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Webinar on Lessons Learned in Application of the OHAT Framework for Systematic Review and Evidence Integration to Case Studies

July 31, 2014, 12:30 - 3:30 PM EDT, Webinar

The NTP held a public webinar to present “lessons learned” in applying the OHAT Framework for Systematic Review and Evidence Integration to case studies as part of exploring the methods. The meeting was conducted in a presentation and discussion format. The majority of the webinar consisted of a series of presentations focused on 5 overarching topics or “lessons,” each followed by an open question-and-answer period to engage the participants and provide the public with the opportunity to make brief comments or ask questions on the topic. The end of the webinar included additional time for a general discussion period about any additional subjects related to the application of the OHAT Approach to the case studies and lessons learned.


The OHAT has developed a systematic review framework, the OHAT Approach, to address environmental health questions by extending approaches developed for clinical medicine to address the greater range of data relevant to environmental health sciences (e.g., human, animal, and mechanistic studies) (available at the OHAT Implementation of Systematic Review page). The OHAT adapted guidance from authorities on systematic-review and sought advice during development of the OHAT Approach through consultation with technical experts in systematic review and human health assessment as well as scientific advisory groups and the public.

The approach includes seven steps that provide a framework for incorporating systematic review and evidence integration into NTP literature-based, non-cancer health assessments. The framework, released as the Draft OHAT Approach in February 2013 and published in April 2014, was assessed and refined through application of the procedures to case-study evaluations. OHAT applied the approach to two case studies: (1) an evaluation of the association of bisphenol A (BPA) exposure with obesity and (2) an evaluation of the association of perflurooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) exposure with immunotoxicity.

Note: Individuals with disabilities who need accommodation must request it at least five business days prior to the meeting. TTY users should contact the Federal TTY Relay Service at 800-877-8339. Otherwise, contact Dr. Rooney for assistance.

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