Alimentary System
Pancreas
Narrative
The pancreas is surrounded by a thin capsule of loose connective tissue and is composed of exocrine (acinar) tissue and endocrine (Islets of Langerhans) tissue. The exocrine tissue is primarily glandular parenchymal cells separated into lobules by septa of connective tissue with ducts, blood vessels, neuronal cells, and lymphatics. The parenchymal epithelial cells are organized into acini surrounded by basal laminae. Acini have tall columnar or pyramidal epithelial cells with basally located nuclei and apical regions filled with secretory (zymogen) granules surrounding the acinar lumen. The epithelial cell surface bordering the acinar lumen has short microvilli. The endocrine tissue (Islets of Langerhans) can be found throughout the pancreas but is more prevalent in the tail region. There is no capsule separating the Islets of Langerhans cells from the acinar tissue, but there are collagen fibrils and a thin basal lamina between these two types of tissue. The epithelial cells of the Islets are subdivided into four major types of cells. The alpha cells make up approximately 20% of the Islets and are located primarily at the periphery of the Islets. These cells have numerous fairly uniform secretory granules and mitochondria that tend to be elongated and to be smaller than those found in the beta cells. Glucagon is produced by alpha cells. The most common cell is the beta cell. These cells are found more at the interior of the Islets and produce insulin. They tend to have more mitochondria that are larger and more spherical than those of the alpha cells and are reported to have less rough endoplasmic reticulum (Rhodin 1974). The secretory granules of these cells tend to be more polymorphic than those of the alpha cells, with prominent spaces between the granule surface and the electron-dense core. Two other cell types, delta cells and c cells are less common and have also been described by Rhodin (1974).
Cross PC, Mercer KL. 1993. Cell and Tissue Ultrastructure: A Functional Perspective. New York: W.H. Freeman and Company. |
Dellmann HD, Eurell J, eds. 1998. Textbook of Veterinary Histology. 5th ed. Philadelphia: Lippincott Williams & Wilkins. |
Rhodin JAG. 1974. Histology: A Text and Atlas. New York: Oxford University Press. |
Weiss L, ed. 1988. Cell and Tissue Biology: A Textbook of Histology. 6th ed. Baltimore: Urban & Schwarzenberg. |
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