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  • Stomach, Forestomach - Hemorrhage

    Image of hemorrhage in the forestomach from a female B6C3F1 mouse in a chronic study
    Stomach, Forestomach - Hemorrhage in a female B6C3F1 mouse from a chronic study. Hemorrhage is present in the submucosa of the forestomach.
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    comment:

    Hemorrhage in the forestomach ( Figure 1image opens in a pop-up window ) may be spontaneous (idiopathic), related to the gavage procedure, or due to direct/indirect chemical toxicity. It is often associated with inflammation.

    recommendation:

    Hemorrhage should be diagnosed and graded based on the extent of the lesion. Hemorrhage that is a minor component of another process such as ulceration, necrosis, or inflammation is not diagnosed separately unless the hemorrhage is a prominent component of the lesion.

    references:

    Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.
    Abstract: http://www.cacheriverpress.com/books/pathmouse.htm