Alimentary System

Stomach, Forestomach - Foreign Body

Narrative
Comment:
Hair or feed material can become embedded in the wall of the forestomach secondary to injury from a gavage procedure or ulceration from xenobiotics. In Figure 1 and Figure 2, a small granuloma with a central hair shaft (arrow) is in the submucosa; the overlying mucosa has healed from a previous injury. This is considered a small incidental lesion in a control animal that may have occurred secondary to previous gavage trauma.
Recommendations:
A primary foreign body should be diagnosed but not graded. If a foreign body causes a significant inflammatory response, then both the foreign body and inflammation are diagnosed. A foreign body such as hairs or feed material that has been passively pushed into an ulcerated area should not be diagnosed separately but can be described in the narrative.
References:

Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.

Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.

Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
  • Image of foreign body in the forestomach from a male F344/N rat in a chronic study

    Stomach, Forestomach - Foreign body in a male F344/N rat from a chronic study. A foreign body (hair) (arrow) has penetrated the epithelium and submucosa.

Enlarge Image
Enlarge All Images
<p>Stomach, Forestomach - Foreign body in a male F344/N rat from a chronic study. A foreign body (hair) (arrow) has penetrated the epithelium and submucosa.</p>

Stomach, Forestomach - Foreign body in a male F344/N rat from a chronic study. A foreign body (hair) (arrow) has penetrated the epithelium and submucosa.
<p>Stomach, Forestomach - Foreign body in a male F344/N rat from a chronic study (higher magnification of Figure 1). A foreign body (hair) (arrow) with associated granulomatous inflammation is present in the submucosa.</p>

Stomach, Forestomach - Foreign body in a male F344/N rat from a chronic study (higher magnification of Figure 1). A foreign body (hair) (arrow) with associated granulomatous inflammation is present in the submucosa.

Authors:

Linda H. Kooistra, DVM, PhD, DACVP
Pathologist
Charles River Laboratories, Inc.
Research Triangle Park, NC

Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
Expert in Toxicologic Pathology
Visiting Full Professor of Pathology
Sackler School of Medicine, Tel Aviv University Timrat Israel

Reviewers:

Joel R. Leininger, DVM, PhD
Senior Pathologist
MedImmune
Washington, DC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC