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Stomach, Forestomach - Hemorrhage

Image of hemorrhage in the forestomach from a female B6C3F1 mouse in a chronic study
Stomach, Forestomach - Hemorrhage in a female B6C3F1 mouse from a chronic study. Hemorrhage is present in the submucosa of the forestomach.
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comment:

Hemorrhage in the forestomach ( Figure 1image opens in a pop-up window ) may be spontaneous (idiopathic), related to the gavage procedure, or due to direct/indirect chemical toxicity. It is often associated with inflammation.

recommendation:

Hemorrhage should be diagnosed and graded based on the extent of the lesion. Hemorrhage that is a minor component of another process such as ulceration, necrosis, or inflammation is not diagnosed separately unless the hemorrhage is a prominent component of the lesion.

references:

Leininger JR, Jokinen MP, Dangler CA, Whiteley LO. 1999. Oral cavity, esophagus, and stomach. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, St Louis, MO, 29-48.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.