Systemic Toxicity Final Documents April 11-12, 2018 Workshop report (Computational Toxicology) Presentations Workshop: Predictive Models for Acute Oral Systemic Toxicity Presentations April 11-12, 2018 Opening Session Welcome and Introductions Nicole Kleinstreuer, NIEHS/NICEATM Implementation of Non-animal Approaches for Acute Systemic Toxicity Grace Patlewicz, U.S. Environmental Protection Agency (EPA) National Center for Computational Toxicology Amended TSCA: EPA's Strategic Plan to Promote the Development and Implementation of Alternative Test Methods Louis Scarano, EPA Office of Pollution Prevention and Toxics (OPPT) Regulatory Needs and Decision Contexts for Acute Oral Systemic Toxicity Data Emily Reinke, U.S. Department of Defense (DoD) Rat Oral Acute Toxicity Database and Variability Agnes Karmaus, ILS Collaborative Modeling Efforts for the Acute Oral Systemic Toxicity Endpoints Kamel Mansouri, ILS In Silico Approaches for Acute Oral Toxicity: Session 1 NTP Collaboration on Modeling Acute Systemic Oral Toxicity: Results and Ideas Eugene Muratov, University of North Carolina, Chapel Hill Modeling Quantitative Acute Oral Systemic Toxicity Based on a k-Nearest Neighbor (k-NN) Algorithm Alessandra Roncaglioni, Instituto di Ricerche Farmacologiche "Mario Negri" Practical Considerations for Estimation of Oral Rat LD50 Todd Martin, EPA Office of Research and Development UL Cheminformatics Suite Thomas Luechtefeld, Underwriters Laboratories Mechanistic Profiling and Mentored Machine Learning: Application to Acute Toxicity Dan Wilson, The Dow Chemical Company In Silico Approaches for Acute Oral Toxicity: Session 2 Multitask Deep Learning Modelling of Rodent Acute Toxicity Alexey Zakharov, National Center for Advancing Translational Sciences Leadscope Predictive Models for Acute Oral Systemic Toxicity Glenn Myatt, Leadscope, Inc. A Clustering-based QSAR Model for Acute Oral Systemic Toxicity Zhen Zhang, Dow Agrosciences Consensus Approach for Modeling Acute Systemic Oral Toxicity and LD50 Data Using Machine Learning and In Silico Approaches Ahmed Sayed, Rosettastein Consulting Predicting Five Rat Acute Toxicity Endpoints with ANNE Models Michael Lawless, Simulations Plus, Inc. Wrap-up of Day One Donald Cronce, DoD End User Applications Overview of the U.S. Strategic Roadmap Anna Lowit, EPA Office of Pesticide Programs (OPP) Perspective on the U.S. Army's Uses for Predictive Models of Acute Oral Toxicity Lyle Burgoon, U.S. Army Engineer Research and Development Center End User Applications: OECD Landscape Kristie Sullivan, Physicians Committee for Responsible Medicine Predictive Models for Acute Oral Systemic Toxicity Workshop: End User Application Jeffery Gearhart, U.S. Air Force School of Aerospace Medicine End User Applications: EPA Office of Pesticide Programs Edward Odenkirchen, EPA OPP Acute Oral Systemic Toxicity Modeling: End User Applications Lawrence Milchak, 3M Corporation End User Applications: EPA Office of Pollution Prevention and Toxics Louis Scarano, EPA OPPT Breakout Group Sessions Charge to the Breakout Groups Nicole Kleinstreuer, NIEHS/NICEATM Summary of Breakout Group A: Practical Applications David Allen, ILS Summary of Breakout Group B: Interpretation, Characterization, and Extension Grace Patlewicz, EPA NCCT Closing Remarks Nicole Kleinstreuer, NIEHS/NICEATM Videos Workshop: Predictive Models for Acute Oral Systemic Toxicity Videos April 11, 2018 Webcast recordings on NIH Videocast website: Day 1 (6 hours, 23 minutes) Day 2 (3 hours, 14 minutes) Meeting Webpage
Nov 02, 2017	Public Meeting: Alternative Test Methods to Reduce Vertebrate Animal Testing Under the Toxic Substances Control Act	Webinars & Workshops - NICEATM	Videos Public Meeting: Alternative Test Methods to Reduce Vertebrate Animal Testing Under the Toxic Substances Control Act Videos November 2, 2017 View recording of plenary session webcast on National Institutes of Health Videocast site
Aug 20, 2017	Towards Global Elimination of the Acute Toxicity "Six-Pack"	Webinars & Workshops - NICEATM	Agenda
Jun 26, 2017	Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine	Webinars & Workshops - NICEATM	Agenda Final Documents Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Final Documents June 26-27, 2017 Workshop report (Drug Discovery Today) Meeting Materials Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Meeting Materials June 26-27, 2017 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Presentations Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Presentations June 26-27, 2017 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Meeting Webpage
Mar 02, 2017	Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: A Review of Relevant Ontologies and Application of Reasoners	Webinars & Workshops - NICEATM	Presentations Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: A Review of Relevant Ontologies and Application of Reasoners Presentations March 2, 2017 Melissa Haendel, Ph.D., Director, Ontology Development Group, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University Presentation: A Review of Relevant Ontologies and Application of Reasoners
Mar 02, 2017	Webinar Series on the Utility of Zebrafish Models for Toxicology	Webinars & Workshops - NICEATM	Presentations Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations March 2, 2017 John Postlethwait, Ph.D., Professor of Biology, Institute of Neuroscience, University of Oregon Presentation: Genome Duplication
Feb 16, 2017	Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Ontologies 101	Webinars & Workshops - NICEATM	Presentations Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Ontologies 101 Presentations February 16, 2017 Lyle Burgoon, Ph.D., Leader, Bioinformatics and Computational Toxicology Group, U.S. Army Engineer Research and Development Center Presentation: Ontology 101: An Introduction
Feb 02, 2017	Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Introduction to Zebrafish Screening	Webinars & Workshops - NICEATM	Presentations Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Introduction to Zebrafish Screening Presentations February 2, 2017 Nigel Walker, Ph.D., Deputy Division Director for Research, National Toxicology Program Presentation: An Overview of SEAZIT David Reif, Ph.D., Associate Professor, Bioinformatics Research Center and Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University Presentation: Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish Jon Hamm, Ph.D., Senior Staff Toxicologist, Integrated Laboratory Systems, Inc. Presentation: SEAZIT: Current and Proposed Activities
Sep 22, 2016	Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements	Webinars & Workshops - NICEATM	Final Documents Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements Final Documents September 22-23, 2016 Workshop report (Toxicology In Vitro) Presentations Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements Presentations September 22-23, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials.
Sep 08, 2016	Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches	Webinars & Workshops - NICEATM	Final Documents Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Final Documents September 8, 2016 Webinar series and workshop report (Toxicology In Vitro) Presentations Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Presentations September 8, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Videos Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Videos September 8, 2016 Webinar recording (YouTube) Meeting Webpage
Jul 12, 2016	Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways	Webinars & Workshops - NICEATM	Final Documents Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Final Documents July 12, 2016 Webinar series and workshop report (Toxicology In Vitro) Presentations Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Presentations July 12, 2016 Mathieu Vinken, Ph.D., Free University of Brussels (PISC website) Barbara Buckley, Ph.D., U.S. Environmental Protection Agency (PISC website) Videos Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Videos July 12, 2016 Webinar recording (YouTube) Meeting Webpage
Jun 28, 2016	Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity	Webinars & Workshops - NICEATM	Final Documents Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Final Documents June 28, 2016 Webinar series and workshop report (Toxicology In Vitro) Presentations Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Presentations June 28, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Videos Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Videos June 28, 2016 Webinar recording (YouTube) Meeting Webpage
May 26, 2016	Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods	Webinars & Workshops - NICEATM	Final Documents Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Final Documents May 26, 2016 Webinar series and workshop report (Toxicology In Vitro) Presentations Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Presentations May 26, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Videos Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Videos May 26, 2016 Webinar recording (YouTube) Meeting Webpage
Apr 26, 2016	Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods	Webinars & Workshops - NICEATM	Final Documents Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Final Documents April 26, 2016 Webinar series and workshop report (Toxicology In Vitro) Presentations Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Presentations April 26, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Videos Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Videos April 26, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Meeting Webpage
Mar 29, 2016	Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing	Webinars & Workshops - NICEATM	Final Documents Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Final Documents March 29, 2016 Webinar series and workshop report (Toxicology In Vitro) Presentations Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Presentations March 29, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Videos Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Videos March 29, 2016 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials. Meeting Webpage
Feb 17, 2016	In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making	Webinars & Workshops - NICEATM	Agenda Final Documents In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Final Documents February 17-18, 2016 Workshop Report (Toxicology In Vitro) Meeting Materials In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Meeting Materials February 17-18, 2016 Presentation Abstracts Breakout Group Questions Poster Abstracts Speaker Biographies Presentations In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Presentations February 17-18, 2016 Workshop Presentations Opening Session Welcome Warren Casey, NIEHS/NICEATM The EURL ECVAM Toxicokinetics Report and EURL ECVAM Strategy Alicia Paini, European Union Reference Laboratory for Alternatives to Animal Testing Workshop Background and Summaries of Webinars John Wambaugh, U.S. Environmental Protection Agency (EPA) Session 1: Application in Risk Assessment: What Do We Need for Decision-making and Prioritization? Using In Vitro Data in Quantitative Risk Assessments (QRAs) Paul Price, EPA Interindividual Variability in High Throughput Risk Prioritization of Environmental Chemicals Caroline Ring, EPA Quantitative Considerations of Dose-Response for IVIVE Ted Simon, Ted Simon LLC Toxicokinetics in Risk Assessment: From Predictive Evaluations to Regulatory Testing Mike Bartels, The Dow Chemical Company Development and Application of Biologically Based Dose-Response Modeling for Pregnancy Conditions: Evaluation of Thyroid Active Chemical Exposure During Sensitive Life Stages Annie Lumen, U.S. Food and Drug Administration Session 2: Metabolism and Excretion Strength and Limitations of In Vitro Xenobiotic Metabolism Assays and In Silico Models Stephen Ferguson, NIEHS In Silico Screening of Primary Clearance Mechanisms John Troutman, The Procter & Gamble Company In Vitro Models for Quantitative Prediction of Hepatobiliary Clearance Kim Brouwer, University of North Carolina at Chapel Hill Session 3: In Silico Modeling Predictive Power of PBPK Modeling and In Silico/In Vitro-In Vivo Extrapolation Using GastroPlus™ and ADMET Predictor™ Software Tools Grazyna Fraczkiewicz, Simulations Plus, Inc. In Vitro In Vivo Extrapolation and its Applications in Predicting Pharmacokinetic Population Variability Alice Ke, SimCyp, a Certara Company Summary Presentations Day 1 Wrap-up Barbara Wetmore, ScitoVation, LLC Breakout Group Summary Webinar Materials October 7: Setting the Stage: Purpose, Definitions, Scope, and Assumptions Barbara Wetmore, Ph.D., The Hamner Institutes for Health Sciences October webinar slides Wetmore bio November 4: Building Fit-for-purpose Pharmacokinetic Models John Wambaugh, Ph.D., National Center for Computational Toxicology, U.S. Environmental Protection Agency November webinar slides Wambaugh bio December 3: The Role of Pharmacokinetic Model Evaluation Lisa Sweeney, Ph.D., Naval Medical Research Unit Dayton and Jackson Foundation for the Advancement of Military Medicine December webinar slides December webinar abstract Sweeney bio January 6: Framework for Establishing an Internal Threshold of Toxicological Concern Corie Ellison, Ph.D., Sharon Woods Innovation Center, The Procter & Gamble Company January webinar slides January webinar abstract Ellison bio
Jan 06, 2016	Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Framework for Establishing an Internal Threshold of Toxicological Concern	Webinars & Workshops - NICEATM	Meeting Materials Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Framework for Establishing an Internal Threshold of Toxicological Concern Meeting Materials January 6, 2016 Corie Ellison, Ph.D., Sharon Woods Innovation Center, The Procter & Gamble Company January webinar slides January webinar abstract Ellison bio
Dec 03, 2015	Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: The Role of Pharmacokinetic Model Evaluation	Webinars & Workshops - NICEATM	Meeting Materials Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: The Role of Pharmacokinetic Model Evaluation Meeting Materials December 3, 2015 Lisa Sweeney, Ph.D., Naval Medical Research Unit Dayton and Jackson Foundation for the Advancement of Military Medicine December webinar slides December webinar abstract Sweeney bio
Nov 04, 2015	Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Building Fit-for-purpose Pharmacokinetic Models	Webinars & Workshops - NICEATM	Meeting Materials Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Building Fit-for-purpose Pharmacokinetic Models Meeting Materials November 4, 2015 John Wambaugh, Ph.D., National Center for Computational Toxicology, U.S. Environmental Protection Agency November webinar slides Wambaugh bio
Oct 07, 2015	Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Setting the Stage: Purpose, Definitions, Scope, and Assumptions	Webinars & Workshops - NICEATM	Meeting Materials Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Setting the Stage: Purpose, Definitions, Scope, and Assumptions Meeting Materials October 7, 2015 Barbara Wetmore, Ph.D., The Hamner Institutes for Health Sciences October webinar slides Wetmore bio
Sep 24, 2015	Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing	Webinars & Workshops - NICEATM	Agenda Final Documents Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Final Documents September 24-25, 2015 Workshop report (Toxicology in Vitro) Presentations Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Presentations September 24-25, 2015 Session 1: The Regulatory Landscape: When Is Acute Toxicity Data Required and How Is It Used? U.S. Consumer Product Safety Commission Joanna Matheson, Ph.D., Directorate for Health Sciences, U.S. Consumer Product Safety Commission Acute Toxicity Testing: Office of Pesticide Programs Elissa Reaves, Ph.D., Office of Pesticide Programs, U.S. Environmental Protection Agency (EPA) Requirements and Evaluation of Toxicity Testing in the TSCA New Chemicals Program Louis Scarano, Ph.D., Office of Pollution Prevention and Toxics, EPA Session 2: State of the Science for Acute Toxicity Testing Methods Alternative Methods for Acute Systemic Toxicity Testing Rabea Graepel, Ph.D., Systems Toxicity Unit, European Union Reference Laboratory for Alternatives to Animal Testing From QSAR to Big Data: Developing Mechanism-Driven Predictive Models for Animal Toxicity Hao Zhu, Ph.D., Department of Chemistry, Rutgers University-Camden Biokinetic Considerations in the Use of In Vitro Systems for Estimating Acute (Systemic) Toxicity Bas Blaauboer, Institute for Risk Assessment Sciences, Utrecht University NRC Report: Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense David Dorman, D.V.M., Ph.D., Department of Molecular Biosciences, North Carolina State University Session 3: Case Studies Vision for Animal-free Pesticide Formulation Assessments Sean Gehen, Ph.D., Dow AgroSciences LLC Predicting Acute Toxicity Hazard in the Absence of Experimental Data: Case Studies from the Alternatives Assessment Paradigm Jay Tunkel, Ph.D., SRC, Inc. Zebrafish Models for Human Organophosphorus Poisoning Natalia Garcia-Reyero, Ph.D., U.S. Army Engineer R&D Center, U.S. Army Corps of Engineers Session 4: Looking Ahead: Mechanisms and Adverse Outcome Pathways Mechanisms of Acute Toxicity Dan Wilson, Ph.D., The Dow Chemical Company Computationally Predicted AOPs Shannon Bell, Ph.D., Integrated Laboratory Systems, Inc. High-throughput In Vitro Assays at NCATS Menghang Xia, Ph.D., Division of Preclinical Innovation, National Center for Advancing Translational Sciences
Sep 03, 2014	Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation	Webinars & Workshops - NICEATM	Agenda Final Documents Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Final Documents September 3-5, 2014 Group Discussion Summaries Breakout Group 1: The Process of Regulatory Acceptance Breakout Group 2: Using AOPs for Regulatory Decisions: Confidence and Criteria Breakout Group 3: Taking Qualitative AOPs to the Next (Quantitative) Level Other Documents Workshop Report (Regulatory Toxicology and Pharmacology) Presentations Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Presentations September 3-5, 2014 Workshop Presentations Opening Session Welcome Warren Casey, NIEHS/NICEATM Innovation in Toxicology at NCATS Christopher Austin, U.S. National Center for Advancing Translational Sciences From Mode of Action to Adverse Outcome Pathways: Moving Towards Regulatory Applicability Bette Meek, University of Ottawa What is an AOP (and What ISN’T It?) Donna Mendrick, U.S. Food and Drug Administration (FDA) Session 1: Building Upon Other Efforts AOP Activities at the OECD Joop de Knecht, Organisation for Economic Co-operation and Development (OECD) AOP Knowledge Base/Wiki Tool Set Steven Edwards, U.S. Environmental Protection Agency (EPA) Outcomes from the March Somma Lombardo Workshop Edward Perkins, U.S. Army Session 2: AOPs Under Development Embryonic Vascular Disruption and Adverse Prenatal Outcomes Nicole Kleinstreuer, ILS/NICEATM Using Adverse Outcome Pathway Analysis to Identify Gaps in High-Throughput Screening for Thyroid Disruption Katie Paul, Bayer CropScience Application of the Adverse Outcome Pathway (AOP) Concept to Neurotoxicology: A Challenging Approach Ellen Fritsche, IUF Dusseldorf AOP Development: After the Heights of the Mountains – the Hardship of the Plains; the Example of Liver Fibrosis Brigitte Landesmann, European Commission Joint Research Center (JRC) Fish Early Life Stage: Developing AOPs to Support Targeted Reduction and Replacement Dan Villeneuve, EPA Adverse Outcome Pathway for Effects of Anticoagulant Rodenticides on Predatory Birds Barnett Rattner, U.S. Geological Survey, U.S. Department of the Interior Adverse Outcome Pathway (AOP) for Sustained Aryl Hydrocarbon Receptor Activation Leading to Rodent Liver Tumor Promotion Ted Simon, Ted Simon LLC Developing AOPs from PPAR Activation Leading to Reproductive Toxicity Malgorzata Nepelska, European Union Joint Research Centre Framework for Computationally-Predicted AOPs Shannon Bell, EPA Session 3: Case Studies: Regulatory Uses for Well-Identified AOPs Testing of the Predictive Power and Robustness of an AOP Construct for Bile Salt Export Pump Inhibition to Cholestatic Injury Mathieu Vinken, Vrije Universiteit Brussel An Adverse Outcome Pathway (AOP) Framework for Screening for Potential Endocrine Disruption David Dix, EPA AOPs and Regulatory Decisions: Problem Formulation, Development and Acceptance Rita Schoeny, EPA Identifying Integrated In Vitro/In Silico Testing Strategies (IATA/ITS) by Mapping to the Skin Sensitization AOP Joanna Matheson, U.S. Consumer Product Safety Commission Session 4: The Risk Context Exposure and Dosimetry Considerations for AOPs John Wambaugh, EPA Ozone-Induced Lung Inflammation and Injury: From Mechanism to Adversity in Humans Robert Devlin, EPA Suspected Modes of Action Affected by Pesticides Exposure: Informing an Adverse Outcomes Pathway (AOP) for Cancer Michael Alavanja, U.S. National Cancer Institute Breakout Groups Group 1: The Process of Regulatory Acceptance Breakout Group Summary Presentation David Dix, EPA, and Craig Rowlands, The Dow Chemical Company AOP Development Processes in OECD and Regulatory Agency Acceptance Working Group of National Coordinators, OECD Test Guidelines Programme Christine Olinger and Melissa Panger, EPA How Do We Establish Scientific Confidence in AOPs? Rick Becker, American Chemistry Council Regulatory Acceptance: How to Strengthen Protection of Susceptible Populations in AOP Approaches Ruthann Rudel, Silent Spring Institute Group 2: Using AOPs for Regulatory Decisions: Confidence and Criteria Breakout Group Summary Presentation Suzanne Fitzpatrick, FDA, and Annie Jarabek, EPA Contaminants in the Food Supply: How the AOP Concept Can Help Regulators Make Decisions Using Arsenic as a Case Study Christina Powers, EPA Decision Analytic Approach to Advance Application of AOPs in Risk Assessment: Characterization Criteria to Establish Confidence Annie Jarabek, EPA Using Evidence-Based Toxicology to Evaluate AOPs Thomas Hartung, Center for Alternatives to Animal Testing, Johns Hopkins University Group 3: Taking Qualitative AOPs to the Next (Quantitative) Level Breakout Group Summary Presentation Nicole Kleinstreuer, ILS/NICEATM, and Kristie Sullivan, Physicians Committee for Responsible Medicine A Quantitative AOP for Skin Sensitization Gavin Maxwell, Unilever A Conceptual Model that Enables Quantitative Integration of Data Into an AOP Catherine Willett, Humane Society of the United States Applying Semantic and Network Methods in AOP Knowledge David Wild, University of Indiana School of Informatics and Computing Presentations by Junior Investigators with Outstanding Poster Abstracts Quantitative Weight of Evidence Model for Assessing Adverse Outcome Pathways Dasha Agoulnik, University of Massachusetts Lowell/U.S. Army Engineer Research and Development Center Developmental Neurotoxicity of Epigallocatechin Gallate by Interference With beta-1-Integrin Function: A Novel AOP Framework Supporting Neurodevelopmental Toxicity Research and Risk Assessment Marta Barenys, Liebniz Research Institute of Environmental Medicine Cross-Species Extrapolation of an Adverse Outcome Pathway for Ecdysteroid Receptor Activation Carlie LaLone, EPA Short-Term Atrazine Exposure Alters the Plasma Metabolome of Male C57BL/6 Mice and Disrupts Specific Metabolic Pathways Zhoumeng Lin, University of Georgia Hands-On Demonstration/Training Entering an AOP into the OECD Wiki Stephen Edwards, EPA Introduction to Effectopedia Hristo Aladjov, OECD Videos Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Videos September 3, 2014 Videocasts of Workshop Plenary Sessions on NIH Website Day 1 (Wednesday, Sept. 3) Day 2 (Thursday, Sept 4) Day 3 (Friday, Sept 5)
Aug 24, 2014	Workshop on Alternatives to the HIST for Acellular Pertussis Vaccines: Progress and Challenges in the Replacement of HIST	Webinars & Workshops - NICEATM	Agenda Final Documents Workshop on Alternatives to the HIST for Acellular Pertussis Vaccines: Progress and Challenges in the Replacement of HIST Final Documents August 24, 2014 Workshop Report (Pharmeuropa Bio Scientific Notes) Meeting Materials Workshop on Alternatives to the HIST for Acellular Pertussis Vaccines: Progress and Challenges in the Replacement of HIST Meeting Materials August 24, 2014 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials.
May 05, 2014	Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology	Webinars & Workshops - NICEATM	Agenda Final Documents Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology Final Documents May 5-6, 2014 Workshop Report (ALTEX) Meeting Materials Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology Meeting Materials May 5-6, 2014 Speaker Biosketches Poster Presentation Abstracts Presentations Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology Presentations May 5-6, 2014 Opening Session Abstracts Session 1: Cardiovascular Toxicity (abstracts) Session 2: Developmental Processes in Toxicity and Disease (abstracts) Session 3: Emerging Technologies (abstracts) Session 4: Models of Neurobehavior and Neurotoxicity (abstracts) Session 5: Predicting Alterations to the Immune System (abstracts) Session 6: Emerging Issues (abstracts)
Nov 28, 2012	International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward	Webinars & Workshops - NICEATM	Agenda Final Documents International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward Final Documents November 28-29, 2012 Workshop Report (Biologicals) Workshop Summary Presentations International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward Presentations November 28-29, 2012 Supplemental materials for some events, meetings, and workshops prior to 2022 have been archived. These archived materials frequently include presentations, background materials, and public comments. Email us or use our contact form to request a list or copy of archived materials.
Sep 19, 2012	International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward	Webinars & Workshops - NICEATM	Agenda Final Documents International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward Final Documents September 19-21, 2012 Workshop Proceedings (Biologicals) Workshop Summary Meeting Materials International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward Meeting Materials September 19-21, 2012 Breakout Group Questions Poster Session Abstracts Alt DP, et al. Evaluation of Ocular Exposure to Leptospira borgpetersenii Serovar Hardjo in the Golden Syrian Hamster Wilson-Welder J, Alt DP. Evaluation of Bovine Neutrophil Activation by Leptospira Presentations International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward Presentations September 19-21, 2012 Opening Session Welcoming Remarks and Introduction to ICATM Organizations William Stokes, DVM, RADM, USPHS, NIEHS/NICEATM Workshop Overview and Objectives Richard McFarland, PhD, MD, Center for Biologics Evaluation and Research, U.S. FDA View presentation Welcome and Introduction to CVB Richard Hill, DVM, MS, Center for Veterinary Biologics, USDA Session 1: Overview of Public Health Needs, Regulatory Requirements, and Research Initiatives for Leptospira Vaccine Potency Testing Leptospirosis: Public Health Perspectives Marta A. Guerra, MPH, DVM, PhD, Bacterial Special Pathogens Branch, CDC Leptospirosis: Animal Health Perspectives Ronald D. Schultz, MS, PhD, University of Wisconsin–Madison, USA USDA Regulatory Guidelines and Practices for Veterinary Leptospira Vaccine Potency Testing Geetha B. Srinivas, DVM, PhD, Center for Veterinary Biologics, USDA European Regulatory Framework and Practices for Veterinary Leptospira Vaccine Potency Testing Lukas Bruckner, DVM, Institute of Virology and Immunoprophylaxis, Switzerland Next-Generation Human Leptospira Vaccines Albert Ko, MD, Yale School of Public Health, USA Current NIH Research in Human Leptospira Vaccines Joseph J. Breen, PhD, Bacteriology and Mycology Branch, National Institute of Allergy and Infectious Diseases, NIH, USA Session 2: In Vitro Replacement Alternatives for Potency Testing of Leptospira Vaccines: Development, Validation, and Implementation Development of In Vitro Assays for Measuring Relative Potencies of Leptospiral Bacterins Containing Serovars Pomona, Canicola, Grippotyphosa, and Icterohaemorrhagiae Kevin W. Ruby, MS, PhD, Center for Veterinary Biologics, USDA Validation of Monovalent Leptospira Reference Bacterins for In Vitro Potency Testing: Host Efficacy Trials Carole Bolin, DVM, PhD, College of Veterinary Medicine, Michigan State University, USA Product-Specific Validation of an In Vitro Assay for Leptospira Potency Testing: An Industry Perspective (1) Brett Webster, Boehringer Ingelheim Vetmedica, USA Product-Specific Validation of an In Vitro Assay for Leptospira Potency Testing: An Industry Perspective (2) Jeffrey Galvin, PhD, Pfizer Animal Health, USA Development of Leptospira In Vitro Potency Assays: EU/Industry Experience and Perspectives Eric Klaasen, DVM, PhD, MSD Animal Health, The Netherlands Expansion of the In Vitro Assay for Leptospira Potency Testing to Other Serovars: Case Study with Leptospira Hardjo David P. Alt, DVM, PhD, Infectious Bacterial Diseases Research Unit, ARS, USDA Session 3: Reduction and Refinement Alternatives for Potency Testing of Leptospira Vaccines: Development, Validation, and Implementation Development and Validation of a Serological Potency Test for the Release of Leptospira Vaccines in the European Union Elisabeth Balks, DVM, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Germany Product-Specific Validation of a Serological Potency Test for Release of Leptospira Vaccines in the European Union Catrina Stirling, PhD, Pfizer Animal Health, United Kingdom Opportunities and Strategies to Further Reduce Animal Use for Leptospira Vaccine Potency Testing Angela Walker, DVM, PhD, Center for Veterinary Biologics, USDA Opportunities and Strategies to Further Refine Animal Use for Leptospira Vaccine Potency Testing Elsio A. Wunder, Jr., DVM, PhD, Yale School of Public Health, USA Karen K. Brown, PhD, Pair O’Docs Consultants, USA
Oct 11, 2011	International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward	Webinars & Workshops - NICEATM	Agenda Final Documents International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward Final Documents October 11-13, 2011 Workshop Report (Biologicals) Workshop Summary Meeting Materials International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward Meeting Materials October 11-13, 2011 Poster Session Abstracts Workshop Overview

Past Webinars & Workshops - NICEATM

Workshop - Trust Your Gut: Establishing Confidence in Gastrointestinal Models Meeting MaterialsOctober 11-12, 2023

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 3: Evaluating Potential Allergenicity Meeting MaterialsOctober 6, 2023

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 2: Microbiome Effects on Toxicity Meeting MaterialsSeptember 20, 2023

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 1: Absorption and Pharmacokinetics Meeting MaterialsSeptember 18, 2023

Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing Final Documents September 30, 2020

Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing Presentations September 30, 2020

Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Lethality Final Documents October 30-31, 2019

Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations October 25, 2018

Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations September 27, 2018

Workshop: Predictive Models for Acute Oral Systemic Toxicity Final Documents April 11-12, 2018

Workshop: Predictive Models for Acute Oral Systemic Toxicity Presentations April 11-12, 2018

Opening Session

In Silico Approaches for Acute Oral Toxicity: Session 1

In Silico Approaches for Acute Oral Toxicity: Session 2

End User Applications

Breakout Group Sessions

Workshop: Predictive Models for Acute Oral Systemic Toxicity Videos April 11, 2018

Public Meeting: Alternative Test Methods to Reduce Vertebrate Animal Testing Under the Toxic Substances Control Act Videos November 2, 2017

Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Final Documents June 26-27, 2017

Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Meeting MaterialsJune 26-27, 2017

Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Presentations June 26-27, 2017

Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: A Review of Relevant Ontologies and Application of Reasoners Presentations March 2, 2017

Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations March 2, 2017

Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Ontologies 101 Presentations February 16, 2017

Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Introduction to Zebrafish Screening Presentations February 2, 2017

Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements Final Documents September 22-23, 2016

Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements Presentations September 22-23, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Final Documents September 8, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Presentations September 8, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Videos September 8, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Final Documents July 12, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Presentations July 12, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Videos July 12, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Final Documents June 28, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Presentations June 28, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Videos June 28, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Final Documents May 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Presentations May 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Videos May 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Final Documents April 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Presentations April 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Videos April 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Final Documents March 29, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Presentations March 29, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Videos March 29, 2016

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Final Documents February 17-18, 2016

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Meeting MaterialsFebruary 17-18, 2016

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Presentations February 17-18, 2016

Workshop Presentations

Opening Session

Session 1: Application in Risk Assessment: What Do We Need for Decision-making and Prioritization?

Session 2: Metabolism and Excretion

Session 3: In Silico Modeling

Summary Presentations

Webinar Materials

October 7: Setting the Stage: Purpose, Definitions, Scope, and Assumptions

November 4: Building Fit-for-purpose Pharmacokinetic Models

December 3: The Role of Pharmacokinetic Model Evaluation

January 6: Framework for Establishing an Internal Threshold of Toxicological Concern

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Framework for Establishing an Internal Threshold of Toxicological Concern Meeting MaterialsJanuary 6, 2016

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: The Role of Pharmacokinetic Model Evaluation Meeting MaterialsDecember 3, 2015

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Building Fit-for-purpose Pharmacokinetic Models Meeting MaterialsNovember 4, 2015

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Setting the Stage: Purpose, Definitions, Scope, and Assumptions Meeting MaterialsOctober 7, 2015

Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Final Documents September 24-25, 2015

Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Presentations September 24-25, 2015

Session 1: The Regulatory Landscape: When Is Acute Toxicity Data Required and How Is It Used?

Session 2: State of the Science for Acute Toxicity Testing Methods

Session 3: Case Studies

Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Final Documents September 3-5, 2014

Group Discussion Summaries

Other Documents

Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Presentations September 3-5, 2014

Workshop Presentations

Opening Session

Session 1: Building Upon Other Efforts

Session 2: AOPs Under Development

Session 3: Case Studies: Regulatory Uses for Well-Identified AOPs

Session 4: The Risk Context

Breakout Groups

Workshop - Trust Your Gut: Establishing Confidence in Gastrointestinal Models Meeting Materials
October 11-12, 2023

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 3: Evaluating Potential Allergenicity Meeting Materials
October 6, 2023

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 2: Microbiome Effects on Toxicity Meeting Materials
September 20, 2023

Trust Your Gut: Establishing Confidence in Gastrointestinal Models - Webinar 1: Absorption and Pharmacokinetics Meeting Materials
September 18, 2023

Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing Final Documents
September 30, 2020

Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing Presentations
September 30, 2020

Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Lethality Final Documents
October 30-31, 2019

Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations
October 25, 2018

Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations
September 27, 2018

Workshop: Predictive Models for Acute Oral Systemic Toxicity Final Documents
April 11-12, 2018

Workshop: Predictive Models for Acute Oral Systemic Toxicity Presentations
April 11-12, 2018

Workshop: Predictive Models for Acute Oral Systemic Toxicity Videos
April 11, 2018

Public Meeting: Alternative Test Methods to Reduce Vertebrate Animal Testing Under the Toxic Substances Control Act Videos
November 2, 2017

Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Final Documents
June 26-27, 2017

Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Meeting Materials
June 26-27, 2017

Workshop: BioMed21 - A Human Pathway-based Approach to Disease and Medicine Presentations
June 26-27, 2017

Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: A Review of Relevant Ontologies and Application of Reasoners Presentations
March 2, 2017

Webinar Series on the Utility of Zebrafish Models for Toxicology Presentations
March 2, 2017

Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Ontologies 101 Presentations
February 16, 2017

Webinar Series on Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish: Introduction to Zebrafish Screening Presentations
February 2, 2017

Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements Final Documents
September 22-23, 2016

Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements Presentations
September 22-23, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Final Documents
September 8, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Presentations
September 8, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: 21st Century Testing Approaches Videos
September 8, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Final Documents
July 12, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Presentations
July 12, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Adverse Outcome Pathways Videos
July 12, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Final Documents
June 28, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Presentations
June 28, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity Videos
June 28, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Final Documents
May 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Presentations
May 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science and Practical Application of In Silico Methods Videos
May 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Final Documents
April 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Presentations
April 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods Videos
April 26, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Final Documents
March 29, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Presentations
March 29, 2016

Webinar Series on Alternative Approaches for Acute Inhalation Toxicity: Current Testing Practices: Regulatory Requirements and Non-regulatory Testing Videos
March 29, 2016

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Final Documents
February 17-18, 2016

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Meeting Materials
February 17-18, 2016

In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making Presentations
February 17-18, 2016

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Framework for Establishing an Internal Threshold of Toxicological Concern Meeting Materials
January 6, 2016

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: The Role of Pharmacokinetic Model Evaluation Meeting Materials
December 3, 2015

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Building Fit-for-purpose Pharmacokinetic Models Meeting Materials
November 4, 2015

Webinar Series on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making: Setting the Stage: Purpose, Definitions, Scope, and Assumptions Meeting Materials
October 7, 2015

Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Final Documents
September 24-25, 2015

Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Presentations
September 24-25, 2015

Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Final Documents
September 3-5, 2014

Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Presentations
September 3-5, 2014

Scientific Workshop - Adverse Outcome Pathways: From Research to Regulation Videos
September 3, 2014

Workshop on Alternatives to the HIST for Acellular Pertussis Vaccines: Progress and Challenges in the Replacement of HIST Final Documents
August 24, 2014

Workshop on Alternatives to the HIST for Acellular Pertussis Vaccines: Progress and Challenges in the Replacement of HIST Meeting Materials
August 24, 2014

Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology Final Documents
May 5-6, 2014

Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology Meeting Materials
May 5-6, 2014

Collaborative Workshop on Aquatic Toxicity Models and 21st Century Toxicology Presentations
May 5-6, 2014

International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward Final Documents
November 28-29, 2012

International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward Presentations
November 28-29, 2012

International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward Final Documents
September 19-21, 2012

International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward Meeting Materials
September 19-21, 2012

International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing: State of the Science and the Way Forward Presentations
September 19-21, 2012

International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward Final Documents
October 11-13, 2011

International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward Meeting Materials
October 11-13, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Allergic Contact Dermatitis Meeting Materials
January 20, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Allergic Contact Dermatitis Presentations
January 20, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Allergic Contact Dermatitis Videos
January 20, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Eye Injuries Final Documents
January 19, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Eye Injuries Meeting Materials
January 19, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Eye Injuries Presentations
January 19, 2011

Best Practices Workshop: Assessing the Potential for Chemically Induced Eye Injuries Videos
January 19, 2011

Workshop: Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing Final Documents
September 14-16, 2010