https://ntp.niehs.nih.gov/go/750897

Study Reports

About Genetically Modified Model Reports

Genetically modified model reports evaluate the toxicologic potential, including carcinogenic activity, of selected agents in laboratory animals that have been genetically modified. There are two animal types used:

TG.AC: This mouse model has an alteration of specific tumor suppressor genes that have been shown to be associated with induced tumors in rodents and in human malignancies. 

P53 deficient: This mouse model has an alteration of the p53 tumor suppressor gene, which is critical to cell cycle control and DNA repair. 

About Technical Reports

Long-term NTP toxicology and carcinogenicity studies usually involve exposing laboratory animals (rats and mice) to a substance for a period of two years. These studies are designed and conducted to characterize and evaluate the toxicologic potential, including carcinogenic activity, of selected substances. Substances selected for NTP toxicology and carcinogenesis studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. Substance selection is not an indicator of a substance's carcinogenic potential.

The methods, results, and conclusions of these studies are published in NTP's Technical Report (TR) series after undergoing peer review. The interpretive conclusions presented in Technical Reports and Abstracts are based only on the results of these NTP studies.

Learn More About NTP Technical Reports

The studies described in the Technical Reports are performed under the direction of NTP and adhere to the following standards:

  • Studies are conducted in compliance with NTP laboratory health and safety requirements.
  • Studies meet or exceed all applicable federal, state, and local health and safety regulations.
  • Animal care and use are in accord and compliance with the Public Health Service Policy on Humane Care and Use of Animals.
  • Studies are also conducted in compliance with Food and Drug Administration Good Laboratory Practice Regulations (21 CFR, Part 58).

Abstracts are taken from the technical reports and include a link to the full report at the start of the abstracts. When available, the abstracts also link to supporting pathology tables, survival and growth curves; target organs and tumor incidences; and 2-D structures at the end of each abstract.

Definition of Carcinogenicity Results

For more information, contact the NTP Web Team:

About Toxicity Reports

The NTP Toxicity Report Series (TOX) includes reports about short-term studies. These studies usually involve exposing laboratory animals (rats and mice) for 3 months to evaluate the toxicity, but exposure can be any duration less than one year. Substances selected for short-term studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. The selection of a substance is not an indicator of its carcinogenic potential.

The report abstracts in the NTP Toxicity Report Series include brief descriptions of the findings, but a link to the full report is listed at the end of each abstract. In some cases, the short-term studies for a particular substance may be reported with longer term studies and not included in the TOX report series.

The NTP Toxicity Reports are peer-reviewed by at least two external experts, typically in the fields of toxicology, pathology, or other field applicable to the study. NTP also maintains a list of studies undergoing review.

Learn More About Short-Term Studies

Because short-term study experiments are conducted under a limited set of conditions, relating the findings from short-term studies to human health requires additional information and possibly further testing. Positive short-term study findings mean that a substance is toxic for laboratory animals and that exposure to the substance is potentially hazardous to humans. Negative short-term study results mean that study animals did not have a greater incidence of toxicity than control animals; however, negative results do not necessarily mean that a substance is not toxic.

The studies described in the NTP Toxicity Report Series are performed under the direction of NTP. The short-term studies:

  • Comply with NTP laboratory health and safety requirements.
  • Meet or exceed all applicable federal, state, and local health and safety regulations.
  • Comply with the Public Health Service Policy on Humane Care and Use of Animals.
  • Comply with Food and Drug Administration Good Laboratory Practice Regulations (21 CFR, Part 58).

Abstracts are taken from the published reports for the individual studies. A link to the full report is listed at the end of each abstract.

For more information, contact the NTP Web Team:

About Research Reports

NTP research reports cover research and literature-analysis activities that do not fall under the scope of existing report series.

About Developmental & Reproductive Toxicity (DART) Reports

NTP has developed a range of techniques and testing regimes to evaluate the potential of environmental and occupational substances to affect development and damage reproductive systems.

Prenatal developmental toxicity studies identify substances that may pose a risk to the developing fetus if pregnant women are exposed. Regulatory agencies use the results of well-conducted animal studies to help set human exposure guidelines.

We have also developed methods for evaluating the potential toxic effects of exposure to environmental and occupational substances on the reproductive system. These studies are carried out primarily using rodent models.

About Immunotoxicity Reports

NTP has developed a range of techniques and testing regimens for evaluating the potential of environmental and occupational substances to damage the immune system. These materials may include:

  • Food additives
  • Natural products such as mycotoxins
  • Products used in the pharmaceutical, farming, chemical, or consumer product industries

Immunotoxicity tests are designed to evaluate immune function and hypersensitivity. These tests are carried out using rodent models, cultured mammalian cells, and other in vitro methods.

Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, email us or use our contact form and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.

How to search with filtering and sorting

Search for particular reports by filtering or searching the table. As you type in the search box, the page will filter the table results as you type each letter.

Sort by clicking the up or down arrow in a column header. Click again to reverse the order. If only one arrow is displayed, that column is sorted in the direction of the arrow. Only one column can be sorted at a time.

Tools:
AbstractFull TextReport TitleYearType
Filter by Year:Filter by Type:
TR-604 PDF (1.2 MB) Toxicology and Carcinogenesis Study of Triclosan (CASRN 3380-34-5) Administered Dermally to B6C3F1/N Mice 2024 Technical Report
TR-603 PDF (3.02 MB) Toxicology and Carcinogenesis Studies of Black Cohosh Root Extract (CASRN 84776-26-1) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and Female B6C3F1/N Mice 2023 Technical Report
TR-602 PDF (7.96 MB) Toxicology and Carcinogenesis Studies of an Isomeric Mixture of Tris(chloropropyl) Phosphate Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice 2023 Technical Report
TR-601 PDF (4.52 MB) Toxicology and Carcinogenesis Studies of Di(2-ethylhexyl) Phthalate (CASRN 117-81-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats 2021 Technical Report
TR-600 PDF (3.43 MB) Toxicology and Carcinogenesis Studies of Di-n-butyl Phthalate (CASRN 84-74-2) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice 2021 Technical Report
TR-599 PDF (4.15 MB) Toxicology and Carcinogenesis Studies of Sodium Tungstate Dihydrate (CASRN 10213-10-2) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (Drinking Water Studies) 2021 Technical Report
TR-598 PDF (5.51 MB) Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised) 2023 Technical Report
TR-597 PDF (3.25 MB) Toxicology and Carcinogenesis Studies of 2-Hydroxy-4- methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice 2020 Technical Report
TR-596 PDF (4.3 MB) Toxicology and Carcinogenesis Studies in B6C3F1/N Mice Exposed to Whole-Body Radio Frequency Radiation at a Frequency (1,900 MHz) and Modulations (GSM and CDMA) Used by Cell Phones 2018 Technical Report
TR-595 PDF (5.63 MB) Toxicology and Carcinogenesis Studies in Hsd:Sprague Dawley SD Rats Exposed to Whole-Body Radio Frequency Radiation at a Frequency (900 Mhz) and Modulations (GSM and CDMA) Used by Cell Phones 2018 Technical Report
TR-594 PDF (4.27 MB) Toxicology and Carcinogenesis Studies of p-Chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) and B6C3F1/N Mice (Inhalation Studies) 2018 Technical Report
TR-593 PDF (7.24 MB) Toxicology and Carcinogenesis Studies of 2,3-Butanedione (CASRN 431-03-8) in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice (Inhalation Studies) 2018 Technical Report
TR-592 PDF (1.95 MB) Toxicology and Carcinogenesis Study of Dietary Zinc (CASRN 5263-02-5) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Feed Studies) 2019 Technical Report
TR-591 PDF (7.44 MB) Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies) 2016 Technical Report
TR-590 PDF (6.84 MB) Toxicology and Carcinogenesis Studies of Antimony Trioxide (CASRN 1309-64-4) in Wistar Han Rats and B6C3F Mice (Inhalation Studies) 2017 Technical Report
TR-589 PDF (7.33 MB) Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) 2016 Technical Report
TR-588 PDF (3.63 MB) Toxicology and Carcinogenesis Studies of Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and B6C3F1/Nctr Mice (Drinking Water Studies) 2014 Technical Report
TR-587 PDF (3.69 MB) Toxicology Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) 2014 Technical Report
TR-586 PDF (2.83 MB) Toxicology Studies of CIMSTAR 3800 in F344/Ntac Rats and B6C3F1/n Mice and Toxicology and Carcinogenesis Studies of CIMSTAR 3800 in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice (Inhalation Studies) 2015 Technical Report
TR-585 PDF (3.61 MB) Toxicology Studies of Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Green Tea Extract in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) 2016 Technical Report
TR-584 PDF (4.13 MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies) 2017 Technical Report
TR-583 PDF (4.74 MB) Toxicology Studies of Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies) 2015 Technical Report
TR-582 PDF (5.21 MB) Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2015 Technical Report
TR-581 PDF (12.92 MB) Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies) 2014 Technical Report
TR-580 PDF (2.48 MB) Toxicology and Carcinogenesis Studies of beta-Picoline (CASRN 108-99-6) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2014 Technical Report
TR-579 PDF (11.55 MB) Toxicology and Carcinogenesis Studies of N,N-Dimethyl-p-Toluidine (CASRN 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies) 2012 Technical Report
TR-578 PDF (7.96 MB) Toxicology and Carcinogenesis Studies of Ginkgo Biloba Extract (CASRN 90045-36-6) in F344/N Rats and B6C3F1/N Mice (Gavage Studies) 2013 Technical Report
TR-577 PDF (4.69 MB) Toxicology and Carcinogenesis Studies of a Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2013 Technical Report
TR-576 PDF (6.34 MB) Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies) 2012 Technical Report
TR-575 PDF (9.97 MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 Technical Report
TR-574 PDF (13.36 MB) Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 2013 Technical Report
TR-573 PDF (5.77 MB) Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer in F344/N Rats (Perinatal and Postnatal Feed Studies) 2012 Technical Report
TR-572 PDF (8.64 MB) Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CASRN 1896-62-4) in F344/N Rats and B6C3F1 Mice (Feed and Dermal Studies) 2012 Technical Report
TR-571 PDF (12.2 MB) Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2012 Technical Report
TR-570 PDF (15.47 MB) Toxicology and Carcinogenesis Studies of alpha,beta-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2011 Technical Report
TR-569 PDF (7.98 MB) Toxicology and Carcinogenesis Studies of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), Nevirapine (NVP), and Nelfinavir Mesylate (NFV) (CASRNs 30516-87-1, 134678-17-4, 129618-40-2, 159989-65-8) in B6C3F1 Mice (Transplacental Exposure Studies) 2013 Technical Report
TR-568 PDF (19.01 MB) Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid (CASRN 302-79-4) and All-trans-retinyl palmitate (CASRN 79-81-2)) in SKH-1 Mice (Simulated Solar Light and Topical Application Study) 2012 Technical Report
TR-567 PDF (6.78 MB) Toxicology and Carcinogenesis Studies of Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2011 Technical Report
TR-566 PDF (8.5 MB) Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies) 2011 Technical Report
TR-565 PDF (7.68 MB) Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies) 2011 Technical Report
TR-564 PDF (9.39 MB) Toxicology and Carcinogenesis Studies of 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies) 2011 Technical Report
TR-563 PDF (11.14 MB) Toxicology and Carcinogenesis Studies of Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2011 Technical Report
TR-562 PDF (6.44 MB) Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (HYDRASTIS CANADENSIS) in F344/N Rats and B6C3F1 Mice (Feed studies) 2010 Technical Report
TR-561 PDF (13.71 MB) Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2011 Technical Report
TR-560 PDF (7.19 MB) Toxicology and Carcinogenesis Studies of Androstenedione (CASRN 63-05-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2010 Technical Report
TR-559 PDF (6.25 MB) Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies) 2010 Technical Report
TR-558 PDF (22.01 MB) Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (CASRN 14047-09-7) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies) 2010 Technical Report
TR-557 PDF (16.46 MB) Toxicology and Carcinogenesis Studies of beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2010 Technical Report
TR-556 PDF (6.39 MB) Toxicology and Carcinogenesis Studies of Chromium Picolinate Monohydrate (CASRN 27882-76-4) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2010 Technical Report
TR-555 PDF (6.08 MB) Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 2010 Technical Report
Showing 1 to 50 of 754 entries