Urinary System
Kidney - Glomerulosclerosis
Narrative
Comment:
Glomerulosclerosis is a consequence of chronic degenerative changes in the glomerulus and is rarely observed as a primary lesion in NTP studies. Characteristic features include shrinkage and contraction of the glomerular tuft and replacement of the mesangium by fibrosis (Figure 1 and Figure 2). The presence of amyloid deposits must be ruled out because of similar morphologic features. Glomerulosclerosis may be focal, segmental, or global.
Recommendations:
Primary glomerulosclerosis should be diagnosed and given a severity grade. When a component of the spectrum of changes associated with chronic progressive nephropathy or part of a secondary response to some other primary renal disease, glomerulosclerosis should not be diagnosed separately but should be described in the pathology narrative.
References:
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Affected glomeruli often have adhesions (arrow) between the glomerular tuft and Bowman�s capsule.
All Images
Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Several glomeruli (arrows) associated with chronic progressive nephropathy have an increase in eosinophilic matrix and contraction of the glomerular tuft.
Kidney - Glomerulosclerosis in a male Wistar Han rat from a chronic study. Affected glomeruli often have adhesions (arrow) between the glomerular tuft and Bowman�s capsule.